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Recent literature: PI3K inhibitor
Date Journal Article title
2019 Jun Inflammation Salidroside Reduces Inflammation and Brain Injury After Permanent Middle Cerebral Artery Occlusion in Rats by Regulating PI3KPKBNrf2NFκB Signaling Rather than Complement C3 Activity.
2019 Jun iScience Anaplastic Lymphoma Kinase Confers Resistance to BRAF Kinase Inhibitors in Melanoma.
2019 Jun Cell Signal The PI3KAkt pathway is not a main driver in HDL-mediated cell protection.
2019 Jun Eur J Med Chem Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3KmTOR dual inhibitors.
2019 Jun Clin Cancer Res HDAC inhibition enhances the in vivo efficacy of MEK inhibitor therapy in uveal melanoma.
2019 Jun Int J Mol Sci Strategies to Overcome Resistance Mechanisms in T-Cell Acute Lymphoblastic Leukemia.
2019 Jun Mar Drugs Serine Protease from iNereis virensi Inhibits H1299 Lung Cancer Cell Proliferation via the PI3KAKTmTOR Pathway.
2019 Jun Molecules Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3KAkt Signaling Pathway.
2019 Curr Dev Nutr Inositol Deficiency Induces Autophagy Impairing via PI3KAktmTORp70S6K Signaling (P11-032-19).
2019 Curr Dev Nutr Inositol Deficiency Increases Neural Tube Defect Susceptibility by PI3KAKT Signaling Pathway (P11-009-19).
2019 Curr Dev Nutr Mallotus Feretianus Extract Inhibits Ethanol-induced Activation of Hepatic Stellate Cell via PI3K-Akt and cAMP-PKA Pathways (P06-065-19).
2019 Biomed Res Int mTORC2 Regulates Lipogenic Gene Expression through PPARiγi to Control Lipid Synthesis in Bovine Mammary Epithelial Cells.
2019 Jun Circ Res MicroRNA-145 Regulates the Differentiation of Adipose Stem Cells Toward Microvascular Endothelial Cells and Promotes Angiogenesis.
2019 Jun J Clin Endocrinol Metab Endometriosis triggers excessive activation of primordial follicles via PI3K-PTEN-Akt-Foxo3 pathway.
2019 Jun J Cell Biochem The inhibition of BDNFTrkBPI3KAkt signal mediated by AG1601 promotes apoptosis in malignant glioma.
2019 Jun Sheng Li Xue Bao [Wnt5a modulates vincristine resistance through PI3KAktGSK3β signaling pathway in human ovarian carcinoma SKOV3VCR cells].
2019 Iran J Basic Med Sci microRNA-29a functions as a tumor pressor in nasopharyngeal carcinoma 5-8F cells through targeting VEGF.
2019 Jun Oncotarget PI3K inhibition enhances the anti-tumor effect of eribulin in triple negative breast cancer.
2019 Am J Transl Res Tanshinone IIA induces apoptosis and autophagy in acute monocytic leukemia via downregulation of PI3KAkt pathway.
2019 Am J Transl Res Atorvastatin plus therapeutic ultrasound improve postnatal neovascularization in response to hindlimb ischemia via the PI3K-Akt pathway.
2019 Jun Cancer Discov PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
2019 Jun Cells C89 Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI3K-Akt Pathway In Vitro.
2019 Jun Cancer Sci BRD4 inhibitor and HDAC inhibitor synergistically inhibit the proliferation of gallbladder cancer in vitro and in vivo.
2019 Front Oncol Role of Metformin and AKT Axis Modulation in the Reversion of Hypoxia Induced TMZ-Resistance in Glioma Cells.
2019 Cancer Manag Res Loss of ARID1A promotes proliferation, migration and invasion via the Akt signaling pathway in NPC.
2019 Onco Targets Ther Grape seed procyanidin B2 promotes the autophagy and apoptosis in colorectal cancer cells via regulating PI3KAkt signaling pathway.
2019 Jun Biosci Rep iPAR-2i promotes cell proliferation, migration and invasion through activating PI3KAKT signaling pathway in oral squamous cell carcinoma.
2019 Jun Hum Mol Genet Transcription of PIK3CD in human brain and schizophrenia: Regulation by pro inflammatory cytokines.
2019 Eur Rev Med Pharmacol Sci Downregulated miRNA-26a-5p induces the apoptosis of endothelial cells in coronary heart disease by inhibiting PI3KAKT pathway.
2019 Eur Rev Med Pharmacol Sci Effects of miR-21 on hypertensive rats through PTENPI3KAktmTOR signaling pathway.
2019 Eur Rev Med Pharmacol Sci A study on regulatory mechanism of miR-223 in ulcerative colitis through PI3KAkt-mTOR signaling pathway.
2019 Jun Breast Cancer Res Treat Somatic loss of PIK3R1 may sensitize breast cancer to inhibitors of the MAPK pathway.
2019 Jun Nat Commun Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.
2019 Jun BMC Ophthalmol Nerve growth factor promotes the proliferation of Müller cells co-cultured with internal limiting membrane by regulating cell cycle via Trk-API3KAkt pathway.
2019 Jun J Cell Mol Med Long non-coding RNA deleted in lymphocytic leukaemia 1 promotes hepatocellular carcinoma progression by sponging miR-133a to regulate IGF-1R expression.
2019 Zhongguo Shi Yan Xue Ye X... [Effect of PI3KmTOR Signal Pathway Inhibitor XL765 on Human Leukemic KG-1 Cells].
2019 Jun Mol Neurobiol FGF-2 Attenuates Neuronal Apoptosis via FGFR3PI3kAkt Signaling Pathway After Subarachnoid Hemorrhage.
2019 Jun Biomed Pharmacother MMP-9 secreted by tumor associated macrophages promoted gastric cancer metastasis through a PI3KAKTSnail pathway.
2019 Jun Biomed Pharmacother 15-epi-lipoxin A4 inhibits TNF-α-induced tissue factor expression via the PI3KAKT NF-κB axis in human umbilical vein endothelial cells.
2019 Jun Int J Mol Sci Cellular Effects of Butyrate on Vascular Smooth Muscle Cells are Mediated through Disparate Actions on Dual Targets, Histone Deacetylase (HDAC) Activity and PI3KAkt Signaling Network.
2019 Jun J Exp Clin Cancer Res PTENP1miR-20aPTEN axis contributes to breast cancer progression by regulating PTEN via PI3KAKT pathway.
2019 Jun Biol Res The long non-coding RNA H19 induces hypoxiareoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells.
2019 Jun BMC Cancer CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKTCCND1 pathway in vitro and in vivo.
2019 Acta Pharm Sin B Inhibition of FOXO3aBIM signaling pathway contributes to the protective effect of salvianolic acid A against cerebral ischemiareperfusion injury.
2019 Acta Pharm Sin B Aurone derivatives as Vps34 inhibitors that modulate autophagy.
2019 Oxid Med Cell Longev p53-Mediated PI3KAKTmTOR Pathway Played a Role in PtoxDpt-Induced EMT Inhibition in Liver Cancer Cell Lines.
2019 Onco Targets Ther Serum starvation induces cell death in NSCLC via miR-224.
2019 Jun J Cell Biochem Antitumor activity of sevoflurane in HCC cell line is mediated by miR-29a-induced pression of Dnmt3a.
2019 Jun Cancer Chemother Pharmacol Phase I study of BGT226, a pan-PI3K and mTOR inhibitor, in Japanese patients with advanced solid cancers.
2019 Jun Mol Cell Proteomics Phosphoproteome Analysis Reveals Estrogen-ER pathway as a modulator of mTOR activity via DEPTOR.
2019 Jun BMB Rep ATAD2 expression increases [18F]Fluorodeoxyglucose uptake value in lung adenocarcinoma via AKT-GLUT1HK2 pathway.
2019 Jun Cancers (Basel) The iHelicobacter pylorii Urease Virulence Factor Is Required for the Induction of Hypoxia-Induced Factor-1α in Gastric Cells.
2019 Jun J Steroid Biochem Mol Biol Resveratrol inhibits DHT-induced progression of prostate cancer cell line through interfering with the AR and CXCR4 pathway.
2019 Oxid Med Cell Longev Triptolide Inhibits Preformed Fibril-Induced Microglial Activation by Targeting the MicroRNA155-5pSHIP1 Pathway.
2019 Oxid Med Cell Longev Dehydroepiandrosterone Prevents H2O2-Induced BRL-3A Cell Oxidative Damage through Activation of PI3KAkt Pathways rather than MAPK Pathways.
2019 Pain Res Manag Microglial BDNF, PI3K, and p-ERK in the Spinal Cord Are Suppressed by Pulsed Radiofrequency on Dorsal Root Ganglion to Ease SNI-Induced Neuropathic Pain in Rats.
2019 Jun Epilepsia Anticonvulsant and antiepileptogenic effects of system mml:math xmlns:mml="http:www.w3.org1998MathMathML"mml:mmml:mixmml:mi mml:mrowmml:micmml:mimml:mrow mml:mo-mml:momml:m mml:math inactivation in chronic epilepsy models.
2019 Jun Med Sci Monit microRNA-378a Regulates the Reactive Oxygen Species (ROS)Phosphatidylinositol 3-Kinases (PI3K)AKT Signaling Pathway in Human Lens Epithelial Cells and Cataract.
2019 Jun Physiol Res Cyclic hydrostatic compress force regulates apoptosis of meniscus fibrochondrocytes via integrin alpha5beta1.
2019 Jun Biochim Biophys Acta Mol ... Enhanced cellular cholesterol efflux by naringenin is mediated through inhibiting endoplasmic reticulum stress - ATF6 activity in macrophages.
2019 May Bioorg Med Chem Alkylsulfonamide-containing quinazoline derivatives as potent and orally bioavailable PI3Ks inhibitors.
2019 Jun J Gynecol Obstet Hum Reprod High risk endometrial cancer: clues towards a revision of the therapeutic paradigm.
2019 Jun Mol Cancer Ther Identifying candidate druggable targets in canine cancer cell lines using whole exome sequencing.
2019 Jun Cancer Lett Corrigendum to "The dual specificity PI3KmTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL)" [Cancer Lett. 392 (1) (2017) 9-16].
2019 Jun J Exp Clin Cancer Res Calycosin presses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3KAkt signaling pathways in colorectal cancer cells.
2019 Artif Cells Nanomed Biote... LncRNA ANRIL protects against oxygen and glucose deprivation (OGD)-induced injury in PC-12 cells: potential role in ischaemic stroke.
2019 Jun Semin Cancer Biol Akt in cancer: Mediator and more.
2019 Jun Cancer Lett PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.
2019 Jun Cancer Med Embryonic stem cell microenvironment presses the malignancy of cutaneous melanoma cells by down-regulating PI3KAKT pathway.
2019 Eur Rev Med Pharmacol Sci Preliminary results indicate resveratrol affects proliferation and apoptosis of leukemia cells by regulating PTENPI3KAKT pathway.
2019 Eur Rev Med Pharmacol Sci miR-21 regulates the proliferation and apoptosis of ovarian cancer cells through PTENPI3KAKT.
2019 Jun Mol Med Rep UBE2T promotes proliferation and regulates PI3KAkt signaling in renal cell carcinoma.
2019 Jun Mol Med Rep MicroRNA‑214 presses the viability, migration and invasion of human colorectal carcinoma cells via targeting transglutaminase 2.
2019 May Mol Med Rep Preconditioning but not postconditioning treatment with resveratrol stantially ameliorates post‑resuscitation myocardial dysfunction through the PI3KAkt signaling pathway.
2019 Jun Int J Oncol Cystathionine‑γ‑lyase promotes the metastasis of breast cancer via the VEGF signaling pathway.