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Recent literature: NK1 receptor antagonist
Date Journal Article title
2019 Jun Support Care Cancer Cost-effectiveness of a fixed combination of netupitant and palonosetron (NEPA) relative to aprepitant plus granisetron (APR + GRAN) for prophylaxis of chemotherapy-induced nausea and vomiting (CINV): a trial-based analysis.
2019 Vet Med Int Evaluation of the Antinociceptive Effect of Maropitant, a Neurokinin-1 Receptor Antagonist, in Cats Undergoing Ovariohysterectomy.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 Drug Metab Dispos Rolapitant Is a Reversible Inhibitor of CYP2D6.
2019 Mar Pain Med Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain.
2019 Apr Biochem Biophys Res Commun Substance P plays a critical role in synaptic transmission in striatal neurons.
2019 Feb Support Care Cancer One shot NEPA plus dexamethasone to prevent multiple-day chemotherapy in sarcoma patients.
2019 Support Care Cancer Timing flexibility of oral NEPA, netupitant-palonosetron combination, administration for the prevention of chemotherapy-induced nausea and vomiting (CINV).
2019 Apr Acta Derm Venereol Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU).
2019 Jan Nat Commun Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
2019 Int J Biochem Cell Biol Tachykinin NK1 receptor antagonist L-733,060 and stance P deletion exert neuroprotection through inhibiting oxidative stress and cell death after traumatic brain injury in mice.
2018 Dec Proc Natl Acad Sci U S A Crystal structure of the human NK1 tachykinin receptor.
2018 Jun Pharmacoeconomic Review R...
2018 Stem Cells Int Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPKmTOR Pathway in a Coculture System.
2018 J Physiol Pharmacol Hydrogen sulfide modulates gastric acid secretion in rats via involvement of stance P and nuclear factor-κB signaling.
2018 Biomed Pharmacother Differential consequences of neurokinin receptor 1 and 2 antagonists in metastatic breast carcinoma cells; Effects independent of Substance P.
2018 Nihon Yakurigaku Zasshi [Pharmacological profile of a novel nonhuman primate model of knee osteoarthritis].
2018 Exp Eye Res The involvement of NK1 and Y2 receptor in the development of laser-induced CNVs in C57Bl6N mice.
2018 Cancer Manag Res Recent advances in antiemetics: new formulations of 5HT3-receptor antagonists.
2018 Acta Biol Hung Effects of the venom of the brown bullhead catfish (Ameiurus nebulosus) on isolated smooth muscles.
2018 Naunyn Schmiedebergs Arch... Colorectal and cardiovascular effects of [Lys5,MeLeu9,Nle10]-NKA(4-10) in anesthetized macaques.
2018 May Biol Res The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway.
2018 J Pediatr Hematol Oncol Evaluation of the Use of Fosaprepitant for the Prevention of Chemotherapy-induced Nausea and Vomiting in Pediatric Patients.
2018 Br J Pharmacol Central adenosine A1 receptors inhibit cough via pression of excitatory glutamatergic and tachykininergic neurotransmission.
2018 Ann Palliat Med Efficacy of the combination neurokinin-1 receptor antagonist, palonosetron, and dexamethasone compared to others for the prophylaxis of chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials.
2018 Jul J Neuroimmunol Tropisetron attenuates lipopolysaccharide induced neuroinflammation by inhibiting NF-κB and SPNK1R signaling pathway.
2018 Jul Eur J Pharm Sci Salt formation improved the properties of a candidate drug during early formulation development.
2018 J Pharmacol Exp Ther [Lys5,MeLeu9,Nle10]-NKA(4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs.
2018 Curr Opin Oncol The latest consensus on antiemetics.
2018 Neth J Med Drug-drug interactions with aprepitant in antiemetic prophylaxis for chemotherapy.
2018 Crit Rev Oncol Hematol Efficacy of neurokinin-1 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting in patients receiving carboplatin-based chemotherapy: A systematic review and meta-analysis.
2018 Apr Clin J Oncol Nurs Cisplatin-Based Therapy and CINV: Optimal Antiemetics During Germ Cell Testicular Cancer Treatment
2018 Neurobiol Learn Mem Behavioral sensitization induced by dorsal periaqueductal gray electrical stimulation is counteracted by NK1 receptor antagonism in the ventral hippocampus and central nucleus of the amygdala.
2018 Feb J Neuroinflammation Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of stance P-mediated neurokinin 1 receptor.
2018 J Am Acad Dermatol Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial.
2018 Apr J Clin Oncol Placebo-Controlled, Double-Blinded Phase III Study Comparing Dexamethasone on Day 1 With Dexamethasone on Days 1 to 3 With Combined Neurokinin-1 Receptor Antagonist and Palonosetron in High-Emetogenic Chemotherapy.
2018 FASEB J NK1R5-HT1AR interaction is related to the regulation of melanogenesis.
2017 Biomed Res Int A Comparison of Fosaprepitant and Ondansetron for Preventing Postoperative Nausea and Vomiting in Moderate to High Risk Patients: A Retrospective Database Analysis.
2018 May - J Pharmacol Toxicol Methods Strain differences in the development of cisplatin-induced pica behavior in mice.
2018 May Neuropharmacology Involvement of the cystathionine-γ-lyaseCav3.2 pathway in stance P-induced bladder pain in the mouse, a model for nonulcerative bladder pain syndrome.
2018 Naunyn Schmiedebergs Arch... NK2 and NK1 receptor-mediated effects of NKA and analogs on colon, bladder, and arterial pressure in anesthetized dogs.
2017 Aug Magnes Res Magnesium enhances the beneficial effects of NK1 antagonist administration on blood-brain barrier permeability and motor outcome after traumatic brain injury.
2017 PLoS Negl Trop Dis Neurogenic mediators contribute to local edema induced by Micrurus lemniscatus venom.
2018 Heart Lung Circ Substance P Attenuates HypoxiaReoxygenation-Induced Apoptosis via the Akt Signalling Pathway and the NK1-Receptor in H9C2Cells.
2018 Feb Ann Oncol A randomized phase III study evaluating the efficacy of single-dose NEPA, a fixed antiemetic combination of netupitant and palonosetron, versus an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC).
2017 Biomed Res Int Endothelinergic Contractile Hyperreactivity in Rat Contralateral Carotid to Balloon Injury: Integrated Role for ETB Receptors and Superoxide Anion.
2018 Eur J Neurosci Substance P and dopamine interact to modulate the distribution of delta-opioid receptors on cholinergic interneurons in the striatum.
2017 Drugs Rolapitant: A Review in Chemotherapy-Induced Nausea and Vomiting.
2018 Support Care Cancer Is the addition of a neurokinin-1 receptor antagonist beneficial in moderately emetogenic chemotherapy?-a systematic review and meta-analysis.
2017 Nov Am J Physiol Gastrointest... Effects of NK1 receptors on gastric motor functions and satiation in healthy humans: results from a controlled trial with the NK1 antagonist aprepitant.
2017 Aug BMC Vet Res Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study.
2017 Purinergic Signal Colonic motor dysfunctions in a mouse model of high-fat diet-induced obesity: an involvement of A2B adenosine receptors.
2017 J Palliat Med Fosaprepitant for the Management of Refractory Pain in a Patient with Cancer-Related Dermatomyositis.
2017 Dec J Affect Disord NK1 receptor antagonists for depression: Why a validated concept was abandoned.
2017 Sep Eur J Med Chem Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiostituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification.
2017 Oct ACS Chem Neurosci Analgesic Properties of OpioidNK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.
2017 Aug Eur J Pharmacol The anti-asthmatic drug pranlukast presses the delayed-phase vomiting and reverses intracellular indices of emesis evoked by cisplatin in the least shrew (Cryptotis parva).
2017 Front Physiol Cholera Toxin Induces Sustained Hyperexcitability in Myenteric, but Not Submucosal, AH Neurons in Guinea Pig Jejunum.
2018 Mol Psychiatry Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.
2017 Neurogastroenterol Motil Neurokinin-1 receptor blocker CP-99 994 improved emesis induced by cisplatin via regulating the activity of gastric distention responsive neurons in the dorsal motor nucleus of vagus and enhancing gastric motility in rats.
2017 Paediatr Drugs Management of Chemotherapy-Induced Nausea and Vomiting in Pediatric Patients.
2017 Jun Am J Health Syst Pharm New options and controversies in the management of chemotherapy-induced nausea and vomiting.
2017 Jun Ann Oncol Integrated safety analysis of rolapitant with coadministered drugs from phase IIIII trials: an assessment of CYP2D6 or BCRP inhibition by rolapitant.
2017 Drug Res (Stuttg) Effect of a Bicyclic Pyrimidine Derivative (KRP-103), a Novel Selective Tachykinin NK1 Receptor Antagonist, on Bladder Function in Guinea Pigs.
2016 Front Pharmacol Detection of Nausea-Like Response in Rats by Monitoring Facial Expression.
2017 J Pharmacol Exp Ther Xenin Augments Duodenal Anion Secretion via Activation of Afferent Neural Pathways.
2017 Support Care Cancer Prevention of chemotherapy-induced nausea: the role of neurokinin-1 (NK1) receptor antagonists.
2017 FEBS Lett Bidirectional communication between sensory neurons and osteoblasts in an in vitro coculture system.
2017 Feb Eur J Pharmacol Trypsin induces biphasic muscle contraction and relaxation via transient receptor potential vanilloid 1 and neurokinin receptors 12 in porcine esophageal body.
2017 Support Care Cancer Effectiveness of aprepitant in addition to ondansetron in the prevention of nausea and vomiting caused by fractionated radiotherapy to the upper abdomen (AVERT).
2017 Inflamm Res TRPA1, stance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
2017 J Geriatr Oncol Safety and efficacy of NEPA, an oral fixed combination of netupitant and palonosetron, in older patients.
2017 Support Care Cancer NEPA, a fixed oral combination of netupitant and palonosetron, improves control of chemotherapy-induced nausea and vomiting (CINV) over multiple cycles of chemotherapy: results of a randomized, double-blind, phase 3 trial versus oral palonosetron.
2017 Support Care Cancer 2016 updated MASCCESMO consensus recommendations: prevention of nausea and vomiting following multiple-day chemotherapy, high-dose chemotherapy, and breakthrough nausea and vomiting.
2016 Dec Eur J Pharmacol MCRT, a chimeric peptide based on morphiceptin and PFRTic-NH2, regulates the depressor effects induced by endokinin AB.