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Recent literature: PI3K inhibitor
Date Journal Article title
2020 Mar J Mol Histol Effects of rutin on the oxidative stress, proliferation and osteogenic differentiation of periodontal ligament stem cells in LPS-induced inflammatory environment and the underlying mechanism.
2020 Mar Int Immunopharmacol SH2B1 protects cardiomyocytes from ischemiareperfusion injury via the activation of the PI3KAKT pathway.
2020 Mar J Ethnopharmacol The flavonoid-enriched extract from the root of Smilax china L. inhibits inflammatory responses via the TLR-4-mediated signaling pathway.
2020 Mar Clin Cancer Res Genetic alterations in the PI3KAKT pathway and baseline AKT activity define AKT inhibitor sensitivity in breast cancer patient-derived xenografts.
2020 Mar Nanoscale Res Lett The PI3KmTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway.
2020 Front Oncol Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3KAktmTOR Signaling Pathway.
2020 Oncol Lett Advanced glycation end products induce proliferation, invasion and epithelial-mesenchymal transition of human SW480 colon cancer cells through the PI3KAKT signaling pathway.
2020 Front Immunol Inhibition of PI3Kδ Enhances Poly I:C-Induced Antiviral Responses and Inhibits Replication of Human Metapneumovirus in Murine Lungs and Human Bronchial Epithelial Cells.
2020 Front Pharmacol Neuroprotective Effect of Danhong Injection on Cerebral Ischemia-Reperfusion Injury in Rats by Activation of the PI3K-Akt Pathway.
2020 Int J Med Sci FAM83A is amplified and promotes tumorigenicity in non-small cell lung cancer via ERK and PI3KAktmTOR pathways.
2020 Mar Cell Prolif p75NTR-- mice exhibit an alveolar bone loss phenotype and inhibited PI3KAktβ-catenin pathway.
2020 Mar Fundam Clin Pharmacol Cannabidiol alleviates hemorrhagic shock-induced neural apoptosis in rats by inducing autophagy through activation of the PI3KAKT pathway.
2020 Mar Oncotarget Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss.
2020 Clin Interv Aging Downregulation of miR-34a Promotes Proliferation and Inhibits Apoptosis of Rat Osteoarthritic Cartilage Cells by Activating PI3KAkt Pathway.
2020 Drug Des Devel Ther 1,25(OH)2D3 Strengthens the Vasculogenesis of Multipotent Mesenchymal Stromal Cells from Rat Bone Marrow by Regulating the PI3KAKT Pathway.
2020 Mar J Med Chem Design, Synthesis and Biological Evaluation of Quinazolin-4-one Based Hydroxamic Acids as Dual PI3KHDAC Inhibitors.
2020 Saudi J Biol Sci Diabetes as a risk factor for Alzheimer's disease in the Middle East and its shared pathological mediators.
2020 Feb Ann Oncol A phase I dose-escalation study of enzalutamide in combination with the AKT inhibitor AZD5363 (capivasertib) in patients with metastatic castration-resistant prostate cancer.
2020 Mar ACS Chem Neurosci Rapid and prolonged antidepressant-like effect of crocin is associated with GHSR mediated hippocampal plasticity-related proteins in mice exposed to prenatal stress.
2020 J Cancer Inhibition of the PI3K-AKT-mTOR pathway presses the adipocyte-mediated proliferation and migration of breast cancer cells.
2020 Mar J Cell Commun Signal CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells.
2020 Mar Pharmacol Res Systems pharmacology reveals the mechanism of activity of Ge-Gen-Qin-Lian decoction against LPS-induced acute lung injury: A novel strategy for exploring active components and effective mechanism of TCM formulae.
2020 Mar Brain Res Bull Hypothermia protects neurons against ischemiareperfusion-induced pyroptosis via m6A-mediated activation of PTEN and the PI3KAktGSK-3β signaling pathway.
2020 Mar Cells Elevated PDK1 Expression Drives PI3KAKTMTOR Signaling Promotes Radiation-Resistant and Dedifferentiated Phenotype of Hepatocellular Carcinoma.
2020 Eur Rev Med Pharmacol Sci Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3pSIRT1 axis and PI3KAkt signaling pathway.
2020 Theranostics PI3KAKT inhibition reverses R-CHOP resistance by destabilizing SOX2 in diffuse large B cell lymphoma.
2020 J Cancer Curcumol inhibits the proliferation and metastasis of melanoma via the miR-152-3pPI3KAKT and ERKNF-κB signaling pathways.
2020 Oncol Lett Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma.
2020 Oncol Lett Hepatitis B virus upregulates cellular inhibitor of apoptosis protein 2 expression via the PI3KAKTNF-κB signaling pathway in liver cancer.
2020 Oncol Lett Akt inhibitor MK-2206 reduces pancreatic cancer cell viability and increases the efficacy of gemcitabine.
2020 Front Pharmacol Comparing PI3KAkt Inhibitors Used in Ovarian Cancer Treatment.
2020 Mar Eur J Med Res Limb ischemic preconditioning ameliorates renal microcirculation through activation of PI3KAkteNOS signaling pathway after acute kidney injury.
2020 Mar J Clin Invest Oncogene-independent BCR-like signaling adaptation confers drug resistance in Ph-like ALL.
2020 Biomed Pharmacother A novel multitarget kinase inhibitor BZG with potent anticancer activity in vitro and vivo enhances efficacy of sorafenib through PI3K pathways in hepatocellular carcinoma cells.
2020 Mar Shock MiR-433 regulates myocardial ischemia reperfusion injury by targeting NDRG4 via the PI3KAkt pathway.
2020 Mar ACS Med Chem Lett Codrug Approach for the Potential Treatment of EML4-ALK Positive Lung Cancer.
2020 Cancer Manag Res Leucine Zipper-EF-Hand Containing Transmembrane Protein 1 Is a Potential Prognostic Biomarker and Promotes Cell Progression in Prostate Cancer.
2020 Mar Biochem Biophys Res Commun Involvement of MCL1, c-myc, and cyclin D2 protein degradation in ponatinib-induced cytotoxicity against T315I(+) Ph+leukemia cells.
2020 Mar Anticancer Agents Med Chem Copanlisib: Novel PI3K Inhibitor for Treatment of Lymphoma.
2020 Mar Int J Mol Sci Chondroitin Sulfate Promotes the Proliferation of Keloid Fibroblasts Through Activation of the Integrin and Protein Kinase B Pathways.
2020 Mar Aging (Albany NY) Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis.
2020 Mar Acta Biochim Biophys Sin ... HER4 promotes the growth and metastasis of osteosarcoma via the PI3KAKT pathway.
2020 Mar Connect Tissue Res Compression stress induces nucleus pulposus cell autophagy by inhibition of the PI3KAKTmTOR pathway and activation of the JNK pathway.
2020 Mar J Exp Biol iIn vitroi insulin treatment reverses changes elicited by nutrients in cellular metabolic processes that regulate food intake in fish.
2020 Mar World Neurosurg 4-PBA enhances autophagy by inhibiting endoplasmic reticulum stress in recombinant human beta nerve growth factor induced PC12 cells after mechanical injury via PI3KAKTmTOR signaling pathway.
2020 Mar Microb Pathog Suppression of miR-147b contributed to H37Rv-infected macrophage viability and migration in tuberculosis in vitro.
2020 Mar Cancer Sci Bi-allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
2020 Mar J Ocul Pharmacol Ther Application of Cell Impedance as a Screening Tool to Discover Modulators of Intraocular Pressure.
2020 Mar Cancer Biol Ther The histone demethylase KDM2B activates FAK and PI3K that control tumor cell motility.
2020 Ann Transl Med Fentanyl inhibits the progression of gastric cancer through the pression of MMP-9 via the PI3KAkt signaling pathway.
2020 J Enzyme Inhib Med Chem Discovery of novel ATAD2 bromodomain inhibitors that trigger apoptosis and autophagy in breast cells by structure-based virtual screening.
2020 Mar Fitoterapia Aktsurvivin pathway inhibition enhances the apoptotic cell death-induced by alpha-santalol in human prostate cancer cells.
2020 Mar Comput Biol Chem Inverse screening of Simvastatin kinase targets from glioblastoma druggable kinome.
2020 Mar Bioorg Chem Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors.
2020 Mar Biomed Pharmacother CircPIP5K1A activates KRT80 and PI3KAKT pathway to promote gastric cancer development through sponging miR-671-5p.
2020 Mar J Thorac Oncol Alterations in the PI3K pathway drive resistance to MET inhibitors in NSCLC harboring MET exon 14 skipping mutations.
2020 Mar Med Oncol Activation of the HGFc-MET axis promotes lenvatinib resistance in hepatocellular carcinoma cells with high c-MET expression.
2020 Mar Neurochem Res NDRG4 Alleviates Aβ1-40 Induction of SH-SY5Y Cell Injury via Activation of BDNF-Inducing Signalling Pathways.
2020 Mar Haematologica The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia.
2020 Mar Expert Opin Pharmacother Approved and emerging PI3K inhibitors for the treatment of chronic lymphocytic leukemia and non-Hodgkin lymphoma.
2020 Mar Am J Transplant Brain-dead donor heart conservation with a preservation solution plemented by a conditioned medium from mesenchymal stem cells improves graft contractility after transplantation.
2020 Front Pharmacol iShenfui Injection Promotes Vasodilation by Enhancing eNOS Activity Through the PI3KAkt Signaling Pathway iIn Vitroi.
2020 Mar Turk J Haematol PI3K abrogation using pan PI3K inhibitor BKM120 give rise to a weighty anti-cancer effect on AML-derived KG-1 cells by inducing apoptosis and G2M arrest
2020 Mar FEBS Open Bio Thioredoxin mitigates H2 O2 -induced inhibition of myogenic differentiation of rat bone marrow mesenchymal stem cells by enhancing AKT activation.
2020 Mar J Cell Mol Med Maresin Conjugates in Tissue Regeneration 1 improves alveolar fluid clearance by up-regulating alveolar ENaC, Na, K-ATPase in lipopolysaccharide-induced acute lung injury.
2020 Mar Autophagy The P2RY12 receptor promotes VSMC-derived foam cell formation by inhibiting autophagy in advanced atherosclerosis.
2020 Chin Med Cryptotanshinone from iSalvia miltiorrhizai Bunge (Danshen) inhibited inflammatory responses via TLR4MyD88 signaling pathway.
2020 Front Pharmacol Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells iviai PI3KAktNF-κB Signaling Pathway.
2020 Mar Cardiovasc Drugs Ther Oestrogen Receptor β Activation Protects Against Myocardial Infarction via Notch1 Signalling.
2020 Mar Oncogene ADAR1-mediated RNA editing is a novel oncogenic process in thyroid cancer and regulates miR-200 activity.
2020 Mar Int J Mol Sci Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
2020 Mar Leuk Lymphoma IND.216: a phase II study of buparlisib and associated biomarkers, raptor and p70S6K, in patients with relapsed and refractory chronic lymphocytic leukemia.
2020 Mar Hum Exp Toxicol Sulfur dioxide induces vascular relaxation through PI3KAkteNOS and NOcGMP signaling pathways in rats.
2020 Mar Mol Cancer Res PIK3CA and p53 mutations promote 4NQO-initated head and neck tumor progression and metastasis in mice.
2020 Mar J Cell Mol Med Inhibition of PHLPP1 ameliorates cardiac dysfunction via activation of the PI3KAktmTOR signalling pathway in diabetic cardiomyopathy.