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Recent literature: Integrase inhibitor
Date Journal Article title
2019 Feb Retrovirology Replication competence of virions induced from CD4+ lymphocytes latently infected with HIV.
2019 Feb J Antimicrob Chemother Stable prevalence of transmitted drug resistance mutations and increased circulation of non-B types in antiretroviral-naive chronically HIV-infected patients in 20152016 in France.
2019 Feb J Neurovirol Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes.
2019 Feb J Biomol Struct Dyn Effective prediction model and determination of binding residues influential for inhibitors targeting HIV-1 integrase-LEDGFp75 interface by employing solvent accessible surface area energy as key determinant.
2019 Feb Toxicol Appl Pharmacol The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta.
2019 Feb Pharmacotherapy Effectiveness of Once-Daily Dolutegravir plus Boosted Darunavir as a Switch Strategy in Human Immunodeficiency Virus-Infected, Heavily Treated Patients.
2019 Expert Opin Pharmacother Bictegravir in a fixed-dose tablet with emtricitabine and tenofovir alafenamide for the treatment of HIV infection: pharmacology and clinical implications.
2019 HIV Med Discontinuation of dolutegravir, elvitegravircobicistat and raltegravir because of toxicity in a prospective cohort.
2019 Jan J Antimicrob Chemother Progressive increases in fat mass occur in adults living with HIV on antiretroviral therapy, but patterns differ by sex and anatomic depot.
2019 Open Forum Infect Dis Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance.
2018 Jun Pharmacoeconomic Review R...
2019 Jan Clin Drug Investig HIV Integrase Inhibitor Pharmacogenetics: An Exploratory Study.
2019 Jan BMC Public Health HIV treatment regimens and adherence to national guidelines in Australia: an analysis of dispensing data from the Australian pharmaceutical benefits scheme.
2019 Antiviral Res Discovery of 4-oxoquinolines, a new chemical class of anti-HIV-1 compounds.
2018 Dec Br J Clin Pharmacol Atrial fibrillation and human immunodeficiency virus type-1 infection: a systematic review. Implications for anticoagulant and antiarrhythmic therapy.
2018 Dec J Virol PF74 Inhibits HIV-1 Integration by Altering The Composition of the Preintegration Complex.
2018 AIDS Rev Overcoming Obstacles in Lipid-lowering Therapy in Patients with HIV - A Systematic Review of Current Evidence.
2019 Mar J Antimicrob Chemother Integrase strand transfer inhibitors and neuropsychiatric adverse events in a large prospective cohort.
2018 Heliyon Relationship between HIV integrase polymorphisms and integrase inhibitor susceptibility: An iin silicoi analysis.
2018 Lancet HIV Safety and efficacy at 240 weeks of different raltegravir formulations in children with HIV-1: a phase 12 open label, non-randomised, multicentre trial.
2019 Lancet HIV Risks and benefits of dolutegravir-based antiretroviral drug regimens in -Saharan Africa: a modelling study.
2018 Open Forum Infect Dis Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient.
2018 PLoS Med Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial.
2019 Mar AIDS Success and failure of initial antiretroviral therapy in adults: an updated systematic review.
2018 HIV AIDS (Auckl) Profile of bictegraviremtricitabinetenofovir alafenamide fixed dose combination and its potential in the treatment of HIV-1 infection: evidence to date.
2019 HIV Med Prevalence and determinants of resistance mutations in HIV-1-infected patients exposed to integrase inhibitors in a large Italian cohort.
2018 Drugs BictegravirEmtricitabineTenofovir Alafenamide: A Review in HIV-1 Infection.
2018 HIV Clin Trials Sleep and neuropsychological performance in HIV+ jects on efavirenz-based therapy and response to switch in therapy.
2018 HIV Clin Trials Satisfaction and acceptability of cabotegravir long-acting injectable suspension for prevention of HIV: Patient perspectives from the ECLAIR trial.
2018 J Photochem Photobiol B Efficient discrimination of natural stereoisomers of chicoric acid, an HIV-1 integrase inhibitor.
2018 Medicine (Baltimore) Integrase inhibitor-based regimens result in more rapid virologic pression rates among treatment-naïve human immunodeficiency virus-infected patients compared to non-nucleoside and protease inhibitor-based regimens in a real-world clinical setting: A retrospective cohort study.
2018 Nov Med Mal Infect Which antiretrovirals should be prescribed as first-line treatments? Changes over the past 10 years in France.
2018 PLoS Med Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial.
2018 Drugs DolutegravirRilpivirine: A Review in HIV-1 Infection.
2018 Nov Angew Chem Int Ed Engl Corrigendum: 7-Step Flow Synthesis of the HIV Integrase Inhibitor Dolutegravir.
2018 Nov Eur J Drug Metab Pharmaco... Pharmacokinetics and Pharmacodynamics of Cabotegravir, a Long-Acting HIV Integrase Strand Transfer Inhibitor.
2019 Jan J Virol Dolutegravir Monotherapy of Simian Immunodeficiency Virus-Infected Macaques Selects for Several Patterns of Resistance Mutations with Variable Virological Outcomes.
2019 Feb J Antimicrob Chemother Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.
2019 Mar J Clin Endocrinol Metab Changes in Body Fat Distribution in Antiretroviral-Naive HIV-Positive Individuals Initiating Current ART Regimens.
2018 HIV Clin Trials Association of raltegravir use with long-term health outcomes in HIV-infected patients: an observational post-licensure safety study in a large integrated healthcare system.
2018 Oct J Pediatric Infect Dis Soc Compromise of Second-Line Antiretroviral Therapy Due to High Rates of Human Immunodeficiency Virus Drug Resistance in Mozambican Treatment-Experienced Children With Virologic Failure.
2018 Oct Antivir Ther Increased dose of dolutegravir as a potential rescue therapy in multi-experienced patients.
2018 Nov J Med Chem Discovery and Structure-Activity-Relationship Study of N-Alkyl-5-hydroxypyrimidinone Carboxamides as Novel Antitubercular Agents Targeting Decaprenylphosphoryl-β-d-ribose 2'-Oxidase.
2018 Biochem Pharmacol CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor.
2018 Oct Mini Rev Med Chem A review on quinoline derived scaffolds as Anti-HIV Agents.
2019 Oncologist Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.
2018 Innov Clin Neurosci Implementation of the Electronic Columbia-Suicide Severity Rating Scale (eC-SSRS™) Across Four Phase IIIb Clinical Trials in HIV-infected Individuals (ARIA, STRIIVING, DAWNING and INSPIRING).
2018 Sep Clin Pharmacol Drug Dev Effect of a High-Fat Meal on the Pharmacokinetics of the HIV Integrase Inhibitor Cabotegravir.
2019 AIDS Res Hum Retroviruses Integrase Strand Transfer Inhibitor Resistance Mutations in Antiretroviral Therapy-Naive and Treatment-Experienced HIV Patients in South Korea.
2018 Rev Esp Quimioter [HIV-1 integrase inhibitor resistance among treatment naïve patients in Gran Canaria, 2017].
2019 Cell Microbiol Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import.
2018 Dev Dyn Crelox-controlled spatiotemporal perturbation of FGF signaling in zebrafish.
2019 Biomed Chromatogr Development and validation of LC-MSMS method for quantification of bictegravir in human plasma and its application to an intracellular uptake study.
2017 Lancet Child Adolesc Health Safety, efficacy, and pharmacokinetics of single-tablet elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in virologically pressed, HIV-infected children: a single-arm, open-label trial.
2019 Infection Overdose of elvitegravircobicistatemtricitabinetenofovir alafenamide in an HIV-1-infected ject with attempted suicide.
2018 Sep Ann Intern Med HIV Viral Suppression Trends Over Time Among HIV-Infected Patients Receiving Care in the United States, 1997 to 2015: A Cohort Study.
2018 Nov AIDS New antiretroviral agent use affects prevalence of HIV drug resistance in clinical care populations.
2018 Infect Drug Resist HIV-1 genotypic drug resistance in patients with virological failure to single-tablet antiretroviral regimens in southern Taiwan.
2018 Front Microbiol Structural Implications of Genotypic Variations in HIV-1 Integrase From Diverse Subtypes.
2018 Aug Nat Commun Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction.
2018 Nov AIDS The association between oral disease and type of antiretroviral therapy among perinatally HIV-infected youth.
2018 Aug Mol Neurobiol Nanoformulated Antiretroviral Therapy Attenuates Brain Metabolic Oxidative Stress.
2018 Jul BMC Infect Dis Improvement of lipid profile after switching from efavirenz or ritonavir-boosted protease inhibitors to rilpivirine or once-daily integrase inhibitors: results from a large observational cohort study (SCOLTA).
2018 Antimicrob Agents Chemother Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands.
2018 Trop Med Int Health HIV-1 drug resistance testing at second-line regimen failure in Arua, Uganda: avoiding unnecessary switch to an empiric third-line.
2019 Jan Clin Infect Dis Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society-USA Panel.
2018 Jul Molecules HIV-1 Integrase-Targeted Short Peptides Derived from a Viral Protein R Sequence.
2018 Jul J Virol The HIV integrase inhibitor raltegravir inhibits felid alphaherpesvirus 1 (FeHV-1) replication by targeting both DNA replication and late gene expression.
2018 Jul JAMA Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society-USA Panel.
2018 Aug Eur J Med Chem 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.
2018 Open Heart HIV-associated cardiovascular disease: importance of platelet activation and cardiac fibrosis in the setting of specific antiretroviral therapies.
2018 Antimicrob Agents Chemother iIn Vitroi Antiviral Activity of Cabotegravir against HIV-2.
2018 Oct J Infect Dis Accumulation of Multiple Mutations In Vivo Confers Cross-Resistance to New and Existing Integrase Inhibitors.
2018 Int J Antimicrob Agents Time spent with residual viraemia after virological pression below 50 HIV-RNA copiesmL according to type of first-line antiretroviral regimen.
2018 Arch Med Sci Dual therapy based on raltegravir and boosted protease inhibitors - the experience of Polish centers.