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Recent literature: Androgen receptor antagonist
Date Journal Article title
2020 Environ Health Perspect CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity.
2019 Nov Ned Tijdschr Geneeskd [Androgen receptor inhibitors in prostate cancer: new drugs, but for which patient?]
2020 Ann Oncol Deep androgen receptor pression in prostate cancer exploits sexually dimorphic renal expression for systemic glucocorticoid exposure.
2020 Theranostics Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts.
2020 Feb Free Radic Biol Med Methiothepin mesylate causes apoptosis of human prostate cancer cells by mediating oxidative stress and mitochondrial dysfunction.
2020 Feb Cancer Res Modeling acquired resistance to the second-generation androgen receptor antagonist enzalutamide in the TRAMP model of prostate cancer.
2020 Feb Invest New Drugs Metabolomic profiling to evaluate the efficacy of proxalutamide, a novel androgen receptor antagonist, in prostate cancer cells.
2020 Feb Endocrinology Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep.
2020 Feb Xenobiotica Absorption, distribution, metabolism and excretion of darolutamide (a novel non-steroidal androgen receptor antagonist) in rats.
2020 Jan Cell Biol Toxicol Regression of castration-resistant prostate cancer by a novel compound QW07 targeting androgen receptor N-terminal domain.
2020 Jan Environ Pollut The mixture effects of bisphenol derivatives on estrogen receptor and androgen receptor.
2020 Jan J Neuroinflammation The synthetic steroid tibolone exerts sex-specific regulation of astrocyte phagocytosis under basal conditions and after an inflammatory challenge.
2020 Int J Mol Med Echinacoside‑induced nitric oxide production in endothelial cells: Roles of androgen receptor and the PI3K‑Akt pathway.
2020 J Mol Graph Model Optimization of CHARMM force field parameters of a prostate cancer drug enzalutamide.
2020 Jan StatPearls Eplerenone
2020 J Cancer Androgen Receptor (AR)-TLR4 Crosstalk Mediates Gender Disparities in Hepatocellular Carcinoma Incidence and Progression.
2020 Jan Biol Sex Differ 6β-Hydroxytestosterone, a metabolite of testosterone generated by CYP1B1, contributes to vascular changes in angiotensin II-induced hypertension in male mice.
2020 Jan Clin Cancer Res Diverse AR Gene Rearrangements Mediate Resistance to Androgen Receptor Inhibitors in Metastatic Prostate Cancer.
2020 Jan Neoplasia Androgen receptor degraders overcome common resistance mechanisms developed during prostate cancer treatment.
2020 Jan J Biomol Struct Dyn Syringaresinol as a novel androgen receptor antagonist against wild and mutant androgen receptors for the treatment of castration-resistant prostate cancer: molecular docking, iin-vitroi and molecular dynamics study.
2020 Jan Anticancer Drugs Combination treatment of bicalutamide and curcumin has a strong therapeutic effect on androgen receptor-positive triple-negative breast cancers.
2019 Prev Nutr Food Sci Standardized Seed Extract of iQuisqualis indicai (HU-033) Attenuates Testosterone Propionate-Induced Benign Prostatic Hyperplasia iviai α1-Adrenergic Receptors and AndrogenEstrogen Signaling.
2020 Jan Am J Physiol Endocrinol M... CMKLR1 deficiency attenuates androgen-inducedlipid accumulation in mice.
2019 Genes Environ Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers.
2019 Physiol Rep The effects of flutamide on the neonatal rat hypothalamic-pituitary-adrenal and gonadal axes in response to hypoxia.
2020 Prostate A novel androgen receptor antagonist JJ-450 inhibits enzalutamide-resistant mutant ARF876L nuclear import and function.
2019 Dec Animals (Basel) Neonatal Exposure to Agonists and Antagonists of Sex Steroid Receptors Affects AMH and FSH Plasma Level and Their Receptors Expression in the Adult Pig Ovary.
2019 Dec Prostate Cancer Prostatic... A review of prostate cancer treatment impact on the CNS and cognitive function.
2019 Dec Clin Cancer Res TBCRC 032 IBII Multicenter Study: Molecular insights to AR antagonist and PI3K inhibitor efficacy in patients with AR+ metastatic triple-negative breast cancer.
2019 Dec J Med Chem Discovery of Highly Potent and Efficient PROTAC Degraders of Androgen Receptor (AR) by Employing Weak Binding Affinity VHL E3 Ligase Ligands.
2020 Endocr Connect AR mRNA stability is increased with AR-antagonist resistance via 3'UTR variants.
2019 Nov Clin Cancer Res Reciprocal and Autonomous Glucocorticoid and Androgen Receptor Activation in Salivary Duct Carcinoma.
2020 Prostate Peroxisome proliferator-activated receptor gamma controls prostate cancer cell growth through AR-dependent and independent mechanisms.
2019 Nov J Clin Endocrinol Metab Activation of β-catenin signaling and its cross talk with estrogen and histone deacetylases in human uterine fibroids.
2020 Mar Eur J Pharmacol Inhibitory effect of α1D1A antagonist 2-(1H-indol-3-yl)-N-[3-(4-(2-methoxyphenyl) piperazinyl) propyl] acetamide on estrogenandrogen-induced rat benign prostatic hyperplasia model in vivo.
2019 Nov Anticancer Agents Med Chem Design, Synthesis and Evaluation of Novel Substituted (5-methyl-1H-pyrazol-3-yl)-1,3,4-oxadiazole as Potent Androgen Receptor Antagonist.
2020 Mol Biol Rep LPS impairs steroidogenesis and ROS metabolism and induces PPAR transcriptional activity to disturb estrogenandrogen receptor expression in testicular cells.
2019 Dec Hum Reprod The regulation and signalling of anti-Müllerian hormone in human granulosa cells: relevance to polycystic ovary syndrome.
2019 Nov iScience Androgen Receptor Is a Non-canonical Inhibitor of Wild-Type and Mutant Estrogen Receptors in Hormone Receptor-Positive Breast Cancers.
2019 Onco Targets Ther Darolutamide For Castration-Resistant Prostate Cancer.
2020 Steroids New steroidal oxazolines, benzoxazoles and benzimidazoles related to abiraterone and galeterone.
2020 Jan Mol Cell Endocrinol Testosterone induces up-regulation of mitochondrial gene expression in murine C2C12 skeletal muscle cells accompanied by an increase of nuclear respiratory factor-1 and its downstream effectors.
2019 Oct Sci Rep Evaluation of Small Molecule Drug Uptake in Patient-Derived Prostate Cancer Explants by Mass Spectrometry.
2019 Drugs Darolutamide: First Approval.
2020 Mol Cancer Ther The Novel ATR Inhibitor BAY 1895344 Is Efficacious as Monotherapy and Combined with DNA Damage-Inducing or Repair-Compromising Therapies in Preclinical Cancer Models.
2019 Eur J Drug Metab Pharmaco... Drug-Drug Interaction Potential of Darolutamide: In Vitro and Clinical Studies.
2019 Target Oncol Evaluation of Clinically Relevant Drug-Drug Interactions and Population Pharmacokinetics of Darolutamide in Patients with Nonmetastatic Castration-Resistant Prostate Cancer: Results of Pre-Specified and Post Hoc Analyses of the Phase III ARAMIS Trial.
2019 PLoS One TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer.
2019 Sep Gynecol Endocrinol Decreased levels of liver-expressed antimicrobial peptide-2 and ghrelin are related to insulin resistance in women with polycystic ovary syndrome.
2019 Sep Int J Mol Sci Mechanisms of Stress-Induced Spermatogenesis Impairment in Male Rats Following Unpredictable Chronic Mild Stress (uCMS).
2019 Nov Nucleic Acids Res Molecular determinants for enzalutamide-induced transcription in prostate cancer.
2019 Oct Bioorg Med Chem Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety.
2019 Nov Clin Cancer Res Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer.
2019 Sep Elife Androgen-regulated transcription of iESRP2i drives alternative splicing patterns in prostate cancer.
2019 Urologe A [A new androgen receptor antagonist : Darolutamide for patients with non-metastatic castration-resistant prostate cancer].
2019 J Steroid Biochem Mol Biol Androgen receptor activation reduces the endothelial cell proliferation through activating the cSrcAKTp38ERKNFκB-mediated pathway.
2019 J Enzyme Inhib Med Chem Design, synthesis, and biological evaluation of novel androst-17β-amide structurally related compounds as dual 5α-reductase inhibitors and androgen receptor antagonists.
2019 Front Physiol Deep Learning-Based Structure-Activity Relationship Modeling for Multi-Category Toxicity Classification: A Case Study of 10K Tox21 Chemicals With High-Throughput Cell-Based Androgen Receptor Bioassay Data.
2019 Int J Clin Oncol An open-label, phase 1 study of androgen receptor antagonist, apalutamide in Japanese patients with metastatic castration-resistant prostate cancer.
2019 Sep J Phys Chem B Structural Dynamics of Agonist and Antagonist Binding to the Androgen Receptor.
2019 Aug J Infect Public Health Analysis of medication data of women with uterine fibroids based on data mining technology.
2019 Aug Int J Environ Res Public ... The Effects of Endocrine Disrupting Chemicals on Biomarkers of Inflammation Produced by Lipopolysaccharide Stimulated RAW264.7 Macrophages.
2019 J Cancer Res Clin Oncol Dihydrotestosterone promotes kidney cancer cell proliferation by activating the STAT5 pathway via androgen and glucocorticoid receptors.
2019 Aug J Periodontol Role of testosterone and androgen receptor in periodontal disease progression in female rats.
2019 Hypertension Androgen Receptor Blockade Differentially Regulates Blood Pressure in Growth-Restricted Versus Ovarian Deficient Rats.
2019 Sep Circulation Androgenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes.
2019 Mol Cancer Ther GnRH Antagonists Have Direct Inhibitory Effects On Castration-Resistant Prostate Cancer Via Intracrine Androgen and AR-V7 Expression.
2019 Sep Eur J Pharmacol Ginsenoside Rb1 inhibits vascular calcification as a selective androgen receptor modulator.
2019 Jul Invest New Drugs Stimulation of neuroendocrine differentiation in prostate cancer cells by GHRH and its blockade by GHRH antagonists.
2019 J Cell Biochem The androgen receptor antagonist enzalutamide induces apoptosis, dysregulates the heat shock protein system, and diminishes the androgen receptor and estrogen receptor β1 expression in prostate cancer cells.
2019 Sep Chem Biol Interact Very low dose spironolactone protects experimentally-induced polycystic ovarian syndrome from insulin-resistant metabolic disturbances by pressing elevated circulating testosterone.
2019 Jul J Med Chem Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).
2019 Comb Chem High Throughput... In Silico Molecular Docking, Synthesis of 4-(4-benzoylaminophenoxy) Phenol Derivatives as Androgen Receptor Antagonists.
2019 Sep Clin Cancer Res Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.
2019 J Cancer 4-1BBL has a Possible Role in Mediating Castration-Resistant Conversion of Prostate Cancer via Up-Regulation of Androgen Receptor.