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Recent literature: PI3K inhibitor
Date Journal Article title
2019 Apr Breast Cancer Res Treat Regulation of AKT phosphorylation by GSK3β and PTEN to control chemoresistance in breast cancer.
2018 Nov Phytomedicine Allicin attenuates pathological cardiac hypertrophy by inhibiting autophagy via activation of PI3KAktmTOR and MAPKERKmTOR signaling pathways.
2019 Apr Drug Resist Updat YY1 regulates cancer cell immune resistance by modulating PD-L1 expression.
2019 Apr Redox Biol Inhibition of Brd4 alleviates renal ischemiareperfusion injury-induced apoptosis and endoplasmic reticulum stress by blocking FoxO4-mediated oxidative stress.
2019 Apr Exp Mol Pathol Ailanthone up-regulates miR-449a to restrain acute myeloid leukemia cells growth, migration and invasion.
2019 Eur Rev Med Pharmacol Sci MicroRNA-448 inhibits the regeneration of spinal cord injury through PI3KAKTBcl-2 axis.
2019 Apr J Cell Physiol Nimotuzuma restrains proliferation and induces apoptosis in human osteosarcoma cells by regulation of EGFRPI3KAKT signal pathway.
2019 J Diabetes Res A New Way for Beta Cell Neogenesis: Transdifferentiation from Alpha Cells Induced by Glucagon-Like Peptide 1.
2019 Front Oncol CACNA2D3 Enhances the Chemosensitivity of Esophageal Squamous Cell Carcinoma to Cisplatin via Inducing Ca2+-Mediated Apoptosis and Suppressing PI3KAkt Pathways.
2019 Apr Eur J Cancer Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma.
2019 Apr Free Radic Biol Med Upstream signaling events leading to elevated production of pro-survival nitric oxide in photodynamically-challenged glioblastoma cells.
2019 Apr Neuropharmacology Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice.
2019 Apr J Cell Physiol Loss of G3BP1 presses proliferation, migration, and invasion of esophageal cancer cells via Wntβ-catenin and PI3KAKT signaling pathways.
2019 Apr J Muscle Res Cell Motil Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3KAkt signaling pathway.
2019 Exp Ther Med BOS-93, a novel bromophenol derivative, induces apoptosis and autophagy in human A549 lung cancer cells via PI3KAktmTOR and MAPK signaling pathway.
2019 Apr Environ Int PM2.5-induced ADRB2 hypermethylation contributed to cardiac dysfunction through cardiomyocytes apoptosis via PI3KAkt pathway.
2019 Apr Theriogenology Reciprocal stimulating effects of bFGF and FSH on chicken primordial follicle activation through AKT and ERK pathway.
2019 Apr J Clin Invest Nontranslational function of leucyl-tRNA synthetase regulates myogenic differentiation and skeletal muscle regeneration.
2019 Oxid Med Cell Longev Nicotinic Agonist Inhibits Cardiomyocyte Apoptosis in CVB3-Induced Myocarditis via iαi3iβi4-nAChRPI3KAkt-Dependent Survivin Upregulation.
2019 Apr J Cell Physiol Adiponectin inhibits high glucose-induced angiogenesis via inhibiting autophagy in RF6A cells.
2019 Apr Zhonghua Yi Xue Za Zhi [NVP-BKM120 in combination with letrozole inhibit human breast cancer stem cells via PI3KmTOR pathway].
2019 Apr Biochem Biophys Res Commun Rebound pathway overactivation by cancer cells following discontinuation of PI3K or mTOR inhibition promotes cancer cell growth.
2019 Zoology (Jena) Ablation of BMP signaling hampers the blastema formation in Poecilia latipinna by dysregulating the extracellular matrix remodeling and cell cycle turnover.
2019 Apr J Exp Bot Modeling of aluminum-induced malate secretion by pharmacological approach in Arabidopsis: involvement of lipid signaling.
2019 Mar Oncol Rep Microwave hyperthermia enhances the sensitivity of lung cancer cells to gemcitabine through reactive oxygen species‑induced autophagic death.
2019 Apr Bioorg Med Chem Lett Discovery of 1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-ones based novel, potent and PI3Kδ selective inhibitors.
2019 Apr J Cell Mol Med The role of autophagy in the pathogenesis of exposure keratitis.
2019 Apr Aging Male TGF-βPI3KAKTmTORNF-kB pathway. Clinicopathological features in prostate cancer.
2019 Apr Artif Organs The role of PI3KAkt signaling pathway in non-physiological shear stress-induced platelet activation.
2019 Apr J Cell Physiol Ursodeoxycholic acid stimulates alveolar fluid clearance in LPS-induced pulmonary edema via ALXcAMPPI3K pathway.
2019 Am J Transl Res Angiopoietin-2 induces the neuronal differentiation of mouse embryonic NSCs via phosphatidylinositol 3 kinase-Akt pathway-mediated phosphorylation of mTOR.
2019 Am J Transl Res Combined inhibition of FGFR and mTOR pathways is effective in pressing ovarian cancer.
2019 Apr Biomol Ther (Seoul) Novel Isoquinolinamine and Isoindoloquinazolinone Compounds Exhibit Antiproliferative Activity in Acute Lymphoblastic Leukemia Cells.
2019 Int J Immunopathol Pharmacol PCC0208018 exerts antitumor effects by activating effector T cells.
2019 Feb Int J Oncol FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3KAKT signaling pathway.
2019 Apr Chem Biol Interact HO-1 mediates the anti-inflammatory actions of Sulforaphane in monocytes stimulated with a mycoplasmal lipopeptide.
2019 Cell Death Discov The PI3K inhibitor copanlisib synergizes with sorafenib to induce cell death in hepatocellular carcinoma.
2019 Nagoya J Med Sci Enhanced efficacy of histone deacetylase inhibitor panobinostat combined with dual PI3KmTOR inhibitor BEZ235 against glioblastoma.
2019 Apr Bioorg Med Chem Lett Discovery of an EGFR tyrosine kinase inhibitor from Ilex latifolia in breast cancer therapy.
2019 Assay Drug Dev Technol Quantitative Size-Based Analysis of Tumor Spheroids and Responses to Therapeutics.
2019 Apr Cell Biol Int Regulation of insulin resistance by targeting insulin-like growth factor 1 receptor (IGF-1R) with microRNA-122-5p in hepatic cells.
2019 Apr J Cell Biochem Suppression of c-Myc using 10058-F4 exerts caspase-3-dependent apoptosis and intensifies the antileukemic effect of vincristine in pre-B acute lymphoblastic leukemia cells.
2019 Apr Int J Cancer EPHA2 blockade reverses acquired resistance to afatinib induced by EPHA2-mediated MAPK pathway activation in gastric cancer cells and avatar mice.
2019 Apr Heart Rhythm Regulation of TRPC1 channel by endothelin-1 in human atrial myocytes.
2019 Apr Life Sci HIV-1 Nef-GCC185 interaction regulates assembly of cellular protein complexes at TGN targeting MHC-I downregulation.
2019 Apr Sci Rep PCC0208027, a novel tyrosine kinase inhibitor, inhibits tumor growth of NSCLC by targeting EGFR and HER2 aberrations.
2019 Apr J Biomater Appl PLGA nanoparticle-based docetaxelLY294002 drug delivery system enhances antitumor activities against gastric cancer.
2019 Apr Life Sci Lycium barbarum polysaccharides promote osteoblasts viability by regulating microRNA-17PTEN.
2019 Apr Leuk Lymphoma ERK-dependent IL-6 positive feedback loop mediates resistance against a combined treatment using danusertib and BKM120 in Burkitt lymphoma cell lines.
2019 Mar Bioorg Chem Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment.
2019 Apr Inflammation Aquaporin 4 Blockade Attenuates Acute Lung Injury Through Inhibition of Th17 Cell Proliferation in Mice.
2019 Apr Inflamm Res Macrophage migration inhibitory factor (MIF) controls cytokine release during respiratory syncytial virus infection in macrophages.
2019 Apr BMC Cancer Differential effects of the Akt inhibitor MK-2206 on migration and radiation sensitivity of glioblastoma cells.
2019 Mol Med Rep Ginsenoside Rg5 induces apoptosis in human esophageal cancer cells through the phosphoinositide‑3 kinaseprotein kinase B signaling pathway.
2019 Mol Med Rep Inhibition of miR‑214 attenuates the migration and invasion of triple‑negative breast cancer cells.
2019 J BUON The effect of omentin-1 on the proliferation and apoptosis of colon cancer stem cells and the potential mechanism.
2019 Apr J Pharmacol Exp Ther Translation of inhaled drug optimization strategies into clinical pharmacokinetics and pharmacodynamics using GSK2292767A, a novel inhaled PI3Kδ inhibitor.
2019 May Biochem Biophys Res Commun Apelin-13 attenuates early brain injury following arachnoid hemorrhage via pressing neuronal apoptosis through the GLP-1RPI3KAkt signaling.
2019 Cell Physiol Biochem Dual PI3K-BRD4 Inhibitor SF1126 Inhibits Colorectal Cancer Cell Growth in Vitro and in Vivo.
2019 Ren Fail Intermedin protects HUVECs from ischemia reperfusion injury via Wntβ-catenin signaling pathway.
2019 Mar Chem Biol Interact Guajadial reverses multidrug resistance by inhibiting ABC transporter expression and pressing the PI3KAkt pathway in drug-resistant breast cancer cells.
2019 Mar Mol Cancer Ther Targeting the IGF1RPI3KAKT Pathway Sensitizes Ewing Sarcoma to BET Bromodomain Inhibitors.
2019 May Biochem Biophys Res Commun EID1 plays a crucial role in proliferation of neural stem cell.
2019 Mar J Exp Clin Cancer Res miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells.
2019 Mar Connect Tissue Res Resveratrol inhibits the development of obesity-related osteoarthritis via the TLR4 and PI3KAkt signaling pathways.
2019 Mar Biomed Pharmacother BAFF promotes T cell activation through the BAFF-BAFF-R-PI3K-Akt signaling pathway.
2019 Mar JAMA Oncol Safety, Tolerability, and Management of Toxic Effects of Phosphatidylinositol 3-Kinase Inhibitor Treatment in Patients With Cancer: A Review.
2019 Anticancer Drugs Fluvastatin exerts an antitumor effect in vemurafenib-resistant melanoma cells.
2019 Mar Biosci Biotechnol Biochem Phenethyl isothiocyanate stimulates glucose uptake through the Akt pathway in C2C12 myotubes.
2019 Mar Breast Cancer Res Treat Incidence of peripheral edema in patients receiving PI3KmTORCDK46 inhibitors for metastatic breast cancer.
2019 Antimicrob Agents Chemother Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs.
2019 Mar Int J Mol Sci MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice.
2019 Biomed Res Int Ubenimex Reverses MDR in Gastric Cancer Cells by Activating Caspase-3-Mediated Apoptosis and Suppressing the Expression of Membrane Transport Proteins.
2019 Mar Sci Rep Activin A regulates the epidermal growth factor receptor promoter by activating the PI3KSP1 pathway in oral squamous cell carcinoma cells.
2019 May Biochem Biophys Res Commun The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways.