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Recent literature: D2 receptor antagonist
Date Journal Article title
2020 Jan BMC Biol Control of glutamate release by complexes of adenosine and cannabinoid receptors.
2020 Jan Sci Rep Structure-based development of caged dopamine D2D3 receptor antagonists.
2020 Jan Arch Soc Esp Oftalmol Dopamine D2 receptor influences eye development and function in Zebrafish.
2020 Expert Opin Pharmacother The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).
2020 Jan Drug Alcohol Depend Role of the treatment environment in the effects of aripiprazole on ethanol-induced behavioral sensitization and conditioned place preference in female mice.
2020 Jan J Exp Biol Experimental evidence for a role of dopamine on avian personality traits.
2020 Jan Brain Sci Pharmacological Mechanisms Involved in Sensory Gating Disruption Induced by (±)-3,4-Methylene- Dioxymethamphetamine (MDMA): Relevance to Schizophrenia.
2020 Jan Neuropsychopharmacology Dorsal and ventral striatal dopamine D1 and D2 receptors differentially modulate distinct phases of serial visual reversal learning.
2020 Jan Environ Sci Technol Biological Activity-Based Prioritization of Pharmaceuticals in Wastewater for Environmental Monitoring: G Protein-Coupled Receptor Inhibitors.
2020 Jan Neurobiol Learn Mem The D2-family receptor agonist bromocriptine but, not nicotine, reverses NMDA receptor antagonist-induced working memory deficits in the radial arm maze in mice.
2020 Jan Stem Cell Res Ther Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells.
2019 Nov Biol Psychiatry Deletion of Glycogen Synthase Kinase-3β in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.
2019 Dec Neuroscience Dopamine Evokes a Trace Amine Receptor-dependent Inward Current that is Regulated by AMP Kinase in Substantia Nigra Dopamine Neurons.
2019 Dec Hum Brain Mapp Amisulpride and l-DOPA modulate cortical brain nuclei connectivity in resting-state pharmacologic magnetic resonance imaging.
2019 Dec Neurosci Res Dopamine D1 and muscarinic acetylcholine receptors in dorsal striatum are required for high speed running.
2020 J Pharmacol Sci Involvement of the dopamine D1 receptor system in the anxiolytic effect of cedrol in the elevated plus maze and light-dark box tests.
2019 Nov Psychopharmacology (Berl) Binding of the D3-preferring antipsychotic candidate F17464 to dopamine D3 and D2 receptors: a PET study in healthy jects with [11C]-(+)-PHNO.
2020 Mar J Ethnopharmacol Anxiolytic- and antidepressant-like activities of hydroethanol leaf extract of Newbouldia laevis (P.Beauv.) Seem. (Bignoniaceae) in mice.
2019 Ther Adv Psychopharmacol Cannabidiol as a potential treatment for psychosis.
2019 Nihon Yakurigaku Zasshi [Preclinical pharmacological profiles and clinical efficacy of the novel antipsychotic drug brexpiprazole (REXULTI® Tablets 1 mg, 2 mg)].
2019 Nov Sci Rep Sucrose intake lowers μ-opioid and dopamine D23 receptor availability in porcine brain.
2019 Nov Br J Pharmacol The novel antipsychotic cariprazine stabilizes gamma oscillations in rat hippocampal slices.
2019 Nov J Neurosci Res Blockade of dopamine D1 receptors in male rats disrupts morphine reward in pain naïve but not in chronic pain states.
2020 Feb Behav Brain Res Haloperidol-induced hypokinesia in rats is differentially affected by the lightdark phase, age, and melatonin.
2019 Nov Arch Biochem Biophys 15-Deoxy-Δ12,14-prostaglandin J2 ameliorates dextran sulfate sodium-induced colitis in mice through heme oxygenase-1 induction.
2020 Jan Neuro Oncol Biological activity of weekly ONC201 in adult recurrent glioblastoma patients.
2019 Nov Sci Rep Differential effects of D-cycloserine and amantadine on motor behavior and D23 receptor binding in the nigrostriatal and mesolimbic system of the adult rat.
2019 Nov Int J Neuropsychopharmacol Balanced activation of striatal output pathways by faster off-rate PDE10A inhibitors elicits not only antipsychotic-like effects but also procognitive effects in rodents.
2019 J Clin Psychopharmacol Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
2019 JBMR Plus Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus.
2019 Oct Clin Exp Allergy A phase 2 study to evaluate the safety, efficacy and pharmacokinetics of DP2 antagonist GB001 and to explore biomarkers of airway inflammation in mild-to-moderate asthma.
2019 Aug EJNMMI Radiopharm Chem Improved synthesis of [18F] fallypride and characterization of a Huntington's disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2D3 receptors.
2020 Jan Neuropharmacology Neuromedin U induces self-grooming in socially-stimulated mice.
2019 J Cell Mol Med Effect and mechanisms of sacral nerve stimulation on visceral hypersensitivity mediated by nerve growth factor.
2020 Comp Biochem Physiol A Mo... Daily variation of D2 dopamine receptor transcription in the brain of the Japanese eel Anguilla japonica and its regulation with dopamine and melatonin.
2019 PLoS One Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice.
2019 Exp Physiol The effect of dopamine on pulmonary diffusing capacity and capillary blood volume responses to exercise in young healthy humans.
2019 Nov J Med Chem Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor.
2019 J Pharmacol Exp Ther Newly Developed Dopamine D3 Receptor Antagonists, iRi-VK4-40 and iRi-VK4-116, Do Not Potentiate Cardiovascular Effects of Cocaine or Oxycodone in Rats.
2019 Oct Stress Involvement of D2 receptor in the NAc in chronic unpredictable stress-induced depression-like behaviors.
2019 Nov Bioorg Med Chem Lett Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.
2019 Sep Int J Mol Sci Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress.
2019 Nov Biochem Biophys Res Commun Dopaminergic mechanisms in the lateral hypothalamus regulate feeding behavior in association with neuropeptides.
2019 J Pharmacol Exp Ther The Role of Dopamine D3 Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens.
2019 CNS Spectr Keeping up with the therapeutic advances in schizophrenia: a review of novel and emerging pharmacological entities.
2019 Nov Neuroimage Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain.
2019 Oct Am J Physiol Gastrointest... Roles of the noradrenergic nucleus locus coeruleus and dopaminergic nucleus A11 region as raspinal defecation centers in rats.
2019 J Neurooncol Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201.
2019 Behav Neurosci Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats.
2019 Oct Bioorg Med Chem Lett Rasagiline derivatives combined with histamine H3 receptor properties.
2019 Prog Neurobiol Role of homeostatic feedback mechanisms in modulating methylphenidate actions on phasic dopamine signaling in the striatum of awake behaving rats.
2020 Naunyn Schmiedebergs Arch... Dopamine D1 receptor antagonist reduces stimulant-induced conditioned place preferences and dopamine receptor ersensitivity.
2019 Ann Clin Psychiatry Ecopipam as a pharmacologic treatment of stuttering.
2019 Eur J Neurosci The priming effect of food persists following blockade of dopamine receptors.
2019 Sep Eur J Pharmacol Dopamine D1 and D2 receptors mediate neuropeptide S-induced antinociception in the mouse formalin test.
2019 Psychopharmacology (Berl) Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D23 receptor agents.
2019 Expert Rev Gastroenterol ... Metoclopramide for the treatment of diabetic gastroparesis.
2019 Jul Neurosci Res Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic strates.
2019 Nov Neuropharmacology AMP-activated protein kinase slows D2 dopamine autoreceptor desensitization in stantia nigra neurons.
2019 FEBS Open Bio Dopamine receptor D2 activation presses the radiosensitizing effect of aripiprazole via activation of AMPK.
2020 Jan J Comp Neurol Dopaminergic modulation of olfactory-evoked motor output in sea lampreys (Petromyzon marinus L.).
2019 J Pharmacol Exp Ther Revisiting the Pharmacodynamic Uroselectivity of iαi 1-Adrenergic Receptor Antagonists.
2019 Psychopharmacology (Berl) Role of dopamine D1-like and D2-like receptors in the activation of ingestive behaviour in thirsty rats licking for water.
2019 Allergy Evidence for the induction of Th2 inflammation by group 2 innate lymphoid cells in response to prostaglandin D2 and cysteinyl leukotrienes in allergic rhinitis.
2019 Mol Pharmacol Innovative Bioluminescence Resonance Energy Transfer Assay Reveals Differential Agonist-Induced D2 Receptor Intracellular Trafficking and Arrestin-3 Recruitment.
2019 Neuropharmacology Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites.
2019 Jun Int J Mol Sci A Free-Operant Reward-Tracking Paradigm to Study Neural Mechanisms and Neurochemical Modulation of Adaptive Behavior in Rats.
2019 Neuropharmacology D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
2019 Oct Eur J Med Chem 2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
2019 Sep Eur J Med Chem Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.
2019 Psychoneuroendocrinology Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation.
2019 J Recept Signal Transduct... Dopamine-induced functional activation of Gαq mediated by dopamine D1-like receptor in rat cerebral cortical membranes.
2019 Front Pharmacol Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.
2019 Pulm Pharmacol Ther Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.