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Recent literature: Insulin sensitizer
Date Journal Article title
2020 Mar Bioorg Med Chem High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept.
2020 Mar Am J Hypertens Maternal plementation of inositols, fucoxanthin, and hydroxytyrosol in pregnant murine models of hypertension.
2020 Mar J Nat Prod Potential Antidiabetic Fumiquinazoline Alkaloids from the Marine-Derived Fungus iScedosporium apiospermumi F41-1.
2020 Feb J Diabetes Complications A novel non-PPARgamma insulin sensitizer: MLR-1023 clinicalproof-of-concept in type 2 diabetes mellitus.
2020 J Cell Mol Med Metformin upregulates mitophagy in patients with T2DM: A randomized placebo-controlled study.
2020 Jan Molecules Pharmacological Overview of the BGP-15 Chemical Agent as a New Drug Candidate for the Treatment of Symptoms of Metabolic Syndrome.
2020 Expert Opin Investig Drugs NASH (nonalcoholic steatohepatitis), diabetes, and macrovascular disease: multiple chronic conditions and a potential treatment at the metabolic root.
2020 Jan J Biomol Struct Dyn Virtual screening, molecular dynamics, density functional theory and quantitative structure activity relationship studies to design peroxisome proliferator-activated receptor-γ agonists as anti-diabetic drugs.
2020 Jan Dermatitis Isobornyl Acrylate.
2020 Feb Am J Physiol Endocrinol M... The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment.
2019 J Diabetes Res Monotherapy with Metformin versus Sulfonylureas and Risk of Cancer in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis.
2019 Exp Ther Med Functional network analysis of gene-phenotype connectivity based on pioglitazone.
2019 Diabetol Metab Syndr Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats.
2020 Metabolism Skeletal muscle adiponectin induction in obesity and exercise.
2019 Nov Hum Genomics Identification of key candidate genes and molecular pathways in white fat browning: an anti-obesity drug discovery based on computational biology.
2020 J Hepatol Insulin sensitizer MSDC-0602K in non-alcoholic steatohepatitis: A randomized, double-blind, placebo-controlled phase IIb study.
2019 Oct Curr Mol Pharmacol AdipoRon; A Novel Insulin Sensitizer in Various Complications and the Underlying Mechanisms: A Review.
2019 Oct Nat Commun The tumor pressor TMEM127 regulates insulin sensitivity in a tissue-specific manner.
2019 J Dairy Sci Fibroblast growth factor-21 (FGF21) administration to early-lactating dairy cows. I. Effects on signaling and indices of insulin action.
2019 Aug J Ovarian Res Pioglitazone presses excessive follicular development in murine preantral follicles.
2019 Sep J Agric Food Chem Comparative Study of Dietary Flavonoids with Different Structures as α-Glucosidase Inhibitors and Insulin Sensitizers.
2019 Aug J Agric Food Chem Procyanidin C1, a Component of Cinnamon Extracts, Is a Potential Insulin Sensitizer That Targets Adipocytes.
2020 Gynecol Endocrinol Long-term treatment with α-lipoic acid and myo-inositol positively affects clinical and metabolic features of polycystic ovary syndrome.
2019 Aug Nanoscale Near-infrared light activatable hydrogels for metformin delivery.
2019 Oct Behav Brain Res A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer's Disease in transgenic mice.
2019 Front Pharmacol Analysis of Patents Issued in China for Antihyperglycemic Therapies for Type 2 Diabetes Mellitus.
2019 Phytother Res Anthocyanins ameliorate palmitate-induced inflammation and insulin resistance in 3T3-L1 adipocytes.
2019 Audiol Neurootol Insulin Receptor and Glucose Transporters in the Mammalian Cochlea.
2019 Jul Life Sci Carbenoxolone enhances peripheral insulin sensitivity and GLUT4 expression in skeletal muscle of obese rats: Potential participation of UBC9 protein.
2019 Diabetol Metab Syndr Effect of rosiglitazone on inflammatory cytokines and oxidative stress after intensive insulin therapy in patients with newly diagnosed type 2 diabetes.
2019 J Nutr Biochem High fructose diet induces early mortality via autophagy factors accumulation in the rostral ventrolateral medulla as ameliorated by pioglitazone.
2019 Diabetes Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice.
2019 Jul Am J Physiol Endocrinol M... Effect of PPARγ agonist on aerobic exercise capacity in relation to body fat distribution in men with type 2 diabetes mellitus and coronary artery disease: a 1-yr randomized study.
2019 Apr Int J Mol Sci Association between Polymorphisms of iOCT1i and Metabolic Response to Metformin in Women with Polycystic Ovary Syndrome.
2019 J Chin Med Assoc Cardiovascular protective effect of pioglitazone on oxidative stress in rats with metabolic syndrome.
2019 PPAR Res Rosiglitazone, a Ligand to PPARiγi, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation.
2019 J Mol Med (Berl) MOTS-c: an equal opportunity insulin sensitizer.
2019 Contact Dermatitis N,N-dimethylacrylamide-A new sensitizer in the FreeStyle Libre glucose sensor.
2019 Redox Biol Electrophilic nitro-oleic acid reverses obesity-induced hepatic steatosis.
2019 Magn Reson Imaging MRI estimates of brown adipose tissue in children - Associations to adiposity, osteocalcin, and thigh muscle volume.
2019 J Clin Pharm Ther Scope of new formulation approaches in the repurposing of pioglitazone for the management of Alzheimer's disease.
2019 Diab Vasc Dis Res Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes.
2019 Jan - Diabetes Metab Syndr The antidiabetic and antioxidant properties of some phenolic phytochemicals: A review study.
2019 Gynecol Endocrinol Short-term effects of metformin and myo-inositol in women with polycystic ovarian syndrome (PCOS): a meta-analysis of randomized clinical trials.
2019 Environ Toxicol Pharmacol Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats.
2018 Dec Stroke Scoring System to Optimize Pioglitazone Therapy After Stroke Based on Fracture Risk.
2019 Apr Clin Cancer Res PRE-surgical Metformin In Uterine Malignancy (PREMIUM): a Multi-Center, Randomized Double-Blind, Placebo-Controlled Phase III Trial.
2019 Biomed Pharmacother A novel recombinant peptide INSR-IgG4Fc (Yiminsu) restores insulin sensitivity in experimental insulin resistance models.
2018 Dec Exp Mol Med Sodium butyrate reduces high-fat diet-induced non-alcoholic steatohepatitis through upregulation of hepatic GLP-1R expression.
2018 PLoS One A metabolome-wide characterization of the diabetic phenotype in ZDF rats and its reversal by pioglitazone.
2018 Nov BMC Vet Res Fibroblast growth factor-1 as a mediator of paracrine effects of canine adipose tissue-derived mesenchymal stem cells on in vitro-induced insulin resistance models.
2018 Adv Ther Polycystic Ovary Syndrome: Implication for Drug Metabolism on Assisted Reproductive Techniques-A Literature Review.
2018 Pharmacol Res Idebenone is a cytoprotective insulin sensitizer whose mechanism is Shc inhibition.
2018 Jul Cureus Idiopathic Hyperprolactinemia Presenting as Polycystic Ovary Syndrome in Identical Twin Sisters: A Case Report and Literature Review.
2018 J Diabetes Res Rosiglitazone Elicits an Adiponectin-Mediated Insulin-Sensitizing Action at the Adipose Tissue-Liver Axis in Otsuka Long-Evans Tokushima Fatty Rats.
2018 Dec Ecotoxicol Environ Saf Impairment of bisphenol F on the glucose metabolism of zebrafish larvae.
2019 FASEB J Dexamethasone decreases the autotaxin-lysophosphatidate-inflammatory axis in adipose tissue: implications for the metabolic syndrome and breast cancer.
2018 Nov Structure Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism.
2018 Biomed Pharmacother Ameliorative effects of indomethacin at different concentrations on endothelial insulin resistance through two distinct pathways.
2019 World J Mens Health Obesity and Erectile Dysfunction: From Bench to Clinical Implication.
2018 Diabetol Metab Syndr Association of adiponectin with cognitive function precedes overt diabetes in the Brazilian Longitudinal Study of Adult Health: ELSA.
2018 Oct J Ethnopharmacol Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS.
2018 Aug Cell Metab Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.
2018 Front Horm Res Metabolic Syndrome in Male Hypogonadism.
2018 Drug Discov Today Dual-therapy strategy for modification of adiponectin receptor signaling in aging-associated chronic diseases.
2018 Jun Biochem Biophys Res Commun ER stress attenuation by Aloe-derived polysaccharides in the protection of pancreatic β-cells from free fatty acid-induced lipotoxicity.
2018 Biomed Pharmacother Moringa concanensis Nimmo ameliorates hyperglycemia in 3T3-L1 adipocytes by upregulating PPAR-γ, CEBP-α via Akt signaling pathway and STZ-induced diabetic rats.
2018 Evid Based Complement Alt... The Effect of Sanggua Drink Extract on Insulin Resistance through the PI3KAKT Signaling Pathway.
2018 Contact Dermatitis Allergic contact dermatitis caused by isobornyl acrylate in OmniPod, an innovative tubeless insulin pump.
2018 Curr Drug Targets The Molecular Targets of Swertiamarin and its Derivatives Confer Anti- Diabetic and Anti-Hyperlipidemic Effects.
2018 May Bioorg Med Chem Lett Synthesis, biological evaluation, and molecular docking investigation of benzhydrol- and indole-based dual PPAR-γFFAR1 agonists.
2018 Mar J Ovarian Res Pioglitazone is effective for multiple phenotyepes of the Zucker fafa rat with polycystc ovary morphology and insulin resistance.
2018 Diabetes Obes Metab Rosiglitazone lowers resting and blood pressure response to exercise in men with type 2 diabetes: A 1-year randomized study.
2018 Apr J Clin Endocrinol Metab Treatment Options for Hirsutism: A Systematic Review and Network Meta-Analysis.
2018 Mar Int J Mol Sci Insulin-Sensitizer Effects of Fenugreek Seeds in Parallel with Changes in Plasma MCH Levels in Healthy Volunteers.