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Recent literature: Bone resorption inhibitor
Date Journal Article title
2019 Aug Int Immunopharmacol LDC000067 presses RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced osteolysis in vivo.
2019 Theranostics Licorice isoliquiritigenin-encapsulated mesoporous silica nanoparticles for osteoclast inhibition and bone loss prevention.
2019 Exp Ther Med Eldecalcitol, an active vitamin D analog, effectively prevents cyclophosphamide-induced osteoporosis in rats.
2019 Aug J Periodontol Role of testosterone and androgen receptor in periodontal disease progression in female rats.
2019 Jul Oral Dis JAK2-STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis.
2019 Aug J Med Chem Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
2019 J Dent Res Activation of the STAT1 Pathway Accelerates Periodontitis in iNos3--i Mice.
2019 Cell Biochem Funct Suppressive effects of N-bisphosphonate in osteoblastic cells mitigated by non-N-bisphosphonate but not by sodium-dependent phosphate cotransporter inhibitor.
2019 Jul IUBMB Life MicroRNA-155 inhibition up-regulates LEPR to inhibit osteoclast activation and bone resorption via activation of AMPK in alendronate-treated osteoporotic mice.
2019 Jul J Cell Mol Med MicroRNA-92b-5p modulates melatonin-mediated osteogenic differentiation of bone marrow mesenchymal stem cells by targeting ICAM-1.
2019 Jul FASEB J The effects of tranylcypromine on osteoclastogenesis iin vitroi and iin vivoi.
2019 Jul Proc Natl Acad Sci U S A Sfrp4 repression of the Ror2Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption.
2019 Jun Int Immunopharmacol Lysophosphatidic acid induces interleukin-6 and CXCL15 secretion from MLO-Y4 cells through activation of the LPA1 receptor and PKCθ signaling pathway.
2019 Sep Exp Cell Res Nirogacestat presses RANKL-Induced osteoclast formation in vitro and attenuates LPS-Induced bone resorption in vivo.
2019 Pharmacol Rep From bone resorption inhibitor to neuroprotective drug: The effects of bisphosphonates.
2019 Case Rep Nephrol Dial Severe, Symptomatic Hypocalcemia due to Denosumab Administration: Treatment and Clinical Course.
2019 Jun Mar Drugs Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of AktGSK3βPTENNFATc1 Signaling Pathway and Calcineurin Activity.
2019 Calcif Tissue Int Reversal of Osteopenia in Ovariectomized Rats by Pentoxifylline: Evidence of Osteogenic and Osteo-Angiogenic Roles of the Drug.
2019 J Cancer Res Clin Oncol Targeting cathepsin K diminishes prostate cancer establishment and growth in murine bone.
2019 Int Immunopharmacol Multitarget-based cotreatment with cilostazol and celecoxib synergistically presses collagen-induced arthritis in mice by enhancing interleukin-10 expression.
2019 Jun J Appl Oral Sci Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage.
2019 Cancer Treat Rev Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody.
2019 May Aging (Albany NY) A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening presses osteoclast function, but not osteoclast differentiation, iin vitroi.
2019 May J Bone Miner Res Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.
2019 Jul Biochem Biophys Res Commun Vx-11e protects against titanium-particle-induced osteolysis and osteoclastogenesis by ressing ERK activity.
2019 Jun J Med Chem Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.
2019 Jul Endocrinology Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2Anoikis Signaling.
2019 May J Periodontol Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: A 6-month randomized controlled clinical trial.
2019 May Sci Rep Specific targeting of PKCδ presses osteoclast differentiation by accelerating proteolysis of membrane-bound macrophage colony-stimulating factor receptor.
2019 Apr BMC Mol Cell Biol Compression and tension variably alter Osteoprotegerin expression via miR-3198 in periodontal ligament cells.
2019 Bone Agonist-induced activation of the S1P receptor 2 constitutes a novel osteoanabolic therapy for the treatment of osteoporosis in mice.
2019 J Cell Physiol LY411575, a potent γ-secretase inhibitor, presses osteoclastogenesis in vitro and LPS-induced calvarial osteolysis in vivo.
2019 J Bone Miner Res An Ectosteric Inhibitor of Cathepsin K Inhibits Bone Resorption in Ovariectomized Mice.
2019 Apr JCI Insight Activation of the calcium sensing receptor attenuates TRPV6-dependent intestinal calcium absorption.
2019 J Bone Oncol Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients.
2019 May J Endocr Soc The Bone Phenotype and Pain Response to Pamidronate in Tyrosine Kinase Inhibitor-Treated Chronic Myelogenous Leukemia.
2019 Apr JCI Insight Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness.
2019 Expert Opin Pharmacother Current and emerging osteoporosis pharmacotherapy for women: state of the art therapies for preventing bone loss.
2019 Bone Rep Bruton's tyrosine kinase (Btk) inhibitor tirabrutinib presses osteoclastic bone resorption.
2019 J Bone Oncol Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone growth model.
2019 Biomed Res Int Positive Correlation between Activated CypACD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion.
2019 Jpn Dent Sci Rev Imaging modalities for drug-related osteonecrosis of the jaw (2), Overview of the position paper on medication-related osteonecrosis of the jaw and the current status of the MRONJ in Japan.
2019 Basic Clin Pharmacol Toxicol Lansoprazole inhibits the cysteine protease legumain by binding to the active site.
2019 Bone Vibration enhances osteoclastogenesis by inducing RANKL expression via NF-κB signaling in osteocytes.
2019 FASEB J Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP presses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway.
2019 Mar J Periodontal Res Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts.
2019 May Exp Cell Res Fusion and hemagglutinin proteins of canine distemper virus promote osteoclast formation through NF-κB dependent and independent mechanisms.
2018 Dec Cureus Malignant Sarcomatous Transformation of Benign Giant Cell Tumor of Bone after Treatment with Denosumab Therapy: A Literature Review of Reported Cases.
2019 Bone Oral dosing of pentoxifylline, a pan-phosphodiesterase inhibitor restores bone mass and quality in osteopenic rabbits by an osteogenic mechanism: A comparative study with human parathyroid hormone.
2019 Mol Med Rep NEMO‑binding domain peptide ameliorates inflammatory bone destruction in a Staphylococcus aureus‑induced chronic osteomyelitis model.
2019 Clin Calcium [Regulations of osteoclast formation and function by Wnt signals.]
2019 J Tissue Eng Regen Med Nanoparticulate mineralized collagen glycosaminoglycan materials directly and indirectly inhibit osteoclastogenesis and osteoclast activation.
2019 Arthritis Rheumatol Activation of the Peroxisome Proliferator-Activated Receptor γ Coactivator 1βNFATc1 Pathway in Circulating Osteoclast Precursors Associated With Bone Destruction in Rheumatoid Arthritis.
2019 Bone Sostdc1: A soluble BMP and Wnt antagonist that is induced by the interaction between myeloma cells and osteoblast lineage cells.
2019 Feb Nutrients Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity.
2019 Free Radic Res Glutathione accelerates osteoclast differentiation and inflammatory bone destruction.
2019 Osteoporos Int Association of blood n-3 fatty acid with bone mass and bone marrow TRAP-5b in the elderly with and without hip fracture.
2019 Mar Biochem Biophys Res Commun Proton pumping V-ATPase inhibitor bafilomycin A1 affects Rab7 lysosomal localization and abolishes anterograde trafficking of osteoclast secretory lysosomes.
2019 Tohoku J Exp Med Antiresorptive Agent-Related Osteonecrosis of the Jaw (ARONJ): A Twist of Fate in the Bone.
2019 Feb J Bone Miner Metab Novel bisphosphonate compound FYB-931 preferentially inhibits aortic calcification in vitamin D3-treated rats.
2019 FASEB J Psoralen accelerates bone fracture healing by activating both osteoclasts and osteoblasts.
2019 Mar Biochem Biophys Res Commun Role of ANTXR1 in the regulation of RANKL-induced osteoclast differentiation and function.
2019 Apr Eur J Pharmacol Histone deacetylase inhibitor CI-994 inhibits osteoclastogenesis via pressing NF-κB and the downstream c-FosNFATc1 signaling pathways.
2019 Drug Dev Ind Pharm Bioactive injectable triple acting thermosensitive hydrogel enriched with nano-hydroxyapatite for bone regeneration: in-vitro characterization, Saos-2 cell line cell viability and osteogenic markers evaluation.
2019 Metabolism Extracellular vesicles from human umbilical cord blood ameliorate bone loss in senile osteoporotic mice.
2019 Br J Clin Pharmacol Clinical and translational pharmacology of the cathepsin K inhibitor odanacatib studied for osteoporosis.
2019 J Cell Physiol AZD8835 inhibits osteoclastogenesis and periodontitis-induced alveolar bone loss in rats.
2019 Feb J Med Chem Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing.
2018 J Dent Anesth Pain Med Propofol promotes osteoclastic bone resorption by increasing DC-STAMP expression.
2019 J Clin Periodontol Inhibition of Ctsk alleviates periodontitis and comorbid rheumatoid arthritis via downregulation of the TLR9 signalling pathway.
2019 Jan Biomolecules Specialized Roles for Actin in Osteoclasts: Unanswered Questions and Therapeutic Opportunities.
2019 Bone Res Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis.
2019 Feb Biochem J Identification of strate-specific inhibitors of cathepsin K through high-throughput screening.
2019 J Bone Miner Res The Novel p38 Inhibitor, Pamapimod, Inhibits Osteoclastogenesis and Counteracts Estrogen-Dependent Bone Loss in Mice.
2019 PLoS One Calcium mimics the chemotactic effect of conditioned media and is an effective inducer of bone regeneration.