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Recent literature: Endonuclease inhibitor
Date Journal Article title
2019 Aug J Biol Chem The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.
2019 Nov Emerg Infect Dis Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019.
2019 Aug Biochem Biophys Res Commun JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing.
2019 Cell Death Discov Cigarette smoke activates the parthanatos pathway of cell death in human bronchial epithelial cells.
2019 Aug J Med Chem Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.
2019 Aug Curr Drug Targets Potential Role of Endonuclease Inhibition and Other Targets in the Treatment of Influenza.
2019 Jun Chem Sci Probing and regulating the activity of cellular enzymes by using DNA tetrahedron nanostructures.
2019 PLoS One Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors.
2019 Aug Anal Chem Single-Molecule Fluorescence Imaging for Ultrasensitive DNA Methyltransferase Activity Measurement and Inhibitor Screening.
2019 Int J Clin Oncol Genetic and genomic basis of the mismatch repair system involved in Lynch syndrome.
2019 Drugs Today (Barc) Baloxavir marboxil: a novel cap-dependent endonuclease (CEN) inhibitor for the treatment of acute uncomplicated influenza.
2019 Jun Medicina (Kaunas) Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
2019 J Oral Biol Craniofac Res Plasminogen activator inhibitor-1 polymorphisms as a risk factor for chronic periodontitis in North Indian population.
2019 May Cell Snatch-and-Grab Inhibitors to Fight the Flu.
2019 Mol Cancer Ther The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
2019 Arch Virol Characterization of the endonuclease activity of the replication-associated protein of beak and feather disease virus.
2019 PLoS One Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently presses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models.
2019 Clin Exp Med Mutation analysis of POLE gene in patients with early-onset colorectal cancer revealed a rare silent variant within the endonuclease domain with potential effect on splicing.
2019 FASEB J Inflammation-mediated deacetylation of the ribonuclease 1 promoter iviai histone deacetylase 2 in endothelial cells.
2019 J Pharm Sci Population Pharmacokinetics of Baloxavir Marboxil in Japanese Pediatric Influenza Patients.
2019 Jun Biosens Bioelectron A dual-response biosensor for electrochemical and glucometer detection of DNA methyltransferase activity based on functionalized metal-organic framework amplification.
2019 Apr Sr Care Pharm Baloxavir: A Novel Single-Dose Oral Antiviral for the Treatment of Influenza.
2019 Mar Nat Commun Rad52 prevents excessive replication fork reversal and protects from nascent strand degradation.
2019 Euro Surveill Influenza A(H3N2) virus exhibiting reduced susceptibility to baloxavir due to a polymerase acidic unit I38T stitution detected from a hospitalised child without prior baloxavir treatment, Japan, January 2019.
2019 Int J Mol Med Sirt1 promotes autophagy and inhibits apoptosis to protect cardiomyocytes from hypoxic stress.
2019 Mar Sci Rep Inhibition of avian-origin influenza A(H7N9) virus by the novel cap-dependent endonuclease inhibitor baloxavir marboxil.
2019 Mar Mikrochim Acta A FRET assay for the quantitation of inhibitors of exonuclease EcoRV by using parchment paper inkjet-printed with graphene oxide and FAM-labelled DNA.
2019 Mar Proc Natl Acad Sci U S A OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
2019 Curr Med Res Opin A network meta-analysis of the efficacy and safety of baloxavir marboxil versus neuraminidase inhibitors for the treatment of influenza in otherwise healthy patients.
2019 Gynecol Oncol ERCC1-XPF deficiency is a predictor of olaparib induced synthetic lethality and platinum sensitivity in epithelial ovarian cancers.
2019 Antiviral Res Baloxavir marboxil susceptibility of influenza viruses from the Asia-Pacific, 2012-2018.
2019 Feb Sci Transl Med Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.
2019 Curr Opin Infect Dis Influenza virus polymerase inhibitors in clinical development.
2019 Clin Transl Oncol Letrozole improves the sensitivity of breast cancer cells overexpressing aromatase to cisplatin via down-regulation of FEN1.
2019 Mar J Biol Chem Endonuclease and redox activities of human apurinicapyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination.
2019 Feb J Agric Food Chem Discovery of Myricetin as a Potent Inhibitor of Human Flap Endonuclease 1, Which Potentially Can Be Used as Sensitizing Agent against HT-29 Human Colon Cancer Cells.
2019 Jan Nat Commun IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2019 Rev Esp Quimioter [Baloxavir marboxil: a potent cap-dependent endonuclease inhibitor of influenza viruses].
2019 Ann Pharmacother Baloxavir Marboxil: The First Cap-Dependent Endonuclease Inhibitor for the Treatment of Influenza.
2019 Euro Surveill Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 201617 and 201718 seasons.
2019 Euro Surveill Detection of influenza A(H3N2) viruses exhibiting reduced susceptibility to the novel cap-dependent endonuclease inhibitor baloxavir in Japan, December 2018.
2019 Food Chem Toxicol Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1αTNF-α pathway and protective effect of taurine.
2019 Biochim Biophys Acta Mol ... SET protein accumulation prevents cell death in head and neck squamous cell carcinoma through regulation of redox state and autophagy.
2019 Mar J Biol Chem DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
2018 Biomed Environ Sci Coxsackievirus B3 Infection Triggers Autophagy through 3 Pathways of Endoplasmic Reticulum Stress.
2019 Jan Mikrochim Acta A hairpin-type DNA probe for direct colorimetric detection of endonuclease activity and inhibition based on the deaggregation of gold nanoparticles.
2019 Jan BMC Immunol Treatment of established TH2 cells with 4μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion.
2019 Feb Neuroscience Cell Death Mechanisms in a Mouse Model of Retinal Degeneration in Spinocerebellar Ataxia 7.
2019 J Antibiot (Tokyo) Flupyranochromene, a novel inhibitor of influenza virus cap-dependent endonuclease, from Penicillium sp. f28743.
2019 Feb Mol Cell Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race.
2019 Feb Mol Cell Temperature-Responsive Competitive Inhibition of CRISPR-Cas9.
2018 J Oral Sci Hypoxia-induced upregulation of angiogenic factors in immortalized human periodontal ligament fibroblasts.
2018 Front Microbiol Susceptibility of Influenza Viruses to the Novel Cap-Dependent Endonuclease Inhibitor Baloxavir Marboxil.
2019 Oncol Rep Imatinib‑induced apoptosis of gastric cancer cells is mediated by endoplasmic reticulum stress.
2019 J Pharm Sci Population Pharmacokinetic and Exposure-Response Analyses of Baloxavir Marboxil in Adults and Adolescents Including Patients With Influenza.
2018 Cancer Genet Identification and characterization of a novel nuclear structure containing members of the homologous recombination and DNA damage response pathways.
2019 Mol Med Rep MEK inhibitor enhanced the antitumor effect of oxaliplatin and 5‑fluorouracil in MEK1 Q56P‑mutant colorectal cancer cells.
2019 Oncogene Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition.
2018 Dec MBio Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.
2018 Nov Genome Med A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers.
2019 Mar J Antimicrob Chemother Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection.
2018 Fa Yi Xue Za Zhi Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues.
2018 Nature DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.
2019 Feb Biosens Bioelectron Sensitive surface plasmon resonance detection of methyltransferase activity and screening of its inhibitors amplified by p53 protein bound to methylation-specific ds-DNA consensus sites.
2019 Mol Pharmacol Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1iαi-XBP1.
2018 Nov Molecules Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells.
2018 Nov Nutrients Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells.
2018 Comput Biol Chem Identification of novel inhibitor against endonuclease unit of Influenza pH1N1 polymerase: A combined molecular docking, molecular dynamics, MMPBSA, QMMM and ADME studies to combat influenza A viruses.
2019 Jan Eur J Med Chem Non-chelating p-phenylidene-linked bis-imidazoline analogs of known influenza virus endonuclease inhibitors: Synthesis and anti-influenza activity.
2019 J Enzyme Inhib Med Chem From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.
2018 Dec J Immunol ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism.
2019 Jan Eur J Pharm Sci FRET-based assay using a three-way junction DNA strate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity.
2018 Nat Rev Genet Base editing: precision chemistry on the genome and transcriptome of living cells.
2019 Jan Stem Cells Dev p53-NF-κB Crosstalk in Febrile Temperature-Treated Human Umbilical Cord-Derived Mesenchymal Stem Cells.
2018 Antiviral Res In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA unit.