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Recent literature: Ion channel blocker
Date Journal Article title
2019 Jun J Pharmacol Toxicol Methods Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp.
2019 Jun Eur J Pharmacol Evidence for TRPV4 channel induced skin vasodilatation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans.
2019 Jun Fundam Clin Pharmacol AR-C 118925XX stimulates cation influx in bEND.3 endothelial cells.
2019 Jun Arch Toxicol Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia).
2019 Jun Eur J Pharmacol Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells.
2019 Jun Pain A randomised, double blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial.
2019 Adv Exp Med Biol Excitation-Contraction Coupling in Ureteric Smooth Muscle: Mechanisms Driving Ureteric Peristalsis.
2019 Jun Mol Pharmacol The L46P mutant confers a novel allosteric mechanism of resistance towards the influenza A virus M2 S31N proton channel blockers.
2019 May Chem Biol Drug Des Molecular determinants of chemical modulation of two-pore domain potassium channels.
2019 May J Chem Phys Blocker escape kinetics from a membrane channel analyzed by mapping blocker diffusive dynamics onto a two-site model.
2019 May Proc Natl Acad Sci U S A Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.
2019 J Physiol Sci Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia.
2019 May Int J Mol Sci StructureActivity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine.
2019 Jul Neuropharmacology A loss-of-function mutation of an inhibitory zinc- and proton-binding site reduces channel blocker potency in the glycine receptor.
2019 May J Am Chem Soc Rhodopsin-Like Ionic Gate Fabricated with Graphene Oxide and Isomeric DNA Switch for Efficient Photocontrol of Ion Transport.
2019 May Food Funct Piperine-mediated pression of voltage-dependent Ca2+ influx and glutamate release in rat hippocampal nerve terminals involves 5HT1A receptors and G protein βγ activation.
2019 J Physiol Involvement of the epithelial sodium channel in initiation of mechanically evoked swallows in anaesthetized rats.
2019 Basic Clin Neurosci Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal Ca2+ Spikes: A Possible Action on Ca2+-Dependent Dependent K+ Channels.
2019 Apr Sci Rep In vivo synaptic activity-independent co-uptakes of amyloid β1-42 and Zn2+ into dentate granule cells in the normal brain.
2019 Apr Cardiol Rev Sudden Cardiac Death in Brugada Syndrome.
2019 Apr Br J Pharmacol A photoswitchable GABA receptor channel blocker.
2019 PLoS One MEK12 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after arachnoid haemorrhage in rats.
2019 May J Biol Chem A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.
2019 Apr Langmuir Effects of Amiloride, an Ion Channel Blocker, on Alamethicin Pore Formation in Negatively Charged, Gold-Supported, Phospholipid Bilayers: A Molecular View.
2019 Mar Neuropharmacology Identification of potassium channel proteins Kv7.27.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1.
2019 May Bioorg Med Chem Lett Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents.
2019 Exp Eye Res Effects of amantadine on corneal endothelium.
2019 Feb Cancers (Basel) Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect.
2018 Chin J Cancer Res Voltage-gated K+ channels promote BT-474 breast cancer cell migration.
2019 Mar ChemMedChem Discovery of N-Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel NaV 1.2-Subtype-Selective Inhibitors.
2019 Mol Med Rep Participation of the AngIITRPC6NFAT axis in the pathogenesis of podocyte injury in rats with type 2 diabetes.
2019 Am J Cardiovasc Drugs Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.
2018 Front Physiol Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.
2019 Biomed Pharmacother The antiarrhythmic actions of bisaramil and penticainide result from mixed cardiac ion channel blockade.
2019 Int J Toxicol A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
2019 Ultrason Sonochem Ultrasonication-assisted synthesis of sphere-like strontium cerate nanoparticles (SrCeO3 NPs) for the selective electrochemical detection of calcium channel antagonists nifedipine.
2019 Feb Neuroscience Inhibition of Nerve Growth Factor Signaling Alleviates Repeated Dural Stimulation-induced Hyperalgesia in Rats.
2019 J Mol Graph Model Molecular basis of Tityus stigmurus alpha toxin and potassium channel kV1.2 interactions.
2019 J Plant Physiol Orchestration of Cu-Zn SOD and class III peroxidase with upstream interplay between NADPH oxidase and PM H+-ATPase mediates root growth in Vigna radiata (L.) Wilczek.
2019 Feb Eur J Pharmacol Parecoxib, a selective blocker of cyclooxygenase-2, directly inhibits neuronal delayed-rectifier K+ current, M-type K+ current and Na+ current.
2018 Dec Curr Biol Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.
2019 J Comp Physiol B Mechanisms of Ca2+ uptake in freshwater and seawater-acclimated killifish, Fundulus heteroclitus, and their response to acute salinity transfer.
2018 Nov Int J Mol Sci Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [Cl-]i Decrease in Ciliated Human Nasal Epithelial Cells.
2019 Mar Neuropharmacology Molecular basis involved in the blocking effect of antidepressant metergoline on C-type inactivation of Kv1.4 channel.
2018 Nov Acta Biochim Pol Aquaporins in human platelets: intracellular localization and possible role in granule and lysosome secretion.
2018 Dec Chem Res Toxicol Fluorescence-Based High Throughput Screening Technologies for Natural Chloride Ion Channel Blockers.
2019 Clin Pharmacol Ther Assessment of Multi-Ion Channel Block in a Phase I Randomized Study Design: Results of the CiPA Phase I ECG Biomarker Validation Study.
2019 Mar J Ethnopharmacol Effect of apigenin isolated from Aster yomena against Candida albicans: apigenin-triggered apoptotic pathway regulated by mitochondrial calcium signaling.
2019 Biosci Biotechnol Biochem Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3.
2019 J Physiol ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain.
2018 Nov Biochem Biophys Res Commun Oxidant-induced increase in norepinephrine secretion from PC12 cells is dependent on TRPM8 channel-mediated intracellular calcium elevation.
2019 Amino Acids Benzenesulfonamides act as open-channel blockers on KV3.1 potassium channel.
2018 Oct Molecules NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency.
2018 Oct Cochrane Database Syst Rev Drugs for preventing red blood cell dehydration in people with sickle cell disease.
2019 Arch Toxicol Novel neurotoxic peptides from Protopalythoa variabilis virtually interact with voltage-gated sodium channel and display anti-epilepsy and neuroprotective activities in zebrafish.
2018 Gen Physiol Biophys Role of protein kinase C, PI3 kinase, tyrosine kinases, NO-synthase, KATP channels and MPT pore in the signaling pathway of the cardioprotective effect of chronic continuous hypoxia.
2018 Plant Signal Behav An interconnection between tip-focused Ca2+ and anion homeostasis controls pollen tube growth.
2018 Adv Exp Med Biol Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms.
2018 Calcium Entry Channels in... Determining the Crystal Structure of TRPV6
2018 Front Plant Sci Hydrogen Sulfide Mediates K+ and Na+ Homeostasis in the Roots of Salt-Resistant and Salt-Sensitive Poplar Species Subjected to NaCl Stress.
2018 Dec Am J Physiol Cell Physiol Inhibitory effects of openers of large-conductance Ca2+-activated K+ channels on agonist-induced phasic contractions in rabbit and mouse bronchial smooth muscle.
2018 Neuropharmacology KV1.2 channel-specific blocker from Mesobuthus eupeus scorpion venom: Structural basis of selectivity.
2019 Feb Toxicol Sci Sex-Related Differences in Drug-Induced QT Prolongation and Torsades de Pointes: A New Model System with Human iPSC-CMs.
2019 Breast Cancer Res Treat T-Type voltage gated calcium channels: a target in breast cancer?
2018 Biomed Res Int All-Trans Retinoic Acid Enhances Matrix Metalloproteinase 2 Expression and Secretion in Human Myeloid Leukemia THP-1 Cells.
2018 Mol Pharmacol Activation of iCaenorhabditis elegansi Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium.
2018 Aug Int J Mol Sci Calcium Ion Channels: Roles in Infection and Sepsis Mechanisms of Calcium Channel Blocker Benefits in Immunocompromised Patients at Risk for Infection.
2018 J Pharmacol Sci Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.
2018 Sep Neuron Mechanisms of Channel Block in Calcium-Permeable AMPA Receptors.
2018 Sep Neuropharmacology 7-Methoxyderivative of tacrine is a 'foot-in-the-door' open-channel blocker of GluN1GluN2 and GluN1GluN3 NMDA receptors with neuroprotective activity in vivo.
2018 Br J Pharmacol Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine.
2018 Nov Clin Cancer Res SK3 Gene Polymorphism Is Associated with Taxane Neurotoxicity and Cell Calcium Homeostasis.
2018 Jun Invest Ophthalmol Vis Sci D-cis-Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo.
2018 Nov J Infect Dis In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus.
2018 Jul AAPS J Virtual Thorough QT (TQT) Trial-Extrapolation of In Vitro Cardiac Safety Data to In Vivo Situation Using Multi-Scale Physiologically Based Ventricular Cell-wall Model Exemplified with Tolterodine and Fesoterodine.