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Recent literature: Endonuclease inhibitor
Date Journal Article title
2019 Apr J Pharm Sci Population Pharmacokinetics of Baloxavir Marboxil in Japanese Pediatric Influenza Patients.
2019 Jun Biosens Bioelectron A dual-response biosensor for electrochemical and glucometer detection of DNA methyltransferase activity based on functionalized metal-organic framework amplification.
2019 Apr Sr Care Pharm Baloxavir: A Novel Single-Dose Oral Antiviral for the Treatment of Influenza.
2019 Euro Surveill Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic unit I38T stitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.
2019 Mar Sci Rep Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil.
2019 Mar Mikrochim Acta A FRET assay for the quantitation of inhibitors of exonuclease EcoRV by using parchment paper inkjet-printed with graphene oxide and FAM-labelled DNA.
2019 Apr Curr Med Res Opin A network meta-analysis of the efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors for the treatment of influenza in otherwise healthy patients.
2019 Antiviral Res Baloxavir marboxil susceptibility of influenza viruses from the Asia-Pacific, 2012-2018.
2019 Feb Sci Transl Med Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.
2019 Curr Opin Infect Dis Influenza virus polymerase inhibitors in clinical development.
2019 Feb Clin Transl Oncol Letrozole improves the sensitivity of breast cancer cells overexpressing aromatase to cisplatin via down-regulation of FEN1.
2019 Mar J Biol Chem Endonuclease and redox activities of human apurinicapyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
2019 Feb J Agric Food Chem Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells.
2019 Jan Nat Commun IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2019 Rev Esp Quimioter [Baloxavir marboxil: a potent cap-dependent endonuclease inhibitor of influenza viruses].
2019 Jan Ann Pharmacother Baloxavir Marboxil: The First Cap-Dependent Endonuclease Inhibitor for the Treatment of Influenza.
2019 Euro Surveill Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 201617 and 201718 seasons.
2019 Euro Surveill Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018.
2019 Biochim Biophys Acta Mol ... SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy.
2019 Mar J Biol Chem DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
2019 Jan Mikrochim Acta A hairpin-type DNA probe for direct colorimetric detection of endonuclease activity and inhibition based on the deaggregation of gold nanoparticles.
2019 J Antibiot (Tokyo) Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743.
2018 Front Microbiol Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil.
2019 Oncol Rep Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress.
2018 Dec J Pharm Sci Population Pharmacokinetic and Exposure-Response Analyses of Baloxavir Marboxil in Adults and Adolescents Including Patients With Influenza.
2018 Dec MBio Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.
2018 Nov Genome Med A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers.
2019 Mar J Antimicrob Chemother Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection.
2018 Fa Yi Xue Za Zhi Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues.
2018 Nature DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.
2019 Feb Biosens Bioelectron Sensitive surface plasmon resonance detection of methyltransferase activity and screening of its inhibitors amplified by p53 protein bound to methylation-specific ds-DNA consensus sites.
2018 Nov Molecules Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells.
2018 Nov Nutrients Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells.
2018 Comput Biol Chem Identification of novel inhibitor against endonuclease unit of Influenza pH1N1 polymerase: A combined molecular docking, molecular dynamics, MMPBSA, QMMM and ADME studies to combat influenza A viruses.
2019 Jan Eur J Med Chem Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity.
2019 J Enzyme Inhib Med Chem From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.
2019 Jan Eur J Pharm Sci FRET-based assay using a three-way junction DNA strate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity.
2019 Jan Stem Cells Dev p53-NF-κB Crosstalk in Febrile Temperature-Treated Human Umbilical Cord-Derived Mesenchymal Stem Cells.
2018 Antiviral Res In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA unit.
2018 Oct Mikrochim Acta Photoelectrochemical determination of the activity of M.SssI methyltransferase, and a method for inhibitor screening.
2019 Oncogene Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality.
2018 Oct Science Systematic discovery of natural CRISPR-Cas12a inhibitors.
2018 Sep Proc Natl Acad Sci U S A Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.
2018 Sep N Engl J Med Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents.
2018 Sep Biochem Biophys Res Commun Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate.
2018 Aug Viruses A Human DPP4-Knockin Mouse's Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV.
2018 Oct Anal Biochem Fluorescent copper nanoclusters as a nano-dye for DNA methyltransferase activity analysis and inhibitor screening.
2018 Cancer Med The regulatory role of APE1 in epithelial-to-mesenchymal transition and in determining EGFR-TKI responsiveness in non-small-cell lung cancer.
2018 Sep Biochem Biophys Res Commun Fenofibrate inhibits the growth of prostate cancer through regulating autophagy and endoplasmic reticulum stress.
2018 Aug Bioorg Med Chem Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening.
2018 Oct Biosens Bioelectron Silver nanoclusters-assisted triple-amplified biosensor for ultrasensitive methyltransferase activity detection based on AuNPsERGO hybrids and hybridization chain reaction.
2018 J Pharmacol Exp Ther Ref-1APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization.
2018 Medicine (Baltimore) Excision repair cross-complementing group 1 (ERCC1) overexpression inhibits cell apoptosis and is associated with unfavorable prognosis of esophageal squamous cell carcinoma.
2018 Oncol Rep Co-treatment with BEZ235 enhances chemosensitivity of A549DDP cells to cisplatin via inhibition of PI3KAktmTOR signaling and downregulation of ERCC1 expression.
2018 Jul Lipids Health Dis Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells.
2018 Mol Immunol Inhibition of ER stress-related IRE1αCREBNLRP1 pathway promotes the apoptosis of human chronic myelogenous leukemia cell.
2019 Jan J Infect Dis Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.
2018 Aug Eur J Med Chem 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity.
2018 Jul Vet Res Endonuclease G takes part in AIF-mediated caspase-independent apoptosis in Mycobacterium bovis-infected bovine macrophages.
2018 Vascular Nuclear factor-kappa B activation inhibits proliferation and promotes apoptosis of vascular smooth muscle cells.
2018 Front Immunol Kruppel-Like Factor 4 Positively Regulates Autoimmune Arthritis in Mouse Models and Rheumatoid Arthritis in Patients iviai Modulating Cell Survival and Inflammation Factors of Fibroblast-Like Synoviocyte.
2018 Oncogene Exposure of Barrett's and esophageal adenocarcinoma cells to bile acids activates EGFR-STAT3 signaling axis via induction of APE1.
2018 Jul Lab Chip An automated microfluidic gene-editing platform for deciphering cancer genes.
2018 Jul Mol Cell The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication.
2018 Nature CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
2018 Jun Oncotarget The small molecule STF-62247 induces apoptotic and autophagic cell death in leukemic cells.
2018 Sep Phys Chem Chem Phys Prediction of the binding mode and resistance profile for a dual-target pyrrolyl diketo acid scaffold against HIV-1 integrase and reverse-transcriptase-associated ribonuclease H.
2018 Jun Sci Rep Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.
2018 Aug EMBO J Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression.
2018 Jul Proc Natl Acad Sci U S A The mutagen and carcinogen cadmium is a high-affinity inhibitor of the zinc-dependent MutLα endonuclease.
2018 Jul Eur J Med Chem 5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.
2018 Jun J Vis Exp Characterizing DNA Repair Processes at Transient and Long-lasting Double-strand DNA Breaks by Immunofluorescence Microscopy.
2018 Jul Cell LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade.
2018 PLoS Pathog Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus.
2018 Antivir Ther Phase I study on safety and pharmacokinetics of a novel influenza endonuclease inhibitor, AL-794 (JNJ-64155806), following single- and multiple-ascending doses in healthy adults.