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Recent literature: NK1 receptor antagonist
Date Journal Article title
2020 Oncologist Phase IIIb Safety and Efficacy of Intravenous NEPA for Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Patients with Breast Cancer Receiving Initial and Repeat Cycles of Anthracycline and Cyclophosphamide (AC) Chemotherapy.
2020 Mol Biol Rep The role of stance Pneurokinin 1 receptor in the pathogenesis of esophageal squamous cell carcinoma through constitutively active PI3KAktNF-κB signal transduction pathways.
2020 Oncologist A Nationwide, Multicenter Registry Study of Antiemesis for Carboplatin-Based Chemotherapy-Induced Nausea and Vomiting in Japan.
2020 Ann Hematol Antiemetic prophylaxis in patients undergoing hematopoietic stem cell transplantation: a multicenter survey of the Gruppo Italiano Trapianto Midollo Osseo (GITMO) transplant programs.
2020 Jan J Cancer Educ Evaluation of Adherence to Antiemetic Treatment Guidelines in Patients With Chemotherapy-Induced Nausea and Vomiting in Teaching Hospitals in Tehran.
2020 Jan J Biomed Sci Neuropeptide S-initiated sequential cascade mediated by OX1, NK1, mGlu5 and CB1 receptors: a pivotal role in stress-induced analgesia.
2019 Dec Sci Rep [18F]SPA-RQPET Study of NK1 receptors in the Whole Body of Guinea Pig and Rat.
2019 Dec Molecules Synthesis and Pharmacological Evaluation of Hybrids Targeting Opioid and Neurokinin Receptors.
2019 Dec Oncologist Phase IIIb Safety and Efficacy of Intravenous NEPA for Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Patients with Breast Cancer Receiving Initial and Repeat Cycles of Anthracycline and Cyclophosphamide (AC) Chemotherapy.
2019 Gan To Kagaku Ryoho [Recent Findings in Antiemetic Therapy and the Role of Pharmacists].
2019 Dec Eur J Pharmacol Δ9-THC and related cannabinoids press stance P- induced neurokinin NK1-receptor-mediated vomiting via activation of cannabinoid CB1 receptor.
2020 Neuropeptides Substance P: A neuropeptide involved in the psychopathology of anxiety disorders.
2019 Oct Oncologist A Nationwide, Multicenter Registry Study of Antiemesis for Carboplatin-Based Chemotherapy-Induced Nausea and Vomiting in Japan.
2019 Pulm Pharmacol Ther Emerging targets for cough therapies; NK1 receptor antagonists.
2019 Sep J Am Acad Dermatol Phase 2 trial of a neurokinin-1 receptor antagonist for the treatment of chronic itch in patients with epidermolysis bullosa: A randomized clinical trial.
2019 Oct J Immunol Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties.
2020 Support Care Cancer Randomized open-label phase II trial of 5-day aprepitant plus ondansetron compared to ondansetron alone in the prevention of chemotherapy-induced nausea-vomiting (CINV) in glioma patients receiving adjuvant temozolomide.
2019 Oct Eur J Pharmacol Enhancement of swallowing motor activity by the ACE inhibitor imidapril in an arterially perfused rat preparation.
2019 Front Neurosci NK1-r Antagonist Treatment Comparable to Decompressive Craniectomy in Reducing Intracranial Pressure Following Stroke.
2019 Sep Chem Biol Interact Characterizing fucoxanthin as a selective dopamine D3D4 receptor agonist: Relevance to Parkinson's disease.
2019 Jul Sci Rep Effect of neurokinin-1-receptor blockage on fracture healing in rats.
2019 Expert Opin Investig Drugs The NK1 receptor antagonist serlopitant for treatment of chronic pruritus.
2020 Support Care Cancer Cost-effectiveness of a fixed combination of netupitant and palonosetron (NEPA) relative to aprepitant plus granisetron (APR + GRAN) for prophylaxis of chemotherapy-induced nausea and vomiting (CINV): a trial-based analysis.
2019 Vet Med Int Evaluation of the Antinociceptive Effect of Maropitant, a Neurokinin-1 Receptor Antagonist, in Cats Undergoing Ovariohysterectomy.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 Drug Metab Dispos Rolapitant Is a Reversible Inhibitor of CYP2D6.
2019 Oct Pain Med Involvement of Substance P in the Analgesic Effect of Low-Level Laser Therapy in a Mouse Model of Chronic Widespread Muscle Pain.
2019 Apr Biochem Biophys Res Commun Substance P plays a critical role in synaptic transmission in striatal neurons.
2019 Support Care Cancer One shot NEPA plus dexamethasone to prevent multiple-day chemotherapy in sarcoma patients.
2019 Support Care Cancer Timing flexibility of oral NEPA, netupitant-palonosetron combination, administration for the prevention of chemotherapy-induced nausea and vomiting (CINV).
2019 Apr Acta Derm Venereol Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU).
2019 Jan Nat Commun Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists.
2019 Int J Biochem Cell Biol Tachykinin NK1 receptor antagonist L-733,060 and stance P deletion exert neuroprotection through inhibiting oxidative stress and cell death after traumatic brain injury in mice.
2018 Dec Proc Natl Acad Sci U S A Crystal structure of the human NK1 tachykinin receptor.
2018 Jun Pharmacoeconomic Review R...
2018 Stem Cells Int Dorsal Root Ganglion Maintains Stemness of Bone Marrow Mesenchymal Stem Cells by Enhancing Autophagy through the AMPKmTOR Pathway in a Coculture System.
2018 J Physiol Pharmacol Hydrogen sulfide modulates gastric acid secretion in rats via involvement of stance P and nuclear factor-κB signaling.
2018 Biomed Pharmacother Differential consequences of neurokinin receptor 1 and 2 antagonists in metastatic breast carcinoma cells; Effects independent of Substance P.
2018 Nihon Yakurigaku Zasshi [Pharmacological profile of a novel nonhuman primate model of knee osteoarthritis].
2018 Exp Eye Res The involvement of NK1 and Y2 receptor in the development of laser-induced CNVs in C57Bl6N mice.
2018 Cancer Manag Res Recent advances in antiemetics: new formulations of 5HT3-receptor antagonists.
2018 Acta Biol Hung Effects of the venom of the brown bullhead catfish (Ameiurus nebulosus) on isolated smooth muscles.
2018 Naunyn Schmiedebergs Arch... Colorectal and cardiovascular effects of [Lys5,MeLeu9,Nle10]-NKA(4-10) in anesthetized macaques.
2018 May Biol Res The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway.
2018 J Pediatr Hematol Oncol Evaluation of the Use of Fosaprepitant for the Prevention of Chemotherapy-induced Nausea and Vomiting in Pediatric Patients.
2018 Br J Pharmacol Central adenosine A1 receptors inhibit cough via pression of excitatory glutamatergic and tachykininergic neurotransmission.
2018 Ann Palliat Med Efficacy of the combination neurokinin-1 receptor antagonist, palonosetron, and dexamethasone compared to others for the prophylaxis of chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials.
2018 Jul J Neuroimmunol Tropisetron attenuates lipopolysaccharide induced neuroinflammation by inhibiting NF-κB and SPNK1R signaling pathway.
2018 Jul Eur J Pharm Sci Salt formation improved the properties of a candidate drug during early formulation development.
2018 J Pharmacol Exp Ther [Lys5,MeLeu9,Nle10]-NKA(4-10) Elicits NK2 Receptor-Mediated Micturition and Defecation, and NK1 Receptor-Mediated Emesis and Hypotension, in Conscious Dogs.
2018 Curr Opin Oncol The latest consensus on antiemetics.
2018 Neth J Med Drug-drug interactions with aprepitant in antiemetic prophylaxis for chemotherapy.
2018 Crit Rev Oncol Hematol Efficacy of neurokinin-1 receptor antagonists in the prevention of chemotherapy-induced nausea and vomiting in patients receiving carboplatin-based chemotherapy: A systematic review and meta-analysis.
2018 Apr Clin J Oncol Nurs Cisplatin-Based Therapy and CINV: Optimal Antiemetics During Germ Cell Testicular Cancer Treatment
2018 Neurobiol Learn Mem Behavioral sensitization induced by dorsal periaqueductal gray electrical stimulation is counteracted by NK1 receptor antagonism in the ventral hippocampus and central nucleus of the amygdala.
2018 Feb J Neuroinflammation Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of stance P-mediated neurokinin 1 receptor.
2018 J Am Acad Dermatol Serlopitant for the treatment of chronic pruritus: Results of a randomized, multicenter, placebo-controlled phase 2 clinical trial.
2018 Apr J Clin Oncol Placebo-Controlled, Double-Blinded Phase III Study Comparing Dexamethasone on Day 1 With Dexamethasone on Days 1 to 3 With Combined Neurokinin-1 Receptor Antagonist and Palonosetron in High-Emetogenic Chemotherapy.
2018 FASEB J NK1R5-HT1AR interaction is related to the regulation of melanogenesis.
2017 Biomed Res Int A Comparison of Fosaprepitant and Ondansetron for Preventing Postoperative Nausea and Vomiting in Moderate to High Risk Patients: A Retrospective Database Analysis.
2018 May - J Pharmacol Toxicol Methods Strain differences in the development of cisplatin-induced pica behavior in mice.
2018 May Neuropharmacology Involvement of the cystathionine-γ-lyaseCav3.2 pathway in stance P-induced bladder pain in the mouse, a model for nonulcerative bladder pain syndrome.
2018 Naunyn Schmiedebergs Arch... NK2 and NK1 receptor-mediated effects of NKA and analogs on colon, bladder, and arterial pressure in anesthetized dogs.
2017 Aug Magnes Res Magnesium enhances the beneficial effects of NK1 antagonist administration on blood-brain barrier permeability and motor outcome after traumatic brain injury.
2017 PLoS Negl Trop Dis Neurogenic mediators contribute to local edema induced by Micrurus lemniscatus venom.
2018 Heart Lung Circ Substance P Attenuates HypoxiaReoxygenation-Induced Apoptosis via the Akt Signalling Pathway and the NK1-Receptor in H9C2Cells.
2018 Feb Ann Oncol A randomized phase III study evaluating the efficacy of single-dose NEPA, a fixed antiemetic combination of netupitant and palonosetron, versus an aprepitant regimen for prevention of chemotherapy-induced nausea and vomiting (CINV) in patients receiving highly emetogenic chemotherapy (HEC).
2017 Biomed Res Int Endothelinergic Contractile Hyperreactivity in Rat Contralateral Carotid to Balloon Injury: Integrated Role for ETB Receptors and Superoxide Anion.
2018 Eur J Neurosci Substance P and dopamine interact to modulate the distribution of delta-opioid receptors on cholinergic interneurons in the striatum.
2017 Drugs Rolapitant: A Review in Chemotherapy-Induced Nausea and Vomiting.
2018 Support Care Cancer Is the addition of a neurokinin-1 receptor antagonist beneficial in moderately emetogenic chemotherapy?-a systematic review and meta-analysis.
2017 Nov Am J Physiol Gastrointest... Effects of NK1 receptors on gastric motor functions and satiation in healthy humans: results from a controlled trial with the NK1 antagonist aprepitant.
2017 Aug BMC Vet Res Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study.
2017 Purinergic Signal Colonic motor dysfunctions in a mouse model of high-fat diet-induced obesity: an involvement of A2B adenosine receptors.
2017 J Palliat Med Fosaprepitant for the Management of Refractory Pain in a Patient with Cancer-Related Dermatomyositis.