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Recent literature: Androgen receptor antagonist
Date Journal Article title
2019 Feb N Engl J Med Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer.
2019 Feb Eur J Med Chem Discovery of deshydroxy bicalutamide derivatives as androgen receptor antagonists.
2019 Feb Toxicol In Vitro Assessment of human estrogen receptor agonisticantagonistic effects of veterinary drugs used for livestock and farmed fish by OECD in vitro stably transfected transcriptional activation assays.
2019 Feb Curr Treat Options Oncol Management of Nonmetastatic Castration-Resistant Prostate Cancer: Recent Advances and Future Direction.
2019 Jan Eur J Med Chem Rational drug design for androgen receptor and glucocorticoids receptor dual antagonist.
2019 Jan Mol Cell Endocrinol Rapid effect of bisphenol A on glutamate-induced Ca2+ influx in hippocampal neurons of rats.
2019 Jan J Cell Physiol PLCε knockdown overcomes drug resistance to androgen receptor antagonist in castration-resistant prostate cancer by pressing the wnt3aβ-catenin pathway.
2019 Jan J Cell Physiol Dihydrotestosterone synthesis in the sheep corpus luteum and its potential mechanism in luteal regression.
2018 Dec Neuro Endocrinol Lett Selected bisphenols and phthalates screened for estrogen and androgen disruption by in silico and in vitro methods.
2019 Feb J Chem Inf Model Communication between the Ligand-Binding Pocket and the Activation Function-2 Domain of Androgen Receptor Revealed by Molecular Dynamics Simulations.
2019 Jan Horm Behav Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.
2019 Jan Toxicol Sci A Conflicted Tale of Two Novel AR Antagonists In vitro and In vivo: Pyrifluquinazon versus Bisphenol C.
2019 Jan J Steroid Biochem Mol Biol A 3-(4-nitronaphthen-1-yl) amino-benzoate analog as a bifunctional AKR1C3 inhibitor and AR antagonist: Head to head comparison with other advanced AKR1C3 targeted therapeutics.
2019 Jan J Mol Cell Cardiol Prenatal exposure to testosterone induces cardiac hypertrophy in adult female rats through enhanced Pkcδ expression in cardiac myocytes.
2019 Jan Genomics Proteomics Bioin... Discovery of Novel Androgen Receptor Ligands by Structure-based Virtual Screening and Bioassays.
2019 Neural Regen Res Protective mechanism of testosterone on cognitive impairment in a rat model of Alzheimer's disease.
2019 Jan J Steroid Biochem Mol Biol Halogen-stituted anthranilic acid derivatives provide a novel chemical platform for androgen receptor antagonists.
2019 Chemosphere Evaluation of endocrine activities of ellagic acid and urolithins using reporter gene assays.
2018 Dec Mol Ecol Experimentally induced variation in neuroendocrine processes affects male reproductive behaviour, sperm characteristics and social interactions.
2019 J Cell Physiol Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
2018 Dec Biomed Pharmacother Effect of AR antagonist combined with PARP1 inhibitor on sporadic triple-negative breast cancer bearing AR expression and methylation-mediated BRCA1 dysfunction.
2018 Ther Adv Urol Apalutamide in the treatment of castrate-resistant prostate cancer: evidence from clinical trials.
2018 Dec Neoplasma Pituitary tumor transforming gene binding factor (PBF) is required for androgen-induced prostate cancer proliferation and invasion.
2019 Feb Endocr Relat Cancer Non-canonical AR activity facilitates endocrine resistance in breast cancer.
2018 Front Pharmacol Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site.
2018 Dec Hum Pathol Molecular characterization of metaplastic breast carcinoma via next generation sequencing.
2018 Dec J Med Chem A New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity.
2019 Prostate Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response.
2018 Dec Cell Rep Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator.
2018 Dec Aging (Albany NY) BCAR4 activates GLI2 signaling in prostate cancer to contribute to castration resistance.
2019 Jan Neuroscience Toxic Impact of Anabolic Androgenic Steroids in Primary Rat Cortical Cell Cultures.
2019 Jan Bioorg Med Chem Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents.
2018 Nov J Endocrinol Invest Cadmium exposure alters steroid receptors and proinflammatory cytokine levels in endothelial cells in vitro: a potential mechanism of endocrine disruptor atherogenic effect.
2018 Nov Andrology Effect of hormone modulations on donor-derived spermatogenesis or colonization after syngeneic and xenotransplantation in mice.
2018 Nov Chem Biol Drug Des Suitability of MMGBSA for the selection of correct ligand binding modes from docking results.
2018 Nov Expert Opin Pharmacother Perspectives on the current and emerging chemical androgen receptor antagonists for the treatment of prostate cancer.
2018 Nov J Clin Med Androgen Receptor Splice Variant 7 Drives the Growth of Castration Resistant Prostate Cancer without Being Involved in the Efficacy of Taxane Chemotherapy.
2018 Pharmacol Res Perspect Dual androgen receptor (AR) and STAT3 inhibition by a compound targeting the AR amino-terminal domain.
2018 Oct J Endocrinol Androgens modulate glucocorticoid receptor activity in adipose tissue and liver.
2019 Jan Endocr Relat Cancer Inhibition of TAMs improves the response to docetaxel in castration-resistant prostate cancer.
2018 Nov J Agric Food Chem Effects of Flavored Nonalcoholic Beverages on Transcriptional Activities of Nuclear and Steroid Hormone Receptors: Proof of Concept for Novel Reporter Cell Line PAZ-PPARg.
2019 Toxicol Lett In vitro bioassay investigations of suspected obesogen monosodium glutamate at the level of nuclear receptor binding and steroidogenesis.
2018 Nov Endocrine Limited short-term effects on human prostate cancer xenograft growth and epidermal growth factor receptor gene expression by the ghrelin receptor antagonist [D-Lys3]-GHRP-6.
2018 Oct Endocr Relat Cancer Enzalutamide therapy for advanced prostate cancer: efficacy, resistance and beyond
2018 Oct J Invest Surg Retardation of Preputial Wound Healing in Rats with Hypospadias Induced by Flutamide.
2019 Cell Mol Life Sci Chemokine-like receptor 1 deficiency leads to lower bone mass in male mice.
2018 Oct Stress Disruptions in the reproductive system of female rats after prenatal lipopolysaccharide-induced immunological stress: role of sex steroids.
2018 Oct Int J Mol Sci Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
2018 Oct J Cell Biochem IL-1 induces p62SQSTM1 and autophagy in ERα+ PR+ BCa cell lines concomitant with ERα and PR repression, conferring an ERα- PR- BCa-like phenotype.
2018 Arch Pharm (Weinheim) Synthesis of androgen receptor antagonists containing a pentafluorosulfanyl (SF5 ) moiety.
2018 Oct J Cell Physiol Androgen receptor transcriptional activity and chromatin modifications on the ABCB1MDR gene are critical for taxol resistance in ovarian cancer cells.
2018 Oct Invest New Drugs Phase 1 trial of enzalutamide in combination with gemcitabine and nab-paclitaxel for the treatment of advanced pancreatic cancer.
2018 Oct Biochem Biophys Res Commun BAF53A regulates androgen receptor-mediated gene expression and proliferation in LNCaP cells.
2018 Commun Biol Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance.
2018 Sep Biosci Biotechnol Biochem Chemistry and biology for the small molecules targeting characteristics of cancer cells.
2019 J Invest Dermatol Spironolactone Depletes the XPB Protein and Inhibits DNA Damage Responses in UVB-Irradiated Human Skin.
2019 J Exp Zool A Ecol Integr ... Effect of glucocorticoids on androgen biosynthesis in the testes of the toad Rhinella arenarum (Amphibia, Anura).
2018 Sep Curr Med Chem Non-Steroidal Androgen Receptor Antagonists and Prostate Cancer: a Survey on Chemical Structures Binding this Fast-Mutating Target.
2018 Reprod Toxicol Evaluation of androgen assay results using a curated Hershberger database.
2018 Clin Genitourin Cancer Clinical Development of Darolutamide: A Novel Androgen Receptor Antagonist for the Treatment of Prostate Cancer.
2019 Jan Am J Physiol Endocrinol M... Effect of metformin and flutamide on insulin, lipogenic and androgen-estrogen signaling, and cardiometabolic risk in a PCOS-prone metabolic syndrome rodent model.
2018 Aug J Med Ultrason (2001) Cancer therapeutics-related cardiac dysfunction in a patient treated with abiraterone for castration-resistant prostate cancer.
2018 Aug Horm Mol Biol Clin Investig Dehydroepiandrosterone andor its metabolites: possible androgen receptor antagonistic effects on digitized mammographic breast density in normal breast tissue of postmenopausal women.
2018 Oct Toxicol Lett The effects of benzophenone-3 on apoptosis and the expression of sex hormone receptors in the frontal cortex and hippocampus of rats.
2018 Sep J Med Chem Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
2018 Nov Toxicol Sci Identification of Androgen Receptor Modulators in a Prostate Cancer Cell Line Microarray Compendium.
2018 Kidney Int Androgen exposure potentiates formation of intratubular communities and renal abscesses by Escherichia coli.
2018 Jul Int J Mol Sci Efficient Lead Finding, Activity Enhancement and Preliminary Selectivity Control of Nuclear Receptor Ligands Bearing a Phenanthridinone Skeleton.
2018 Int J Endocrinol GnRH Antagonist Improves Pubertal Cyclophosphamide-Induced Long-Term Testicular Injury in Adult Rats.
2018 Jul Curr Urol Rep Is Tamsulosin Linked to Dementia in the Elderly?
2018 Oct Gene Dihydrotestosterone regulates expression of CD44 via miR-328-3p in triple-negative breast cancer cells.
2018 Neuroendocrinology Accelerated Episodic Luteinizing Hormone Release Accompanies Blunted Progesterone Regulation in PCOS-like Female Rhesus Monkeys (Macaca Mulatta) Exposed to Testosterone during Early-to-Mid Gestation.
2018 Andrologia Systemic hormonal modulation induces sperm nucleosomal imbalance in rat spermatozoa.
2018 Jun Int J Mol Sci Endocrine Disruption at the Androgen Receptor: Employing Molecular Dynamics and Docking for Improved Virtual Screening and Toxicity Prediction.
2018 Sep Theriogenology Membrane receptor-independent inhibitory effect of melatonin on androgen production in porcine theca cells.