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Recent literature: Ca++ channel blocker
Date Journal Article title
2019 Ann Clin Transl Neurol Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease.
2019 Apr J Immunother Cancer STIM1 at the plasma membrane as a new target in progressive chronic lymphocytic leukemia.
2019 Apr Cells Parabolic, Flight-Induced, Acute Hypergravity and Microgravity Effects on the Beating Rate of Human Cardiomyocytes.
2019 Apr Neurogastroenterol Motil Flavonoids in a crude extract of Catha edulis inhibit rat intestinal contraction via blocking Ca2+ channels.
2019 Pain Adenosine A3 receptor activation inhibits pronociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.
2019 Apr Epilepsia First-in-man study of ACT-709478, a novel selective triple T-type calcium channel blocker.
2019 Apr Cancers (Basel) TRPC3 Regulates the Proliferation and Apoptosis Resistance of Triple Negative Breast Cancer Cells through the TRPC3RASA4MAPK Pathway.
2019 Jan Pharmacol Rep Verapamil prevents the effect of calcium-sensing receptor activation on the blood glucose and insulin levels in rats.
2019 Apr Int Immunopharmacol The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca2+PKCp38NF-κB signaling pathway in macrophages.
2019 Apr Brain Res Bull Ca2+-PKCα-ERK12 signaling pathway is involved in the pressive effect of propofol on proliferation of neural stem cells from the neonatal rat hippocampus.
2019 Front Cell Neurosci Estradiol-Mediated Axogenesis of Hypothalamic Neurons Requires ERK12 and Ryanodine Receptors-Dependent Intracellular Ca2+ Rise in Male Rats.
2019 Apr Nat Commun Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
2019 JACC Clin Electrophysiol Comparison of Ajmaline and Procainamide Provocation Tests in the Diagnosis of Brugada Syndrome.
2019 Apr Biochem Biophys Res Commun CACNB2 is associated with aberrant RAS-MAPK signaling in hypertensive Dahl Salt-Sensitive rats.
2019 Apr J Med Food Allicin Inhibits Glutamate Release from Rat Cerebral Cortex Nerve Terminals Through Suppressing Ca2+ Influx and Protein Kinase C Activity.
2019 Oxid Med Cell Longev Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells.
2019 Apr Biochem Biophys Res Commun Structural basis for efonidipine block of a voltage-gated Ca2+ channel.
2019 Apr Acta Physiol (Oxf) [Ca2+ ] changes in sympathetic varicosities and Schwann cells in rat mesenteric arteries - relation to noradrenaline release and contraction.
2019 Apr Toxins (Basel) iD. russeliii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels.
2019 Jan Pain Adenosine A3 receptor activation inhibits pro-nociceptive N-type Ca2+ currents and cell excitability in dorsal root ganglion neurons.
2019 Mar Int J Mol Sci Nifedipine Modulates Renal Lipogenesis via the AMPK-SREBP Transcriptional Pathway.
2019 Mar Clin Exp Pharmacol Physiol Mechanisms of U46619-induced contraction in mouse intrarenal artery.
2019 Am J Kidney Dis KDOQI US Commentary on the 2017 ACCAHA Hypertension Guideline.
2019 Mol Biol Rep Vincristine combination with Ca+2 channel blocker increase antitumor effects.
2019 Aug Food Chem Effects of exogenous Ca2+ on phenolic accumulation and physiological changes in germinated wheat (Triticum aestivum L.) under UV-B radiation.
2019 Mar Mol Psychiatry Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons.
2019 Mar Dig Dis Sci Functional Role of Basolateral ClC-2 Channels in the Regulation of Duodenal Anion Secretion in Mice.
2019 Mar Chem Biol Interact CRMP2-derived peptide ST2-104 (R9-CBD3) protects SH-SY5Y neuroblastoma cells against Aβ25-35-induced neurotoxicity by inhibiting the pCRMP2NMDAR2B signaling pathway.
2019 Mar Antioxidants (Basel) Hydroxycobalamin Reveals the Involvement of Hydrogen Sulfide in the Hypoxic Responses of Rat Carotid Body Chemoreceptor Cells.
2019 Pac Symp Biocomput Precision drug repurposing via convergent eQTL-based molecules and pathway targeting independent disease-associated polymorphisms.
2019 Biotechnol Biofuels iNi,iNi-dimethylformamide induces cellulase production in the filamentous fungus iTrichoderma reeseii.
2019 Cell Physiol Biochem Identification of Verapamil Binding Sites Within Human Kv1.5 Channel Using Mutagenesis and Docking Simulation.
2019 Feb Future Med Chem Discovery of new phthalazinones as vasodilator agents and novel pharmacological tools to study calcium channels.
2019 Front Neurosci Mechanisms Underlying Neuroprotection by the NSAID Mefenamic Acid in an Experimental Model of Stroke.
2019 Front Physiol Role of Phosphatidylinositol 3-Kinase (PI3K), Mitogen-Activated Protein Kinase (MAPK), and Protein Kinase C (PKC) in Calcium Signaling Pathways Linked to the α1-Adrenoceptor in Resistance Arteries.
2019 Clin Pharmacol Small-cell lung cancer growth inhibition: synergism between NMDA receptor blockade and chemotherapy.
2019 Patient Prefer Adherence The association of angiotensin receptor blocker-based combination therapy with persistence and adherence in newly treated, uncomplicated hypertensive patients.
2019 Cell Calcium Persistent Na+ influx drives L-type channel resting Ca2+ entry in rat melanotrophs.
2019 Mar Life Sci Luteolin-induced coronary arterial relaxation involves activation of the myocyte voltage-gated K+ channels and inward rectifier K+ channels.
2019 Apr Int J Cardiol Epigenetic down-regulation of BKCa channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life.
2019 Can J Physiol Pharmacol Relaxant effect of atorvastatin on isolated rat gastric fundus strips: implications for Ca2+-signalling mechanisms.
2019 Apr Biol Pharm Bull Effect of Selective Serotonin (5-HT)2B Receptor Agonist BW723C86 on Epidermal Growth FactorTransforming Growth Factor-α Receptor Tyrosine Kinase and Ribosomal p70 S6 Kinase Activities in Primary Cultures of Adult Rat Hepatocytes.
2018 Chin J Cancer Res Voltage-gated K+ channels promote BT-474 breast cancer cell migration.
2019 Plant Signal Behav A calcium sensor calcineurin B-like 9 negatively regulates cold tolerance via calcium signaling in Arabidopsis thaliana.
2019 Apr J Neurosci Presynaptic Diversity Revealed by Ca2+-Permeable AMPA Receptors at the Calyx of Held Synapse.
2019 Jan Protoplasma Glutamate signaling enhances the heat tolerance of maize seedlings by plant glutamate receptor-like channels-mediated calcium signaling.
2019 Feb J Gen Physiol Facilitation of iIi Kr current by some hERG channel blockers presses early afterdepolarizations.
2019 Mar Am J Physiol Cell Physiol TRPV2 channels mediate insulin secretion induced by cell swelling in mouse pancreatic β-cells.
2019 Jan Sci Rep Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow.
2019 J Physiol Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers.
2019 Jan Annu Rev Pharmacol Toxicol The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson's Disease.
2018 Front Physiol Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.
2019 Brain Res Bull The ventral hippocampus is required for behavioral flexibility but not for allocentricegocentric learning.
2019 Biomed Pharmacother Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line.
2019 Biomed Pharmacother Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: An in vitro and in vivo approach.
2019 Int J Toxicol A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
2019 Mar Am J Physiol Cell Physiol Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinase-activated receptor 1.
2019 Jan Am J Physiol Heart Circ P... VNUT and VMAT2 segregate within sympathetic varicosities and localize near preferred Cav2 isoforms in the rat tail artery.
2019 Feb Toxicology Critical role of Cav3.2 T-type calcium channels in the peripheral neuropathy induced by bortezomib, a proteasome-inhibiting chemotherapeutic agent, in mice.
2019 Mar Biochim Biophys Acta Biom... Receptor- and store-operated mechanisms of calcium entry during the nanosecond electric pulse-induced cellular response.
2019 Biomed Pharmacother Polysaccharides from Portulaca oleracea L. regulated insulin secretion in INS-1 cells through voltage-gated Na+ channel.
2019 Biomed Pharmacother Ivabradine possesses anticonvulsant and neuroprotective action in mice.
2019 Biomed Pharmacother Endothelium-dependent and endothelium-independent vasorelaxant effects of tiliacorinine 12'-O-acetate and mechanisms on isolated rat aorta.
2019 Biomed Pharmacother Effects of nimodipine, vinpocetine and their combination on isoproterenol-induced myocardial infarction in rats.
2019 J Plant Physiol Orchestration of Cu-Zn SOD and class III peroxidase with upstream interplay between NADPH oxidase and PM H+-ATPase mediates root growth in Vigna radiata (L.) Wilczek.
2019 Andrologia The methanolic extract of Guibourtia tessmannii (caesalpiniaceae) and selenium modulate cytosolic calcium accumulation, apoptosis and oxidative stress in R2C tumour Leydig cells: Involvement of TRPV1 channels.
2019 Feb Eur J Pharmacol Arrhythmogenic β-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII.
2018 Dec Cardiovasc Toxicol Vildagliptin, an Anti-diabetic Drug of the DPP-4 Inhibitor, Induces Vasodilation via Kv Channel and SERCA Pump Activation in Aortic Smooth Muscle.
2019 Feb J Vet Med Sci Involvement of transient receptor potential melastatin 4 channels in the resting membrane potential setting and cholinergic contractile responses in mouse detrusor and ileal smooth muscles.
2019 J Comp Physiol B Mechanisms of Ca2+ uptake in freshwater and seawater-acclimated killifish, Fundulus heteroclitus, and their response to acute salinity transfer.
2019 Jan ACS Chem Neurosci CGRPergic Nerve TRPA1 Channels Contribute to Epigallocatechin Gallate-Induced Neurogenic Vasodilation.
2019 Clin Toxicol (Phila) A 10-year review of single medication double-dose ingestions in the nation's largest poison control system.
2018 Front Pharmacol TRPM8 Activation via 3-Iodothyronamine Blunts VEGF-Induced Transactivation of TRPV1 in Human Uveal Melanoma Cells.
2018 Nov Molecules 8-Oxo-9-Dihydromakomakine Isolated from iAristotelia chilensisi Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx.
2018 Nov Phytomedicine Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum (Phil) V.A Funk (Compositae) on rats.