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Recent literature: PI3K inhibitor
Date Journal Article title
2019 Nov Biomol Ther (Seoul) PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis.
2019 Am J Transl Res LMO4 promotes the invasion and proliferation of gastric cancer by activating PI3K-Akt-mTOR signaling.
2019 Oxid Med Cell Longev Nrf2 Overexpression for the Protective Effect of Skin-Derived Precursors against UV-Induced Damage: Evidence from a Three-Dimensional Skin Model.
2019 Nov Biochem Biophys Res Commun PICK1 attenuates high glucose-induced pancreatic β-cell death through the PI3KAkt pathway and is negatively regulated by miR-139-5p.
2019 Nov Microvasc Res Low-level laser therapy induces human umbilical vascular endothelial cell proliferation, migration and tube formation through activating the PI3KAkt signaling pathway.
2019 Nov Peptides Catestatin in defense of oxidative-stress-induced apoptosis: a novel mechanism by activating the beta2 adrenergic receptor and PKBAkt pathway in ischemic-reperfused myocardium.
2019 Nov Neurotherapeutics Vildagliptin Attenuates Huntington's Disease through Activation of GLP-1 ReceptorPI3KAktBDNF Pathway in 3-Nitropropionic Acid Rat Model.
2019 Pathol Res Pract MicroRNA-129-5p presses proliferation, migration and invasion of retinoblastoma cells through PI3KAKT signaling pathway by targeting PAX6.
2019 Nov Biochem Biophys Res Commun FAM60A, increased by Helicobacter pylori, promotes proliferation and presses apoptosis of gastric cancer cells by targeting the PI3KAKT pathway.
2019 Nov Parasit Vectors Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3KAKTmTOR pathway.
2019 Nov Mol Med Inhibition of phosphatidylinositol 3-kinase by PX-866 presses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells.
2019 Nov Int J Biol Macromol An exopolysaccharide from Lactobacillus plantarum H31 in pickled cabbage inhibits pancreas α-amylase and regulating metabolic markers in HepG2 cells by AMPKPI3KAkt pathway.
2019 Nov Food Chem Toxicol Homoharringtonine presses LoVo cell growth by inhibiting EphB4 and the PI3KAKT and MAPKEKR12 signaling pathways.
2019 Nov JCI Insight TSLP protects against liver IR injury via activation of the PI3KAkt pathway.
2019 Nov Cell Mol Neurobiol PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit.
2019 Nov ACS Omega Deoxynivalenol-Induced Cytotoxicity and Apoptosis in IPEC-J2 Cells Through the Activation of Autophagy by Inhibiting PI3K-AKT-mTOR Signaling Pathway.
2019 Cell Mol Bioeng Dual Inhibitors-Loaded Nanotherapeutics that Target Kinase Signaling Pathways Synergize with Immune Checkpoint Inhibitor.
2019 Cancer Cell Int Silencing of TRIM11 presses the tumorigenicity of chordoma cells through improving the activity of PHLPP1AKT.
2019 Nov J Dermatol Sci Y-27632 preserves epidermal integrity in a human skin organ-culture (hSOC) system by regulating AKT and ERK signaling pathways.
2019 Nov Cancers (Basel) Targeted-Gene Sequencing to Catch Triple Negative Breast Cancer Heterogeneity before and after Neoadjuvant Chemotherapy.
2019 Nov Int J Cancer Phase II, 2-Stage, 2-Arm, PIK3CA Mutation Stratified Trial of MK-2206 in Recurrent Endometrial Cancer.
2019 Nov Br J Pharmacol PI3K-δ controls endoplasmic reticulum membrane fluidity and permeability in fungus-induced allergic inflammation.
2019 Nov Inflamm Res MIR-140-5p affects chondrocyte proliferation, apoptosis, and inflammation by targeting HMGB1 in osteoarthritis.
2019 Oct iScience HIF-mediated Suppression of DEPTOR Confers Resistance to mTOR Kinase Inhibition in Renal Cancer.
2019 Nov Br J Pharmacol Guanidine Modifications Enhance the Anti-Herpes Simplex Virus Activity of (E, E)-4,6-bis (styryl)-pyrimidine Derivatives in vitro and in vivo.
2019 Nov Invest New Drugs A phase I study of vistusertib (dual mTORC12 inhibitor) in patients with previously treated glioblastoma multiforme: a CCTG study.
2019 Nov Biomed Pharmacother LNCRNA CDKN2B-AS1 regulates mesangial cell proliferation and extracellular matrix accumulation via miR-424-5pHMGA2 axis.
2019 Oct Int J Parasitol Drugs Dru... Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia.
2019 Nov Exp Mol Pathol LETM1 is a potential biomarker that predicts poor prognosis in gastric adenocarcinoma.
2019 Nov Clin Exp Pharmacol Physiol Calcium-sensing receptor activating ERK12 and PI3K-Akt pathways to induce the proliferation of osteosarcoma cells.
2019 Anticancer Res Efficacy of Afatinib and Lapatinib Against iHER2i Gene-amplified Trastuzumab-sensitive and -resistant Human Gastric Cancer Cells.
2019 Nov BMC Complement Altern Med Total saponins of Bolbostemma paniculatum (maxim.) Franquet exert antitumor activity against MDA-MB-231 human breast cancer cells via inhibiting PI3KAktmTOR pathway.
2019 Nov Glia Epigenetic regulation of microglial phosphatidylinositol 3-kinase pathway involved in long-term potentiation and synaptic plasticity in rats.
2019 Mol Med Rep Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κBIκBα pathways in the skeletal muscle of rats fed with a high fat diet.
2019 Oct Curr Mol Med miR-7 reduces high glucose induced-damage via HoxB3 and PI3KAKTmTOR signaling pathways in retinal pigment epithelial cells.
2019 Oct Curr Mol Med Effects of morphine on interstitial cells of Cajal in rabbit colon and small intestinal transit: An experimental study.
2019 Mol Med Rep Dexmedetomidine protects against sepsis‑associated encephalopathy through Hsp90AKT signaling.
2019 Mol Med Rep PTEN modulates neurites outgrowth and neuron apoptosis involving the PI3KAktmTOR signaling pathway.
2019 Sep J Virus Erad Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency iex vivoi without T cell activation.
2019 Sep J Virus Erad Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency iex vivoi without T cell activation.
2019 Nov Cell Death Dis Agmatinase promotes the lung adenocarcinoma tumorigenesis by activating the NO-MAPKs-PI3KAkt pathway.
2019 Nov J Agric Food Chem A New Possible Mechanism by which Punicalagin Protects Against Liver Injury Induced by Type 2 Diabetes Mellitus: Upregulation of Autophagy via the AktFoxO3a Signaling Pathway.
2019 Nov Int J Mol Sci AEG-1miR-221 Axis Cooperatively Regulates the Progression of Hepatocellular Carcinoma by Targeting PTENPI3KAKT Signaling Pathway.
2019 Nov ChemMedChem Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics.
2019 Nov J Exp Clin Cancer Res Apatinib potentiates irradiation effect via pressing PI3KAKT signaling pathway in hepatocellular carcinoma.
2019 Nov J Cell Biochem AIB1 induces epithelial-mesenchymal transition in gastric cancer via the PI3KAKT signaling.
2019 Nov J Cell Biochem The circular RNA-NRIP1 plays oncogenic roles by targeting microRNA-505 in the renal carcinoma cell lines.
2019 Nov Cell Signal Differentiation of human neuroblastoma cell line IMR-32 by sildenafil and its newly discovered analogue IS00384.
2019 Nov J Clin Invest Correcting Smad158, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models.
2019 Nov Kaohsiung J Med Sci Paris saponin VII enhanced the sensitivity of HepG2ADR cells to ADR via modulation of PI3KAKTMAPK signaling pathway.
2019 Mediators Inflamm Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3KAKT-eNOS Signalling in HUVECs.
2019 Nov J Exp Clin Cancer Res Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3KAkt pathway in hepatocellular carcinoma.
2019 Oct Cancers (Basel) Dual PDK1Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation.
2019 Oct Cancer Biomark Upregulation of ITGBL1 predicts poor prognosis and promotes chemoresistance in ovarian cancer.
2019 Nov J Invest Dermatol Preclinical Evidence for Targeting PI3KmTOR Signaling with Dual-Inhibitors as a New Therapeutic Strategy against Cutaneous T Cell Lymphoma.
2019 Front Pharmacol FGF10 Enhances Peripheral Nerve Regeneration iviai the Preactivation of the PI3KAkt Signaling-Mediated Antioxidant Response.
2019 Nov J Cell Biochem Silence of cZNF292 presses the growth, migration, and invasion of human esophageal cancer Eca-109 cells via upregulating miR-206.
2019 Crit Rev Oncog The Possible Interactions and Therapeutic Roles of Lithium Chloride and Midkine on Cancer Treatment.
2019 Oct Int J Radiat Oncol Biol Phys A Phase Ib Study of Cetuximab and BYL719 (Alpelisib) Concurrent with Intensity-Modulated Radiation Therapy in Stage III-IVB Head and Neck Squamous Cell Carcinoma.
2019 Oct Eur J Pharm Sci Role of P-glycoprotein in the brain disposition of seletalisib: Evaluation of the potential for drug-drug interactions.
2019 Oct Microvasc Res PEAR1 presses the proliferation of pulmonary microvascular endothelial cells via PI3KAKT pathway in ALI model.
2019 Oct Life Sci Tetramethylprazine attenuates myocardial ischemiareperfusion injury through modulation of autophagy.
2019 Nov Exp Mol Pathol Propofol weakens hypoxia-aroused apoptosis and autophagy via elevating microRNA-137 in neurocytes.
2019 Oct Exp Cell Res Rafoxanide promotes apoptosis and autophagy of gastric cancer cells by pressing PI3K AktmTOR pathway.
2019 Nov Invest Ophthalmol Vis Sci Growth Hormone Neuroprotection Against Kainate Excitotoxicity in the Retina is Mediated by NotchPTENAkt Signaling.
2019 Oct Mol Cancer Ther Inhibition of Y box binding protein 1 presses cell growth and motility in colorectal cancer.
2019 Nov Expert Opin Ther Pat PI3Kδ inhibitors for the treatment of cancer: a patent review (2015-present).
2019 Oct Med Sci Monit Baicalin Regulates Proliferation, Apoptosis, Migration, and Invasion in Mesothelioma.
2019 Oct Bosn J Basic Med Sci Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5pPTEN signaling in diabetic nephropathy.
2019 Oct Biochem J Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44.
2019 Oct Clin Exp Med B7-H4 facilitates proliferation and metastasis of colorectal carcinoma cell through PI3KAktmTOR signaling pathway.
2019 Oct Cell Biol Int PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors.
2019 Nov J Endocr Soc Ghrelin-Induced Sodium Reabsorption Is Mediated by PKA and Microtubule-Dependent iαiENaC Translocation in Female Rats.
2019 Oct Mol Biol Rep Induction of p73, Δ133p53, Δ160p53, pAKT lead to neuroprotection via DNA repair by 5-LOX inhibition.
2019 Ren Fail The imiR-15a-5p-XIST-CUL3i regulatory axis is important for sepsis-induced acute kidney injury.