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Recent literature: AhR Agonist
Date Journal Article title
2019 Aug Daru Encapsulation of Leflunomide (LFD) in a novel niosomal formulation facilitated its delivery to THP-1 monocytic cells and enhanced Aryl hydrocarbon receptor (AhR) nuclear translocation and activation.
2019 Aug Environ Pollut The emerging contaminant 3,3'-dichlorobiphenyl (PCB-11) impedes Ahr activation and Cyp1a activity to modify embryotoxicity of Ahr ligands in the zebrafish embryo model (Danio rerio).
2019 Aug Biochem Pharmacol Parkin is transcriptionally regulated by the aryl hydrocarbon receptor: Impact on α-synuclein protein levels.
2019 Aug Nutrients The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.
2019 Jul Mol Cell Biol Aryl Hydrocarbon Receptor Directly Regulates iArtemini Gene Expression.
2019 Jun Immunohorizons Genome-Wide Transcriptional Analysis Reveals Novel AhR Targets That Regulate Dendritic Cell Function during Influenza A Virus Infection.
2019 Jul Mol Cell Endocrinol GH3 and RC-4BC cell lines are not suitable as in vitro models to study prolactin modulation and AHR responsiveness in rat pituitary.
2019 Jun Environ Toxicol Chem Polycyclic aromatic hydrocarbons phenanthrene and retene modify the action potential via multiple ion currents in rainbow trout Oncorhynchus mykiss cardiac myocytes.
2019 Oct Toxicol Lett Mono-methylindoles induce CYP1A genes and inhibit CYP1A1 enzyme activity in human hepatocytes and HepaRG cells.
2019 Jun Sci Rep Endocrine aryl hydrocarbon receptor signaling is induced by moderate cutaneous exposure to ultraviolet light.
2019 Sep J Ethnopharmacol Hazard assessment of Maerua cordata (Gilg) DeWolf. for selected endpoints using a battery of in vitro tests.
2019 Arch Toxicol The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver.
2019 PLoS One Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis.
2019 Apr Int J Drug Policy Transitioning from interferon-based to direct antiviral treatment options: A potential shift in barriers and facilitators of treatment initiation among people who use drugs?
2019 Apr Respir Res Salicylic acid amplifies Carbachol-induced bronchoconstriction in human precision-cut lung slices.
2019 Apr Am J Respir Cell Mol Biol Role of Differential Estrogen Receptor Activation on Airway Hyperreactivity and Remodeling in a Murine Model of Asthma.
2019 Apr Int J Obes (Lond) Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity.
2019 Mar J Allergy Clin Immunol Toll-like receptor 9-dependent interferon production prevents group 2 innate lymphoid cell-driven airway hyperreactivity.
2019 Mar Int J Mol Sci Transcriptomic Impact of IMA-08401, a Novel AHR Agonist Resembling Laquinimod, on Rat Liver.
2019 Mar Sci Rep Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation.
2019 Feb Clin Infect Dis Sex discrepancies in the protective effect of opioid agonist therapy on incident hepatitis C infection.
2019 Jun Toxicol Sci Molecular Mechanisms of Polybrominated Diphenyl Ethers (BDE-47, BDE-100, and BDE-153) in Human Breast Cancer Cells and Patient-Derived Xenografts.
2019 Front Immunol Protective Effects of Aryl Hydrocarbon Receptor Signaling in Celiac Disease Mucosa and in Poly I:C-Induced Small Intestinal Atrophy Mouse Model.
2019 Apr J Proteome Res Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline.
2019 Int J Oncol 2,3,7,8‑tetrachlorodibenzo‑p‑dioxin presses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.
2019 Feb Chem Res Toxicol The Multiple Biological Targets of Hops and Bioactive Compounds.
2019 Chemosphere Bioassay system for the detection of aryl hydrocarbon receptor agonists in waterborne pesticides using zebrafish cyp1a1 promoter-luciferase recombinant hepatic cells.
2019 Food Chem Toxicol The azole fungicide tebuconazole affects human CYP1A1 and CYP1A2 expression by an aryl hydrocarbon receptor-dependent pathway.
2019 J Cell Biochem Putative tumor pressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death.
2019 Eur J Immunol STAT6 inhibitory peptide reduces dendritic cell migration to the lymph nodes to control Th2 adaptive immunity in the mouse lung.
2019 Clin Exp Rheumatol Aromatic hydrocarbon receptor provides a link between smoking and rheumatoid arthritis in peripheral blood mononuclear cells.
2018 Environ Int In vitro assessment of endocrine disrupting potential of organic fractions extracted from hydraulic fracturing flowback and produced water (HF-FPW).
2019 Feb Toxicol Sci Developmental Regulation of Nuclear Factor Erythroid-2 Related Factors (nrfs) by AHR1b in Zebrafish (Danio rerio).
2018 Autoimmunity Immunoregulatory effects of indole-3-carbinol on monocyte-derived macrophages in systemic lupus erythematosus: A crucial role for aryl hydrocarbon receptor.
2018 Biochem Pharmacol Evidence of selective activation of aryl hydrocarbon receptor nongenomic calcium signaling by pyrene.
2018 Sep Int J Mol Sci Comparative In Vitro and In Silico Analysis of the Selectivity of Indirubin as a Human Ah Receptor Agonist.
2018 Front Pharmacol Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine iCYP1A1i at the Proximal Promoter.
2018 Front Pharmacol Lobeglitazone Attenuates Airway Inflammation and Mucus Hypersecretion in a Murine Model of Ovalbumin-Induced Asthma.
2018 Aug Molecules Raspberry Polyphenolic Extract Regulates Obesogenic Signals in Hepatocytes.
2018 PLoS One Aryl hydrocarbon receptor (AHR) is a novel druggable pathway controlling malignant progenitor proliferation in chronic myeloid leukemia (CML).
2018 Front Immunol Aryl Hydrocarbon Receptor Regulates Apoptosis and Inflammation in a Murine Model of Experimental Autoimmune Uveitis.
2018 Biochem Biophys Rep The anti-inflammatory effect of LMWF5A and N-acetyl kynurenine on macrophages: Involvement of aryl hydrocarbon receptor in mechanism of action.
2018 Oct Drug Alcohol Depend Improved treatment-retention for patients receiving methadone dosing within the clinic providing physician and other health services (onsite) versus dosing at community (offsite) pharmacies.
2018 Nov Cell Metab Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome.
2019 J Innate Immun Aryl Hydrocarbon Receptor Modulates the Expression of TNF-α and IL-8 in Human Sebocytes via the MyD88-p65NF-κBp38MAPK Signaling Pathways.
2018 Jul Sci Rep Cytokine Regulation in Human CD4 T Cells by the Aryl Hydrocarbon Receptor and Gq-Coupled Receptors.
2018 Inflammation PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model.
2018 Innate Immun Aryl hydrocarbon receptorIL-22Stat3 signaling pathway is involved in the modulation of intestinal mucosa antimicrobial molecules by commensal microbiota in mice.
2018 Toxicol In Vitro In vitro toxicity and in silico docking analysis of two novel selective AH-receptor modulators.
2018 Jun Arthritis Res Ther Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells.
2018 Basic Clin Pharmacol Toxicol Cyp2a5 Promoter-based Gene Reporter Assay: A Novel Design of Cell-based Bioassay for Toxicity Prediction.
2018 Aug Toxicol Sci Ancestral TCDD Exposure Induces Multigenerational Histologic and Transcriptomic Alterations in Gonads of Male Zebrafish.
2018 May Int J Mol Sci Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor.
2018 Aug Toxicol Sci The Role of Endocrine and Dioxin-Like Activity of Extracts of Petroleum Substances in Developmental Toxicity as Detected in a Panel of CALUX Reporter Gene Assays.
2018 Neuropharmacology Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
2018 Aug Water Res In vitro bioanalysis of drinking water from source to tap.
2018 Mol Pharmacol Methylindoles and Methoxyindoles are Agonists and Antagonists of Human Aryl Hydrocarbon Receptor.
2018 Jul Toxicol Sci Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids.
2018 Chin J Nat Med Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome.
2018 Apr J Proteome Res Metabolomics Reveals Aryl Hydrocarbon Receptor Activation Induces Liver and Mammary Gland Metabolic Dysfunction in Lactating Mice.
2018 Biochem Pharmacol Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells.
2018 J Dermatol Sci Protective role of 6-formylindolo[3,2-b]carbazole (FICZ), an endogenous ligand for arylhydrocarbon receptor, in chronic mite-induced dermatitis.
2018 Mar Acta Pharm Induction of xenobiotic-metabolizing enzymes in hepatocytes by beta-naphthoflavone: Time-dependent changes in activities, protein and mRNA levels.
2018 Mar Toxicol Appl Pharmacol Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.
2018 Feb Cell Death Dis Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and sequent NAD+SIRT1SUV39H1H3K9me3 signaling pathway.
2018 Am Heart J Effect of adding GLP-1RA on mortality, cardiovascular events, and metabolic outcomes among insulin-treated patients with type 2 diabetes: A large retrospective UK cohort study.
2018 Int Immunopharmacol High-fat-diet induces airway hyperresponsiveness partly through activating CD38 signaling pathway.
2018 Clin Pharmacol Drug Dev Systemic Pharmacokinetics, Safety, and Preliminary Efficacy of Topical AhR Agonist Tapinarof: Results of a Phase 1 Study.
2018 Jan Sci Rep Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome.
2018 Feb J Biol Chem Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR).
2018 Feb ChemMedChem Binding Mode and Structure-Activity Relationships of ITE as an Aryl Hydrocarbon Receptor (AhR) Agonist.
2017 Nagoya J Med Sci Indole-3-propionic acid presses indoxyl sulfate-induced expression of fibrotic and inflammatory genes in proximal tubular cells.
2018 Int J Mol Med Aryl hydrocarbon receptor inhibits inflammation in DSS‑induced colitis via the MK2p‑MK2TTP pathway.
2017 Dec Biology (Basel) Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells.
2018 Food Chem Toxicol Essential oils of culinary herbs and spices display agonist and antagonist activities at human aryl hydrocarbon receptor AhR.