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Recent literature: PDE5 inhibitor
Date Journal Article title
2020 JACC Basic Transl Sci Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy.
2020 Mar Mol Cell Biochem Chronic inhibition of phosphodiesterase 5 with tadalafil affords cardioprotection in a mouse model of metabolic syndrome: role of nitric oxide.
2020 Mar Biomol Ther (Seoul) The Altered Signaling on EFS-Induced Colon Contractility in Diabetic Rats.
2020 Feb Bone Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: Evidence of osteoanabolic and osteoangiogenic effects of the drugs.
2020 Feb Synapse Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation.
2020 Jan J Transl Med Phase I and registry study of autologous bone marrow concentrate evaluated in PDE5 inhibitor refractory erectile dysfunction.
2020 Jan Carcinogenesis Sildenafil triggers tumor lethality through altered expression of HSP90 and degradation of PKD2.
2019 Transl Androl Urol An open-label, single-arm pilot study to evaluate the efficacy of daily low dose tadalafil on depression in patients with erectile dysfunction.
2019 Ther Adv Chronic Dis Sildenafil improves exercise capacity in patients with cystic fibrosis: a proof-of-concept clinical trial.
2020 Jan StatPearls PDE5 Inhibitor
2019 J Physiol Pharmacol Cyclic nucleotide-dependent relaxation in human umbilical vessels.
2019 Nov J Matern Fetal Neonatal Med Tadalafil treatment for preeclampsia (medication in preeclampsia; MIE): a multicenter phase II clinical trial.
2019 Nihon Yakurigaku Zasshi [Most recent findings of curative drugs for lower urinary tract symptoms in clinical practice].
2020 Jan Biochem Biophys Res Commun Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.
2020 J Psychopharmacol Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking.
2020 Vascul Pharmacol Sildenafil reduces aortic endothelial dysfunction and structural damage in spontaneously hypertensive rats: Role of NO, NADPH and COX-1 pathways.
2020 Cell Signal Differentiation of human neuroblastoma cell line IMR-32 by sildenafil and its newly discovered analogue IS00384.
2019 Int J Appl Basic Med Res Avanafil Inhibits the Contractility of the Isolated Caprine Detrusor Muscle.
2019 Oct BMC Urol A phosphodiesterase 5 inhibitor, tadalafil, presses stromal predominance and inflammation in a rat model of nonbacterial prostatitis.
2012 LiverTox: Clinical and Re... Vardenafil
2012 LiverTox: Clinical and Re... Sildenafil
2012 LiverTox: Clinical and Re... Avanafil
2012 LiverTox: Clinical and Re... Tadalafil
2019 Oct BMC Urol Adherence and barriers to penile rehabilitation over 2 years following radical prostatectomy.
2019 Transl Androl Urol Erectile dysfunction management after failed phosphodiesterase-5-inhibitor trial: a cost-effectiveness analysis.
2019 Nov Eur J Pharmacol L-cysteinehydrogen sulfide pathway induces cGMP-dependent relaxation of corpus cavernosum and penile arteries from patients with erectile dysfunction and improves arterial vasodilation induced by PDE5 inhibition.
2020 J Card Fail P66Shc Deletion Ameliorates Oxidative Stress and Cardiac Dysfunction in Pressure Overload-Induced Heart Failure.
2019 Food Chem Toxicol Phosphodiesterase inhibitors say NO to Alzheimer's disease.
2020 Eur J Health Econ A cost-utility analysis of phosphodiesterase type 5 inhibitors in the treatment of erectile dysfunction.
2019 Vet J Pulmonary hypertension secondary to respiratory disease andor hypoxia in dogs: Clinical features, diagnostic testing and survival.
2019 Aug Med Sci (Basel) Erectile Dysfunction: A Primer for in Office Management.
2019 J Sex Med An Evaluation of a Clinical Care Pathway for the Management of Men With Nonorganic Erectile Dysfunction.
2020 Andrology Regulation of PDE5 expression in normal prostate, benign prostatic hyperplasia, and adenocarcinoma.
2019 Aug J Clin Med Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis.
2019 Aug Clin Psychopharmacol Neur... The Effect of Daily Low Dose Tadalafil on Cerebral Perfusion and Cognition in Patients with Erectile Dysfunction and Mild Cognitive Impairment.
2019 Nov Brain Res Inhibition of PDE5 attenuates streptozotocin-induced neuroinflammation and tau hyperphosphorylation in a streptozotocin-treated rat model.
2019 Sep Toxicol Appl Pharmacol Tadalafil restores long-term memory and synaptic plasticity in mice with hepatic encephalopathy.
2019 Redox Biol Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention.
2019 Jun Int J Mol Sci Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes.
2019 Front Immunol The Reversal of Immune Exclusion Mediated by Tadalafil and an Anti-tumor Vaccine Also Induces PDL1 Upregulation in Recurrent Head and Neck Squamous Cell Carcinoma: Interim Analysis of a Phase I Clinical Trial.
2019 Jun J Clin Med Safety Evaluation of Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER): Results from the Phase II Trial.
2019 EBioMedicine Placental effects and transfer of sildenafil in healthy and preeclamptic conditions.
2019 Aug Eur J Pharmacol Rottlerin is a pan phosphodiesterase inhibitor and can induce neurodifferentiation in IMR-32 human neuroblastoma cells.
2019 Pharmacol Rep Sildenafil corrects the increased contractility of rat detrusor muscle induced by alprostadil in vitro.
2019 Sep Eur J Med Chem Design and synthesis of 3-aminophthalazine derivatives and structural analogues as PDE5 inhibitors: anti-allodynic effect against neuropathic pain in a mouse model.
2019 J Alzheimers Dis A Pilot Study of Changes in Medial Temporal Lobe Fractional Amplitude of Low Frequency Fluctuations after Sildenafil Administration in Patients with Alzheimer's Disease.
2019 Acta Otolaryngol Endolymphatic hydrops induced by different mechanisms responds differentially to spironolactone: a rationale for understanding the diversity of treatment responses in hydropic inner ear disease.
2019 Jun J Chem Inf Model Application of Free Energy Perturbation (FEP+) to Understanding Ligand Selectivity: A Case Study to Assess Selectivity Between Pairs of Phosphodiesterases (PDE's).
2019 Jun J Matern Fetal Neonatal Med Phase-1 clinical study of tadalafil administered for selective fetal growth restriction in twin pregnancy.
2019 Gastroenterology Use of Phosphodiesterase 5 Inhibitors Is Associated With Lower Risk of Colorectal Cancer in Men With Benign Colorectal Neoplasms.
2019 Jul J Clin Endocrinol Metab PDE5 Inhibition Stimulates Tie2-Expressing Monocytes and Angiopoietin-1 Restoring Angiogenic Homeostasis in Diabetes.
2019 Aug J Pharm Biomed Anal Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatographyquadrupole time-of-flight mass spectrometry.
2019 May Sci Rep Effect of a phosphodiesterase-5A (PDE5A) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension.
2019 Pharmacol Rep Antioxidant effect of sildenafil: Potential hepatoprotection via differential expression of mitochondrial proteins in apolipoprotein E knockout mice.
2019 Rev Assoc Med Bras (1992) Positive outcomes of phosphodiesterase type 5 inhibitor on histopathologic and biochemical changes induced by ureteral obstruction.
2019 Apr Exp Clin Endocrinol Diabetes Mirabegron, A Selective β3-Adrenoceptor Agonist Causes an Improvement in Erectile Dysfunction in Diabetic Rats.
2019 Jul Biomol Ther (Seoul) Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells.
2019 Jun J Appl Physiol (1985) Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.
2019 May Life Sci Chronic administration of sildenafil improves endothelial function in spontaneously hypertensive rats by decreasing COX-2 expression and oxidative stress.
2019 J Sex Med Comparison of the Effects of Tadalafil and α1-Adrenoceptor Antagonists on Spontaneous Seminal Emission and Electrical Field Stimulation-Induced Seminal Vesicle Contraction in Rats.
2019 Mar Sci Rep Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration.
2019 ASN Neuro Sildenafil Inhibits Myelin Expression and Myelination of Oligodendroglial Precursor Cells.
2019 Biosci Biotechnol Biochem Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMPcGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension.
2019 Int J Endocrinol PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes.
2019 J Sex Med Ultrastructural Study of Clitoral Cavernous Tissue and Clitoral Blood Flow From Type 1 Diabetic Premenopausal Women on Phosphodiesterase-5 Inhibitor.
2019 J Sex Med Potential for Long-Term Benefit of Cognitive Behavioral Therapy as an Adjunct Treatment for Men with Erectile Dysfunction.
2019 Br J Pharmacol Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.
2018 Front Oncol Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.
2019 Jan Cochrane Database Syst Rev Phosphodiesterase 5 inhibitors for pulmonary hypertension.
2019 Int J Impot Res Carotid artery intima-media thickness can predict the response of patients with erectile dysfunction to phosphodiesterase 5 inhibitors.
2018 J Physiol Pharmacol Effects of phosphodiesterase 5 inhibitor sildenafil on the respiratory parameters, inflammation and apoptosis in a saline lavage-induced model of acute lung injury.
2019 Cardiovasc Drugs Ther Two Birds with One Stone: Regular Use of PDE5 Inhibitors for Treating Male Patients with Erectile Dysfunction and Cardiovascular Diseases.
2019 Exp Ther Med PDE5 inhibitor protects the mitochondrial function of hypoxic myocardial cells.
2019 BJU Int Sildenafil, a phosphodiesterase type 5 inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice.
2019 Jan J Phys Chem B Catalytic Domains of Phosphodiesterase 5, 6, and 56 Chimera Display Differential Dynamics and Ligand Dissociation Energy Barriers.