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Recent literature: Androgen receptor antagonist
Date Journal Article title
2019 Apr Prostate A bypass mechanism of abiraterone-resistant prostate cancer: Accumulating CYP17A1 strates activate androgen receptor signaling.
2019 Apr Cancer Res Activation of MAPK signaling by CXCR7 leads to enzalutamide resistance in prostate cancer.
2019 Apr J Biol Chem NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells.
2019 Jun Eur J Med Chem Discovery and biological evaluation of novel androgen receptor antagonist for castration-resistant prostate cancer.
2019 Mar J Neuroendocrinol Age-dependent regulation by androgens of gene expression in the anterior hypothalamus and stress-induced release of adrenal hormones in adolescent and adult male rats.
2019 Jul Ecotoxicol Environ Saf A comparison of endocrine disruption potential of nonylphenol ethoxylate, vanillin ethoxylate, 4-n-nonylphenol and vanillin in vitro.
2019 Apr Mol Cell Endocrinol Maternal exposure to imazalil disrupts the endocrine system in F1 generation mice.
2019 Mar Br J Pharmacol Androgen receptor antagonism accelerates disease onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis.
2019 Mar Int J Cancer Darolutamide is a potent androgen receptor antagonist with strong efficacy in prostate cancer models.
2019 Cancer Discov Darolutamide Slows Metastasis in Prostate Cancer.
2019 Feb J Drugs Dermatol Cortexolone 17α-Propionate (Clascoterone) is an Androgen Receptor Antagonist in Dermal Papilla Cells In Vitro
2019 Feb Mol Cancer Res Lipid Uptake Is an Androgen-Enhanced Lipid Supply Pathway Associated with Prostate Cancer Disease Progression and Bone Metastasis.
2019 Front Endocrinol (Lausanne) Testosterone Promotes Glioblastoma Cell Proliferation, Migration, and Invasion Through Androgen Receptor Activation.
2019 Mar N Engl J Med Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer.
2019 Apr Eur J Med Chem Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists.
2019 Feb Toxicol In Vitro Assessment of human estrogen receptor agonisticantagonistic effects of veterinary drugs used for livestock and farmed fish by OECD in vitro stably transfected transcriptional activation assays.
2019 Feb Curr Treat Options Oncol Management of Nonmetastatic Castration-Resistant Prostate Cancer: Recent Advances and Future Direction.
2019 Mar Eur J Med Chem Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist.
2019 Apr Mol Cell Endocrinol Rapid effect of bisphenol A on glutamate-induced Ca2+ influx in hippocampal neurons of rats.
2019 Jan J Cell Physiol PLCε knockdown overcomes drug resistance to androgen receptor antagonist in castration-resistant prostate cancer by pressing the wnt3aβ-catenin pathway.
2019 Jan J Cell Physiol Dihydrotestosterone synthesis in the sheep corpus luteum and its potential mechanism in luteal regression.
2018 Neuro Endocrinol Lett Selected bisphenols and phthalates screened for estrogen and androgen disruption by in silico and in vitro methods.
2019 Feb J Chem Inf Model Communication between the Ligand-Binding Pocket and the Activation Function-2 Domain of Androgen Receptor Revealed by Molecular Dynamics Simulations.
2019 Jan Horm Behav Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.
2019 Apr Toxicol Sci A Conflicted Tale of Two Novel AR Antagonists In Vitro and In Vivo: Pyrifluquinazon Versus Bisphenol C.
2019 Jan J Steroid Biochem Mol Biol A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics.
2019 J Mol Cell Cardiol Prenatal exposure to testosterone induces cardiac hypertrophy in adult female rats through enhanced Pkcδ expression in cardiac myocytes.
2018 Genomics Proteomics Bioin... Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays.
2019 Neural Regen Res Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease.
2019 J Steroid Biochem Mol Biol Halogen-stituted anthranilic acid derivatives provide a novel chemical platform for androgen receptor antagonists.
2019 Chemosphere Evaluation of endocrine activities of ellagic acid and urolithins using reporter gene assays.
2018 Dec Mol Ecol Experimentally induced variation in neuroendocrine processes affects male reproductive behaviour, sperm characteristics and social interactions.
2019 J Cell Physiol Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
2019 Biomed Pharmacother Effect of AR antagonist combined with PARP1 inhibitor on sporadic triple-negative breast cancer bearing AR expression and methylation-mediated BRCA1 dysfunction.
2018 Ther Adv Urol Apalutamide in the treatment of castrate-resistant prostate cancer: evidence from clinical trials.
2018 Dec Neoplasma Pituitary tumor transforming gene binding factor (PBF) is required for androgen-induced prostate cancer proliferation and invasion.
2019 Feb Endocr Relat Cancer Non-canonical AR activity facilitates endocrine resistance in breast cancer.
2018 Front Pharmacol Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site.
2019 Hum Pathol Molecular characterization of metaplastic breast carcinoma via next-generation sequencing.
2019 Jan J Med Chem New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity.
2019 Prostate Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response.
2018 Dec Cell Rep Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator.
2018 Dec Aging (Albany NY) BCAR4 activates GLI2 signaling in prostate cancer to contribute to castration resistance.
2019 Jan Neuroscience Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures.
2019 Jan Bioorg Med Chem Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents.
2018 Nov J Endocrinol Invest Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: a potential mechanism of endocrine disruptor atherogenic effect.
2019 Andrology Effect of hormone modulations on donor-derived spermatogenesis or colonization after syngeneic and xenotransplantation in mice.
2019 Chem Biol Drug Des Suitability of MMGBSA for the selection of correct ligand binding modes from docking results.
2019 Expert Opin Pharmacother Perspectives on the current and emerging chemical androgen receptor antagonists for the treatment of prostate cancer.
2018 Nov J Clin Med Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy.
2018 Pharmacol Res Perspect Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino-terminal domain.
2018 Oct J Endocrinol Androgens modulate glucocorticoid receptor activity in adipose tissue and liver.
2019 Jan Endocr Relat Cancer Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer.
2018 Nov J Agric Food Chem Effects of Flavored Nonalcoholic Beverages on Transcriptional Activities of Nuclear and Steroid Hormone Receptors: Proof of Concept for Novel Reporter Cell Line PAZ-PPARg.
2019 Toxicol Lett In vitro bioassay investigations of suspected obesogen monosodium glutamate at the level of nuclear receptor binding and steroidogenesis.
2018 Nov Endocrine Limited short-term effects on human prostate cancer xenograft growth and epidermal growth factor receptor gene expression by the ghrelin receptor antagonist [D-Lys3]-GHRP-6.
2018 Oct Endocr Relat Cancer Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond
2018 Oct J Invest Surg Retardation of Preputial Wound Healing in Rats with Hypospadias Induced by Flutamide.
2019 Cell Mol Life Sci Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice.
2019 Stress Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids.
2018 Oct Int J Mol Sci Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
2018 Oct J Cell Biochem IL-1 induces p62SQSTM1 and autophagy in ERα+ PR+ BCa cell lines concomitant with ERα and PR repression, conferring an ERα- PR- BCa-like phenotype.
2018 Arch Pharm (Weinheim) Synthesis of androgen receptor antagonists containing a pentafluorosulfanyl (SF5 ) moiety.
2019 J Cell Physiol Androgen receptor transcriptional activity and chromatin modifications on the ABCB1MDR gene are critical for taxol resistance in ovarian cancer cells.
2018 Oct Invest New Drugs Phase 1 trial of enzalutamide in combination with gemcitabine and nab-paclitaxel for the treatment of advanced pancreatic cancer.
2018 Oct Biochem Biophys Res Commun BAF53A regulates androgen receptor-mediated gene expression and proliferation in LNCaP cells.
2018 Commun Biol Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance.
2018 Sep Biosci Biotechnol Biochem Chemistry and biology for the small molecules targeting characteristics of cancer cells.
2019 J Invest Dermatol Spironolactone Depletes the XPB Protein and Inhibits DNA Damage Responses in UVB-Irradiated Human Skin.
2019 J Exp Zool A Ecol Integr ... Effect of glucocorticoids on androgen biosynthesis in the testes of the toad Rhinella arenarum (Amphibia, Anura).
2018 Sep Curr Med Chem Non-Steroidal Androgen Receptor Antagonists and Prostate Cancer: a Survey on Chemical Structures Binding this Fast-Mutating Target.
2018 Reprod Toxicol Evaluation of androgen assay results using a curated Hershberger database.
2018 Clin Genitourin Cancer Clinical Development of Darolutamide: A Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
2019 Jan Am J Physiol Endocrinol M... Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model.
2019 J Med Ultrason (2001) Cancer therapeutics-related cardiac dysfunction in a patient treated with abiraterone for castration-resistant prostate cancer.