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Recent literature: GLP-1 receptor agonist
Date Journal Article title
2020 Mar J Clin Endocrinol Metab Randomized 52-week Phase 2 Trial of Albiglutide Versus Placebo in Adult Patients With Newly Diagnosed Type 1 Diabetes.
2020 Diabetol Int The development of oral semaglutide, an oral GLP-1 analog, for the treatment of type 2 diabetes.
2020 JHEP Rep imiR-22i inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction.
2020 Mar Diabetes Ther Once-Weekly Semaglutide Reduces HbA1c and Body Weight in Patients with Type 2 Diabetes Regardless of Background Common OAD: a Subgroup Analysis from SUSTAIN 2-4 and 10.
2020 Mar Chem Res Toxicol Protective Effects of Lixisenatide against Lipopolysaccharide-Induced Inflammation Response in MAC-T Bovine Mammary Epithelial Cells: A Therapeutic Implication in Mastitis.
2020 Apr J Endocr Soc Effects of Semaglutide Versus Dulaglutide on Epicardial Fat Thickness in Subjects with Type 2 Diabetes and Obesity.
2020 Mar Intern Med SGLT2 Inhibitor and GLP-1 Receptor Agonist Combination Therapy Substantially Improved the Renal Function in a Patient with Type 2 Diabetes: Implications for Additive Renoprotective Effects of the Two Drug Classes.
2019 Dec Pharmacoeconomic Review R...
2020 Mar Am J Manag Care Cost-effectiveness of diabetes treatment sequences to inform step therapy policies.
2020 Mol Metab Role of ATP-binding cassette transporter A1 in pressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes.
2020 Mar Physiol Behav Hindbrain melanocortin 34 receptors modulate the food intake and body weight pressive effects of the GLP-1 receptor agonist, liraglutide.
2020 Mar Expert Opin Investig Drugs Brain insulin resistance: role in neurodegenerative disease and potential for targeting.
2020 Mar Diabetes Obes Metab Pharmacokinetic and dose-finding studies of efpeglenatide in patients with type 2 diabetes.
2020 Mar Int J Mol Sci Antidiabetic Therapy in the Treatment of Nonalcoholic Steatohepatitis.
2020 Mar Curr Diab Rep A Systematic Review of Cost-Effectiveness of Sodium-Glucose Cotransporter Inhibitors for Type 2 Diabetes.
2020 Mar J Am Coll Cardiol Effects of Liraglutide on Cardiovascular Outcomes in Patients With Diabetes With or Without Heart Failure.
2020 Hypertension DPP (Dipeptidyl Peptidase)-4 Inhibitor Attenuates Ang II (Angiotensin II)-Induced Cardiac Hypertrophy via GLP (Glucagon-Like Peptide)-1-Dependent Suppression of Nox (Nicotinamide Adenine Dinucleotide Phosphate Oxidase) 4-HDAC (Histone Deacetylase) 4 Pathway.
2020 Mar Endocrinology Human sperm express the receptor for glucagon-like peptide-1 (GLP-1) which affects sperm function and metabolism.
2020 Front Pharmacol Preventive Effects of Dulaglutide on Disuse Muscle Atrophy Through Inhibition of Inflammation and Apoptosis by Induction of Hsp72 Expression.
2020 Mar Nat Commun Full-length human GLP-1 receptor structure without orthosteric ligands.
2020 Mar Clin Exp Pharmacol Physiol Exendin-4 protects the hearts of rats from ischemiareperfusion injury by boosting antioxidant levels and inhibition of JNKp66 ShcNADPH axis.
2020 Mar Peptides Glucagon-based therapy: Past, present and future.
2020 Mar J Diabetes Investig Activation of overexpressed GLP-1R attenuates prostate cancer growth by inhibiting cell cycle progression.
2020 Mar Diabetes Ther Expert Opinion on the Therapeutic Use of the Fixed-Ratio Combination of Insulin Glargine 100 UmL and Lixisenatide: a CentralEastern European Perspective.
2020 Feb Diabetes Metab Syndr Gender difference in cardiovascular outcomes with SGLT-2 inhibitors and GLP-1 receptor agonist in type 2 diabetes: A systematic review and meta-analysis of cardio-vascular outcome trials.
2020 Lancet Diabetes Endocrinol Efficacy and safety of meal-time administration of short-acting exenatide for glycaemic control in type 1 diabetes (MAG1C): a randomised, double-blind, placebo-controlled trial.
2020 Mar Sci Transl Med GABA neurons in the nucleus tractus solitarius express GLP-1 receptors and mediate anorectic effects of liraglutide in rats.
2020 Mar Clin J Am Soc Nephrol Safety of Liraglutide in Type 2 Diabetes and Chronic Kidney Disease.
2020 Mar Diabetes Obes Metab Efficacy and safety of once-monthly efpeglenatide in patients with type 2 diabetes: Results of a phase 2 placebo-controlled, 16-week randomized dose-finding study.
2020 Feb Diabetes Ther Impact of Simultaneous Versus Sequential Initiation of Basal Insulin and Glucagon-like Peptide-1 Receptor Agonists on HbA1c in Type 2 Diabetes: A Retrospective Observational Study.
2020 Exp Ther Med GLP-1 receptor agonist on cardiovascular complications of diabetes mellitus.
2020 Feb Endocrine GLP-1 receptor agonists and pancreatic safety concerns in type 2 diabetic patients: data from cardiovascular outcome trials.
2020 Feb Int J Mol Sci GIP as a Potential Therapeutic Target for Atherosclerotic Cardiovascular Disease-A Systematic Review.
2020 Feb Eur J Prev Cardiol Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.
2020 Feb Adv Exp Med Biol Effects of GLP-1 and Its Analogs on Gastric Physiology in Diabetes Mellitus and Obesity.
2020 Feb Eur J Nutr Early protein restriction increases intra-islet GLP-1 production and pancreatic β-cell proliferation mediated by the β-catenin pathway.
2020 Feb Pediatr Obes A 6-month randomized, double-blind, placebo-controlled trial of weekly exenatide in adolescents with obesity.
2020 Feb Sci Transl Med GLP-1 receptor agonists synergize with DYRK1A inhibitors to potentiate functional human β cell regeneration.
2020 Feb Sci Transl Med Two drugs converged in a pancreatic β cell.
2020 Adv Ther A Relative Cost of Control Analysis of Once-Weekly Semaglutide Versus Exenatide Extended-Release, Dulaglutide and Liraglutide in the UK.
2020 Diabetes L-Cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling.
2020 Feb Am J Med Nonalcoholic Fatty Liver Disease: What Does the Primary Care Physician Need to Know?
2019 Nov Chem Sci Ureidopeptide GLP-1 analogues with prolonged activity iin vivo viai signal bias and altered receptor trafficking.
2020 Jan J Endocr Soc Glucagon-Like Peptide 1 and Atrial Natriuretic Peptide in a Female Mouse Model of Obstructive Pulmonary Disease.
2020 Clin Ther GLP1 Receptor Agonist and SGLT2 Inhibitor Combination: An Effective Approach in Real-world Clinical Practice.
2020 Jan Chem Biol Interact The protective effects of dulaglutide against advanced glycation end products (AGEs)-induced degradation of type Ⅱ collagen and aggrecan in human SW1353 chondrocytes.
2020 Apr Am J Physiol Gastrointest... Bile acid treatment and FXR agonism lower postprandial lipemia in mice.
2020 Drugs Dulaglutide: A Review in Type 2 Diabetes.
2019 Dec Nucl Med Biol Synthesis and evaluation of zirconium-89 labelled and long-lived GLP-1 receptor agonists for PET imaging.
2020 Jan Eur Heart J Cardiovasc Ph... Glucagon-like peptide-1 receptor agonists and the risk of cardiovascular events in diabetes patients surviving an acute myocardial infarction.
2020 Apr Biochem Biophys Res Commun Intratracheal GLP-1 receptor agonist treatment up-regulates mucin via p38 and exacerbates emphysematous phenotype in mucus hypersecretory obstructive lung diseases.
2020 Feb J Med Econ Oral semaglutide versus injectable glucagon-like peptide-1 receptor agonists: a cost of control analysis.
2020 Jan Neurogastroenterol Motil Colokinetic effect of an insulin-like peptide 5-related agonist of the RXFP4 receptor.
2020 Physiol Rep CCK-1 and CCK-2 receptor agonism do not stimulate GLP-1 and neurotensin secretion in the isolated perfused rat small intestine or GLP-1 and PYY secretion in the rat colon.
2020 Jan Diabetes Obes Metab Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: A 12-week, randomized, double-blind, placebo-controlled study to evaluate different dose-escalation regimens.
2020 Pharmacol Res Incretins and microRNAs: Interactions and physiological relevance.
2020 Clin Diabetes Clinical Use of IDegLira: Initiation to Titration After Basal Insulin.
2020 Mar Mol Pharm Self-Assembly of Exendin-4-Derived Dual Peptide Agonists is Mediated by Acylation and Correlated to the Length of Conjugated Fatty Acyl Chains.
2020 Neural Regen Res Exendin-4 attenuates pain-induced cognitive impairment by alleviating hippocampal neuroinflammation in a rat model of spinal nerve ligation.
2020 Brain Behav The novel GLP-1GIP analogue DA5-CH reduces tau phosphorylation and normalizes theta rhythm in the icv. STZ rat model of AD.
2020 Drugs Clinical Considerations When Initiating and Titrating Insulin DegludecLiraglutide (IDegLira) in People with Type 2 Diabetes.
2020 Jan J Parkinsons Dis The Novel Dual GLP-1GIP Receptor Agonist DA-CH5 Is Superior to Single GLP-1 Receptor Agonists in the MPTP Model of Parkinson's Disease.
2020 Clin Diabetes Endocrinol Achieving postprandial glucose control with lixisenatide improves glycemic control in patients with type 2 diabetes on basal insulin: a post-hoc analysis of pooled data.
2020 Jan Diabetes Metab Res Rev Efficacy of exenatide and insulin glargine on nonalcoholic fatty liver disease in patients with type 2 diabetes.
2020 Apr Prog Neuropsychopharmacol... The GLP-1 receptor agonist liraglutide reverses mania-like alterations and memory deficits induced by D-amphetamine and augments lithium effects in mice: Relevance for bipolar disorder.
2020 J Diabetes Complications Oral semaglutide in type 2 diabetes.
2020 Diabetes Care No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes.
2020 Mar Biochem Biophys Res Commun Liraglutide promotes the angiogenic ability of human umbilical vein endothelial cells through the JAK2STAT3 signaling pathway.
2020 Jan Diabetes Obes Metab Comparison of the glucagon-like-peptide-1 receptor agonists dulaglutide and liraglutide for the management of diabetes in solid organ transplant: A retrospective study.
2019 Cardiovasc Endocrinol Metab Cardioprotective diabetes drugs: what cardiologists need to know.
2020 Jan JCI Insight Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable.
2020 Jan Sci Rep The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids.
2020 Jan Ann Intern Med Assessing the Risk for Gout With Sodium-Glucose Cotransporter-2 Inhibitors in Patients With Type 2 Diabetes: A Population-Based Cohort Study.
2020 Jan Endocrine Efficacy and safety of long-acting glucagon-like peptide-1 receptor agonist dulaglutide in patients with type 2 diabetes: a systematic review and meta-analysis of 21 randomized controlled trials.
2020 Diabetes Ther The Short-Term Cost-Effectiveness of Once-Weekly Semaglutide Versus Once-Daily Sitagliptin and Once-Weekly Dulaglutide for the Treatment of Patients with Type 2 Diabetes: A Cost of Control Analysis in Spain.