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Recent literature: CXCR2 antagonist
Date Journal Article title
2019 Aug Cell Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.
2019 Aug Cell Rep Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer.
2019 Immunopharmacol Immunotox... Inhibitory effect of recombinant human CXCL8(3-72)K11RG31P on atherosclerotic plaques in a mouse model of atherosclerosis.
2019 May JCI Insight Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2.
2019 Open Forum Infect Dis Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza.
2019 Open Forum Infect Dis Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease.
2019 Open Forum Infect Dis Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability, and Clinical Effect of Danirixin in Adults With Acute, Uncomplicated Influenza.
2019 Apr Hepatology Receptor-Interacting Protein Kinase 3 Deficiency Recruits Myeloid-Derived Suppressor Cells to Hepatocellular Carcinoma Through the Chemokine (C-X-C Motif) Ligand 1-Chemokine (C-X-C Motif) Receptor 2 Axis.
2019 J Invest Dermatol Cellular Senescence in Diabetic Wounds: When Too Many Retirees Stress the System.
2019 Alcohol Clin Exp Res Novel Role of Macrophage Migration Inhibitory Factor in Upstream Control of the Unfolded Protein Response After Ethanol Feeding in Mice.
2019 Front Physiol CXCR2 Blockade Mitigates Neural Cell Injury Following Preclinical Chorioamnionitis.
2019 Neuropharmacology Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice.
2019 Front Pharmacol Activation of CXCL6CXCR12 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells iin vitroi and iin vivoi.
2019 Feb Shock Inhibition of Aerobic Glycolysis Promotes Neutrophil to Influx to The Infectious Site via CXCR2 In Sepsis.
2019 Mar Biochemistry Fine-Tuning of GPCR-Chemokine Interactions. Design and Identification of Chemokine Analogues as Receptor Agonists, Biased Agonists, and Antagonists.
2019 Mar J Immunol Efficacy of Chemokine Receptor Inhibition in Treating IL-36α-Induced Psoriasiform Inflammation.
2019 Jan Int J Mol Sci Human Brain Endothelial CXCR2 is Inflammation-Inducible and Mediates CXCL5- and CXCL8-Triggered Paraendothelial Barrier Breakdown.
2019 Cell Mol Gastroenterol He... Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity.
2019 Cell Biosci 1-Palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (PLAG) attenuates gemcitabine-induced neutrophil extravasation.
2019 Oral Oncol Reciprocal activation of cancer-associated fibroblasts and oral squamous carcinoma cells through CXCL1.
2019 Jan J Neuroinflammation Crosstalk between NFκB-dependent astrocytic CXCL1 and neuron CXCR2 plays a role in descending pain facilitation.
2019 Cancer Biol Ther Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways.
2019 J Neuroimmune Pharmacol P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL6J Mice Exposed to Chronic Ethanol and High Fat Diet.
2019 Jun Med Clin (Barc) A small-molecule antagonist of CXCR1 and CXCR2 inhibits cell proliferation, migration and invasion in melanoma via PI3KAKT pathway.
2018 Biomed Pharmacother CXCR1CXCR2 antagonist G31P inhibits nephritis in a mouse model of uric acid nephropathy.
2018 Neuropsychopharmacol Rep Chemokine CXCL1 is responsible for cocaine-induced reward in mice.
2018 Eur Respir J Effect of the CXCR2 antagonist danirixin on symptoms and health status in COPD.
2018 Hum Immunol IL-8 analogue CXCL8 (3-72) K11RG31P, modulates LPS-induced inflammation via AKT1-NF-kβ and ERK12-AP-1 pathways in THP-1 monocytes.
2018 R Soc Open Sci Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents.
2018 Immunology Interleukin-33 contributes to disease severity in Dengue virus infection in mice.
2018 Oncol Rep SB225002 inhibits prostate cancer invasion and attenuates the expression of BSP, OPN and MMP‑2.
2018 Drugs R D Pharmacokinetics of the Oral Selective CXCR2 Antagonist AZD5069: A Summary of Eight Phase I Studies in Healthy Volunteers.
2018 Int J Oncol Inhibition of interleukin 8C‑X-C chemokine receptor 1,2 signaling reduces malignant features in human pancreatic cancer cells.
2018 Apr Nat Commun Snail promotes ovarian cancer progression by recruiting myeloid-derived pressor cells via CXCR2 ligand upregulation.
2018 Mol Cancer Ther Involvement of Prokineticin 2-expressing Neutrophil Infiltration in 5-Fluorouracil-induced Aggravation of Breast Cancer Metastasis to Lung.
2018 Apr Sci Rep Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis.
2017 Front Immunol Intravital Microscopic Evaluation of the Effects of a CXCR2 Antagonist in a Model of Liver Ischemia Reperfusion Injury in Mice.
2018 Jan Cell Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell.
2018 Eur J Immunol CXCR2 is critical for bacterial control and development of joint damage and pain in Staphylococcus aureus-induced septic arthritis in mouse.
2018 J Autoimmun Decrease of galectin-3 in keratinocytes: A potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis.
2017 Nov Cancer Cell Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors.
2017 Front Cell Neurosci Different Effects of Human Umbilical Cord Mesenchymal Stem Cells on Glioblastoma Stem Cells by Direct Cell Interaction or Via Released Soluble Factors.
2018 Am J Respir Cell Mol Biol Myeloid-derived Suppressor Cells Are Necessary for Development of Pulmonary Hypertension.
2017 Mol Pain The Chemokine Receptor CXCR2 Supports Nociceptive Sensitization after Traumatic Brain Injury.
2017 Front Immunol Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease.
2017 Oct Biochem Biophys Res Commun Synergistic pression of a disintegrin acurhagin-C in combination with AZD4547 and reparixin on terminating development for human osteosarcoma MG-63 cell.
2018 Clin Exp Pharmacol Physiol ELR+ chemokine-mediated neutrophil recruitment is involved in 2,4,6-trinitrochlorobenzene-induced contact hypersensitivity.
2017 Jul Molecules Effects of K11R and G31P Mutations on the Structure and Biological Activities of CXCL8: Solution Structure of Human CXCL8(3-72)K11RG31P.
2017 Brain Res Bull The effect of CXCR2 inhibition on seizure activity in the pilocarpine epilepsy mouse model.
2017 J Pharmacol Exp Ther Danirixin: A Reversible and Selective Antagonist of the CXC Chemokine Receptor 2.
2017 Pulm Pharmacol Ther Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma.
2017 Stem Cells Human Adipose-Derived Mesenchymal Stem Cell-Secreted CXCL1 and CXCL8 Facilitate Breast Tumor Growth By Promoting Angiogenesis.
2017 Front Immunol Blockade of Neutrophil's Chemokine Receptors CXCR12 Abrogate Liver Damage in Acute-on-Chronic Liver Failure.
2017 Jun Endocrinology CXCL8 Antagonist Improves Diabetic Nephropathy in Male Mice With Diabetes and Attenuates High Glucose-Induced Mesangial Injury.
2017 Eur J Immunol GRPR antagonist protects from drug-induced liver injury by impairing neutrophil chemotaxis and motility.
2017 Cytokine Duffy antigen receptor for chemokines (DARC) expressing in cancer cells inhibits tumor progression by pressing CXCR2 signaling in human pancreatic ductal adenocarcinoma.
2017 Expert Opin Pharmacother New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma.
2017 Jan Clin Sci (Lond) CXCR2 is involved in pulmonary intravascular macrophage accumulation and angiogenesis in a rat model of hepatopulmonary syndrome.
2016 Nov Neurosci Lett Spinal CXCL5 contributes to nerve injury-induced neuropathic pain via modulating GSK-3β phosphorylation and activity in rats.
2017 Haematologica The chemokine CXCR2 antagonist (AZD5069) preserves neutrophil-mediated host immunity in non-human primates.
2016 Pulm Pharmacol Ther The effects of a CXCR1CXCR2 antagonist on neutrophil migration in mild atopic asthmatic jects.
2016 Lancet Respir Med Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial.
2016 J Labelled Comp Radiopharm Syntheses of a radiolabelled CXCR2 antagonist AZD5069 and its major human metabolite.
2016 Pancreatology Effect of oral administration of AZD8309, a CXCR2 antagonist, on the severity of experimental pancreatitis.
2016 May Sci Rep Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor.
2016 May J Labelled Comp Radiopharm The synthesis of [(14) C]AZD5122. Incorporation of an IV (14) C-microtracer dose into a first in human study to determine the absolute oral bioavailability of AZD5122.
2016 Jul AIDS HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response.
2016 Sep J Mol Biol Differential Regulation of CXCL8 Production by Different G Protein Subunits with Synergistic Stimulation by Gi- and Gq-Regulated Pathways.
2016 Cell Signal A promiscuous recognition mechanism between GPR17 and SDF-1: Molecular insights.
2016 Jul Neurosci Lett Up-regulation of CXCL1 and CXCR2 contributes to remifentanil-induced hypernociception via modulating spinal NMDA receptor expression and phosphorylation in rats.
2015 Br J Pharmacol Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage.
2015 Nov Oncotarget Interleukin-1 beta transactivates epidermal growth factor receptor via the CXCL1-CXCR2 axis in oral cancer.
2015 J Allergy Clin Immunol Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes.
2015 Eur Respir J A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis.
2015 Stroke Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice.