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Recent literature: Bone resorption inhibitor
Date Journal Article title
2020 Jan Exp Cell Res PP121 presses RANKL-Induced osteoclast formation in vitro and attenuates LPS-Induced bone resorption in vivo.
2020 Jan FASEB J High shear stress amplitude in combination with prolonged stimulus duration determine induction of osteoclast formation by hematopoietic progenitor cells.
2019 Mediators Inflamm Concomitant Treatment with Etanercept and Tacrolimus Synergistically Attenuates Arthritis Progression via Inhibition of Matrix Metalloproteinase-3 Production and Osteoclastogenesis in Human TNF-iαi Transgenic Mice.
2020 Jan Sci Rep Hyaluronan presses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-28 cells.
2019 Front Immunol Loss of Dkk-1 in Osteocytes Mitigates Alveolar Bone Loss in Mice With Periodontitis.
2020 Jan Med Sci Monit Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway.
2019 Dec Nurs Womens Health New Osteoporosis Treatment Means New Bone Formation.
2020 Thromb Res Inhibitory effects of dabigatran etexilate, a direct thrombin inhibitor, on osteoclasts and osteoblasts.
2019 Dec Calcif Tissue Int Effects of Long-Term Sclerostin Deficiency on Trabecular Bone Mass and Adaption to Limb Loading Differ in Male and Female Mice.
2019 Dec Arthritis Res Ther Pharmacological inhibition of TAK1, with the selective inhibitor takinib, alleviates clinical manifestation of arthritis in CIA mice.
2019 Dec J Bone Miner Res Inhibition of Osteoclastogenesis by the RNA-Binding Protein QKI5: a Novel Approach to Protect from Bone Resorption.
2019 Oxid Med Cell Longev Dnmt3a-Mediated DNA Methylation Changes Regulate Osteogenic Differentiation of hMSCs Cultivated in the 3D Scaffolds under Oxidative Stress.
2019 Nov Immunobiology Potential anti-arthritic and anti-inflammatory effects of TNF-α processing inhibitor-1 (TAPI-1): A new approach to the treatment of S. aureus arthritis.
2020 Small A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis.
2019 Dec AAPS PharmSciTech QbD Approach for Novel Crosslinker-Free Ionotropic Gelation of Risedronate Sodium-Chitosan Nebulizable Microspheres: Optimization and Characterization.
2019 Nov Mol Cancer Ther A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption.
2020 Biochim Biophys Acta Prot... Rat cathepsin K: Enzymatic specificity and regulation of its collagenolytic activity.
2019 Nov Rheumatol Ther Spebrutinib (CC-292) Affects Markers of B Cell Activation, Chemotaxis, and Osteoclasts in Patients with Rheumatoid Arthritis: Results from a Mechanistic Study.
2019 Dec Toxicol Appl Pharmacol Two novel peptides from ark shell protein stimulate osteoblast differentiation and rescue ovariectomy-induced bone loss.
2020 Cell Prolif Suppression of AMP-activated protein kinase reverses osteoprotegerin-induced inhibition of osteoclast differentiation by reducing autophagy.
2019 Dec J Phys Chem B Inhibiting Human Calcitonin Fibril Formation with Its Most Relevant Aggregation-Resistant Analog.
2019 Lancet Diabetes Endocrinol Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study.
2019 Regen Ther An osteogenic helioxanthin derivative presses the formation of bone-resorbing osteoclasts.
2019 J Bone Oncol An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain.
2019 Oct Sci Rep Roles of monocarboxylate transporter types in promotion and pression of osteoclast differentiation and survival on bone.
2019 Oct J Cell Physiol YAP1 inhibits the induction of TNF-α-stimulated bone-resorbing mediators by pressing the NF-κB signaling pathway in MC3T3-E1 cells.
2019 Oct Int J Mol Sci Inhibitory Effects of iNi-[2-(4-acetyl-1-piperazinyl) phenyl]-2-(2-chlorophenoxy) acetamide on Osteoclast Differentiation In Vitro via the Downregulation of TRAF6.
2019 Oct Drug Dev Res Chronic administration of Cl-amidine, a pan-peptidylarginine deiminase inhibitor, does not reverse bone loss in two different murine models of osteoporosis.
2019 Oct J Bone Miner Res Alveolar Bone Protection by Targeting the SH3BP2-SYK Axis in Osteoclasts.
2019 Oct J Bone Miner Res Targeting Bortezomib to Bone Increases Its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice.
2020 Orthod Craniofac Res Impact of pharmacologic inhibition of tooth movement on periodontal and tooth root tissues during orthodontic force application.
2019 Oct J Clin Med TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss.
2019 Sep JAMA Netw Open Association of Fat Body Mass With Vertebral Fractures in Postmenopausal Women With Early Breast Cancer Undergoing Adjuvant Aromatase Inhibitor Therapy.
2019 Ann Transl Med Effects of GLP-1 receptor analogue liraglutide and DPP-4 inhibitor vildagliptin on the bone metabolism in ApoE-- mice.
2019 Sep Exp Mol Med Adaptor protein CrkII negatively regulates osteoblast differentiation and function through JNK phosphorylation.
2019 Sep Nutrients Egg White Ovotransferrin Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption.
2019 Nov Biochem Biophys Res Commun Lung tumor cells inhibit bone mineralization and osteoblast activity.
2020 Cell Biol Int Melatonin promotes osteoblastic differentiation and regulates PDGFAKT signaling pathway.
2020 J Cell Physiol Antiosteoclastic bone resorption activity of osteoprotegerin via enhanced AKTmTORULK1-mediated autophagic pathway.
2019 Sep Endocr J Elevated levels of circulating fibroblast growth factor 23 with hypercalcemia following discontinuation of denosumab.
2020 Jan Int J Biol Macromol Inhibition of protein phosphatase 2A attenuates titanium-particle induced pression of bone formation.
2019 Sep Cell Death Dis The emerging role of IMD 0354 on bone homeostasis by pressing osteoclastogenesis and bone resorption, but without affecting bone formation.
2020 J Bone Miner Res EZH2 Supports Osteoclast Differentiation and Bone Resorption Via Epigenetic and Cytoplasmic Targets.
2019 Sep J Periodontol Occlusal trauma inhibits osteoblast differentiation and bone formation through IKK-NF-κB signaling.
2019 Oxid Med Cell Longev Methylene Blue-Mediated Photodynamic Therapy Induces Macrophage Apoptosis via ROS and Reduces Bone Resorption in Periodontitis.
2019 Front Pharmacol Administration of SB239063 Ameliorates Ovariectomy-Induced Bone Loss iviai Suppressing Osteoclastogenesis in Mice.
2020 Cytokine Proteasome inhibition press microgravity elevated RANK signaling during osteoclast differentiation.
2019 Int Immunopharmacol LDC000067 presses RANKL-induced osteoclastogenesis in vitro and prevents LPS-induced osteolysis in vivo.
2019 Theranostics Licorice isoliquiritigenin-encapsulated mesoporous silica nanoparticles for osteoclast inhibition and bone loss prevention.
2019 Exp Ther Med Eldecalcitol, an active vitamin D analog, effectively prevents cyclophosphamide-induced osteoporosis in rats.
2019 Aug J Periodontol Role of testosterone and androgen receptor in periodontal disease progression in female rats.
2019 Oral Dis JAK2-STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis.
2019 Aug J Med Chem Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis.
2019 J Dent Res Activation of the STAT1 Pathway Accelerates Periodontitis in iNos3--i Mice.
2019 Cell Biochem Funct Suppressive effects of N-bisphosphonate in osteoblastic cells mitigated by non-N-bisphosphonate but not by sodium-dependent phosphate cotransporter inhibitor.
2019 IUBMB Life MicroRNA-155 inhibition up-regulates LEPR to inhibit osteoclast activation and bone resorption via activation of AMPK in alendronate-treated osteoporotic mice.
2019 J Cell Mol Med MicroRNA-92b-5p modulates melatonin-mediated osteogenic differentiation of bone marrow mesenchymal stem cells by targeting ICAM-1.
2019 FASEB J The effects of tranylcypromine on osteoclastogenesis iin vitroi and iin vivoi.
2019 Jul Proc Natl Acad Sci U S A Sfrp4 repression of the Ror2Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption.
2019 Int Immunopharmacol Lysophosphatidic acid induces interleukin-6 and CXCL15 secretion from MLO-Y4 cells through activation of the LPA1 receptor and PKCθ signaling pathway.
2019 Sep Exp Cell Res Nirogacestat presses RANKL-Induced osteoclast formation in vitro and attenuates LPS-Induced bone resorption in vivo.
2019 Pharmacol Rep From bone resorption inhibitor to neuroprotective drug: The effects of bisphosphonates.
2019 Case Rep Nephrol Dial Severe, Symptomatic Hypocalcemia due to Denosumab Administration: Treatment and Clinical Course.
2019 Jun Mar Drugs Fucoidan Prevents RANKL-Stimulated Osteoclastogenesis and LPS-Induced Inflammatory Bone Loss via Regulation of AktGSK3βPTENNFATc1 Signaling Pathway and Calcineurin Activity.
2019 Calcif Tissue Int Reversal of Osteopenia in Ovariectomized Rats by Pentoxifylline: Evidence of Osteogenic and Osteo-Angiogenic Roles of the Drug.
2019 J Cancer Res Clin Oncol Targeting cathepsin K diminishes prostate cancer establishment and growth in murine bone.
2019 Int Immunopharmacol Multitarget-based cotreatment with cilostazol and celecoxib synergistically presses collagen-induced arthritis in mice by enhancing interleukin-10 expression.
2019 Jun J Appl Oral Sci Periapical bone response to bacterial lipopolysaccharide is shifted upon cyclooxygenase blockage.
2019 EBioMedicine Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice.
2019 Cancer Treat Rev Management of bone health in solid tumours: From bisphosphonates to a monoclonal antibody.
2019 May Aging (Albany NY) A small molecular inhibitor of LRRK1 identified by homology modeling and virtual screening presses osteoclast function, but not osteoclast differentiation, iin vitroi.
2019 J Bone Miner Res Novel Role for Claudin-11 in the Regulation of Osteoblasts via Modulation of ADAM10-Mediated Notch Signaling.
2019 Jul Biochem Biophys Res Commun Vx-11e protects against titanium-particle-induced osteolysis and osteoclastogenesis by ressing ERK activity.
2019 Jun J Med Chem Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Receptor Activator of Nuclear Factor-κB (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization.
2019 Jul Endocrinology Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2Anoikis Signaling.