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Recent literature: PI3K inhibitor
Date Journal Article title
2019 Feb BMC Cancer Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells.
2019 Feb J Cell Mol Med Matrine attenuates high-fat diet-induced in vivo and ox-LDL-induced in vitro vascular injury by regulating the PKCαeNOS and PI3KAkteNOS pathways.
2019 Feb Redox Biol Tumoral NOX4 recruits M2 tumor-associated macrophages via ROSPI3K signaling-dependent various cytokine production to promote NSCLC growth.
2019 Feb Eur Respir J A Randomised, Placebo-Controlled Study of Omipalisib (PI3KmTOR) in Idiopathic Pulmonary Fibrosis.
2019 Feb Biochem Biophys Res Commun Inhibition of gastric cancer cell growth by a PI3K-mTOR dual inhibitor GSK1059615.
2019 Feb J Gen Virol Influenza virus entry via the GM3 ganglioside-mediated platelet-derived growth factor receptor β signalling pathway.
2019 Feb Naunyn Schmiedebergs Arch... Glucagon-like peptide-1 attenuates endoplasmic reticulum stress-induced apoptosis in H9c2 cardiomyocytes during hypoxiareoxygenation through the GLP-1RPI3KAkt pathways.
2019 Feb Lab Invest Lipopolysaccharide promotes lung fibroblast proliferation through autophagy inhibition via activation of the PI3K-Akt-mTOR pathway.
2019 Feb Acta Pharmacol Sin Magnesium lithospermate B ameliorates microcirculation perfusion in rats by promoting vascular NO production via activating the PI3KAKT pathway.
2019 Am J Cancer Res Synergistic effects of SHP2 and PI3K pathway inhibitors in GAB2-overexpressing ovarian cancer.
2019 Feb Bioorg Med Chem Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor.
2019 Feb Cancer Biol Ther Lamc1 promotes the Warburg effect in hepatocellular carcinoma cells by regulating PKM2 expression through AKT pathway.
2019 Feb Int J Mol Sci mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy.
2019 Feb Eur J Pharmacol Dacomitinib, a new pan-EGFR inhibitor, is effective in attenuating pulmonary vascular remodeling and pulmonary hypertension.
2019 Jan Oncol Rep Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.
2019 Jan Oncol Rep Downregulation of BAG‑1 in T47D cells promotes resistance to tamoxifen via activation of the PI3KAktmTOR signaling pathway.
2019 Jan Oncol Rep miRNA-223 is an anticancer gene in human non-small cell lung cancer through the PI3KAKT pathway by targeting EGFR.
2019 Int J Biol Sci Melatonin Stimulates STAR Expression and Progesterone Production via Activation of the PI3KAKT Pathway in Bovine Theca Cells.
2019 Int J Biol Sci Icariin Inhibits Endoplasmic Reticulum Stress-induced Neuronal Apoptosis after Spinal Cord Injury through Modulating the PI3KAKT Signaling Pathway.
2019 Feb J Biol Chem Melanocortin type 4 receptor-mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats.
2019 Feb Biochem Biophys Res Commun CircRNA hsa-circ-0014359 promotes glioma progression by regulating miR-153PI3K signaling.
2019 Feb Semin Cancer Biol PIK3CA in cancer: the past 30 years.
2019 Feb Anticancer Drugs Novel small molecule decreases cell proliferation, migration, clone formation, and gene expression through ERK inhibition in MCF-7 and MDA-MB-231 breast cancer cell lines.
2019 Feb J Cell Physiol Uric acid induced epithelial-mesenchymal transition of renal tubular cells through PI3Kp-Akt signaling pathway.
2019 Feb Anat Rec (Hoboken) Chrysophanol Suppresses Hypoxia-induced Epithelial-mesenchymal Transition in Colorectal Cancer Cells.
2019 Feb Int J Cancer Idelalisib for optimized CD19-specific chimeric antigen receptor T cells in chronic lymphocytic leukemia patients.
2019 Feb EBioMedicine PI3K inhibitors protect against glucocorticoid-induced skin atrophy.
2019 Jan Eur J Med Chem 2-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)benzonitrile as novel inhibitor of receptor tyrosine kinase and PI3KAKTmTOR signaling pathway in glioblastoma.
2019 Feb J Clin Invest Targeting compensatory MEKERK activation increases JAK inhibitor efficacy in myeloproliferative neoplasms.
2019 Feb J Exp Clin Cancer Res Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells.
2019 J Toxicol Sci Benzo[a]pyrene induces pyroptotic and autophagic death through inhibiting PI3KAkt signaling pathway in HL-7702 human normal liver cells.
2019 Feb Life Sci Protective effects of febuxostat against paraquat-induced lung toxicity in rats: Impact on RAGEPI3KAkt pathway and downstream inflammatory cascades.
2019 Feb Environ Toxicol Nickel-induced VEGF expression via regulation of Akt, ERK12, NFκB, and AMPK pathways in H460 cells.
2019 Mar Biochem Biophys Res Commun GDNF family receptor alpha 2 promotes neuroblastoma cell proliferation by interacting with PTEN.
2019 Feb J Cell Physiol Exosomes derived from SDF1-overexpressing mesenchymal stem cells inhibit ischemic myocardial cell apoptosis and promote cardiac endothelial microvascular regeneration in mice with myocardial infarction.
2019 Jan Mol Med Rep Insulin‑like growth factor I promotes adipogenesis in hemangioma stem cells from infantile hemangiomas.
2019 Jan Int J Oncol Partial agonistic effect of cetuximab on epidermal growth factor receptor and Src kinase activation in triple‑negative breast cancer cell lines.
2019 Ther Adv Hematol Novel treatment approaches and future perspectives in follicular lymphoma.
2019 Feb Nat Chem Biol A class of highly selective inhibitors bind to an active state of PI3Kγ.
2018 Dec Pediatr Res IGF-1 alleviates serum IgG-induced neuronal cytolysis through PI3K signaling in children with opsoclonus-myoclonus syndrome and neuroblastoma.
2018 Zhongguo Zhong Yao Za Zhi [Effects of PI3KAkt-eNOS signaling pathway on total flavones in Clematis filamentosa post-conditioning alleviated of myocardial ischemia-reperfusion injury in rats].
2019 Feb Osteoarthritis Cartilage Pharmacological inhibition of mTORC1 but not mTORC2 protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism through Akt and autophagy induction.
2019 Feb Cell Signal Minocycline inhibits PDGF-BB-induced human aortic smooth muscle cell proliferation and migration by reversing miR-221- and -222-mediated RECK pression.
2019 Feb Eur J Pharmacol IRS-1 targets TAZ to inhibit adipogenesis of rat bone marrow mesenchymal stem cells through PI3K-Akt and MEK-ERK pathways.
2019 Feb J Clin Oncol Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.
2019 Feb Zygote A molecular mechanism of mouse placental spongiotrophoblast differentiation regulated by prolyl oligopeptidase.
2019 Feb Chem Asian J Synthesis and Evaluation of Imidazo[1,2-a]pyridine Analogues of the ZSTK474 Class of Phosphatidylinositol 3-Kinase Inhibitors.
2019 Feb Biosci Rep Overexpression of UHRF1 promoted the proliferation of vascular smooth cells via the regulation of Geminin protein levels.
2019 Zhonghua Wei Zhong Bing J... [Therapeutic hypothermia reduced brain damage on rats after cardiopulmonary resuscitation by activating III-type PI3K pathway to increase autophagy].
2019 Jan Pflugers Arch SGK1-dependent stimulation of vascular smooth muscle cell osteo-chondrogenic transdifferentiation by interleukin-18.
2019 Redox Biol LRP1 activation attenuates white matter injury by modulating microglial polarization through Shc1PI3KAkt pathway after arachnoid hemorrhage in rats.
2019 Jan Chem Biol Interact Buparlisib is a novel inhibitor of daunorubicin reduction mediated by aldo-keto reductase 1C3.
2018 Dec Oncotarget Targeting protein kinase CK2 and CDK46 pathways with a multi-kinase inhibitor ON108110 presses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
2018 Dec Oncotarget Preclinical characterization of tyrosine kinase inhibitor-based targeted therapies for neuroendocrine thyroid cancer.
2019 Jan Leukemia New roles for B cell receptor associated kinases: when the B cell is not the target.
2019 Mar Biochem Biophys Res Commun PI3KAkt-Beclin1 signaling pathway positively regulates phagocytosis and negatively mediates NF-κB-dependent inflammation in Staphylococcus aureus-infected macrophages.
2019 Jan Endocr Relat Cancer PI3KmTOR inhibition potentiates and extends palbociclib activity in anaplastic thyroid cancer.
2019 Arch Med Sci Renin-angiotensin system inhibitor attenuates oxidative stress induced human coronary artery endothelial cell dysfunction via the PI3KAKTmTOR pathway.
2019 Jan Oncologist Clinicopathological and Preclinical Findings of NUT Carcinoma: A Multicenter Study.
2019 J Surg Res Melatonin Attenuates Acute Pancreatitis-Induced Liver Damage Through Akt-Dependent PPAR-γ Pathway.
2019 Jan J Immunol The PI3K p110δ Isoform Inhibitor Idelalisib Preferentially Inhibits Human Regulatory T Cell Function.
2019 Jan J Exp Clin Cancer Res Receptor tyrosine kinase-dependent PI3K activation is an escape mechanism to vertical pression of the EGFRRASMAPK pathway in KRAS-mutated human colorectal cancer cell lines.
2019 Jan Med Sci Monit Sulforaphane Attenuates H₂O₂-induced Oxidant Stress in Human Trabecular Meshwork Cells (HTMCs) via the Phosphatidylinositol 3-Kinase (PI3K)SerineThreonine Kinase (Akt)-Mediated Factor-E2-Related Factor 2 (Nrf2) Signaling Activation.
2019 Cytotechnology Thiocoraline mediates drug resistance in MCF-7 cells via PI3KAktBCRP signaling pathway.
2018 J Cell Biochem EGFR-mediated signaling pathway influences the sensitivity of oral squamous cell carcinoma to JQ1.
2019 Jan Gynecol Oncol A novel PI3KmTOR dual inhibitor, CMG002, overcomes the chemoresistance in ovarian cancer.
2019 Jan J Inorg Biochem Mir-215-5p induces autophagy by targeting PI3K and activating ROS-mediated MAPK pathways in cardiomyocytes of chicken.
2019 Jan Cell Mol Life Sci The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways.
2019 Jan Cell Death Dis CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells.
2019 Jan J Hematol Oncol Identifying and targeting cancer stem cells in leiomyosarcoma: prognostic impact and role to overcome secondary resistance to PI3KmTOR inhibition.
2019 Exp Ther Med MicroRNA-146b induces the PI3KAktNF-κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN.
2019 Jan Asian Pac J Cancer Prev EGFR inhibitor C225 Increases the Radio-Sensitivity of Human Breast Cancer Cells
2019 Jan Cancer Lett CDK46 inhibitor palbociclib enhances the effect of pyrotinib in HER2-positive breast cancer.
2019 Oncol Lett Tanshinone IIA induces apoptosis of ovarian cancer cells iin vitroi and iin vivoi through attenuation of PI3KAKTJNK signaling pathways.
2019 Jan J Neurotrauma Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3KAKT-mTOR signaling following traumatic spinal injuries.