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Recent literature: Endonuclease inhibitor
Date Journal Article title
2020 Jan Nat Commun Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.
2020 Jan Fish Shellfish Immunol Molecular cloning and the involvement of IRE1α-XBP1s signaling pathway in palmitic acid induced - Inflammation in primary hepatocytes from large yellow croaker (Larimichthys crocea).
2019 Dec Chem Biol Drug Des Computer-Aided Drug Design of Small Molecule Inhibitors of the ERCC1-XPF Protein-Protein Interaction.
2019 Dec J Infect Chemother Duration of fever and PAI38X-stituted virus emergence in patients treated with baloxavir in the 2018-2019 influenza season.
2019 Dec Sci Rep Expression of XBP1s in peritoneal mesothelial cells is critical for inflammation-induced peritoneal fibrosis.
2019 Nov Int J Mol Sci Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity-Short Communication.
2019 Nov Spectrochim Acta A Mol Bi... Label-free one-step fluorescent method for the detection of endonuclease activity based on thioflavin TG-quadruplex.
2019 J Photochem Photobiol B Raffinose increases autophagy and reduces cell death in UVB-irradiated keratinocytes.
2019 IDCases Adult influenza A (H3N2) with reduced susceptibility to baloxavir or peramivir cured after switching anti-influenza agents.
2020 Jan J Bacteriol Molecular Basis of Substrate Recognition of Endonuclease Q from the Euryarchaeon Pyrococcus furiosus.
2019 Front Pharmacol An Improved Enzyme-Linked Focus Formation Assay Revealed Baloxavir Acid as a Potential Antiviral Therapeutic Against Hantavirus Infection.
2019 Oct Invest Ophthalmol Vis Sci Cyclin-Dependent Kinase Inhibitor 2b Mediates Excitotoxicity-Induced Death of Retinal Ganglion Cells.
2020 Expert Rev Respir Med Recommended hospital preparations for future cases and outbreaks of novel influenza viruses.
2012 LiverTox: Clinical and Re... Baloxavir
2019 Oct Neuropathol Appl Neurobiol Oxidative DNA damage is concurrently repaired by base excision repair (BER) and apyrimidinic endonuclease 1 (APE1)-initiated nonhomologous end joining (NHEJ) in cortical neurons.
2019 Oct Cancers (Basel) Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies.
2019 Dec Eur J Pharmacol High expression of NAMPT in adult T-cell leukemialymphoma and anti-tumor activity of a NAMPT inhibitor.
2019 Nov Nucleic Acids Res Structure and function of the Toscana virus cap-snatching endonuclease.
2019 Oncol Rep Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin‑mediated mitophagy.
2019 Dec Biosens Bioelectron Terminal deoxynucleotidyl transferase-activated nicking enzyme amplification reaction for specific and sensitive detection of DNA methyltransferase and polynucleotide kinase.
2019 J Gen Virol Mutated influenza A virus exhibiting reduced susceptibility to baloxavir marboxil from an experimentally infected horse.
2019 Sep Chem Commun (Camb) Optimised oligonucleotide strates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
2019 DNA Repair (Amst) A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels.
2019 Mol Cancer Ther Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1.
2019 DNA Repair (Amst) Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway.
2019 Oct ACS Infect Dis An Influenza Virus Entry Inhibitor Targets Class II PI3 Kinase and Synergizes with Oseltamivir.
2019 Oct J Biol Chem The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.
2019 Emerg Infect Dis Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019.
2019 Oct Biochem Biophys Res Commun JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing.
2019 Cell Death Discov Cigarette smoke activates the parthanatos pathway of cell death in human bronchial epithelial cells.
2019 Oct J Biol Chem Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response.
2019 Sep J Med Chem Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.
2019 Aug Curr Drug Targets Potential Role of Endonuclease Inhibition and Other Targets in the Treatment of Influenza.
2019 Cancer Sci Novel p97VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
2019 Jun Chem Sci Probing and regulating the activity of cellular enzymes by using DNA tetrahedron nanostructures.
2019 Aug EMBO J Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor.
2019 Phytomedicine Benzoquinones from Cyperus spp. trigger IRE1α-independent and PERK-dependent ER stress in human stomach cancer cells and are novel proteasome inhibitors.
2019 Aug Org Biomol Chem Sulfonic nucleic acids (SNAs): a new class of strate mimics for ribonuclease A inhibition.
2019 PLoS One Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors.
2019 Aug Anal Chem Single-Molecule Fluorescence Imaging for Ultrasensitive DNA Methyltransferase Activity Measurement and Inhibitor Screening.
2019 Sep J Anim Sci Bta-miR-34b regulates milk fat biosynthesis by targeting mRNA decapping enzyme 1A (DCP1A) in cultured bovine mammary epithelial cells1.
2019 Int J Clin Oncol Genetic and genomic basis of the mismatch repair system involved in Lynch syndrome.
2019 Drugs Today (Barc) Baloxavir marboxil: a novel cap-dependent endonuclease (CEN) inhibitor for the treatment of acute uncomplicated influenza.
2019 Jun Medicina (Kaunas) Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
2019 J Oral Biol Craniofac Res Plasminogen activator inhibitor-1 polymorphisms as a risk factor for chronic periodontitis in North Indian population.
2019 J Dairy Sci Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows.
2019 May Cell Snatch-and-Grab Inhibitors to Fight the Flu.
2019 Mol Cancer Ther The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
2019 Arch Virol Characterization of the endonuclease activity of the replication-associated protein of beak and feather disease virus.
2019 May Med Sci Monit Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis.
2019 Int Immunopharmacol Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor STF-083010 protects the liver from thioacetamide-induced oxidative stress, inflammation and injury by triggering hepatocyte autophagy.
2019 Jul Nucleic Acids Res RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.
2019 PLoS One Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently presses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models.
2019 Clin Exp Med Mutation analysis of POLE gene in patients with early-onset colorectal cancer revealed a rare silent variant within the endonuclease domain with potential effect on splicing.
2019 FASEB J Inflammation-mediated deacetylation of the ribonuclease 1 promoter iviai histone deacetylase 2 in endothelial cells.
2019 Immunol Invest MicroRNA-31 Negatively Regulates Interleukin-34 Expression In Vitro.
2019 J Pharm Sci Population Pharmacokinetics of Baloxavir Marboxil in Japanese Pediatric Influenza Patients.
2019 Jul Nucleic Acids Res CRISPRai for simultaneous gene activation and inhibition to promote stem cell chondrogenesis and calvarial bone regeneration.
2019 Jun Biosens Bioelectron A dual-response biosensor for electrochemical and glucometer detection of DNA methyltransferase activity based on functionalized metal-organic framework amplification.
2019 Nat Struct Mol Biol Broad-spectrum enzymatic inhibition of CRISPR-Cas12a.
2019 Apr Sr Care Pharm Baloxavir: A Novel Single-Dose Oral Antiviral for the Treatment of Influenza.
2019 Mar Nat Commun Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation.
2019 Euro Surveill Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic unit I38T stitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.
2019 PLoS Genet Cellular response to small molecules that selectively stall protein synthesis by the ribosome.
2019 Int J Mol Med Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress.
2019 Mar Sci Rep Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil.
2019 Mar Mikrochim Acta A FRET assay for the quantitation of inhibitors of exonuclease EcoRV by using parchment paper inkjet-printed with graphene oxide and FAM-labelled DNA.
2019 Mar Proc Natl Acad Sci U S A OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
2019 Curr Med Res Opin A network meta-analysis of the efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors for the treatment of influenza in otherwise healthy patients.
2019 Apr Biochem Biophys Res Commun A novel method for stabilizing microRNA mimics.
2019 Gynecol Oncol ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
2019 Biotechnol J Target-Activated DNA Polymerase Activity for Sensitive RNase H Activity Assay.
2019 Antiviral Res Baloxavir marboxil susceptibility of influenza viruses from the Asia-Pacific, 2012-2018.
2019 Feb Cell Host Microbe Discovery and Characterization of Cas9 Inhibitors Disseminated across Seven Bacterial Phyla.
2019 Feb Sci Transl Med Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.