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Recent literature: M1 receptor antagonist
Date Journal Article title
2019 Nov Neuroscience Cysteinyl Leukotriene Receptor 2 is Involved in Inflammation and Neuronal Damage by Mediating Microglia M1M2 Polarization through NF-κB Pathway.
2019 Nov Zool Res D-dopachrome tautomerase from Japanese sea bass (Lateolabrax japonicus) is a chemokine-like cytokine and functional homolog of macrophage migration inhibitory factor.
2019 Nov Behav Brain Res Title: Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus gallus domesticus).
2019 Nov J Cell Mol Med Effect of (R)-salbutamol on the switch of phenotype and metabolic pattern in LPS-induced macrophage cells.
2019 Jun Pharmacol Rep Muscarinic M1 and M2 receptor types play opposite roles in LPS-induced septic shock.
2019 Oct Eur J Neurosci Dorsal hippocampus cholinergic and nitrergic neurotransmission modulate the cardiac baroreflex function in rats.
2019 Oct Pharmacology Inhibition of Canonical Transient Receptor Potential 5 Channels Polarizes Macrophages to an M1 Phenotype.
2019 Oct Neurochem Res A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice.
2019 Mol Pharmacol N-Terminal Modification of the Tetrapeptide Arg-Leu-Tyr-Glu, a Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Antagonist, Improves Antitumor Activity by Increasing its Stability against Serum Peptidases.
2019 Oct Am J Physiol Endocrinol M... The Antagonist of CXCR1 and CXCR2 Protects dbdb mice from Metabolic Diseases through Modulating Inflammation.
2019 Sep Sci Rep M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera.
2019 Dec Eur J Pharmacol Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis.
2019 Sep Clin Drug Investig Effect of Macitentan on the Pharmacokinetics of the Breast Cancer Resistance Protein Substrates, Rosuvastatin and Riociguat, in Healthy Male Subjects.
2019 Expert Opin Drug Metab To... Pharmacokinetic considerations for current state-of-the-art antidepressants.
2019 Oct Int J Neurosci Central muscarinic receptor types (M1 and M3) involved in carbacol-induced hypophagia in neonatal broiler chicken.
2019 Sep Cereb Cortex A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response.
2019 Front Immunol Tumor Necrosis Factor-Alpha Antagonist Interferes With the Formation of Granulomatous Multinucleated Giant Cells: New Insights Into iMycobacterium tuberculosisi Infection.
2019 Aug Mol Neurobiol The Role of Aberrations in the Immune-Inflammatory Response System (IRS) and the Compensatory Immune-Regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: the IRS-CIRS Theory of Schizophrenia.
2019 Oct J Neurosci Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits.
2019 Front Immunol Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages.
2019 Aug Stem Cell Res Ther Decitabine assists umbilical cord-derived mesenchymal stem cells in improving glucose homeostasis by modulating macrophage polarization in type 2 diabetic mice.
2019 Redox Biol Vitamin D receptor activation regulates microglia polarization and oxidative stress in spontaneously hypertensive rats and angiotensin II-exposed microglial cells: Role of renin-angiotensin system.
2019 Jul Skelet Muscle Estrogen signaling effects on muscle-specific immune responses through controlling the recruitment and function of macrophages and T cells.
2019 Sep Am J Physiol Renal Physiol Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury.
2019 Am J Transl Res Anti-atherosclerotic effects of LXRα agonist through induced conversion of M1 macrophage to M2.
2019 Biomed Res Int Montelukast, a Cysteinyl Leukotriene Receptor 1 Antagonist, Induces M2 Macrophage Polarization and Inhibits Murine Aortic Aneurysm Formation.
2019 Aug Psychiatry Res Neuroimaging Influence of muscarinic M1 receptor antagonism on brain choline levels and functional connectivity in medication-free jects with psychosis: A placebo controlled, cross-over study.
2019 Apr Cureus The Role of Revefenacin in Chronic Obstructive Pulmonary Disease.
2019 Jun Biomol Ther (Seoul) S1P1 Regulates M1M2 Polarization toward Brain Injury after Transient Focal Cerebral Ischemia.
2019 Jul ChemMedChem Novel BQCA- and TBPB-Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
2019 Front Immunol Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells.
2019 Naunyn Schmiedebergs Arch... Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
2019 Jun Neuroscience Effects of Muscarinic Acetylcholine m1 and m4 Receptor Blockade on Dyskinesia in the Hemi-Parkinsonian Rat.
2019 Stem Cells Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist.
2019 Liver Transpl Hyperglycemia-Triggered Sphingosine-1-Phosphate and Sphingosine-1-Phosphate Receptor 3 Signaling Worsens Liver IschemiaReperfusion Injury by Regulating M1M2 Polarization.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 May Chem Biol Interact Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors.
2019 PLoS One TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.
2019 Mar Neuroreport Antipruritic effects of electroacupuncture on morphine-induced pruritus model mice through the TLR24-MyD88-NF-κB pathway.
2019 FASEB J Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunopression in the tumor microenvironment.
2019 Mol Pain Inhibition by O-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal stantia gelatinosa neurons.
2019 Mar Toxicol Appl Pharmacol PCB 126 induces monocytemacrophage polarization and inflammation through AhR and NF-κB pathways.
2019 Curr Drug Metab Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer Accelerator Mass Spectrometry.
2018 eNeuro Cell Type- and Layer-Specific Muscarinic Potentiation of Excitatory Synaptic Drive onto Parvalbumin Neurons in Mouse Prefrontal Cortex.
2019 Apr Neuroscience Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition.
2019 Mar Toxicology Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation.
2019 Mar J Biol Chem Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.
2019 Jan Food Funct Theanine attenuates memory impairments induced by klotho gene depletion in mice.
2019 Feb Bioorg Med Chem Lett Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low type selectivity for human M1 - M5 muscarinic acetylcholine receptors.
2019 J Ocul Pharmacol Ther In Vivo Choroidal Neovascularization and Macrophage Studies Provide Further Evidence for a Broad Role of Prostacyclin in Angiogenesis.
2018 J Inflamm (Lond) Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages.
2019 J Bone Miner Res Cannabinoid Receptor 2 Agonist Prevents Local and Systemic Inflammatory Bone Destruction in Rheumatoid Arthritis.
2018 Front Cell Neurosci Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus.
2019 Neuropsychopharmacology Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation.
2019 Pharmacol Biochem Behav The role of dopamine D1- and D2-like receptors related to muscarinic M1 receptors in impulsive choice in high-impulsive and low-impulsive rats.
2018 Nov Proc Biol Sci Of molecules, memories and migration: M1 acetylcholine receptors facilitate spatial memory formation and recall during migratory navigation.
2019 J Clin Pharmacol Complementary Pharmacokinetic Profiles of Netupitant and Palonosetron Support the Rationale for Their Oral Fixed Combination for the Prevention of Chemotherapy-Induced Nausea and Vomiting.
2019 J Dent Res Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models.
2019 Feb Brain Res Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.
2018 Zhonghua Wei Zhong Bing J... [Effect of Galectin-9Tim-3 pathway on the polarization of M1M2 type in murine macrophages induced by lipopolysaccharide].
2018 Oct J Neuroinflammation Sphingosine 1-phosphate receptor type 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization.
2018 Sep BMC Res Notes Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaVβ unit expression.
2018 Front Neurol Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury.
2018 Cell Biol Int Ky-2, a hybrid compound histone deacetylase inhibitor, regulated inflammatory response in LPS-driven human macrophages.
2018 Eur J Neurosci Striatal cholinergic interneurons regulate cognitive and affective dysfunction in partially dopamine-depleted mice.
2018 Oct Environ Sci Technol Quantification of Pharmaceutical Related Biological Activity in Effluents from Wastewater Treatment Plants in UK and Japan.
2018 Sep Cell Rep Dual Dopaminergic Regulation of Corticostriatal Plasticity by Cholinergic Interneurons and Indirect Pathway Medium Spiny Neurons.
2018 Drug Metab Dispos Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro.
2018 Front Neural Circuits Ten-Hour Exposure to Low-Dose Ketamine Enhances Corticostriatal Cross-Frequency Coupling and Hippocampal Broad-Band Gamma Oscillations.
2018 J Pharmacol Sci Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model.
2018 Sep J Chromatogr B Analyt Tec... Identification of novel ondansetron metabolites using LCMSn and NMR.
2018 Oncogene GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine.
2018 Asian J Androl Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling.
2018 Acta Neurobiol Exp (Wars) Administration of muscarinic antagonists induce changes in passive avoidance learning and in synaptic transmission in the CA1 area of the hippocampus.
2019 Acta Pharmacol Sin Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasomeIL-1 signaling pathway.