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Recent literature: M1 receptor antagonist
Date Journal Article title
2019 Jun Biomol Ther (Seoul) S1P1 Regulates M1M2 Polarization toward Brain Injury after Transient Focal Cerebral Ischemia.
2019 Jun ChemMedChem Novel BQCA and TBPB derived M1 Receptor Hybrid-Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
2019 Front Immunol Cannabinoid Receptor 1 Blockade Attenuates Obesity and Adipose Tissue Type 1 Inflammation Through miR-30e-5p Regulation of Delta-Like-4 in Macrophages and Consequently Downregulation of Th1 Cells.
2019 May Naunyn Schmiedebergs Arch... Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
2019 Jun Neuroscience Effects of Muscarinic Acetylcholine m1 and m4 Receptor Blockade on Dyskinesia in the Hemi-Parkinsonian Rat.
2019 Apr Stem Cells Newly Defined ATP-binding cassette family B member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist.
2019 Liver Transpl Hyperglycemia-Triggered Sphingosine-1-Phosphate and Sphingosine-1-Phosphate Receptor 3 Signaling Worsens Liver IschemiaReperfusion Injury by Regulating M1M2 Polarization.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 May Chem Biol Interact Methiopropamine, a methamphetamine analogue, produces neurotoxicity via dopamine receptors.
2019 PLoS One TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.
2019 Mar Neuroreport Antipruritic effects of electroacupuncture on morphine-induced pruritus model mice through the TLR24-MyD88-NF-κB pathway.
2019 FASEB J Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunopression in the tumor microenvironment.
2019 Mol Pain Inhibition by O-desmethyltramadol of glutamatergic excitatory transmission in adult rat spinal stantia gelatinosa neurons.
2019 Mar Toxicol Appl Pharmacol PCB 126 induces monocytemacrophage polarization and inflammation through AhR and NF-κB pathways.
2019 Curr Drug Metab Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer Accelerator Mass Spectrometry.
2018 eNeuro Cell Type- and Layer-Specific Muscarinic Potentiation of Excitatory Synaptic Drive onto Parvalbumin Neurons in Mouse Prefrontal Cortex.
2019 Apr Neuroscience Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition.
2019 Mar Toxicology Bradykinin contributes to immune liver injury via B2R receptor-mediated pathways in trichloroethylene sensitized mice: A role in Kupffer cell activation.
2019 Mar J Biol Chem Overexpression of the C-domain of angiotensin-converting enzyme reduces melanoma growth by stimulating M1 macrophage polarization.
2019 Jan Food Funct Theanine attenuates memory impairments induced by klotho gene depletion in mice.
2019 Feb Bioorg Med Chem Lett Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low type selectivity for human M1 - M5 muscarinic acetylcholine receptors.
2019 J Ocul Pharmacol Ther In Vivo Choroidal Neovascularization and Macrophage Studies Provide Further Evidence for a Broad Role of Prostacyclin in Angiogenesis.
2018 J Inflamm (Lond) Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages.
2019 J Bone Miner Res Cannabinoid Receptor 2 Agonist Prevents Local and Systemic Inflammatory Bone Destruction in Rheumatoid Arthritis.
2018 Front Cell Neurosci Clemastine Alleviates Depressive-Like Behavior Through Reversing the Imbalance of Microglia-Related Pro-inflammatory State in Mouse Hippocampus.
2019 Neuropsychopharmacology Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation.
2019 Pharmacol Biochem Behav The role of dopamine D1- and D2-like receptors related to muscarinic M1 receptors in impulsive choice in high-impulsive and low-impulsive rats.
2018 Nov Proc Biol Sci Of molecules, memories and migration: M1 acetylcholine receptors facilitate spatial memory formation and recall during migratory navigation.
2019 J Clin Pharmacol Complementary Pharmacokinetic Profiles of Netupitant and Palonosetron Support the Rationale for Their Oral Fixed Combination for the Prevention of Chemotherapy-Induced Nausea and Vomiting.
2019 J Dent Res Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models.
2019 Feb Brain Res Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.
2018 Zhonghua Wei Zhong Bing J... [Effect of Galectin-9Tim-3 pathway on the polarization of M1M2 type in murine macrophages induced by lipopolysaccharide].
2018 Oct J Neuroinflammation Sphingosine 1-phosphate receptor type 3 (S1P3) contributes to brain injury after transient focal cerebral ischemia via modulating microglial activation and their M1 polarization.
2018 Sep BMC Res Notes Modulation of CaV1.3b L-type calcium channels by M1 muscarinic receptors varies with CaVβ unit expression.
2018 Front Neurol Modulation of Microglial Activation by Adenosine A2a Receptor in Animal Models of Perinatal Brain Injury.
2018 Cell Biol Int Ky-2, a hybrid compound histone deacetylase inhibitor, regulated inflammatory response in LPS-driven human macrophages.
2018 Eur J Neurosci Striatal cholinergic interneurons regulate cognitive and affective dysfunction in partially dopamine-depleted mice.
2018 Oct Environ Sci Technol Quantification of Pharmaceutical Related Biological Activity in Effluents from Wastewater Treatment Plants in UK and Japan.
2018 Sep Cell Rep Dual Dopaminergic Regulation of Corticostriatal Plasticity by Cholinergic Interneurons and Indirect Pathway Medium Spiny Neurons.
2018 Drug Metab Dispos Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro.
2018 Front Neural Circuits Ten-Hour Exposure to Low-Dose Ketamine Enhances Corticostriatal Cross-Frequency Coupling and Hippocampal Broad-Band Gamma Oscillations.
2018 J Pharmacol Sci Involvement of GABAB receptor in the antihypersensitive effect in anterior cingulate cortex of partial sciatic nerve ligation model.
2018 Sep J Chromatogr B Analyt Tec... Identification of novel ondansetron metabolites using LCMSn and NMR.
2018 Oncogene GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine.
2018 Asian J Androl Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling.
2018 Acta Neurobiol Exp (Wars) Administration of muscarinic antagonists induce changes in passive avoidance learning and in synaptic transmission in the CA1 area of the hippocampus.
2019 Acta Pharmacol Sin Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasomeIL-1 signaling pathway.
2018 Jul Cereb Cortex NMDA Receptor-Mediated Motor Cortex Plasticity After 20 Hz Transcranial Alternating Current Stimulation.
2018 Jul Exp Mol Med Modulation of M1M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned stantia nigra in vivo.
2018 Mol Pharmacol Equilibrium Assays Are Required to Accurately Characterize the Activity Profiles of Drugs Modulating Gq-Protein-Coupled Receptors.
2018 Naunyn Schmiedebergs Arch... Characterization of methanthelinium binding and function at human M1-M5 muscarinic acetylcholine receptors.
2018 Jun FASEB J Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts.
2018 Neurobiol Dis Bexarotene protects against neurotoxicity partially through a PPARγ-dependent mechanism in mice following traumatic brain injury.
2018 Front Pharmacol Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-- Mice by Skewing Macrophages to the M2 Phenotype.
2018 J Hepatol Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice.
2018 Biomed Pharmacother Effects of penehyclidine hydrochloride on severe acute pancreatitis-associated acute lung injury in rats.
2018 Neurochem Res Antidepressant Effects of the Ginsenoside Metabolite Compound K, Assessed by Behavioral Despair Test and Chronic Unpredictable Mild Stress Model.
2018 Cell Biol Int Angiotensin II enhances the acetylation and release of HMGB1 in RAW264.7 macrophage.
2018 Aging Cell Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway.
2018 Jun Biochem Biophys Res Commun PKC delta activation increases neonatal rat retinal cells survival in vitro: Involvement of neurotrophins and M1 muscarinic receptors.
2018 Sep ACS Chem Neurosci A Novel M1 PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity.
2018 Psychopharmacology (Berl) Mnemonic and behavioral effects of biperiden, an M1-selective antagonist, in the rat.
2018 J Pharm Pharmacol Muscarinic and nicotinic acetylcholine receptor agonists: current scenario in Alzheimer's disease therapy.
2018 Oct J Neurotrauma Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice.
2018 Jun Exp Cell Res Reduced strate stiffness promotes M2-like macrophage activation and enhances peroxisome proliferator-activated receptor γ expression.
2018 Apr J Med Chem 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor.
2018 Jun Brain Res Inhibition of basal and amphetamine-stimulated extracellular signal-regulated kinase (ERK) phosphorylation in the rat forebrain by muscarinic acetylcholine M4 receptors.
2018 Neurochem Int Exposure to far-infrared rays attenuates methamphetamine-induced recognition memory impairment via modulation of the muscarinic M1 receptor, Nrf2, and PKC.
2018 J Pharmacol Exp Ther Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622.
2018 Chin Med Paeoniflorin exerts neuroprotective effects by modulating the M1M2 set polarization of microgliamacrophages in the hippocampal CA1 region of vascular dementia rats via cannabinoid receptor 2.
2018 Front Pharmacol Autoradiography of 3H-pirenzepine and 3H-AFDX-384 in Mouse Brain Regions: Possible Insights into M1, M2, and M4 Muscarinic Receptors Distribution.
2018 Apr J Neuroimmunol The inhibition of CB1 receptor accelerates the onset and development of EAE possibly by regulating microgliamacrophages polarization.
2018 Clin Drug Investig Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, SUVN-502, in Healthy Young Adults and Elderly Subjects.
2018 Obesity (Silver Spring) Dual CCR25 Antagonist Attenuates Obesity-Induced Insulin Resistance by Regulating Macrophage Recruitment and M1M2 Status.
2017 Dec Stem Cell Res Ther Preconditioning of murine mesenchymal stem cells synergistically enhanced immunomodulation and osteogenesis.