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Recent literature: Endonuclease inhibitor
Date Journal Article title
2020 Mar Proc Natl Acad Sci U S A Influenza A and B viruses with reduced baloxavir susceptibility display attenuated in vitro fitness but retain ferret transmissibility.
2020 Mar J Cell Commun Signal Mechanism of inositol-requiring enzyme 1-alpha inhibition in endoplasmic reticulum stress and apoptosis in ovarian cancer cells.
2020 Mar Cancer Res Endonuclease FEN1 coregulates ERα activity and provides a novel drug interface in tamoxifen resistant breast cancer.
2020 Mar Am J Transplant Brain-dead donor heart conservation with a preservation solution plemented by a conditioned medium from mesenchymal stem cells improves graft contractility after transplantation.
2020 Mar Nat Microbiol Core components of DNA lagging strand synthesis machinery are essential for hepatitis B virus cccDNA formation.
2020 Mar Anal Chem Self-Powered Biosensing Platform Based on "Signal-On" Enzymatic Biofuel Cell for DNA Methyltransferase Activity Analysis and Inhibitor Screening.
2020 Front Microbiol Anthralin Suppresses the Proliferation of Influenza Virus by Inhibiting the Cap-Binding and Endonuclease Activity of Viral RNA Polymerase.
2020 Int J Mol Med Curcumin exerts protective effects against hypoxia‑reoxygenation injury via the enhancement of apurinicapyrimidinic endonuclease 1 in SH‑SY5Y cells: Involvement of the PI3KAKT pathway.
2020 Feb Transl Res Next-generation direct-acting influenza therapeutics.
2020 Feb Influenza Other Respir Vi... Rapid detection of an I38T amino acid stitution in influenza polymerase acidic unit associated with reduced susceptibility to baloxavir marboxil.
2020 Feb Influenza Other Respir Vi... A rapid pyrosequencing assay for the molecular detection of influenza viruses with reduced baloxavir susceptibility due to PAI38X amino acid stitutions.
2020 Antiviral Res Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2017-2018.
2020 Jan Nat Commun Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.
2020 Fish Shellfish Immunol Molecular cloning and the involvement of IRE1α-XBP1s signaling pathway in palmitic acid induced - Inflammation in primary hepatocytes from large yellow croaker (Larimichthys crocea).
2020 Chem Biol Drug Des Computer-aided drug design of small molecule inhibitors of the ERCC1-XPF protein-protein interaction.
2020 J Infect Chemother Duration of fever and PAI38X-stituted virus emergence in patients treated with baloxavir in the 2018-2019 influenza season.
2019 Dec Sci Rep Expression of XBP1s in peritoneal mesothelial cells is critical for inflammation-induced peritoneal fibrosis.
2019 Nov Int J Mol Sci Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells Lipotoxicity-Short Communication.
2020 Mar Spectrochim Acta A Mol Bi... Label-free one-step fluorescent method for the detection of endonuclease activity based on thioflavin TG-quadruplex.
2020 Jan Nucleic Acids Res Identification of a novel structure-specific endonuclease AziN that contributes to the repair of azinomycin B-mediated DNA interstrand crosslinks.
2019 J Photochem Photobiol B Raffinose increases autophagy and reduces cell death in UVB-irradiated keratinocytes.
2019 IDCases Adult influenza A (H3N2) with reduced susceptibility to baloxavir or peramivir cured after switching anti-influenza agents.
2020 Jan J Bacteriol Molecular Basis of Substrate Recognition of Endonuclease Q from the Euryarchaeon Pyrococcus furiosus.
2019 Front Pharmacol An Improved Enzyme-Linked Focus Formation Assay Revealed Baloxavir Acid as a Potential Antiviral Therapeutic Against Hantavirus Infection.
2019 Oct Invest Ophthalmol Vis Sci Cyclin-Dependent Kinase Inhibitor 2b Mediates Excitotoxicity-Induced Death of Retinal Ganglion Cells.
2020 Expert Rev Respir Med Recommended hospital preparations for future cases and outbreaks of novel influenza viruses.
2012 LiverTox: Clinical and Re... Baloxavir
2019 Oct Neuropathol Appl Neurobiol Oxidative DNA damage is concurrently repaired by base excision repair (BER) and apyrimidinic endonuclease 1 (APE1)-initiated nonhomologous end joining (NHEJ) in cortical neurons.
2019 Oct Cancers (Basel) Antileukemic Efficacy in Vitro of Talazoparib and APE1 Inhibitor III Combined with Decitabine in Myeloid Malignancies.
2019 Dec Eur J Pharmacol High expression of NAMPT in adult T-cell leukemialymphoma and anti-tumor activity of a NAMPT inhibitor.
2019 Dec Mol Cell Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.
2019 Nov Nucleic Acids Res Structure and function of the Toscana virus cap-snatching endonuclease.
2019 Oncol Rep Apurinic endonuclease 1 promotes the cisplatin resistance of lung cancer cells by inducing Parkin‑mediated mitophagy.
2019 Dec Biosens Bioelectron Terminal deoxynucleotidyl transferase-activated nicking enzyme amplification reaction for specific and sensitive detection of DNA methyltransferase and polynucleotide kinase.
2019 J Gen Virol Mutated influenza A virus exhibiting reduced susceptibility to baloxavir marboxil from an experimentally infected horse.
2019 Mol Med Rep High glucose and bupivacaine‑induced cytotoxicity is mediated by enhanced apoptosis and impaired autophagy via the PERK‑ATF4‑CHOP and IRE1‑TRAF2 signaling pathways.
2019 Sep BMC Res Notes Deficiency in the double-stranded RNA binding protein HYPONASTIC LEAVES1 increases sensitivity to the endoplasmic reticulum stress inducer tunicamycin in Arabidopsis.
2019 Sep Chem Commun (Camb) Optimised oligonucleotide strates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors.
2019 DNA Repair (Amst) A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels.
2019 Aug Hum Genomics Novel analytical methods to interpret large sequencing data from small sample sizes.
2019 Mol Cancer Ther Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1.
2019 DNA Repair (Amst) Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway.
2019 Oct ACS Infect Dis An Influenza Virus Entry Inhibitor Targets Class II PI3 Kinase and Synergizes with Oseltamivir.
2019 Oct J Biol Chem The DNA repair helicase RECQ1 has a checkpoint-dependent role in mediating DNA damage responses induced by gemcitabine.
2019 Emerg Infect Dis Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019.
2019 Oct Biochem Biophys Res Commun JTE-607, a multiple cytokine production inhibitor, targets CPSF3 and inhibits pre-mRNA processing.
2019 Cell Death Discov Cigarette smoke activates the parthanatos pathway of cell death in human bronchial epithelial cells.
2019 Oct J Biol Chem Dephosphorylation activates the interferon-stimulated Schlafen family member 11 in the DNA damage response.
2019 Sep J Med Chem Targeting DNA Repair in Tumor Cells via Inhibition of ERCC1-XPF.
2020 Curr Drug Targets Potential Role of Endonuclease Inhibition and Other Targets in the Treatment of Influenza.
2019 Cancer Sci Novel p97VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
2019 Jun Chem Sci Probing and regulating the activity of cellular enzymes by using DNA tetrahedron nanostructures.
2019 Aug EMBO J Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor.
2019 Phytomedicine Benzoquinones from Cyperus spp. trigger IRE1α-independent and PERK-dependent ER stress in human stomach cancer cells and are novel proteasome inhibitors.
2019 Aug Org Biomol Chem Sulfonic nucleic acids (SNAs): a new class of strate mimics for ribonuclease A inhibition.
2019 PLoS One Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors.
2019 Aug Anal Chem Single-Molecule Fluorescence Imaging for Ultrasensitive DNA Methyltransferase Activity Measurement and Inhibitor Screening.
2019 Oxid Med Cell Longev Upregulation of miR-34a by Inhibition of IRE1iαi Has Protective Effect against Aiβi-Induced Injury in SH-SY5Y Cells by Targeting Caspase-2.
2019 Sep J Anim Sci Bta-miR-34b regulates milk fat biosynthesis by targeting mRNA decapping enzyme 1A (DCP1A) in cultured bovine mammary epithelial cells1.
2019 Int J Clin Oncol Genetic and genomic basis of the mismatch repair system involved in Lynch syndrome.
2019 Drugs Today (Barc) Baloxavir marboxil: a novel cap-dependent endonuclease (CEN) inhibitor for the treatment of acute uncomplicated influenza.
2019 Jun Medicina (Kaunas) Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
2019 J Oral Biol Craniofac Res Plasminogen activator inhibitor-1 polymorphisms as a risk factor for chronic periodontitis in North Indian population.
2019 J Dairy Sci Fatty acid-induced endoplasmic reticulum stress promoted lipid accumulation in calf hepatocytes, and endoplasmic reticulum stress existed in the liver of severe fatty liver cows.
2019 May Cell Snatch-and-Grab Inhibitors to Fight the Flu.
2019 Mol Cancer Ther The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
2019 Arch Virol Characterization of the endonuclease activity of the replication-associated protein of beak and feather disease virus.
2019 May Med Sci Monit Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis.
2019 Int Immunopharmacol Inositol-requiring enzyme 1 alpha endoribonuclease specific inhibitor STF-083010 protects the liver from thioacetamide-induced oxidative stress, inflammation and injury by triggering hepatocyte autophagy.
2019 Jul Nucleic Acids Res RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.
2019 PLoS One Baloxavir marboxil, a novel cap-dependent endonuclease inhibitor potently presses influenza virus replication and represents therapeutic effects in both immunocompetent and immunocompromised mouse models.
2019 Iran Biomed J BIRC5 Gene Disruption via CRISPRCas9n Platform Suppress Acute Myelocytic Leukemia Progression
2019 May Cell A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
2019 Clin Exp Med Mutation analysis of POLE gene in patients with early-onset colorectal cancer revealed a rare silent variant within the endonuclease domain with potential effect on splicing.
2019 FASEB J Inflammation-mediated deacetylation of the ribonuclease 1 promoter iviai histone deacetylase 2 in endothelial cells.