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Recent literature: PI3K inhibitor
Date Journal Article title
2019 Aug J Mol Diagn A Novel Next-Generation Sequencing Approach to Detecting Microsatellite Instability (MSI) and Pan-Tumor Characterization of One Thousand MSI-High Cases in 67,000 Patient Samples.
2019 Aug Sci Rep TLR-2 mediated cytosolic-Ca2+ surge activates ER-stress-eroxide-NO signalosome augmenting TNF-α production leading to apoptosis of Mycobacterium smegmatis-infected fish macrophages.
2019 Aug Cancers (Basel) Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer.
2019 Aug Neoplasia Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.
2019 Aug Cell Biol Int Protosappanin-A and oleanolic acid protect injured podocytes from apoptosis through inhibition of AKT-mTOR signaling.
2019 Aug Cell Death Dis Retraction Note: HDAC6 inhibitor TST strengthens the antiproliferative effects of PI3KmTOR inhibitor BEZ235 in breast cancer cells via pressing RTK activation.
2019 Aug Mol Cancer Ther Targeting PI3KAktmTOR pathway identifies differential expression and functional role of IL-8 in liver cancer stem cell enrichment.
2019 Aug Clin Cancer Res POSEIDON phase 1b results: safety, efficacy and ctDNA response of taselisib combined with tamoxifen in hormone receptor positive metastatic breast cancer patients.
2019 Aug Respir Res Lipoxin A4 ameliorates lipopolysaccharide-induced lung injury through stimulating epithelial proliferation, reducing epithelial cell apoptosis and inhibits epithelial-mesenchymal transition.
2019 Aug Antioxidants (Basel) Induction of G2M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3kAkt Signal Transduction Pathway.
2019 Aug Mol Cell Biochem The effects of MAPK p38α on AZT resistance against reactivating HIV-1 replication in ACH2 cells.
2019 Aug Cancers (Basel) Maintenance BEZ235 Treatment Prolongs the Therapeutic Effect of the Combination of BEZ235 and Radiotherapy for Colorectal Cancer.
2019 Aug Elife CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity.
2019 Front Endocrinol (Lausanne) iIn vitroi Activation Prior to Transplantation of Human Ovarian Tissue: Is It Truly Effective?
2019 Aug J Orthop Res Transcriptomic analysis of cellular pathways in healing flexor tendons of plasminogen activator inhibitor 1 (PAI-1Serpine1) null mice.
2019 Aug Phytomedicine Rooibos presses proliferation of castration-resistant prostate cancer cells via inhibition of Akt signaling.
2019 Zhongguo Shi Yan Xue Ye X... [Apoptosis-Inducing Effect of Ginsenoside Rh2 on Human Acute T Lymphoblastic Leukemia Jurkat Cells and Its Mechanism].
2019 Aug Cancer Res Tie2-FGFR1 interaction induces adaptive PI3K inhibitor resistance by upregulating Aurora APLK1CDK1 signaling in glioblastoma.
2019 Aug Adv Clin Exp Med Effect of PI3KPKB signal pathway inhibitor wortmannin pretreatment on intestinal barrier function in severe acute pancreatitic rats.
2019 Aug Sci Transl Med MDM2 antagonists overcome intrinsic resistance to CDK46 inhibition by inducing p21.
2019 Aug J Virol Highly pathogenic PRRSV induces IL-17 production via the activation of IRAK1-PI3K-p38MAPK-CEBPβCREB pathways.
2019 Aug Pulmonology LncRNA-CASC7 enhances corticosteroid sensitivity via inhibiting the PI3KAKT signaling pathway by targeting miR-21 in severe asthma.
2019 Cancer Invest Synergistic Effects of PI3K and c-Myc Co-targeting in Acute Leukemia: Shedding New Light on Resistance to Selective PI3K-δ Inhibitor CAL-101.
2019 Aug Int J Mol Sci TUBB3 Reverses Resistance to Docetaxel and Cabazitaxel in Prostate Cancer.
2019 Aug Cell Rep p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas.
2019 Aug J Clin Invest Identifying and targeting pathogenic PI3KAKTmTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease.
2019 Aug Lancet Oncol Neoadjuvant letrozole plus taselisib versus letrozole plus placebo in postmenopausal women with oestrogen receptor-positive, HER2-negative, early-stage breast cancer (LORELEI): a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
2019 Aug Neoplasia The Adiponectin-AdipoR1 Axis Mediates Tumor Progression and Tyrosine Kinase Inhibitor Resistance in Metastatic Renal Cell Carcinoma.
2019 Aug Stem Cell Res Ther Human amniotic mesenchymal stem cells and their paracrine factors promote wound healing by inhibiting heat stress-induced skin cell apoptosis and enhancing their proliferation through activating PI3KAKT signaling pathway.
2019 Commun Biol TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion.
2019 Aug Oncologist Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3-Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with iRASRAFi Alterations.
2019 Aug Blood Resolving PI3K-δ inhibitor resistance in CLL.
2019 Aug Cancers (Basel) The Hedgehog Signaling Pathway: A Viable Target in Breast Cancer?
2019 Aug Cell Signal HMGA1 exacerbates tumor progression by activating miR-222 through PI3KAktMMP-9 signaling pathway in uveal melanoma.
2019 Aug Mol Oncol Disruption of the RICTORmTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition.
2019 J Neurooncol Phase III study of bevacizumab with BKM120, an oral PI3K inhibitor, in patients with refractory solid tumors (phase I) and relapsedrefractory glioblastoma (phase II).
2019 Aug Oncogene PORCN inhibition synergizes with PI3KmTOR inhibition in Wnt-addicted cancers.
2019 Aug Radiat Res The Involvement of SDF-1αCXCR4 Axis in Radiation-Induced Acute Injury and Fibrosis of Skin.
2019 Eur Rev Med Pharmacol Sci MiR-126 promotes endothelial cell apoptosis by targeting PI3KAkt in rats with lower limb arteriosclerosis obliterans.
2019 Eur Rev Med Pharmacol Sci TAZ accelerates osteogenesis differentiation of mesenchymal stem cells via targeting PI3KAkt.
2019 Aug Inflammopharmacology Microglial-induced apoptosis is potentially responsible for hyperalgesia variations during CFA-induced inflammation.
2019 Aug Cancer Chemother Pharmacol Preclinical efficacy of a novel dual PI3KmTOR inhibitor, CMG002, alone and in combination with sorafenib in hepatocellular carcinoma.
2019 Aug Biosci Rep Liraglutide inhibits the apoptosis of human nucleus pulposus cells induced by high glucose through PI3KAktcaspase-3 signaling pathway.
2019 Aug Proc Natl Acad Sci U S A Repurposing dasatinib for diffuse large B cell lymphoma.
2019 Aug Neurosci Lett EPO promotes axonal sprouting via upregulating GDF10.
2019 Eur Rev Med Pharmacol Sci Effects of dexmedetomidine on myocardial ischemia-reperfusion injury through PI3K-Akt-mTOR signaling pathway.
2019 Cell Cycle Silencing of EPCAM presses hepatic fibrosis and hepatic stellate cell proliferation in mice with alcoholic hepatitis via the PI3KAktmTOR signaling pathway.
2019 Aug Curr Drug Targets Targeting protein kinase inhibitors with Traditional Chinese Medicine.
2019 Jul Ecotoxicol Environ Saf Expression of Clusterin presses Cr(VI)-induced premature senescence through activation of PI3KAKT pathway.
2019 Aug J Neurosci Inhibition of FGF receptor-1 presses alcohol consumption: role of PI3 kinase signaling in dorsomedial striatum.
2019 Aug Biomolecules Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.
2019 Aug Diagnostics (Basel) Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review.
2019 Jul Cell Signal Synergistic inhibition of GP130 and ERK signaling blocks chemoresistant bladder cancer cell growth.
2019 Aug EMBO Mol Med Inhibition of phosphatidylinositol 3-kinase α (PI3Kα) prevents heterotopic ossification.
2019 J Bone Oncol The role of CXCR4 in multiple myeloma: Cells' journey from bone marrow to beyond.
2019 Cancer Manag Res Ezrin promotes pancreatic cancer cell proliferation and invasion through activating the AktmTOR pathway and inducing YAP translocation.
2019 Aug Clin Cancer Res FGFR1 gene amplification mediates endocrine resistance but retains TORC sensitivity in metastatic hormone receptor positive (HR+) breast cancer.
2019 Jul Breast Cancer Res Treat A phase Ib, open-label, dose-escalation study of the safety and pharmacology of taselisib (GDC-0032) in combination with either docetaxel or paclitaxel in patients with HER2-negative, locally advanced, or metastatic breast cancer.
2019 Jul J Control Release Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the pressive tumor microenvironment in desmoplastic tumors.
2019 Jul Biochim Biophys Acta Mol ... Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia.
2019 Anal Cell Pathol (Amst) Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3KAktmTOR Survival Pathway.
2019 Evid Based Complement Alt... Brazilian Green Propolis Inhibits Ox-LDL-Stimulated Oxidative Stress in Human Umbilical Vein Endothelial Cells Partly through PI3KAktmTOR-Mediated Nrf2HO-1 Pathway.
2019 Cancer Cell Int p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and pression of EGFRPI3KAKT signaling.
2019 Onco Targets Ther Dual PI3KmTOR Inhibitor, XL765, presses glioblastoma growth by inducing ER stress-dependent apoptosis.
2019 Jul IUBMB Life AMP-kinase inhibitor dorsomorphin reduces the proliferation and migration behavior of colorectal cancer cells by targeting the AKTmTOR pathway.
2019 Jul Sci Rep Immunofluorescence can assess the efficacy of mTOR pathway therapeutic agent Everolimus in breast cancer models.
2019 Sep Biochem Biophys Res Commun Interleukin-15 inhibits adipogenic differentiation of cattle bone marrow-derived mesenchymal stem cells via regulating the crosstalk between signal transducer and activator of transcription 5A and Akt signalling.
2019 Jul Biomol Ther (Seoul) β-Amyrin Ameliorates Alzheimer's Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus.
2019 Jul Molecules A Derivate of Benzimidazole-Isoquinolinone Induces SKP2 Transcriptional Inhibition to Exert Anti-Tumor Activity in Glioblastoma Cells.
2019 Jul Life Sci Vps15 is critical to mediate autophagy in AngII treated HUVECs probably by PDK1PKC signaling pathway.
2019 Jul J Hypertens β2AR-dependent signaling contributes to in-vivo reendothelialization capacity of endothelial progenitor cells by shear stress.
2019 Jul Br J Haematol Single and combined BTK and PI3Kδ inhibition with acalabrutinib and ACP-319 in pre-clinical models of aggressive lymphomas.
2019 Oxid Med Cell Longev Classic Prescription, Kai-Xin-San, Ameliorates Alzheimer's Disease as an Effective Multitarget Treatment: From Neurotransmitter to Protein Signaling Pathway.
2019 Artif Cells Nanomed Biote... MicroRNA-183 affects the development of gastric cancer by regulating autophagy via MALAT1-miR-183-SIRT1 axis and PI3KAKTmTOR signals.
2019 Jul BMC Anesthesiol Dexmedetomidine presses sevoflurane anesthesia-induced neuroinflammation through activation of the PI3KAktmTOR pathway.