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Recent literature: Integrase inhibitor
Date Journal Article title
2020 Feb J Mol Biol A peptide derived from lens epithelium-derived growth factor stimulates HIV-1 DNA integration and facilitates intasome structural studies.
2020 Feb Int J STD AIDS Development of gynecomastia following initiation of bictegraviremtricitabinetenofovir alafenamide.
2020 Feb Lancet HIV Updated assessment of risks and benefits of dolutegravir versus efavirenz in new antiretroviral treatment initiators in -Saharan Africa: modelling to inform treatment guidelines.
2020 HIV Med The potential role of bictegraviremtricitabinetenofovir alafenamide (BICFTCTAF) single-tablet regimen in the expanding spectrum of fixed-dose combination therapy for HIV.
2020 Jan J Pharm Biomed Anal HPLC-MSMS method for the simultaneous quantification of dolutegravir, elvitegravir, rilpivirine, darunavir, ritonavir, raltegravir and raltegravir-β-d-glucuronide in human plasma.
2020 Feb Science Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
2020 Feb Science Structural basis for strand-transfer inhibitor binding to HIV intasomes.
2020 Jan Curr HIV Res Binding Insight of Anti-HIV Phytocompounds with Prime Targets of HIV: A Molecular Dynamics Simulation Analysis.
2020 Curr Opin HIV AIDS Antiretroviral therapy in older people with HIV.
2020 Jan J Antimicrob Chemother Efficacy of intermittent short cycles of integrase inhibitor-based maintenance ART in virologically pressed HIV patients.
2020 Jan J Antimicrob Chemother HIV MDR is still a relevant issue despite its dramatic drop over the years.
2020 PLoS One HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells.
2020 Jan J Infect Dis Expanded Spectrum of Antiretroviral-Selected Mutations in Human Immunodeficiency Virus Type 2.
2020 Jan Pharmacoepidemiol Drug Saf Comedication prescription patterns and potential for drug-drug interactions with antiretroviral therapy in people living with human immunodeficiency virus type 1 infection in Germany.
2020 Expert Opin Ther Pat A literature review of the patent application publications on cabotegravir - an HIV integrase strand transfer inhibitor.
2020 Jan J Virol Capsid labelled HIV to investigate the role of capsid during nuclear import and integration.
2020 Jan Int J Antimicrob Agents Retrospective Study On The Outcomes Of Two-drugs Regimens Based On Dolutegravir Plus One Reverse Transcriptase Inhibitor In Virologically Suppressed, HIV-Infected Patients.
2020 Mar J Acquir Immune Defic Syndr Uptake and Discontinuation of Integrase Inhibitors (INSTIs) in a Large Cohort Setting.
2020 Jan MMWR Morb Mortal Wkly Rep Neural Tube Defects in Pregnancies Among Women With Diagnosed HIV Infection - 15 Jurisdictions, 2013-2017.
2020 Jan J Acquir Immune Defic Syndr Raltegravir (RAL) in neonates: Dosing, pharmacokinetics (PK), and safety in HIV-1 exposed neonates at risk of infection (IMPAACT P1110).
2020 Jan Sex Transm Infect Anal dysplasia and HIV shedding in ART-treated men.
2020 Jan Clin Infect Dis Efficacy and Safety of Switching to DolutegravirLamivudine Fixed-Dose Two-Drug Regimen Versus Continuing a Tenofovir Alafenamide-Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1: Phase 3, Randomized, Non-inferiority TANGO Study.
2019 Infect Chemother Comparison of Characteristics and Survival between Prospective and Retrospective Korea Human Immunodeficiency VirusAcquired Immune Deficiency Syndrome Cohort Studies.
2019 Dec AIDS Switch from tenofovir DF to raltegravir is not associated with weight gain over 96 weeks.
2020 Jan Infection Pregnancy and neonatal outcomes in women with HIV-1 exposed to integrase inhibitors, protease inhibitors and non-nucleoside reverse transcriptase inhibitors: an observational study.
2019 EClinicalMedicine Immune reconstitution inflammatory syndrome in HIV infected late presenters starting integrase inhibitor containing antiretroviral therapy.
2019 EClinicalMedicine Initiation of antiretroviral therapy with integrase strand-transfer inhibitor-based regimens and reduction of the risk of horizontal transmission of HIV-1.
2019 Dec J Med Virol Analyses of HIV-1 integrase gene sequences among treatment-naive patients in the Eastern Cape, South Africa.
2019 Dec Int J Infect Dis Weight gain and dyslipidemia among virally pressed HIV-positive patients switching to co-formulated elvitegravircobicistatemtricitabinetenofovir alafenamide.
2020 Jan Acc Chem Res Cutting into the Substrate Dominance: Pharmacophore and Structure-Based Approaches toward Inhibiting Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H.
2019 Oct Pharmacoeconomic Review R...
2020 Feb AIDS Time to rethink endpoints for new clinical trials of antiretrovirals? Long-term re-pression of HIV RNA with integrase inhibitors.
2020 Infect Dis (Lond) No progression of clinical atherosclerosis in HIV-infected patients starting an initial regimen including tenofovir alafenamideemtricitabine plus raltegravir, dolutegravir or elvitegravircobicistat during a two-year follow-up.
2020 Mar J Antimicrob Chemother Pharmacokinetics and antiviral activity of cabotegravir and rilpivirine in cerebrospinal fluid following long-acting injectable administration in HIV-infected adults.
2020 Drugs DolutegravirLamivudine Single-Tablet Regimen: A Review in HIV-1 Infection.
2020 Mar J Antimicrob Chemother Prediction of dolutegravir pharmacokinetics and dose optimization in neonates via physiologically based pharmacokinetic (PBPK) modelling.
2019 Dec Infez Med Clinical pharmacology of the single tablet regimen bictegraviremtricitabinetenofovir alafenamide (BICFTCTAF).
2019 Drugs Today (Barc) Bictegravir, a novel integrase inhibitor for the treatment of HIV infection.
2019 Dec Molecules Characterization of Nine Compounds Isolated from the Acid Hydrolysate of iLonicera fulvotomentosai Hsu et S. C. Cheng and Evaluation of Their In Vitro Activity towards HIV Protease.
2020 Jan AIDS Res Hum Retroviruses HIV-1 Integrase Diversity and Resistance-Associated Mutations and Polymorphisms Among Integrase Strand Transfer Inhibitor-Naive HIV-1 Patients from Cameroon.
2019 Dec Antimicrob Agents Chemother Detectability of HIV residual viremia despite therapy is highly associated with treatment with a protease inhibitor-based combination ART.
2020 Antiviral Res Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors.
2020 Jan J Acquir Immune Defic Syndr Forecasting Prevalence of HIV-1 Integrase Strand Transfer Inhibitor (INSTI) Drug Resistance: A Modeling Study.
2019 Medicine (Baltimore) Non-traumatic perforation of the jejunum in a human immunodeficiency virus-infected patient receiving combination antiretroviral therapy: A case report.
2020 Int J STD AIDS Changes in HIV antiretroviral prescribing practices in the United States.
2020 Curr Opin Infect Dis Weight gain and integrase inhibitors.
2020 J Biomol Struct Dyn Dual inhibitor design for HIV-1 reverse transcriptase and integrase enzymes: a molecular docking study.
2019 Nov Planta Up-regulation of microRNA targets correlates with symptom severity in Citrus sinensis plants infected with two different isolates of citrus psorosis virus.
2019 Nov J Clin Med Impact of Antiretroviral Therapy on the Risk of Recurrence in HIV-1 Infected Patients with Kaposi Sarcoma: A Multicenter Cohort Experience.
2019 Obstet Gynecol Combination Antiretroviral Therapy and Hypertensive Disorders of Pregnancy.
2019 Nov AIDS Virological and immunological impact of integrase inhibitor-based regimens initiated during primary HIV-1 infection.
2020 Feb Bioorg Med Chem Lett Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
2020 Jan Bioorg Med Chem Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGFp75 disruptors and inhibitors of microbial pathogens.
2019 PLoS One Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon.
2019 HIV AIDS (Auckl) Dolutegravir And Lamivudine Combination For The Treatment Of HIV-1 Infection.
2019 Nov Sci Rep Similar plasma lipidomic profile in people living with HIV treated with a darunavir-based or an integrase inhibitor-based antiretroviral therapy.
2020 J Manag Care Spec Pharm Rapid Initiation of Antiretroviral Therapy Following Diagnosis of Human Immunodeficiency Virus Among Patients with Commercial Insurance Coverage.
2020 J Manag Care Spec Pharm Long-Term Benefits of Rapid Antiretroviral Therapy Initiation in Reducing Medical and Overall Health Care Costs Among Medicaid-Covered Patients with Human Immunodeficiency Virus.
2019 Dec J Antimicrob Chemother Variability of the HIV-1 3' polypurine tract (3'PPT) region and implication in integrase inhibitor resistance.
2019 Nov AIDS Time to rethink endpoints for new antiretroviral regimen registration? HIV RNA re-pression in the ADVANCE trial.
2019 Nov Med Mal Infect High rates of antiretroviral coverage and virological pression in HIV-1-infected children and adolescents.
2019 Nov Infection Weight gain in antiretroviral therapy-naive HIV-1-infected patients starting a regimen including an integrase strand transfer inhibitor or darunavirritonavir.
2019 Nov J Matern Fetal Neonatal Med Comparison of two combined antiretroviral treatment regimens in the management of HIV in pregnancy: an observational study.
2020 Cytokine The impact of integrase inhibitor-based regimens on markers of inflammation among HIV naïve patients.
2019 PLoS One CCR5 receptor antagonism inhibits hepatitis C virus (HCV) replication in vitro.
2019 Open Forum Infect Dis Recent Trends and Effectiveness of Antiretroviral Regimens Among Men Who Have Sex With Men Living With HIV in the United States: The Multicenter AIDS Cohort Study (MACS) 2008-2017.
2020 Curr Opin HIV AIDS HIV treatment and prevention 2019: current standards of care.
2012 LiverTox: Clinical and Re... Antiviral Agents
2012 LiverTox: Clinical and Re... Dolutegravir
2012 LiverTox: Clinical and Re... Raltegravir
2012 LiverTox: Clinical and Re... Bictegravir
2012 LiverTox: Clinical and Re... Elvitegravir
2020 Jan J Antimicrob Chemother Surveillance of HIV-1 primary infections in France from 2014 to 2016: toward stable resistance, but higher diversity, clustering and virulence?
2020 Jan ACS Infect Dis Rational Design of Doravirine: From Bench to Patients.
2020 Jan J Antimicrob Chemother Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.