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Recent literature: PDE5 inhibitor
Date Journal Article title
2019 Jan Pharmacol Rep Antioxidant effect of sildenafil: Potential hepatoprotection via differential expression of mitochondrial proteins in apolipoprotein E knockout mice.
2019 Rev Assoc Med Bras (1992) Positive outcomes of phosphodiesterase type 5 inhibitor on histopathologic and biochemical changes induced by ureteral obstruction.
2019 Apr Exp Clin Endocrinol Diabetes Mirabegron, A Selective β3-Adrenoceptor Agonist Causes an Improvement in Erectile Dysfunction in Diabetic Rats.
2019 Apr Biomol Ther (Seoul) Udenafil Induces the Hair Growth Effect of Adipose-Derived Stem Cells.
2019 Apr J Appl Physiol (1985) Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.
2019 Mar Life Sci Chronic administration of sildenafil improves endothelial function in spontaneously hypertensive rats by decreasing COX-2 expression and oxidative stress.
2019 Mar J Sex Med Comparison of the Effects of Tadalafil and α1-Adrenoceptor Antagonists on Spontaneous Seminal Emission and Electrical Field Stimulation-Induced Seminal Vesicle Contraction in Rats.
2019 Mar Sci Rep Vascular Response to Sildenafil Citrate in Aging and Age-Related Macular Degeneration.
2019 ASN Neuro Sildenafil Inhibits Myelin Expression and Myelination of Oligodendroglial Precursor Cells.
2019 Mar Biosci Biotechnol Biochem Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMPcGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension.
2019 Mar Br J Pharmacol Cyclic nucleotide signalling compartmentation by phosphodiesterases in cultured vascular smooth muscle cells.
2019 Int J Endocrinol PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes.
2019 J Sex Med Ultrastructural Study of Clitoral Cavernous Tissue and Clitoral Blood Flow From Type 1 Diabetic Premenopausal Women on Phosphodiesterase-5 Inhibitor.
2019 J Sex Med Potential for Long-Term Benefit of Cognitive Behavioral Therapy as an Adjunct Treatment for Men with Erectile Dysfunction.
2019 Br J Pharmacol Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.
2018 Front Oncol Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.
2019 Jan Cochrane Database Syst Rev Phosphodiesterase 5 inhibitors for pulmonary hypertension.
2019 Int J Impot Res Carotid artery intima-media thickness can predict the response of patients with erectile dysfunction to phosphodiesterase 5 inhibitors.
2018 J Physiol Pharmacol Effects of phosphodiesterase 5 inhibitor sildenafil on the respiratory parameters, inflammation and apoptosis in a saline lavage-induced model of acute lung injury.
2019 Cardiovasc Drugs Ther Two Birds with One Stone: Regular Use of PDE5 Inhibitors for Treating Male Patients with Erectile Dysfunction and Cardiovascular Diseases.
2019 Exp Ther Med PDE5 inhibitor protects the mitochondrial function of hypoxic myocardial cells.
2019 Jan BJU Int Sildenafil, a phosphodiesterase type 5 inhibitor, augments sphincter bursting and bladder afferent activity to enhance storage function and voiding efficiency in mice.
2019 Jan J Phys Chem B Catalytic Domains of Phosphodiesterase 5, 6, and 56 Chimera Display Differential Dynamics and Ligand Dissociation Energy Barriers.
2019 Jan J Mol Model Revisiting the halogen bonding between phosphodiesterase type 5 and its inhibitors.
2019 Prostate Phosphodiesterase type 5 inhibitor attenuates chronic ischemia-induced prostatic hyperplasia in a rat model.
2018 Dec Drug Dev Res Tadalafil: 15 years' journey in male erectile dysfunction and beyond.
2019 Feb Biochemistry Probing the Effect of Sildenafil on Progesterone and Testosterone Production by an Intracellular FRETBRET Combined Approach.
2019 Jan Bioorg Med Chem Lett Design, synthesis and evaluation of N2,N4-diaminoquinazoline based inhibitors of phosphodiesterase type 5.
2018 Nov Phytomedicine Eulophia macrobulbon extract relaxes rat isolated pulmonary artery and protects against monocrotaline-induced pulmonary arterial hypertension.
2017 Sep Pharmacoeconomic Review R...
2018 Sci Justice Isolation and characterisation of a novel sildenafil analogue adulterant, desmethylpiperazinyl propoxysildenafil, in a dietary plement.
2019 Jan Biomol Ther (Seoul) The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat.
2018 Nov J Endocrinol Invest The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence.
2019 J Hepatol Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived pressor cells in hepatocellular carcinoma.
2018 Nov N Z Med J A prospective audit of the 10-year outcomes from low dose-rate brachytherapy for early stage prostate cancer.
2018 Oct BMJ Open TADAFER II: Tadalafil treatment for fetal growth restriction - a study protocol for a multicenter randomised controlled phase II trial.
2018 Neuromuscul Disord Role of neuronal nitric oxide synthase (nNOS) in Duchenne and Becker muscular dystrophies - Still a possible treatment modality?
2018 Oct World J Mens Health No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma.
2018 Transplant Proc Pulmonary Arterial Pressure Management Based on Oral Medicine for Pediatric Living Donor Liver Transplant With Portopulmonary Hypertension.
2018 Nat Rev Rheumatol Author Correction: Major lung complications of systemic sclerosis.
2018 Nov Biochem Biophys Res Commun Novel effect of sildenafil on hair growth.
2018 Dec Am J Physiol Lung Cell Mo... Pulmonary microvascular remodeling in chronic thrombo-embolic pulmonary hypertension.
2018 Biomed Pharmacother Evaluation of the role of different neurotransmission systems in the anticonvulsant action of sildenafil in the 6 Hz-induced psychomotor seizure threshold test in mice.
2019 Neurobiol Dis Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration.
2018 Laryngoscope Sudden hearing loss after cialis (tadalafil) use: A unique case of cochlear hydrops.
2018 Sep Cancer Biol Ther Palbociclib augments Neratinib killing of tumor cells that is further enhanced by HDAC inhibition.
2018 Korean J Physiol Pharmacol The change of signaling pathway on the electrical stimulated contraction in streptozotocin-induced bladder dysfunction of rats.
2019 Respirology Pulmonary arterial hypertension in a multi-ethnic Asian population: Characteristics, survival and mortality predictors from a 14-year follow-up study.
2018 Sep J Med Chem Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension.
2018 Pulm Circ Hepatic safety of ambrisentan alone and in combination with tadalafil: a post-hoc analysis of the AMBITION trial.
2018 Aug World J Urol Objective impacts of tadalafil on storage and voiding function in male patients with benign prostatic hyperplasia: 1-year outcomes from a prospective urodynamic study.
2018 Future Sci OA Urine miR-21-5p as a potential biomarker for predicting effectiveness of tadalafil in benign prostatic hyperplasia.
2018 Int J Impot Res Combination therapy for erectile dysfunction involving a PDE5 inhibitor and alprostadil.
2018 Jul Molecules Development of Validated and Stability-Indicating LC-DAD and LC-MSMS Methods for Determination of Avanafil in Pharmaceutical Preparations and Identification of a Novel Degradation Product by LCMS-IT-TOF.
2019 World J Urol Alpha-blockers with or without phosphodiesterase type 5 inhibitor for treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: a systematic review and meta-analysis.
2018 Oct Am J Physiol Endocrinol M... Analysis of short-term treatment with the phosphodiesterase type 5 inhibitor tadalafil on long bone development in young rats.
2018 Jun Turk J Med Sci Effect of phosphodiesterase-5 inhibition on joint and muscle damage in rats with adjuvant arthritis
2018 Sex Med The Association Between Phosphodiesterase Type 5 Inhibitor Use and Risk of Non-Arteritic Anterior Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis.
2018 Br J Pharmacol The phosphodiesterase 5 inhibitor, KJH-1002, reverses a mouse model of amnesia by activating a cGMPcAMP response element binding protein pathway and decreasing oxidative damage.
2018 J Cell Physiol Chronic phosphodiesterase type 5 inhibition has beneficial effects on cutaneous adipose tissue plasticity in type 2 diabetic mice.
2018 Front Physiol HypoxiaReoxygenation of Rat Renal Arteries Impairs Vasorelaxation via Modulation of Endothelium-Independent sGCcGMPPKG Signaling.
2018 World J Urol A randomized controlled trial evaluating sildenafil citrate in relieving ureteral stent-related symptoms.
2019 ASAIO J Evaluation of Clinical Outcomes with Phosphodiesterase-5 Inhibitor Therapy for Right Ventricular Dysfunction After Left Ventricular Assist Device Implantation.
2018 May Sci Rep Transdermal water-in-oil nanocarriers of nitric oxide for triggering penile erection.
2018 May BMC Urol Longitudinal recovery patterns of penile length and the underexplored benefit of long-term phosphodiesterase-5 inhibitor use after radical prostatectomy.
2018 Hypertension Evaluation of Sildenafil and Tadalafil for Reversing Constriction of Fetal Arteries in a Human Placenta Perfusion Model.
2018 Ann Clin Transl Neurol Phosphodiesterase-5 inhibition potentiates cerebrovascular reactivity in chronic traumatic brain injury.
2018 PPAR Res PPARiγi Antagonizes Hypoxia-Induced Activation of Hepatic Stellate Cell through Cross Mediating PI3KAKT and cGMPPKG Signaling.
2018 PLoS One Synergistic interaction between a PDE5 inhibitor (sildenafil) and a new adenosine A2A receptor agonist (LASSBio-1359) improves pulmonary hypertension in rats.
2018 Jun Eur J Pharmacol 3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NOcGMP activation in rats.
2018 Jul Exp Gerontol Long-term inhibition of PDE5 ameliorates aging-induced changes in rat testis.
2018 Arch Pharm (Weinheim) Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors.
2018 Neurourol Urodyn Tadalafil attenuates hypotonicity-induced Ca2+ influx via TRPV2 and TRPV4 in primary rat bladder urothelial cell cultures.
2018 Jun Nitric Oxide Effect of ginger, Paullinia cupana, muira puama and l- citrulline, singly or in combination, on modulation of the inducible nitric oxide- NO-cGMP pathway in rat penile smooth muscle cells.
2018 Circ Heart Fail Prevention of PKG-1α Oxidation Suppresses AntihypertrophicAntifibrotic Effects From PDE5 Inhibition but not sGC Stimulation.