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Recent literature: GABAA α5 receptor modulator
Date Journal Article title
2019 Adv Pharmacol Rapid-acting antidepressants.
2019 Br J Anaesth Analgesic potential of PF-06372865, an α2α3α5 type-selective GABAA partial agonist, in humans.
2018 Pharmacol Res Perspect The role of loops B and C in determining the potentiation of GABAA receptors by midazolam.
2018 Dec Neuroscience Enhanced GABAergic Tonic Inhibition Reduces Intrinsic Excitability of Hippocampal CA1 Pyramidal Cells in Experimental Autoimmune Encephalomyelitis.
2018 Feb Neuroscience The GABAAα5-selective Modulator, RO4938581, Rescues Protein Anomalies in the Ts65Dn Mouse Model of Down Syndrome.
2018 Neuropharmacology Loop F of the GABAA receptor alpha unit governs GABA potency.
2017 Brain Res Bull Pharmacological and antihyperalgesic properties of the novel α23 preferring GABAA receptor ligand MP-III-024.
2017 Jun ACS Chem Neurosci Antinociceptive Effects of a Novel α2α3-Subtype Selective GABAA Receptor Positive Allosteric Modulator.
2016 Front Pharmacol Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator.
2016 Nov Eur J Pharmacol Ester to amide stitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 unit.
2017 J Cereb Blood Flow Metab Quantification of [11C]Ro15-4513 GABAAα5 specific binding and regional selectivity in humans.
2016 Neuropsychopharmacology A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice.
2016 Chem Biol Drug Des An Investigation of the Differential Effects of Ursane Triterpenoids from Centella asiatica, and Their Semisynthetic Analogues, on GABAA Receptors.
2015 Front Behav Neurosci Assessment of Cognitive Scales to Examine Memory, Executive Function and Language in Individuals with Down Syndrome: Implications of a 6-month Observational Study.
2015 Neuropsychopharmacology Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.
2015 Jan Int J Neuropsychopharmacol Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model.
2015 Feb Biochem Pharmacol GABAA α5 unit-containing receptors do not contribute to reversal of inflammatory-induced spinal sensitization as indicated by the unique selectivity profile of the GABAA receptor allosteric modulator NS16085.
2014 Mar Brain Res Sh-I-048A, an in vitro non-selective er-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor types may explain behavioral effects.
2013 J Pharmacol Exp Ther SB-205384 is a positive allosteric modulator of recombinant GABAA receptors containing rat α3, α5, or α6 unit types coexpressed with β3 and γ2 units.
2013 Feb J Neurosci Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.
2013 Mar Eur J Pharmacol Enhancing the function of alpha5-unit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states.
2012 Jul J Physiol Lack of an endogenous GABAA receptor-mediated tonic current in hypoglossal motoneurons.
2012 Psychopharmacology (Berl) Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete -chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats.
2006 Synapse GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon.
2006 J Pharmacol Exp Ther Indiplon is a high-affinity positive allosteric modulator with selectivity for alpha1 unit-containing GABAA receptors.
1998 J Pharmacol Exp Ther Substituted 3beta-phenylethynyl derivatives of 3alpha-hydroxy-5alpha-pregnan-20-one: remarkably potent neuroactive steroid modulators of gamma-aminobutyric acidA receptors.