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Recent literature: D2 receptor antagonist
Date Journal Article title
2019 Jun Eur J Med Chem 2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
2019 Jun Eur J Med Chem Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.
2019 Jun Psychoneuroendocrinology Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation.
2019 Jun J Recept Signal Transduct... Dopamine-induced functional activation of Gαq mediated by dopamine D1-like receptor in rat cerebral cortical membranes.
2019 Front Pharmacol Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.
2019 Jun Pulm Pharmacol Ther Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.
2019 Jun Neurogastroenterol Motil Regulation of stress-induced gastric ulcers via central oxytocin and a potential mechanism through the VTA-NAc dopamine pathway.
2019 Jun Psychopharmacology (Berl) Dopamine D1 and D2 receptors mediate analgesic and hypnotic effects of l-tetrahydropalmatine in a mouse neuropathic pain model.
2019 Jun Acta Pharmacol Sin Preclinical PKPD model for the combinatorial use of dexamethasone and sulpiride in the treatment of breast cancer.
2019 Jun J Psychopharmacol Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.
2019 May Nat Prod Res Study on antidepressant-like effect of protoilludane sesquiterpenoid aromatic esters from iArmillaria Melleai.
2019 May Biochem Pharmacol A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes.
2019 Sep Neuropharmacology Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit.
2019 Case Rep Psychiatry Accidental Overdose of Paliperidone Palmitate.
2019 May CNS Neurosci Ther Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress.
2019 Iran J Pharm Res The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area.
2019 Brain Struct Funct Dissociable effects of dopamine D1 and D2 receptors on compulsive ingestion and pivoting movements elicited by disinhibiting the ventral pallidum.
2019 J Psychopharmacol Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
2019 May Psychopharmacology (Berl) Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain.
2019 Mar Arch Iran Med The Involvement of D1 and D2 Dopamine Receptors in the Restoration Effect of Left Frontal Anodal, but not Cathodal, tDCS on Streptozocin-Induced Amnesia.
2019 Front Neurosci Voluntary Wheel Running Reverses Deficits in Social Behavior Induced by Chronic Social Defeat Stress in Mice: Involvement of the Dopamine System.
2019 Apr CNS Spectr The role of dopamine D3 receptors in the mechanism of action of cariprazine.
2019 Apr J Neurochem Differential regulation of phasic dopamine release in the forebrain by the VTA noradrenergic receptor signaling.
2019 Apr Neurochem Int Blonanserin ameliorates social deficit through dopamine-D3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.
2019 Apr Int J Mol Sci Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.
2019 May Bioorg Med Chem Chemical synthesis, microbial transformation and biological evaluation of tetrahydroprotoberberines as dopamine D1D2 receptor ligands.
2019 Front Neurosci GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 Cogn Neurodyn L-menthol exhibits antidepressive-like effects mediated by the modification of 5-HTergic, GABAergic and DAergic systems.
2019 Apr J Neurosurg Pediatr First clinical experience with DRD23 antagonist ONC201 in H3 K27M-mutant pediatric diffuse intrinsic pontine glioma: a case report.
2019 Jul Eur J Pharmacol A CRTH2 antagonist, CT-133, presses NF-κB signalling to relieve lipopolysaccharide-induced acute lung injury.
2019 Neurourol Urodyn Dopaminergic urethral closure mechanisms in a rat model of Parkinson's disease.
2019 Mar BMJ Case Rep Can typical and atypical antipsychotics show differential effectiveness in treating paranoia and hallucinations in schizophrenia?
2019 Jun Eur J Pharmacol Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome.
2019 May Neuroscience Presynaptic control of [3H]-glutamate release by dopamine receptor types in the rat stantia nigra. Central role of D1 and D3 receptors.
2019 May Chem Biol Interact Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors.
2019 Mar Psychopharmacology (Berl) Effects of intrastriatal dopamine D1 or D2 antagonists on methamphetamine-induced egocentric and allocentric learning and memory deficits in Sprague-Dawley rats.
2019 J Smooth Muscle Res Sustained exposure to prostaglandin D2 augments the contraction induced by acetylcholine via a DP1 receptor-mediated activation of p38 in bronchial smooth muscle of naive mice.
2019 Mar J Biomol Struct Dyn Design of novel dopamine D2 and serotonin 5-HT2A receptors dual antagonists toward schizophrenia: An integrated study with QSAR, molecular docking, virtual screening and molecular dynamics simulations.
2019 Front Pharmacol Participation of Dopamine D1 and D2 Receptors in the Rapid-Onset Behavioral Sensitization to Modafinil.
2019 Eur Neuropsychopharmacol Atypical but not typical antipsychotic drugs ameliorate phencyclidine-induced emotional memory impairments in mice.
2019 Pharmacol Biochem Behav 5-HT2A receptors modulate dopamine D2-mediated maternal effects.
2019 Br Poult Sci Interaction of the dopaminergic and NociceptinOrphanin FQ on central feed intake regulation in chicken.
2019 Apr J Med Chem Dopamine D4 Receptor-Selective Compounds Reveal Structure-Activity Relationships that Engender Agonist Efficacy.
2019 Neuropsychopharmacology Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens.
2019 Int Arch Allergy Immunol Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria.
2019 J Pharmacol Exp Ther Inhibition of Methamphetamine Self-Administration and Reinstatement by Central Blockade of Angiotensin II Receptor in Rats.
2019 CNS Spectr 30 Lumateperone (ITI-007) for the Treatment of Schizophrenia: Overview of Placebo-Controlled Clinical Trials and an Open-label Safety Switching Study.
2019 J Comput Aided Mol Des Significantly different effects of tetrahydroberberrubine enantiomers on dopamine D1D2 receptors revealed by experimental study and integrated in silico simulation.
2019 eNeuro An Adenosine A2A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis.
2019 J Allergy Clin Immunol Fevipiprant, a selective prostaglandin D2 receptor 2 antagonist, inhibits human group 2 innate lymphoid cell aggregation and function.
2019 Pharmacol Rev Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges.
2019 Apr Bioorg Med Chem Lett Biotinylated-spiperone ligands for quantum dot labeling of the dopamine D2 receptor in live cell cultures.
2019 Pharmacol Biochem Behav Enrichment-induced differences in methamphetamine drug discrimination in male rats.
2019 J Psychopharmacol The role of prefrontal cortex dopamine D2 and D3 receptors in the mechanism of action of venlafaxine and deep brain stimulation in animal models of treatment-responsive and treatment-resistant depression.
2019 May J Ethnopharmacol Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating.
2019 Synapse Interaction of nicotinic acetylcholine receptors with dopamine receptors in synaptic plasticity of the mouse insular cortex.
2018 Front Psychiatry The Group of Treatment Resistant Schizophrenias. Heterogeneity in Treatment Resistant Schizophrenia (TRS).
2019 Feb Sci Transl Med DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.
2019 Nat Struct Mol Biol Structures of the 5-HT2A receptor in complex with the antipsychotics risperidone and zotepine.
2019 Gastroenterology Effects of Promotility Agents on Gastric Emptying and Symptoms: A Systematic Review and Meta-analysis.
2019 Mar Eur J Med Chem Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands.
2019 PLoS One Kami-shoyo-san improves ASD-like behaviors caused by decreasing allopregnanolone biosynthesis in an SKF mouse model of autism.
2019 Pharmacology Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.
2019 Jan Schizophr Bull Potent Dopamine D2 Antagonists Block the Reward-Enhancing Effects of Nicotine in Smokers With Schizophrenia.
2019 Eur Neuropsychopharmacol Acute and chronic PCP attenuate D2 autoreceptor signaling in stantia nigra dopamine neurons.
2019 Brain Struct Funct The lateral preoptic area and ventral pallidum embolden behavior.
2019 Drugs Brexpiprazole: A Review in Schizophrenia.
2019 J Neurochem Neuronal KIF5b deletion induces striatum-dependent locomotor impairments and defects in membrane presentation of dopamine D2 receptors.
2019 J Asthma Allergy Spotlight on fevipiprant and its potential in the treatment of asthma: evidence to date.
2019 Cortex Dopamine guides competition for cognitive control: Common effects of haloperidol on working memory and response conflict.
2019 Apr Neurosci Lett Validation of the xylazineketamine anesthesia test as a predictor of the emetic potential of pharmacological compounds in rats.
2019 Apr Behav Brain Res Dopamine type 1- and 2-like signaling in the modulation of spatial reference learning and memory.
2019 Neuropharmacology cAMP-producing chemogenetic and adenosine A2a receptor activation inhibits the inwardly rectifying potassium current in striatal projection neurons.
2018 Nov Cureus Acute Dystonia Secondary to Domperidone in a Pediatric Patient.