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Recent literature: 5-HT1B and 5-HT1D receptor agonist
Date Journal Article title
2018 Nov Neuroscience Expression of Pituitary Adenylate Cyclase-activating Peptide, Calcitonin Gene-related Peptide and Headache Targets in the Trigeminal Ganglia of Rats and Humans.
2018 Dec Eur J Pharmacol Sumatriptan inhibits the electrophysiological activity of ASICs in rat trigeminal ganglion neurons.
2018 Sep Handb Exp Pharmacol Other Antidepressants.
2018 Apr J Anim Sci Pharmacologic assessment of bovine ruminal and mesenteric vascular serotonin receptor populations.
2018 Jun Brain Res The multimodal antidepressant vortioxetine may facilitate pyramidal cell firing by inhibition of 5-HT3 receptor expressing interneurons: An in vitro study in rat hippocampus slices.
2018 Fundam Clin Pharmacol Pharmacological evidence of involvement of nitric oxide pathway in anti-pruritic effects of sumatriptan in chloroquine-induced scratching in mice.
2017 Clin Exp Pharmacol Physiol 5-HT modulates the rat mesenteric vasopressor outflow by 5-HT1D sympatholytic receptors.
2017 Aug Int J Neuropsychopharmacol Preclinical Evidence That 5-HT1B Receptor Agonists Show Promise as Medications for Psychostimulant Use Disorders.
2017 Expert Opin Investig Drugs Serotonin receptor targeted therapy for migraine treatment: an overview of drugs in phase I and II clinical development.
2016 Riv Psichiatr [Vortioxetine in the treatment of major depression].
2017 Apr Int J Neuropsychopharmacol Chronic Vortioxetine Treatment Reduces Exaggerated Expression of Conditioned Fear Memory and Restores Active Coping Behavior in Chronically Stressed Rats.
2016 Nov Sci Rep Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats.
2016 Oct J Neurophysiol Firing characteristics of deep dorsal horn neurons after acute spinal transection during administration of agonists for 5-HT1B1D and NMDA receptors.
2016 Encephale [The pharmacological basis of the serotonin system: Application to antidepressant response].
2016 Neuropharmacology Involvement of 5-HT3 receptors in the action of vortioxetine in rat brain: Focus on glutamatergic and GABAergic neurotransmission.
2016 Pain Gi-protein-coupled 5-HT1BD receptor agonist sumatriptan induces type I hyperalgesic priming.
2016 Jun Eur J Pharmacol Role of 5-HT5A and 5-HT1B1D receptors in the antinociception produced by ergotamine and valerenic acid in the rat formalin test.
2016 Expert Rev Neurother New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine.
2016 Jul Prog Neuropsychopharmacol... Histamine may contribute to vortioxetine's procognitive effects; possibly through an orexigenic mechanism.
2016 Encephale [Pharmacological properties of vortioxetine and its pre-clinical consequences].
2016 Neuropharmacology Vortioxetine promotes maturation of dendritic spines in vitro: A comparative study in hippocampal cultures.
2015 J Psychopharmacol Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism.
2015 Vascul Pharmacol 5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats.
2015 Clin Exp Pharmacol Physiol Pharmacological evidence that 5-HT1D activation induces renal vasodilation by NO pathway in rats.
2015 J Pharmacol Sci The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats.
2015 Pharmacol Res Perspect 5-HT is a potent relaxant in rat erior mesenteric veins.
2015 Psychopharmacology (Berl) Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain.
2015 Apr Prog Neuropsychopharmacol... Effect of the multimodal acting antidepressant vortioxetine on rat hippocampal plasticity and recognition memory.
2015 J Cardiovasc Pharmacol GR-127935-sensitive mechanism mediating hypotension in anesthetized rats: are 5-HT5B receptors involved?
2015 Neuropharmacology Involvement of 5-HT₇ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents.
2014 Expert Rev Neurother The efficacy of vortioxetine for the treatment of major depressive disorder.
2014 Pharmacol Biochem Behav Possible involvement of CA1 5-HT1B1D and 5-HT2A2B2C receptors in harmaline-induced amnesia.
2014 J Psychopharmacol Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus.
2015 Pharmacol Ther Vortioxetine, a novel antidepressant with multimodal activity: review of preclinical and clinical data.
2014 Int J Neuropsychopharmacol Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats.
2014 Br J Pharmacol Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine--a quantitative EEG study in rats.
2014 Bull Exp Biol Med Effect of peptides corresponding to extracellular domains of serotonin 1B1D receptors and melanocortin 3 and 4 receptors on hormonal regulation of adenylate cyclase in rat brain.
2014 Neuropsychiatr Dis Treat Emerging therapeutic options for acute migraine: focus on the potential of lasmiditan.
2013 Drugs Today (Barc) Vortioxetine for the treatment of major depression.
2014 Int Sch Res Notices Sublingual Delivery of Frovatriptan: An Indication of Potential Alternative Route.
2014 Eur Neuropsychopharmacol Vortioxetine, but not escitalopram or duloxetine, reverses memory impairment induced by central 5-HT depletion in rats: evidence for direct 5-HT receptor modulation.
2013 Pharmacol Biochem Behav Vortioxetine (Lu AA21004), a novel multimodal antidepressant, enhances memory in rats.
2013 J Psychopharmacol The 5-HT1D1B receptor agonist sumatriptan enhances fear of simulated speaking and reduces plasma levels of prolactin.
2013 Mar Neuroscience Role of endothelial cells in antihyperalgesia induced by a triptan and β-blocker.
2013 J Neurophysiol Reduction of spinal sensory transmission by facilitation of 5-HT1BD receptors in noninjured and spinal cord-injured humans.
2013 Cephalalgia NXN-188, a selective nNOS inhibitor and a 5-HT1B1D receptor agonist, inhibits CGRP release in preclinical migraine models.
2004 Molecular Imaging and Con... 3-Chloro-4-[18F]fluorophenyl-(4-fluoro-4-[[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl]-piperidin-1-yl)methanone (F15599)
2004 Molecular Imaging and Con... 3-Chloro-4-[18F]fluorophenyl-(4-fluoro-4-[[((5-methyl-4-methylamino-pyridin-2-ylmethyl)-amino]-methyl]-piperidin-1-yl)methanone (F13714)
2004 Molecular Imaging and Con... [O-imethyli-11C]2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2iHi,4iHi)dione
2012 Pain mRNA expression of 5-hydroxytryptamine 1B, 1D, and 1F receptors and their role in controlling the release of calcitonin gene-related peptide in the rat trigeminovascular system.
2010 Jun J Exp Biol Homeostasis of glucose in the rainbow trout (Oncorhynchus mykiss Walbaum): the role of serotonin.
2010 Arzneimittelforschung Differential involvement of 5-HT(1A) and 5-HT(1B1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test.
2009 Arch Cardiol Mex [Role of serotonin receptors in vascular tone in the pithed rat].
2010 Feb Neuroscience Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
2009 Reprod Sci Regulation of human umbilical artery contractility by different serotonin and histamine receptors.
2009 Dec Behav Brain Res Tonic serotonergic control of ingestive behaviours in the pigeon (Columba livia): the role of the arcopallium.
2009 Aug Eur J Pharmacol Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.
2008 Nov Mol Pain Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey.
2008 Jun J Med Chem Designing selective, high affinity ligands of 5-HT1D receptor by covalent dimerization of 5-HT1F ligands derived from 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide.
2008 Pain Activation of the 5-HT1BD receptor reduces hindlimb neurogenic inflammation caused by sensory nerve stimulation and capsaicin.
2007 Br J Pharmacol Activation of 5-HT1B and 5-HT1D receptors in the rat nucleus tractus solitarius: opposing action on neurones that receive an excitatory vagal C-fibre afferent input.
2006 Pharmacol Rep Functional and molecular identification of 5-hydroxytryptamine receptors in rabbit pulmonary artery: involvement in complex regulation of noradrenaline release.
2006 Apr Eur J Pharmacol SB-649915, a novel, potent 5-HT1A and 5-HT1B autoreceptor antagonist and 5-HT re-uptake inhibitor in native tissue.
2006 Naunyn Schmiedebergs Arch... 5-HT-stimulated [35S]guanosine-5'-O-(3-thio)triphosphate binding as an assay for functional activation of G proteins coupled with 5-HT1B receptors in rat striatal membranes.
2005 Clin Exp Pharmacol Physiol Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.
2005 Oct Bioorg Med Chem Lett 8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands.
2005 Clin Sci (Lond) Triptan-induced contractile (5-HT1B receptor) responses in human cerebral and coronary arteries: relationship to clinical effect.
2005 Br J Pharmacol Postsynaptic 5-HT1B receptors modulate electroshock-induced generalised seizures in rats.
2004 Pharmacol Biochem Behav Effect of 5-HT1BD receptor agonist and antagonist administration on motor function in haloperidol and MPTP-treated common marmosets.
2004 Nov Brain Res Ingestive behaviors and metabolic fuels after central injections of 5-HT1A and 5-HT1D1B receptors agonists in the pigeon.
2004 Oct Eur J Pharmacol Roles of serotonin receptor types for the antinociception of 5-HT in the spinal cord of rats.
2004 Neurologia [Spanish contribution to the clinical development of eletriptan: an analysis of controlled studies].
2004 Sep Eur J Pharmacol In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist.
2004 Ann Neurol Activation of 5-HT(1B1D) receptor in the periaqueductal gray inhibits nociception.
2004 Sep Brain Res Involvement of 5-HT1B receptors within the ventral tegmental area in regulation of mesolimbic dopaminergic neuronal activity via GABA mechanisms: a study with dual-probe microdialysis.