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Recent literature: Ion channel blocker
Date Journal Article title
2019 Apr Sci Rep In vivo synaptic activity-independent co-uptakes of amyloid β1-42 and Zn2+ into dentate granule cells in the normal brain.
2019 Apr Cardiol Rev Sudden Cardiac Death in Brugada Syndrome.
2019 Apr Br J Pharmacol A photoswitchable GABA receptor channel blocker.
2019 PLoS One MEK12 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after arachnoid haemorrhage in rats.
2019 Mar J Biol Chem A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.
2019 Apr Langmuir Effects of Amiloride, an Ion Channel Blocker, on Alamethicin Pore Formation in Negatively Charged, Gold-Supported, Phospholipid Bilayers: A Molecular View.
2019 Mar Neuropharmacology Identification of potassium channel proteins Kv7.27.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1.
2019 May Bioorg Med Chem Lett Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents.
2019 Exp Eye Res Effects of amantadine on corneal endothelium.
2019 Feb Cancers (Basel) Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect.
2018 Chin J Cancer Res Voltage-gated K+ channels promote BT-474 breast cancer cell migration.
2019 Mar ChemMedChem Discovery of N-Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel NaV 1.2-Subtype-Selective Inhibitors.
2019 Mol Med Rep Participation of the AngIITRPC6NFAT axis in the pathogenesis of podocyte injury in rats with type 2 diabetes.
2019 Jan Am J Cardiovasc Drugs Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.
2018 Front Physiol Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.
2019 Biomed Pharmacother The antiarrhythmic actions of bisaramil and penticainide result from mixed cardiac ion channel blockade.
2019 Int J Toxicol A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
2019 Feb Neuroscience Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats.
2019 J Mol Graph Model Molecular basis of Tityus stigmurus alpha toxin and potassium channel kV1.2 interactions.
2019 J Plant Physiol Orchestration of Cu-Zn SOD and class III peroxidase with upstream interplay between NADPH oxidase and PM H+-ATPase mediates root growth in Vigna radiata (L.) Wilczek.
2018 Dec Curr Biol Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.
2019 J Comp Physiol B Mechanisms of Ca2+ uptake in freshwater and seawater-acclimated killifish, Fundulus heteroclitus, and their response to acute salinity transfer.
2018 Nov Int J Mol Sci Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [Cl-]i Decrease in Ciliated Human Nasal Epithelial Cells.
2019 Mar Neuropharmacology Molecular basis involved in the blocking effect of antidepressant metergoline on C-type inactivation of Kv1.4 channel.
2018 Nov Acta Biochim Pol Aquaporins in human platelets: intracellular localization and possible role in granule and lysosome secretion.
2018 Dec Chem Res Toxicol Fluorescence-Based High Throughput Screening Technologies for Natural Chloride Ion Channel Blockers.
2019 Clin Pharmacol Ther Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.
2019 Mar J Ethnopharmacol Effect of apigenin isolated from Aster yomena against Candida albicans: apigenin-triggered apoptotic pathway regulated by mitochondrial calcium signaling.
2019 Biosci Biotechnol Biochem Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3.
2019 J Physiol ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain.
2018 Oct Molecules NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency.
2018 Oct Cochrane Database Syst Rev Drugs for preventing red blood cell dehydration in people with sickle cell disease.
2019 Arch Toxicol Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish.
2018 Gen Physiol Biophys Role of protein kinase C, PI3 kinase, tyrosine kinases, NO-synthase, KATP channels and MPT pore in the signaling pathway of the cardioprotective effect of chronic continuous hypoxia.
2018 Adv Exp Med Biol Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms.
2018 Calcium Entry Channels in... Determining the Crystal Structure of TRPV6
2018 Front Plant Sci Hydrogen Sulfide Mediates K+ and Na+ Homeostasis in the Roots of Salt-Resistant and Salt-Sensitive Poplar Species Subjected to NaCl Stress.
2018 Dec Am J Physiol Cell Physiol Inhibitory effects of openers of large-conductance Ca2+-activated K+ channels on agonist-induced phasic contractions in rabbit and mouse bronchial smooth muscle.
2018 Neuropharmacology KV1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity.
2019 Feb Toxicol Sci Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs.
2019 Breast Cancer Res Treat T-Type voltage gated calcium channels: a target in breast cancer?
2018 Biomed Res Int All-Trans Retinoic Acid Enhances Matrix Metalloproteinase 2 Expression and Secretion in Human Myeloid Leukemia THP-1 Cells.
2018 Mol Pharmacol Activation of iCaenorhabditis elegansi Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium.
2018 Aug Int J Mol Sci Calcium Ion Channels: Roles in Infection and Sepsis Mechanisms of Calcium Channel Blocker Benefits in Immunocompromised Patients at Risk for Infection.
2018 J Pharmacol Sci Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.
2018 Sep Neuron Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
2018 Sep Neuropharmacology 7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1GluN2 and GluN1GluN3 NMDA receptors with neuroprotective activity in vivo.
2018 Br J Pharmacol Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine.
2018 Nov Clin Cancer Res SK3 Gene Polymorphism Is Associated with Taxane Neurotoxicity and Cell Calcium Homeostasis.
2018 Jun Invest Ophthalmol Vis Sci D-cis-Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo.
2018 Nov J Infect Dis In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus.
2018 Jul AAPS J Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine.
2018 Sep J Vet Med Sci Possible antagonistic effects of the TRPC4 channel blocker ML204 on M2 and M3 muscarinic receptors in mouse ileal and detrusor smooth muscles and atrial myocardium.
2018 Front Physiol Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility.
2018 Aug J Biol Chem Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor.
2018 Nov Behav Brain Res Mechanism of nitric oxide and acid-sensing ion channel 1a modulation of panic-like behaviour in the dorsal periaqueductal grey of the mouse.
2018 PLoS One Influenza D virus M2 protein exhibits ion channel activity in Xenopus laevis oocytes.
2018 Comp Biochem Physiol A Mo... Assessing the role of the acid-sensing ion channel ASIC4b in sodium uptake by larval zebrafish.
2018 J Dent Res Defective NaCl Reabsorption in Salivary Glands of Eda-Null X-LHED Mice.
2018 Jun J Chem Phys Strontium and barium in aqueous solution and a potassium channel binding site.
2018 Aug J Gen Physiol Tracking the sarcoplasmic reticulum membrane voltage in muscle with a FRET biosensor.
2018 Pestic Biochem Physiol The immediate influence of deltamethrin on ion transport through rabbit skin. An in vitro study.
2018 Physiol Rep Diltiazem improves contractile properties of skeletal muscle in dysferlin-deficient BLAJ mice, but does not reduce contraction-induced muscle damage.
2018 Mol Pharmacol Identification of WB4101, an iαi1-Adrenoceptor Antagonist, as a Sodium Channel Blocker.
2018 Jul Brain De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene.
2018 Front Cell Neurosci Probenecid Disrupts a Novel Pannexin 1-Collapsin Response Mediator Protein 2 Interaction and Increases Microtubule Stability.
2018 Oncol Lett Expression of KATP channels in human cervical cancer: Potential tools for diagnosis and therapy.
2018 Cell Mol Neurobiol Curcumin Modulates the NMDA Receptor Subunit Composition Through a Mechanism Involving CaMKII and SerThr Protein Phosphatases.
2018 May Nat Commun Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3.
2018 Jul Endocrinology Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats.
2018 Jul Neuropharmacology Effects of Mg2+ on recovery of NMDA receptors from inhibition by memantine and ketamine reveal properties of a second site.
2018 Toxicon Synthesis, folding, structure and activity of a predicted peptide from the sea anemone Oulactis sp. with an ShKT fold.
2018 PLoS One Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone.
2018 Jul Bioorg Med Chem Lett Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6).
2018 Cell Calcium The effects of mitochondrial inhibitors on Ca2+ signalling and electrical conductances required for pacemaking in interstitial cells of Cajal in the mouse small intestine.