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Recent literature: Ion channel blocker
Date Journal Article title
2019 Mini Rev Med Chem 1,4-Dihydropyridine: A Dependable Heterocyclic Ring with the Promising and the Most Anticipable Therapeutic Effects.
2019 Nov J Headache Pain Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene.
2019 Nov Mol Pharmacol The IKs ion channel activator, mefenamic acid, requires KCNE1 and modulates channel gating in a unit-dependent manner.
2019 JACC Basic Transl Sci How to Boost Efficacy of a Sodium Channel Blocker: The Devil Is in the Details.
2019 Nov CNS Neurol Disord Drug Ta... Madecassic acid reduces fast transient potassium channels and promotes neurite elongation in hippocampal CA1 neurons.
2019 Nov ACS Chem Neurosci The natural flavonoid Naringenin elicits analgesia through inhibition of NaV1.8 voltage-gated sodium channels.
2019 Nov eNeuro Impaired reliability and precision of spiking in adults but not juveniles in a mouse model of Fragile X Syndrome.
2019 Nov Comp Biochem Physiol C To... Thymol provokes burst of action potentials in neurons of snail Caucasotachea atrolabiata.
2019 Nov Am J Physiol Heart Circ P... ASIC1a plays a key role in evoking the metabolic component of the exercise pressor reflex in rats.
2019 Oct Sci Rep Herbal components of Japanese Kampo medicines exert laxative actions in colonic epithelium cells via activation of BK and CFTR channels.
2019 Oct J Clin Invest β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.
2012 LiverTox: Clinical and Re... Calcium Channel Blockers
2019 Oct Peptides ImKTx96, a peptide blocker of the Kv1.2 ion channel from the venom of the scorpion Isometrus maculates.
2019 Oct Proc Inst Mech Eng H Simulating the effect of sodium channel blockage on cardiac electromechanics.
2019 Oct J Physiol Synaptic cleft microenvironment influences potassium permeation and synaptic transmission in hair cells surrounded by calyx afferents in the turtle.
2019 CNS Drugs Effects of Fampridine in People with Multiple Sclerosis: A Systematic Review and Meta-analysis.
2019 Oct Elife β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons.
2019 J Cancer The voltage-gated sodium channel Nav1.7 associated with endometrial cancer.
2019 Nov Biophys J Exploring the Nature of Cationic Blocker Recognition by the Anthrax Toxin Channel.
2019 Oct J Med Genet Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia.
2019 Sep J Biol Chem Protein Surface Topography as a tool to enhance the selective activity of a potassium channel blocker.
2019 Nov J Biol Chem A Na+ leak channel cloned from iTrichoplax adhaerensi extends extracellular pH and Ca2+ sensing for the DEGENaC family close to the base of Metazoa.
2019 Oct Acc Chem Res Activity-Based Sensing Methods for Monitoring the Reactive Carbon Species Carbon Monoxide and Formaldehyde in Living Systems.
2019 Sep Sci Rep Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration.
2019 Aug Microcirculation Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX.
2019 Aug Oncology Epidermal Growth Factor Potentiates Migration of MDA-MB 231 Breast Cancer Cells by Increasing NaV1.5 Channel Expression.
2019 Aug Int J Mol Sci Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening.
2019 Aug Biomolecules Accumulation of Amyloid Beta (Aβ) Peptide on Blood Vessel Walls in the Damaged Brain after Transient Middle Cerebral Artery Occlusion.
2019 Aug JCI Insight ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity.
2019 Mol Pharmacol Structural Basis for Diltiazem Block of a Voltage-Gated Ca2+ Channel.
2019 Aug J Neurochem NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.
2019 Cell Biochem Funct Different properties between spontaneous and volume-activated chloride currents in human nasopharyngeal carcinoma and its normal counterpart cells.
2019 Jul IEEE Trans Biomed Eng Non-contact High-frequency Ultrasound Microbeam Stimulation: A Novel Finding and Potential Causes of Cell Responses.
2019 J Comp Physiol B Ocean acidification: synergistic inhibitory effects of protons and heavy metals on 45Ca uptake by lobster branchiostegite membrane vesicles.
2019 Eur J Pain Thin-fibre receptors expressing acid-sensing ion channel 3 contribute to muscular mechanical hypersensitivity after exercise.
2019 Nov - J Pharmacol Toxicol Methods Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp.
2019 Sep Eur J Pharmacol Evidence for TRPV4 channel induced skin vasodilatation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans.
2019 Jul Dis Model Mech Genetic variation in iGNB5i causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (iIi K,ACh).
2019 Fundam Clin Pharmacol ARC 118925XX stimulates cation influx in bEND.3 endothelial cells.
2019 Arch Toxicol Combined transcriptomic and proteomic analysis reveals a diversity of venom-related and toxin-like peptides expressed in the mat anemone Zoanthus natalensis (Cnidaria, Hexacorallia).
2019 Sep Eur J Pharmacol Hydrogen sulfide inhibited L-type calcium channels (CaV1.2) via up-regulation of the channel sulfhydration in vascular smooth muscle cells.
2019 Pain A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial.
2019 Adv Exp Med Biol Excitation-Contraction Coupling in Ureteric Smooth Muscle: Mechanisms Driving Ureteric Peristalsis.
2019 Chem Biol Drug Des Molecular determinants of chemical modulation of two-pore domain potassium channels.
2019 May J Chem Phys Blocker escape kinetics from a membrane channel analyzed by mapping blocker diffusive dynamics onto a two-site model.
2019 May Proc Natl Acad Sci U S A Adrenergic receptor antagonism induces neuroprotection and facilitates recovery from acute ischemic stroke.
2019 J Physiol Sci Overexpression of the HCN2 channel increases the arrhythmogenicity induced by hypokalemia.
2019 Chemosphere Influence of salinity and pH on bioconcentration of ionizable pharmaceuticals by the gulf killifish, Fundulus grandis.
2019 May Int J Mol Sci StructureActivity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine.
2019 Jul Neuropharmacology A loss-of-function mutation of an inhibitory zinc- and proton-binding site reduces channel blocker potency in the glycine receptor.
2019 May J Am Chem Soc Rhodopsin-Like Ionic Gate Fabricated with Graphene Oxide and Isomeric DNA Switch for Efficient Photocontrol of Ion Transport.
2019 May Food Funct Piperine-mediated pression of voltage-dependent Ca2+ influx and glutamate release in rat hippocampal nerve terminals involves 5HT1A receptors and G protein βγ activation.
2019 J Physiol Involvement of the epithelial sodium channel in initiation of mechanically evoked swallows in anaesthetized rats.
2019 Basic Clin Neurosci Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal Ca2+ Spikes: A Possible Action on Ca2+-Dependent Dependent K+ Channels.
2019 Apr Int J Mol Sci Extracellular l-arginine Enhances Relaxations Induced by Opening of Calcium-Activated SKCa Channels in Porcine Retinal Arteriole.
2019 Apr Sci Rep In vivo synaptic activity-independent co-uptakes of amyloid β1-42 and Zn2+ into dentate granule cells in the normal brain.
2019 Apr Cardiol Rev Sudden Cardiac Death in Brugada Syndrome.
2019 Br J Pharmacol A photoswitchable GABA receptor channel blocker.
2019 PLoS One MEK12 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after arachnoid haemorrhage in rats.
2019 May J Biol Chem A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor.
2019 Apr Langmuir Effects of Amiloride, an Ion Channel Blocker, on Alamethicin Pore Formation in Negatively Charged, Gold-Supported, Phospholipid Bilayers: A Molecular View.
2019 Mar Neuropharmacology Identification of potassium channel proteins Kv7.27.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1.
2019 Jun Eur J Pharmacol Comparative study of carvedilol and quinidine for inhibiting hKv4.3 channel stably expressed in HEK 293 cells.
2019 May Bioorg Med Chem Lett Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents.
2019 Exp Eye Res Effects of amantadine on corneal endothelium.
2019 Feb Cancers (Basel) Zoledronic Acid Modulation of TRPV1 Channel Currents in Osteoblast Cell Line and Native Rat and Mouse Bone Marrow-Derived Osteoblasts: Cell Proliferation and Mineralization Effect.
2018 Chin J Cancer Res Voltage-gated K+ channels promote BT-474 breast cancer cell migration.
2019 Mar ChemMedChem Discovery of N-Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel NaV 1.2-Subtype-Selective Inhibitors.
2019 Mol Med Rep Participation of the AngIITRPC6NFAT axis in the pathogenesis of podocyte injury in rats with type 2 diabetes.
2019 Am J Cardiovasc Drugs Clinical Pharmacokinetics, Safety, and Tolerability of a Novel, First-in-Class TRPV4 Ion Channel Inhibitor, GSK2798745, in Healthy and Heart Failure Subjects.
2018 Front Physiol Potential Arrhythmogenic Role of TRPC Channels and Store-Operated Calcium Entry Mechanism in Mouse Ventricular Myocytes.
2019 Pharmacol Res Pharmacogenetics of myotonic hNav1.4 sodium channel variants situated near the fast inactivation gate.
2019 Biomed Pharmacother The antiarrhythmic actions of bisaramil and penticainide result from mixed cardiac ion channel blockade.
2019 Int J Toxicol A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.
2019 Ultrason Sonochem Ultrasonication-assisted synthesis of sphere-like strontium cerate nanoparticles (SrCeO3 NPs) for the selective electrochemical detection of calcium channel antagonists nifedipine.