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Recent literature: 5-HT2 receptor agonist
Date Journal Article title
2019 Pharmacol Rep Stimulation of 5-HT2C serotonin receptor type in the hypothalamic arcuate nuclei (ARC) increases the cytochrome P450 activity in the liver.
2020 Mar Bioorg Med Chem Lett Discovery of a lead series of potent benzodiazepine 5-HT2C receptor agonists with high selectivity in functional and binding assays.
2020 Clin Exp Pharmacol Physiol Blockade of 5-HT2 receptors with sarpogrelate uncovers 5-HT7 receptors inhibiting the tachycardic sympathetic drive in pithed rats.
2020 Expert Rev Clin Pharmacol Efficacy and safety of lorcaserin in obesity: a systematic review and meta-analysis of randomized controlled trials.
2019 Nov Neuropharmacology Pharmacological and biotransformation studies of 1-acyl-stituted derivatives of d-lysergic acid diethylamide (LSD).
2019 Pharmacol Rep Stimulation of 5-HT2C serotonin receptor type in the hypothalamic arcuate nuclei (ARC) increases the cytochrome P450 activity in the liver.
2019 Nov ACS Chem Neurosci 5-HT2B, 5-HT7, and DA2 Receptors Mediate the Effects of 5-HT and DA on Agonistic Behavior of the Chinese Mitten Crab (iEriocheir sinensisi).
2019 Nov Life Sci 5-HT2 receptor activation alleviates airway inflammation and structural remodeling in a chronic mouse asthma model.
2019 Drug Des Devel Ther Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine.
2019 Sep Sci Rep Activation of 5-HT2 Receptors Reduces Inflammation in Vascular Tissue and Cholesterol Levels in High-Fat Diet-Fed Apolipoprotein E Knockout Mice.
2019 Sep Molecules Synthesis and Biological Evaluation of Distituted Pyrimidines as Selective 5-HT2C Agonists.
2019 Sep Int J Mol Sci Contribution of Corticotropin-Releasing Factor Receptor 1 (CRF1) to Serotonin Receptor 5-HT2CR Function in Amygdala Neurons in a Neuropathic Pain Model.
2019 Nov Eur J Med Chem Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism.
2019 Korean J Physiol Pharmacol Potentiation of the glycine response by serotonin on the stantia gelatinosa neurons of the trigeminal nucleus caudalis in mice.
2019 Curr Top Med Chem Targeting the 5-HT2C Receptor in Biological Context and the Current State of 5-HT2C Receptor Ligand Development.
2019 Jun Int J Mol Sci Effect of the 5-HT2C Receptor Agonist WAY-163909 on Serotonin and Dopamine Metabolism across the Rat Brain: A Quantitative and Qualitative Neurochemical Study.
2019 Expert Rev Clin Pharmacol Changing the treatment paradigm for Parkinson's disease psychosis with pimavanserin.
2019 Bioelectromagnetics Effects of 5-HT1 and 5-HT 2 Receptor Agonists on Electromagnetic Field-Induced Analgesia in Rats.
2019 Diabetes The BBSome in POMC and AgRP Neurons Is Necessary for Body Weight Regulation and Sorting of Metabolic Receptors.
2019 Jul Neurosci Lett CB1R mediates oleamide's reward while 5HT2cR mediates aversion in the nucleus accumbens shell of rats.
2019 Sep Hum Mol Genet Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition.
2019 Jul Eur J Pharmacol Monoamine receptor interaction profiles of 4-aryl-stituted 2,5-dimethoxyphenethylamines (2C-BI derivatives).
2019 Exp Brain Res Effect of coadministration of the GABAB agonist baclofen and the 5-HT2C agonist Ro60-0175 on the expression of amphetamine-induced locomotor sensitization.
2019 Pharmacol Biochem Behav 5-HT2A receptors modulate dopamine D2-mediated maternal effects.
2019 Oxid Med Cell Longev Enhancement by Hydrogen Peroxide of Calcium Signals in Endothelial Cells Induced by 5-HT1B and 5-HT2B Receptor Agonists.
2019 J Pharmacol Sci Effect of ASP2205 fumarate, a novel 5-HT2C receptor agonist, on urethral closure function in rats.
2019 Drug Test Anal The synthetic cathinone psychostimulant α-PPP antagonizes serotonin 5-HT2A receptors: In vitro and in vivo evidence.
2019 Pharmacol Biochem Behav The serotonin-2C agonist Lorcaserin delays intravenous choice and modifies the jective and cardiovascular effects of cocaine: A randomized, controlled human laboratory study.
2019 Feb Int J Mol Sci Glucagon-Like Peptide-1 (GLP-1) and 5-Hydroxytryptamine 2c (5-HT2c) Receptor Agonists in the Ventral Tegmental Area (VTA) Inhibit Ghrelin-Stimulated Appetitive Reward.
2019 Neurobiol Dis Synergistic action of CB1 and 5-HT2B receptors in preventing pilocarpine-induced status epilepticus in rats.
2019 Apr Biol Pharm Bull Effect of Selective Serotonin (5-HT)2B Receptor Agonist BW723C86 on Epidermal Growth FactorTransforming Growth Factor-α Receptor Tyrosine Kinase and Ribosomal p70 S6 Kinase Activities in Primary Cultures of Adult Rat Hepatocytes.
2019 Hypertens Res Hypertension exhibits 5-HT4 receptor as a modulator of sympathetic neurotransmission in the rat mesenteric vasculature.
2019 Neuropsychopharmacology Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels.
2019 Neuropharmacology Role of 5-HT2C receptors of the dorsal hippocampus in the modulation of anxiety- and panic-related defensive responses in rats.
2019 Neurochem Int Neurochemical impact of the 5-HT2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain.
2019 Exp Clin Psychopharmacol Effects of acute and repeated treatment with serotonin 5-HT2A receptor agonist hallucinogens on intracranial self-stimulation in rats.
2019 JAAPA Can pimavanserin help patients with Parkinson disease psychosis?
2019 Jan Circulation Lorcaserin and Renal Outcomes in Obese and Overweight Patients in the CAMELLIA-TIMI 61 Trial.
2019 Int J Neurosci The effect of serotonin on penicillin-induced epileptiform activity.
2019 Drug Res (Stuttg) Evaluation of Isolated Vascular Response to 5HT1A, 5HT1B1D amp; 5HT2A Receptors Agonist amp; Antagonist in Chronic Endotoxemic Rats.
2019 Drug Metab Dispos Serotonin Receptors of 5-HT2 Type in the Hypothalamic Arcuate Nuclei Positively Regulate Liver Cytochrome P450 via Stimulation of the Growth Hormone-Releasing HormoneGrowth Hormone Hormonal Pathway.
2019 Jan Drug Alcohol Depend Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys.
2019 Can J Physiol Pharmacol Fluoxetine oral treatment discloses 5-HT1D receptor as vagoinhibitor of the cardiac cholinergic neurotransmission in rat.
2019 Exp Physiol Evidence for protein kinase involvement in the 5-HT-[Ca2+ ]i -pannexin-1 signalling pathway in type II glial cells of the rat carotid body.
2019 Psychopharmacology (Berl) Chronic treatment with a metabotropic mGlu23 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen.
2019 Toxicol In Vitro MDMA modulates 5-HT1-mediated contractile response of the human internal thoracic artery in vitro.
2019 Pharmacol Biochem Behav Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin.
2019 Jan Eur J Pharmacol The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice.
2018 Pharmacol Biochem Behav 5‑Hydroxytryptamine 2A receptor inverse agonist pimavanserin impairs maternal behavior in postpartum female rats.
2018 Oct Elife Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor.
2018 Clin Neuropharmacol Nighttime Sleep and Daytime Sleepiness Improved With Pimavanserin During Treatment of Parkinson's Disease Psychosis.
2019 Psychopharmacology (Berl) Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA).
2018 J Prev Alzheimers Dis Pimavanserin: Potential Treatment For Dementia-Related Psychosis.
2018 Psychopharmacology (Berl) The neuropharmacology of sleep paralysis hallucinations: serotonin 2A activation and a novel therapeutic drug.
2018 Nov Neurosci Lett Effect of 5-HT2A receptor antagonist ketanserin on micturition in male rats.
2019 Chem Biol Drug Des In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and α1 receptors.
2018 J Pharmacol Exp Ther 5-HT2A Receptor Agonist-Induced Hyperthermia Is Induced via Vasoconstriction by Peripheral 5-HT2A Receptors and Brown Adipose Tissue Thermogenesis by Peripheral Serotonin Loss at a High Ambient Temperature.
2018 Neuropharmacology Reduced cortical serotonin 5-HT2A receptor binding and glutamate activity in high compulsive drinker rats.
2019 Handb Exp Pharmacol Other Antidepressants.
2019 Neuropsychopharmacology Effects of long-term high-fat food or methamphetamine intake and serotonin 2C receptors on reversal learning in female rhesus macaques.
2018 Oct Cell Metab Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake.
2018 Sep Neuropharmacology Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice.
2018 Neurol Sci Pimavanserin use in a movement disorders clinic: a single-center experience.
2018 Clin Neuropharmacol Pimavanserin for Psychotic Symptoms in People With Parkinsonism: A Second Chart Review.
2018 Pharmacol Biochem Behav Blockade of serotonin 5-HT2A receptors potentiates dopamine D2 activation-induced disruption of pup retrieval on an elevated plus maze, but has no effect on D2 blockade-induced one.
2018 JAAPA Flibanserin for hypoactive sexual desire disorder in premenopausal women.
2018 Am Heart J Design and rationale for the Cardiovascular and Metabolic Effects of Lorcaserin in Overweight and Obese Patients-Thrombolysis in Myocardial Infarction 61 (CAMELLIA-TIMI 61) trial.
2019 BJU Int The serotonin (5-hydroxytryptamine) 5-HT7 receptor is up-regulated in Onuf's nucleus in rats with chronic spinal cord injury.
2018 Psychopharmacology (Berl) Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.
2018 Neurourol Urodyn Effect of a 5-HT2c receptor agonist on urethral closure mechanisms in female rats.
2019 Jan J Med Chem Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor.
2018 Drug Metab Dispos Activation of 5-HT1A Receptors in the Hypothalamic Paraventricular Nuclei Negatively Regulates Cytochrome P450 Expression and Activity in Rat Liver.
2018 Jul Behav Brain Res 5-HT2C receptors in the ventral tegmental area, but not in the arcuate nucleus, mediate the hypophagic and hypolocomotor effects of the selective 5-HT2C receptor agonist AR231630 in rats.
2018 Neuropharmacology Activation of 5-HT2C (but not 5-HT1A) receptors in the amygdala enhances fear-induced antinociception: Blockade with local 5-HT2C antagonist or systemic fluoxetine.
2018 Brain Behav 5-HT2CR antagonist5-HT2CR inverse agonist recovered the increased isolation-induced aggressive behavior of BALBc mice mediated by ADAR1 (p110) expression and Htr2c RNA editing.