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Recent literature: HMG-CoA reductase inhibitor
Date Journal Article title
2019 Feb Med Sci Monit Simvastatin Improves Cardiac Hypertrophy in Diabetic Rats by Attenuation of Oxidative Stress and Inflammation Induced by Calpain-1-Mediated Activation of Nuclear Factor-κB (NF-κB).
2019 Feb Rev Iberoam Micol Simvastatin and other inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase of Ustilago maydis (Um-Hmgr) affect the viability of the fungus, its synthesis of sterols and mating.
2019 Jan J Thorac Cardiovasc Surg Rosuvastatin attenuates bioprosthetic heart valve calcification.
2019 Jan Lab Invest Anti-cancer effect of doxorubicin is mediated by downregulation of HMG-Co A reductase via inhibition of EGFRSrc pathway.
2019 Feb J Biotechnol Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by α-asarone-based synthetic compounds as antifungal agents.
2019 Jan J Lipid Res Therapeutic FGF19 promotes HDL biogenesis and transhepatic cholesterol efflux to prevent atherosclerosis.
2019 Jan Pharmacol Res Effects of statin exposure and lung cancer survival: A meta-analysis of observational studies.
2018 Nov J Am Heart Assoc Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras-Induced ERK (Extracellular Signal-Regulated Kinase) Signaling Pathway.
2018 Dec Trials Prevention of post-operative complications by using a HMG-CoA reductase inhibitor in patients undergoing one-lung ventilation for non-cardiac surgery: study protocol for a randomised controlled trial.
2019 Jan Biochem Biophys Res Commun CEBP homologous protein deficiency inhibits statin-induced myotoxicity.
2018 Nov Front Med Long-term effects of various types of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on changes in glomerular filtration rate in Korea.
2018 Jan StatPearls Simvastatin
2018 Jan StatPearls Ezetimibe
2018 Nov Sci Rep Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells.
2019 J Lipid Res Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels.
2018 Nov Org Lett Base-Mediated Direct Transformation of N-Propargylamines into 2,3,5-Tristituted 1 H-Pyrroles.
2018 Transplant Proc Graft Protective Effect of HMG-CoA Reductase Inhibitor Pravastatin in Murine Cardiac Allograft Transplantation.
2018 J Assoc Physicians India Rosuvastatin: Role in Secondary Prevention of Cardiovascular Disease.
2018 Oct Clin Exp Pharmacol Physiol Unfolding the pleiotropic facades of rosuvastatin in therapeutic intervention of myriads of neurodegenerative disorders.
2018 Oct J Clin Med The Effect of Statin Added to Systemic Anticancer Therapy: A Meta-Analysis of Randomized, Controlled Trials.
2018 J Neurosci Rural Pract The Effect of Statins in Epilepsy: A Systematic Review.
2018 J Cell Mol Med Cardioprotective cytokine interleukin-33 is up-regulated by statins in human cardiac tissue.
2018 Plant Methods Use of a temporary immersion bioreactor system for the sustainable production of thapsigargin in shoot cultures of iThapsia garganicai.
2018 Sep Acta Ophthalmol Systemic use of calcium channel blockers associated with less increase in central retinal thickness after uncomplicated cataract surgery.
2018 Fitoterapia Eight new triterpenoids with inhibitory activity against HMG-CoA reductase from the medical mushroom Ganoderma leucocontextum collected in Tibetan plateau.
2018 Front Cell Neurosci Rosuvastatin Reduces Neuroinflammation in the Hemorrhagic Transformation After rt-PA Treatment in a Mouse Model of Experimental Stroke.
2018 Drug Des Devel Ther Pharmacokinetic interaction between fimasartan and atorvastatin in healthy male volunteers.
2018 Sep Biochem Biophys Res Commun Fluvastatin activates sirtuin 6 to regulate sterol regulatory element-binding proteins and AMP-activated protein kinase in HepG2 cells.
2018 Pak J Pharm Sci Enhanced production of Lovastatin by filamentous fungi through solid state fermentation.
2018 ESC Heart Fail Timing of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor initiation and allograft vasculopathy progression and outcomes in heart transplant recipients.
2018 Jun Pharm Res Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis.
2018 Jun Int J Mol Sci A Synergistic Anti-Cancer Effect of Troglitazone and Lovastatin in a Human Anaplastic Thyroid Cancer Cell Line and in a Mouse Xenograft Model.
2018 Jun Sci Transl Med Statins enhance efficacy of venetoclax in blood cancers.
2018 Jun Vascul Pharmacol Atorvastatin enhances endothelial adherens junctions through promoting VE-PTP gene transcription and reducing VE-cadherin-Y731 phosphorylation.
2018 Jun Naunyn Schmiedebergs Arch... Pharmacokinetics, metabolism, bioavailability, tissue distribution and excretion studies of 16α-hydroxycleroda-3, 13(14) Z -dien-15, 16-olide-a novel HMG-CoA reductase inhibitor.
2018 Cell Physiol Biochem Enhanced Liver Regeneration After Partial Hepatectomy in Sterol Regulatory Element-Binding Protein (SREBP)-1c-Null Mice is Associated with Increased Hepatocellular Cholesterol Availability.
2018 Korean J Food Sci Anim Re... iLactobacillus plantarumi DR7 Reduces Cholesterol via Phosphorylation of AMPK That Down-regulated the mRNA Expression of HMG-CoA Reductase.
2018 Biosci Biotechnol Biochem Isoxanthohumol stimulates ubiquitin-proteasome-dependent degradation of precursor forms of sterol regulatory element-binding proteins.
2018 May Lipids Health Dis Novel Phenoxazinones as potent agonist of PPAR-α: design, synthesis, molecular docking and in vivo studies.
2018 FEBS Open Bio Synergistic effects of HMG-CoA reductase inhibitor and angiotensin II receptor blocker on load-induced heart failure.
2018 Drug Des Devel Ther Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers.
2018 PLoS One Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable.
2018 Sep Food Chem In vitro and in silico studies of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitory activity of the cowpea Gln-Asp-Phe peptide.
2018 Jun Life Sci Long noncoding RNA lncARSR promotes hepatic cholesterol biosynthesis via modulating AktSREBP-2HMGCR pathway.
2018 Korean J Intern Med Effect of the anti-IL-17 antibody on allergic inflammation in an obesity-related asthma model.
2018 Mol Diagn Ther A Discrete Event Simulation Model to Assess the Economic Value of a Hypothetical Pharmacogenomics Test for Statin-Induced Myopathy in Patients Initiating a Statin in Secondary Cardiovascular Prevention.
2018 Apr J Med Chem Structural Modification of Natural Product Ganomycin I Leading to Discovery of a α-Glucosidase and HMG-CoA Reductase Dual Inhibitor Improving Obesity and Metabolic Dysfunction in Vivo.
2018 Apr Xenobiotica Evaluation of interconversion pharmacokinetics of 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide - a novel HMG-CoA reductase inhibitor and its acid metabolite using multi-compartmental pharmacokinetic model in mice.
2018 Jul Crit Rev Anal Chem Analytical Methods for the Determination of Rosuvastatin in Pharmaceutical Formulations and Biological Fluids: A Critical Review.
2018 Clin Pharmacol Drug Dev Risk Factor for Diabetes Mellitus and High Blood Glucose With HMG-CoA Reductase Inhibitors Using a Postmarketing Surveillance Database in Japan.
2018 PLoS One Low apolipoprotein A-I levels in Friedreich's ataxia and in frataxin-deficient cells: Implications for therapy.
2018 Feb Sci Rep Fluvastatin protects cochleae from damage by high-level noise.
2017 May Pharmazie Influence of iSLCO1B1i polymorphisms on atorvastatin efficacy and safety in Macedonian jects.
2018 Neurochem Res Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons.
2018 Feb Curr Atheroscler Rep Human Immunodeficiency Virus Infection, Antiretroviral Therapy, and Statin: a Clinical Update.
2018 Med Princ Pract Do Statins Affect Thyroid Volume and Nodule Size in Patients with Hyperlipidemia in a Region with Mild-to-Moderate Iodine Deficiency? A Prospective Study.
2017 J Biosci Cholesterol-lowering drug, in combination with chromium chloride, induces early apoptotic signals in intracellular L. donovani amastigotes, leading to death.
2018 J Hum Genet Nationwide survey on cerebrotendinous xanthomatosis in Japan.
2018 Jan Trials Effect of eicosapentaenoic aciddocosahexaenoic acid on coronary high-intensity plaques detected with non-contrast T1-weighted imaging (the AQUAMARINE EPADHA study): study protocol for a randomized controlled trial.
2018 Br J Pharmacol Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform.
2017 Hosp Pharm Cholesterol Ester Transfer Protein Inhibitor Review.
2018 Appl Microbiol Biotechnol Knockout of the SREBP system increases production of the polyketide FR901512 in filamentous fungal sp. No. 14919 and lovastatin in Aspergillus terreus ATCC20542.
2018 Neurotox Res Atorvastatin Prevents Early Oxidative Events and Modulates Inflammatory Mediators in the Striatum Following Intranasal 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Administration in Rats.
2018 Apr Int J Biol Macromol Linoleic acid enhance the production of moncolin K and red pigments in Monascus ruber by activating mokH and mokA, and by accelerating cAMP-PkA pathway.
2017 Clin Ther A Randomized, Multicenter, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and the Tolerability of a Triple Combination of AmlodipineLosartanRosuvastatin in Patients With Comorbid Essential Hypertension and Hyperlipidemia.
2018 Phytochemistry Lovastatin analogues and other metabolites from soil-derived Aspergillus terreus YIM PH30711.
2017 Cell Physiol Biochem Atorvastatin Calcium Inhibits PDGF-ββ-Induced Proliferation and Migration of VSMCs Through the G0G1 Cell Cycle Arrest and Suppression of Activated PDGFRβ-PI3K-Akt Signaling Cascade.
2018 Jan Annu Rev Med PCSK9 Inhibitors: Mechanisms of Action, Metabolic Effects, and Clinical Outcomes.
2017 Mil Med Exercise-Induced Anaphylaxis in an Air Force Aviator Taking a HMG-CoA Reductase Inhibitor: A Case Report and Review of the Presentation, Diagnoses, and Treatment.
2017 Assay Drug Dev Technol Risk of Late-Onset Alzheimer's Disease by Plasma Cholesterol: Rational In Silico Drug Investigation of Pyrrole-Based HMG-CoA Reductase Inhibitors.
2018 Mol Cancer Ther HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation.
2017 Intern Med J HMG CoA reductase inhibitor associated myositis and autoimmune hepatitis.
2017 Atheroscler Suppl Detection of familial hypercholesterolemia in patients from a general practice database.
2017 Nov Biochem Biophys Res Commun Inhibiting prenylation augments chemotherapy efficacy in renal cell carcinoma through dual inhibition on mitochondrial respiration and glycolysis.
2017 Biomed Pharmacother Regulation of hepatic hydroxy methyl glutarate - CoA reductase for controlling hypercholesterolemia in rats.