Purchases through the above links give commission which helps fund this website
Recent literature: Ca++ channel blocker
Date Journal Article title
2020 Jan Biochem Pharmacol Volatile anaesthetics inhibit the thermosensitive nociceptor ion channel transient receptor potential melastatin 3 (TRPM3).
2020 Jan J Mol Cell Cardiol Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
2020 Jan Naunyn Schmiedebergs Arch... Mechanism of contractile dysfunction induced by serotonin in coronary artery in spontaneously hypertensive rats.
2020 Jan Cells Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca).
2020 Physiol Rep Calcium-sensing receptor regulates intestinal dipeptide absorption via Ca2+ signaling and IKCa activation.
2020 Jan Hypertens Res Pretreatment with cilnidipine attenuates hypoxiareoxygenation injury in HL-1 cardiomyocytes through enhanced NO production and action potential shortening.
2020 Jan Int J Mol Sci The Mitochondrial Ca2+ Overload via Voltage-Gated Ca2+ Entry Contributes to an Anti-Melanoma Effect of Diallyl Trisulfide.
2020 Jan Inflammopharmacology Vasorelaxant effect of 3,5,4'-trihydroxy-trans-stilbene (resveratrol) and its underlying mechanism.
2020 Mol Autism Biophysical classification of a iCACNA1Di de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder.
2020 Pflugers Arch Characterization and functional roles of KCNQ-encoded voltage-gated potassium (Kv7) channels in human corpus cavernosum smooth muscle.
2020 Jan Am J Physiol Lung Cell Mo... Upregulation of Airway Smooth Muscle Calcium-Sensing Receptor by Low Molecular Weight Hyaluronan.
2020 Jan Am J Physiol Renal Physiol Contribution of Cav1.2 Ca2+ channels and store-operated-Ca2+-entry to pig urethral smooth muscle contraction.
2019 Dec Colloids Surf B Biointerf... How is the interaction of a chloride channel blocker with phospholipids influenced by divalent metal ions? Effect of unsaturation on the lipid side chain.
2020 Exp Neurol Zn2+ entry through the mitochondrial calcium uniporter is a critical contributor to mitochondrial dysfunction and neurodegeneration.
2019 Dec Radiat Res KATP Channel Blocker Glibenclamide Prevents Radiation-Induced Lung Injury and Inhibits Radiation-Induced Apoptosis of Vascular Endothelial Cells by Increased Ca2+ Influx and Subsequent PKC Activation.
2019 Oxid Med Cell Longev Upregulation of Transient Receptor Potential Canonical Type 3 Channel via AT1RTGF-iβi1Smad23 Induces Atrial Fibrosis in Aging and Spontaneously Hypertensive Rats.
2019 Dec Sci Rep Dual action of amitriptyline on NMDA receptors: enhancement of Ca-dependent desensitization and trapping channel block.
2019 Dec Respir Res Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.
2020 J Pharmacol Sci Paracetamol inhibits Ca2+ permeant ion channels and Ca2+ sensitization resulting in relaxation of precontracted airway smooth muscle.
2020 Hypertension Gal-3 (Galectin-3) and KCa3.1 Mediate Heterogeneous Cell Coupling and Myocardial Fibrogenesis Driven by βAR (β-Adrenoceptor) Activation.
2019 Dec J Am Heart Assoc Rhythm Control Versus Rate Control in Patients With Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction: Insights From Get With The Guidelines-Heart Failure.
2019 Dec Toxins (Basel) Curine Inhibits Macrophage Activation and Neutrophil Recruitment in a Mouse Model of Lipopolysaccharide-Induced Inflammation.
2019 J Card Surg Preventing spasm of the radial artery conduit during coronary artery bypass grafting: Nicardipine versus verapamil.
2019 Niger J Clin Pract Investigation the relaxant effects of proton pump ınhibitors and their relaxation mechanism on sheep sphincter of Oddi.
2020 Nat Biomed Eng Identification and local delivery of vasodilators for the reduction of ureteral contractions.
2020 Jan Eur J Pharmacol KCa and KV channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of KATP channels, NOS, and COX.
2019 Aging Dis Verapamil Ameliorates Motor Neuron Degeneration and Improves Lifespan in the SOD1G93A Mouse Model of ALS by Enhancing Autophagic Flux.
2019 Cardiol Res Pract GLP-1 Relaxes Rat Coronary Arteries by Enhancing ATP-Sensitive Potassium Channel Currents.
2019 Nov Br J Pharmacol Ca2+ signalling in fibroblasts and the therapeutic potential of KCa 3.1 channel blockers in fibrotic diseases.
2020 Jan Life Sci Chronic heart failure increases negative chronotropic effects of adenosine in canine sinoatrial cells via A1R stimulation and GIRK-mediated IKado.
2019 Arch Med Sci Modulator role of infliximab and methotrexate through the transient receptor potential melastatin 2 (TRPM2) channel in neutrophils of patients with rheumatoid arthritis: a pilot study.
2019 Nov Hypertens Res Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension.
2019 Nov Aging Male Ivabradine, the hyperpolarization-activated cyclic nucleotide-gated channel blocker, elicits relaxation of the human corpus cavernosum: a potential option for erectile dysfunction treatment.
2019 Mini Rev Med Chem 1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects.
2019 Dec Arch Biochem Biophys Aerobic exercise-induced inhibition of PKCαCaV1.2 pathway enhances the vasodilation of mesenteric arteries in hypertension.
2019 Nov Br J Pharmacol Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain.
2020 Mol Pharmacol The iIi iKsi Ion Channel Activator Mefenamic Acid Requires KCNE1 and Modulates Channel Gating in a Subunit-Dependent Manner.
2020 Peptides Cardiovascular effects of DWORF (dwarf open reading frame) peptide in normal and ischaemiareperfused isolated rat hearts.
2019 Dec ACS Chem Neurosci The Natural Flavonoid Naringenin Elicits Analgesia through Inhibition of NaV1.8 Voltage-Gated Sodium Channels.
2019 Front Plant Sci Genome-Wide Identification of Calcium-Dependent Protein Kinases in iChlamydomonas reinhardtiii and Functional Analyses in Nitrogen Deficiency-Induced Oil Accumulation.
2019 Nov Metab Brain Dis Verapamil attenuates scopolamine induced cognitive deficits by averting oxidative stress and mitochondrial injury - A potential therapeutic agent for Alzheimer's Disease.
2019 EMBO Mol Med Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy.
2019 Pharmacol Rep Lacidipine attenuates caffeine-induced anxiety-like symptoms in mice: Role of calcium-induced oxido-nitrosative stress.
2020 Jan Virology Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication.
2019 Dec Bioorg Med Chem Lett An anthrone-based Kv7.27.3 channel blocker with improved properties for the investigation of psychiatric and neurodegenerative disorders.
2019 J Cardiovasc Transl Res Curcumin Induces Endothelium-Dependent Relaxation by Activating Endothelial TRPV4 Channels.
2020 Feb Behav Brain Res Effects of dopamine and serotonin synthesis inhibitors on the ketamine-, d-amphetamine-, and cocaine-induced locomotor activity of preweanling and adolescent rats: sex differences.
2020 Jan Neuropharmacology Phoneutria toxin PnTx3-5 inhibits TRPV1 channel with antinociceptive action in an orofacial pain model.
2020 Mol Plant Microbe Interact FlgII-28 Is a Major Flagellin-Derived Defense Elicitor in Potato.
2020 Korean Circ J Comparison of First-Line Dual Combination Treatments in Hypertension: Real-World Evidence from Multinational Heterogeneous Cohorts.
2019 Epilepsy Behav Early polytherapy for benzodiazepine-refractory status epilepticus.
2019 Biomed Pharmacother Tambulin from Zanthoxylum armatum acutely potentiates the glucose-induced insulin secretion via KATP-independent Ca2+-dependent amplifying pathway.
2019 Dec Life Sci NS8593 inhibits Ca2+ permeant channels reversing mouse airway smooth muscle contraction.
2019 Oct J Physiol Synaptic cleft microenvironment influences potassium permeation and synaptic transmission in hair cells surrounded by calyx afferents in the turtle.
2019 Front Pharmacol The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy.
2019 Oct BMJ Open SCING-Spinal Cord Injury Neuroprotection with Glyburide: a pilot, open-label, multicentre, prospective evaluation of oral glyburide in patients with acute traumatic spinal cord injury in the USA.
2019 Dec J Neurophysiol Muscarinic acetylcholine receptor-dependent persistent activity of layer 5 intrinsic-bursting and regular-spiking neurons in primary auditory cortex.
2019 Oct Proc Natl Acad Sci U S A L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development.
2019 Biol Pharm Bull Mechanism of Membrane Depolarization Involved in α1A-Adrenoceptor-Mediated Contraction in Rat Tail and Iliac Arteries.
2019 Sep Cells Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation.
2020 Plant J The nuclear transporter SAD2 plays a role in calcium- and H2 O2 -mediated cell death in Arabidopsis.
2019 Nov Eur J Pharmacol L-cysteinehydrogen sulfide pathway induces cGMP-dependent relaxation of corpus cavernosum and penile arteries from patients with erectile dysfunction and improves arterial vasodilation induced by PDE5 inhibition.
2019 Oct J Neurosci Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction.
2019 Nov J Biol Chem A Na+ leak channel cloned from iTrichoplax adhaerensi extends extracellular pH and Ca2+ sensing for the DEGENaC family close to the base of Metazoa.
2020 Clin Exp Pharmacol Physiol Effects of nitric oxide on apoptosis and voltage-gated calcium channels in human cardiac myofibroblasts.
2019 Front Pharmacol IK1 Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure iviai Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats.
2019 J Pharmacol Sci Genetic deletion of Cav3.2 T-type calcium channels abolishes H2S-dependent somatic and visceral pain signaling in C57BL6 mice.
2019 Sep mSphere Potential Role of Extracellular ATP Released by Bacteria in Bladder Infection and Contractility.
2019 Pharmacol Rep GABAA receptor, KATP channel and L-type Ca2+ channel is associated with facilitation effect of H2S on the baroreceptor reflex in spontaneous hypertensive rats.
2019 Pharmacol Rep Cryptostrobin and catechin isolated from Eugenia mattosii D. Legrand leaves induce endothelium-dependent and independent relaxation in spontaneously hypertensive rat aorta.
2019 Aug Nutrients Myocardial Dysfunction after Severe Food Restriction Is Linked to Changes in the Calcium-Handling Properties in Rats.
2020 Microcirculation Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX.
2019 Aug Int J Mol Sci Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening.
2020 Naunyn Schmiedebergs Arch... Neryl butyrate induces contractile effects on isolated preparations of rat aorta.
2020 J Cardiothorac Vasc Anesth Radiological Incidence of Unilateral Pulmonary Edema After Minimally Invasive Cardiac Surgery.