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Recent literature: P2Y1 receptor antagonist
Date Journal Article title
2019 Jan Mol Neurobiol A Targeted Mutation Disrupting Mitochondrial Complex IV Function in Primary Afferent Neurons Leads to Pain Hypersensitivity Through P2Y1 Receptor Activation.
2018 Sep Sci Rep GLS-409, an Antagonist of Both P2Y1 and P2Y12, Potently Inhibits Canine Coronary Artery Thrombosis and Reversibly Inhibits Human Platelet Activation.
2018 Oct Eur J Med Chem Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y1 receptor antagonists.
2019 J Cell Physiol Cyclic tensile force stimulates BMP9 synthesis and in vitro mineralization by human periodontal ligament cells.
2018 Front Pharmacol Microglia P2Y13 Receptors Prevent Astrocyte Proliferation Mediated by P2Y1 Receptors.
2018 Front Physiol High pH-Sensitive Store-Operated Ca2+ Entry Mediated by Ca2+ Release-Activated Ca2+ Channels in Rat Odontoblasts.
2018 Pharmacol Ther Tools and drugs for uracil nucleotide-activated P2Y receptors.
2018 May J Chem Theory Comput The Molecular Mechanism Underlying Ligand Binding to the Membrane-Embedded Site of a G-Protein-Coupled Receptor.
2018 Front Pharmacol Circadian ATP Release in Organotypic Cultures of the Rat Suprachiasmatic Nucleus Is Dependent on P2X7 and P2Y Receptors.
2018 Front Pharmacol P2Y6 Receptors Regulate CXCL10 Expression and Secretion in Mouse Intestinal Epithelial Cells.
2018 Mar Neurogastroenterol Motil Diabetes-induced colonic slow transit mediated by the up-regulation of PDGFRα+ cellsSK3 in streptozotocin-induced diabetic mice.
2018 Mol Med Rep P2Y1 receptor antagonists mitigate oxygen and glucose deprivation‑induced astrocyte injury.
2018 Methods Mol Biol Breakthrough in GPCR Crystallography and Its Impact on Computer-Aided Drug Design.
2017 J Sex Med Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries.
2017 Oct Sci Rep Identification of a Different Agonist-Binding Site and Activation Mechanism of the Human P2Y1 Receptor.
2017 Eur J Oral Sci Interaction between calcitonin gene-related peptide-immunoreactive neurons and satellite cells via P2Y12 R in the trigeminal ganglion is involved in neuropathic tongue pain in rats.
2017 Sep World J Gastroenterol P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome.
2017 Oct J Med Chem Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor.
2017 Mol Pharmacol Distinct Signaling Patterns of Allosteric Antagonism at the P2Y1 Receptor.
2018 Neuropharmacology P2X7 purinergic receptors participate in the expression and extinction processes of contextual fear conditioning memory in mice.
2017 Sep J Neurophysiol Fluorocitrate-mediated depolarization of astrocytes in the retrotrapezoid nucleus stimulates breathing.
2018 J Physiol Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca2+ -dependent P2Y1 receptor mechanism.
2017 Sci Adv Ligand binding to a G protein-coupled receptor captured in a mass spectrometer.
2016 J Physiol Biochem Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors.
2017 Front Cell Neurosci VPAC Receptor Subtypes Tune Purinergic Neuron-to-Glia Communication in the Murine Submucosal Plexus.
2017 Pulm Pharmacol Ther Lipopolysaccharide (LPS) induced pulmonary neutrophil recruitment and platelet activation is mediated via the P2Y1 and P2Y14 receptors in mice.
2017 Jun Oncotarget Carcinoma-specific expression of P2Y11 receptor and its contribution in ATP-induced purinergic signalling and cell migration in human hepatocellular carcinoma cells.
2017 Cell Signal Nucleotide P2Y13-stimulated phosphorylation of CREB is required for ADP-induced proliferation of late developing retinal glial progenitors in culture.
2017 Acta Biol Hung Viability of SH-SY5Y cells is associated with purinergic P2 receptor expression alterations.
2017 Brain Res Bull Involvement of peripheral P2Y1 receptors and potential interaction with IL-1 receptors in IL-1β-induced thermal hypersensitivity in rats.
2016 Front Pharmacol iIn silicoi Approach for Anti-Thrombosis Drug Discovery: P2Y1R Structure-Based TCMs Screening.
2017 Mar Exp Physiol R-Type Ca2+ channels couple to inhibitory neurotransmission to the longitudinal muscle in the guinea-pig ileum.
2017 J Gastroenterol Hepatol Adenosine triphosphate induces P2Y2 activation and interleukin-8 release in human esophageal epithelial cells.
2017 Purinergic Signal Diadenosine tetraphosphate as a potential therapeutic nucleotide to treat glaucoma.
2016 Platelets Validation of a P2Y12-receptor specific whole blood platelet aggregation assay.
2016 PLoS One Nitrergic Pathway Is the Main Contributing Mechanism in the Human Gastric Fundus Relaxation: An In Vitro Study.
2016 Aug Molecules Identification of a New Morpholine Scaffold as a P2Y12 Receptor Antagonist.
2017 Mol Neurobiol Adenine Nucleotides Control Proliferation In Vivo of Rat Retinal Progenitors by P2Y1 Receptor.
2016 Neuropharmacology BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents.
2016 Aug Angew Chem Int Ed Engl The Molecular Mechanism of P2Y1 Receptor Activation.
2016 Jul BMC Pharmacol Toxicol Functional and molecular evidence for heteromeric association of P2Y1 receptor with P2Y2 and P2Y4 receptors in mouse granulocytes.
2017 Mol Neurobiol Purinergic P2Y1 Receptors Control Rapid Expression of Plasma Membrane Processes in Hippocampal Astrocytes.
2016 Glia The inhibitory input to mouse cerebellar Purkinje cells is reciprocally modulated by Bergmann glial P2Y1 and AMPA receptor signaling.
2016 Purinergic Signal Coupling switch of P2Y-IP3 receptors mediates differential Ca(2+) signaling in human embryonic stem cells and derived cardiovascular progenitor cells.
2016 Arterioscler Thromb Vasc ... P2Y12 Receptor Modulates Sepsis-Induced Inflammation.
2016 Neurochem Res Impaired Purinergic Regulation of the Glial (Müller) Cell Volume in the Retina of Transgenic Rats Expressing Defective Polycystin-2.
2016 Acta Pharmacol Sin P2Y receptor-mediated transient relaxation of rat longitudinal ileum preparations involves phospholipase C activation, intracellular Ca(2+) release and SK channel activation.
2016 Vascul Pharmacol Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors.
2016 Feb J Neurosci P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors.
2016 Apr Brain Res Predominant role of spinal P2Y1 receptors in the development of neuropathic pain in rats.
2016 Vet J P2Y(1) receptors mediate purinergic relaxation in the equine pelvic flexure.
2015 Biol Aujourdhui [Anti-platelets without a bleeding risk: novel targets and strategies].
2016 J Thromb Thrombolysis The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys.
2015 Yakugaku Zasshi [Hetero-oligomerization and Functional Interaction between Purinergic Receptors Expressed in Platelets to Regulate Platelet Shape Change].
2015 Cell Physiol Biochem Extracellular Adenosine Diphosphate Ribose Mobilizes Intracellular Ca2+ via Purinergic-Dependent Ca2+ Pathways in Rat Pulmonary Artery Smooth Muscle Cells.
2016 Purinergic Signal Enhancement of acid-sensing ion channel activity by metabotropic P2Y UTP receptors in primary sensory neurons.
2016 Nov Eur Heart J Inhibition of the platelet P2Y12 receptor for adenosine diphosphate does not impair the capacity of platelet to synthesize thromboxane A2.
2016 Jan Neurosci Lett Sigma-1 receptor activation inhibits osmotic swelling of rat retinal glial (Müller) cells by transactivation of glutamatergic and purinergic receptors.
2015 Nov J Biol Chem P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.
2015 Dec Am J Physiol Heart Circ P... Purinergic glio-endothelial coupling during neuronal activity: role of P2Y1 receptors and eNOS in functional hyperemia in the mouse somatosensory cortex.
2015 Integr Cancer Sci Ther Blockade of extracellular NM23 or its endothelial target slows breast cancer growth and metastasis.
2015 Purinergic Signal Cardiomyogenesis of embryonic stem cells upon purinergic receptor activation by ADP and ATP.
2015 Dec J Physiol Shear stress induces a longitudinal Ca(2+) wave via autocrine activation of P2Y1 purinergic signalling in rat atrial myocytes.
2015 Sep Am J Physiol Renal Physiol UTP activates small-conductance Ca2+-activated K+ channels in murine detrusor PDGFRα+ cells.
2015 PLoS One Neuropeptide Y Stimulates Proliferation and Migration of Vascular Smooth Muscle Cells from Pregnancy Hypertensive Rats via Y1 and Y5 Receptors.
2015 PLoS One ROS Production via P2Y1-PKC-NOX2 Is Triggered by Extracellular ATP after Electrical Stimulation of Skeletal Muscle Cells.
2015 Biomed Res Contribution of extracellular ATP on the cell-surface F1F0-ATP synthase-mediated intracellular triacylglycerol accumulation.
2015 Apr Nature Two disparate ligand-binding sites in the human P2Y1 receptor.
2015 Naunyn Schmiedebergs Arch... Potassium 2-(1-hydroxypentyl)-benzoate inhibits ADP-induced rat platelet aggregation through P2Y1-PLC signaling pathways.
2015 Glia P2Y2 receptor antagonists as anti-allodynic agents in acute and -chronic trigeminal sensitization: role of satellite glial cells.
2015 Neuropharmacology P2Y(1) receptor mediated neuronal fibre outgrowth in organotypic brain slice co-cultures.
2015 Apr J Physiol Temporal sequence of activation of cells involved in purinergic neurotransmission in the colon.
2015 Arterioscler Thromb Vasc ... Characterization of a novel function-blocking antibody targeted against the platelet P2Y1 receptor.
2015 Cardiovasc Drugs Ther The ADP antagonist MRS2179 regulates the phenotype of smooth muscle cells to limit intimal hyperplasia.
2014 PLoS One The selective antagonism of P2X7 and P2Y1 receptors prevents synaptic failure and affects cell proliferation induced by oxygen and glucose deprivation in rat dentate gyrus.