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Recent literature: M1 receptor antagonist
Date Journal Article title
2020 Mar Epilepsy Behav Fenfluramine acts as a positive modulator of sigma-1 receptors.
2020 Mar J Gastroenterol Hepatol Regulation of lipid-induced macrophage polarization through modulating peroxisome proliferator-activated receptor-gamma activity affects hepatic lipid metabolism via a Toll-like receptor 4NF-κB signaling pathway.
2020 Front Physiol Imbalance Between Interleukin-1β and Interleukin-1 Receptor Antagonist in Epicardial Adipose Tissue Is Associated With Non ST-Segment Elevation Acute Coronary Syndrome.
2020 Feb J Neuroinflammation Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury.
2020 Int J Ophthalmol Expression and role of aryl hydrocarbon receptor in iAspergillus fumigatusi keratitis.
2020 Feb Brain Sci The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding.
2020 Feb J Appl Toxicol Wastewater-derived antagonistic activities of G protein-coupled receptor-acting pharmaceuticals in river water.
2020 Feb Invest Ophthalmol Vis Sci Angiotensin-(1-7) Attenuates Protein O-GlcNAcylation in the Retina by EPACRap1-Dependent Inhibition of O-GlcNAc Transferase.
2020 Feb J Cell Biochem M3 receptor modulates extracellular matrix synthesis via ERK12 signaling pathway in human bladder smooth muscle cells.
2020 Mar Toxicology Estrogen receptor-regulated SOCS3 modulation via JAK2STAT3 pathway is involved in BPF-induced M1 polarization of macrophages.
2020 Biochim Biophys Acta Mol ... Contribution of FP receptors in M1 macrophage polarization via IL-10-regulated nuclear translocation of NF-κB p65.
2020 Apr Life Sci High-mobility group box 1 protein participates in acute lung injury by activating protein kinase R and inducing M1 polarization.
2019 Pharmacol Rep Muscarinic M1 and M2 receptor types play opposite roles in LPS-induced septic shock.
2020 Mar J Biol Chem Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4.
2020 Mar Neuroscience Exercise Plus Pharmacological Neuromodulation of Synaptic Inhibition Enhance Motor Function Recovery After Ischemic Stroke.
2020 Jan Cells Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPARγ Ligands as a Potential Target in Breast Cancer.
2020 Arch Oral Biol α7-Nicotine acetylcholine receptor mediated nicotine induced cell survival and cisplatin resistance in oral cancer.
2020 Feb Environ Sci Technol Biological Activity-Based Prioritization of Pharmaceuticals in Wastewater for Environmental Monitoring: G Protein-Coupled Receptor Inhibitors.
2020 J Immunotoxicol Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma.
2020 J Mol Neurosci TSPO Modulates IL-4-Induced MicrogliaMacrophage M2 Polarization via PPAR-γ Pathway.
2019 Front Cell Neurosci Electroacupuncture Pretreatment Alleviates Cerebral Ischemic Injury Through α7 Nicotinic Acetylcholine Receptor-Mediated Phenotypic Conversion of Microglia.
2020 Jan ACS Chem Neurosci Discovery of Procognitive Antipsychotics by Combining Muscarinic M1 Receptor Structure-Activity Relationship with Systems Response Profiles in Zebrafish Larvae.
2020 Feb Eur J Pharmacol Direct stimulation of angiotensin II type 2 receptor reduces nitric oxide production in lipopolysaccharide treated mouse macrophages.
2019 Dec Inflammation Toll-Like Receptor 2-Mediated Autophagy Promotes Microglial Cell Death by Modulating the Microglial M1M2 Phenotype.
2020 J Pharmacol Sci Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice.
2019 Mediators Inflamm HuoXueTongFu Formula Alleviates Intraperitoneal Adhesion by Regulating Macrophage Polarization and the SOCSJAK2STATPPAR-iγi Signalling Pathway.
2020 Int J Mol Med HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGENF‑κB signaling pathways.
2019 Mediators Inflamm NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway.
2019 Dec Neuroscience Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1M2 Polarization through NF-κB Pathway.
2020 Jan Zool Res D-dopachrome tautomerase from Japanese sea bass ( iLateolabrax japonicusi) is a chemokine-like cytokine and functional homolog of macrophage migration inhibitory factor.
2020 Feb Behav Brain Res Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus).
2020 J Cell Mol Med Effect of (R)-salbutamol on the switch of phenotype and metabolic pattern in LPS-induced macrophage cells.
2019 Pharmacol Rep Muscarinic M1 and M2 receptor types play opposite roles in LPS-induced septic shock.
2020 Eur J Neurosci Dorsal hippocampus cholinergic and nitrergic neurotransmission modulates the cardiac baroreflex function in rats.
2020 Pharmacology Inhibition of Canonical Transient Receptor Potential 5 Channels Polarizes Macrophages to an M1 Phenotype.
2019 Neurochem Res A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice.
2019 Mol Pharmacol N-Terminal Modification of the Tetrapeptide Arg-Leu-Tyr-Glu, a Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Antagonist, Improves Antitumor Activity by Increasing its Stability against Serum Peptidases.
2019 Dec Am J Physiol Endocrinol M... The antagonist of CXCR1 and CXCR2 protects idbiidbi mice from metabolic diseases through modulating inflammation.
2019 Sep Sci Rep M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera.
2019 Dec Eur J Pharmacol Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis.
2019 Clin Drug Investig Effect of Macitentan on the Pharmacokinetics of the Breast Cancer Resistance Protein Substrates, Rosuvastatin and Riociguat, in Healthy Male Subjects.
2019 Expert Opin Drug Metab To... Pharmacokinetic considerations for current state-of-the-art antidepressants.
2020 Int J Neurosci Central muscarinic receptor types (M1 and M3) involved in carbacol-induced hypophagia in neonatal broiler chicken.
2019 Sep Cereb Cortex A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response.
2019 Front Immunol Tumor Necrosis Factor-Alpha Antagonist Interferes With the Formation of Granulomatous Multinucleated Giant Cells: New Insights Into iMycobacterium tuberculosisi Infection.
2020 Mol Neurobiol The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia.
2019 Oct J Neurosci Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits.
2019 Front Immunol Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages.
2019 Aug Stem Cell Res Ther Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice.
2019 Redox Biol Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
2019 Jul Skelet Muscle Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells.
2019 Sep Am J Physiol Renal Physiol Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury.
2019 Am J Transl Res Anti-atherosclerotic effects of LXRα agonist through induced conversion of M1 macrophage to M2.
2019 Biomed Res Int Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation.
2019 Aug Psychiatry Res Neuroimaging Influence of muscarinic M1 receptor antagonism on brain choline levels and functional connectivity in medication-free jects with psychosis: A placebo controlled, cross-over study.
2019 Apr Cureus The Role of Revefenacin in Chronic Obstructive Pulmonary Disease.
2019 Jun Biomol Ther (Seoul) S1P1 Regulates M1M2 Polarization toward Brain Injury after Transient Focal Cerebral Ischemia.
2019 Jul ChemMedChem Novel BQCA- and TBPB-Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
2019 Front Immunol Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells.
2019 Naunyn Schmiedebergs Arch... Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
2019 Jun Neuroscience Effects of Muscarinic Acetylcholine m1 and m4 Receptor Blockade on Dyskinesia in the Hemi-Parkinsonian Rat.
2019 Stem Cells Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist.
2019 Liver Transpl Hyperglycemia-Triggered Sphingosine-1-Phosphate and Sphingosine-1-Phosphate Receptor 3 Signaling Worsens Liver IschemiaReperfusion Injury by Regulating M1M2 Polarization.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 May Chem Biol Interact Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors.
2019 PLoS One TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.
2019 Drug Test Anal The synthetic cathinone psychostimulant α-PPP antagonizes serotonin 5-HT2A receptors: In vitro and in vivo evidence.
2019 Mar Neuroreport Antipruritic effects of electroacupuncture on morphine-induced pruritus model mice through the TLR24-MyD88-NF-κB pathway.
2019 FASEB J Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunopression in the tumor microenvironment.
2019 Mol Pain Inhibition by O-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal stantia gelatinosa neurons.
2019 Mar Toxicol Appl Pharmacol PCB 126 induces monocytemacrophage polarization and inflammation through AhR and NF-κB pathways.
2019 Curr Drug Metab Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer Accelerator Mass Spectrometry.
2018 eNeuro Cell Type- and Layer-Specific Muscarinic Potentiation of Excitatory Synaptic Drive onto Parvalbumin Neurons in Mouse Prefrontal Cortex.
2019 Apr Neuroscience Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition.
2019 Mar Toxicology Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation.