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Recent literature: μ-opioid receptor agonist
Date Journal Article title
2019 Apr Anesthesiology Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats.
2019 Apr Exp Clin Psychopharmacol Effects of repeated kappa-opioid receptor agonist U-50488 treatment and sequent termination on intracranial self-stimulation in male and female rats.
2019 Apr Pain Med Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.
2019 Apr Neuroscience μ-Opioid Receptor Activation Directly Modulates Intrinsically Photosensitive Retinal Ganglion Cells.
2019 Apr J Neuroinflammation Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10β-endorphin pathway.
2019 Apr Neuropsychopharmacology Effects of stimulation of mu opioid and nociceptinorphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.
2019 Apr Neuropharmacology The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward.
2019 Apr Sci Signal TRPV1 promotes opioid analgesia during inflammation.
2019 Mar Int J Mol Sci Effects of Motilin Receptor Agonists and Ghrelin in Human imotilin receptori Transgenic Mice.
2019 Apr J Med Chem Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonistδ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability.
2019 Mar Chem Biol Drug Des Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site.
2019 Apr J Med Chem Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design.
2019 Feb Br J Anaesth BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
2018 Dec Br J Anaesth The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target.
2019 Mar Alcohol Clin Exp Res Combination of clinically utilized kappa opioid receptor agonist nalfurafine with low-dose naltrexone reduces excessive alcohol drinking in male and female mice.
2019 Mar Cell Mol Life Sci Agonist-dependent development of delta opioid receptor tolerance in the colon.
2019 Mar Curr Pain Headache Rep The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects.
2019 Mar Neuropharmacology Role of agonist efficacy in exposure-induced enhancement of mu opioid reward in rats.
2019 Mar Handb Exp Pharmacol Effects of NOP-Related Ligands in Nonhuman Primates.
2019 Mar Eur J Pharmacol D2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat.
2019 Mar Neuropsychopharmacology Intranasal naloxone rapidly occupies brain mu-opioid receptors in human jects.
2019 Expert Opin Ther Targets Current strategies toward safer mu opioid receptor drugs for pain management.
2019 Pept Sci (Hoboken) Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor.
2019 Feb Neuromodulation Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat.
2019 Feb J Anal Toxicol Analysis of Acetyl Fentanyl in Postmortem Specimens by Gas Chromatography-Mass Spectrometry (GC-MS): Method Validation and Case Report.
2019 Feb Sci Rep Indispensable role of β-arrestin2 in the protection of remifentanil preconditioning against hepatic ischemic reperfusion injury.
2019 PLoS One Evaluating the pharmacological response in fluorescence microscopy images: The Δm algorithm.
2019 May Am J Physiol Cell Physiol The HECT ubiquitin E3 ligase Smurf2 degrades μ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells.
2019 Feb ACS Chem Neurosci Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment.
2019 Jan Semin Perinatol Pharmacological treatment of opioid use disorder in pregnancy.
2019 Feb Pain SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain.
2019 Apr Mol Pharm Novel Kappa Opioid Receptor Agonist as Improved PET Radiotracer: Development and in Vivo Evaluation.
2018 J Physiol Pharmacol The effect of selective agonists of opioid receptors on in vitro secretion of steroid hormones by porcine endometrium during the estrous cycle and early pregnancy.
2019 Jan Neuropharmacology Pharmacological activation of dopamine D4 receptor modulates morphine-induced changes in the expression of GAD6567 and GABAB receptors in the basal ganglia.
2019 Mar Pain Manag Perspectives on cannabis as a stitute for opioid analgesics.
2019 PLoS Comput Biol Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis.
2019 Can J Anaesth Carfentanil: a narrative review of its pharmacology and public health concerns.
2019 J Urol Re: Mechanisms of Inhibitory Action of TRK-130 (Naltalimide), a μ-Opioid Receptor Partial Agonist, on the Micturition Reflex.
2018 Neuro Endocrinol Lett Mu Opioid Receptor Regulation of Gonadotropin-Releasing Hormone-Luteinizing Hormone Axis during Short-Term Food Deprivation: Role of Alpha1-Adrenoreceptor Signaling.
2019 Jan Bioanalysis Simultaneous quantification of high-dose naloxone and naloxone-3-β-d-glucuronide in human plasma by UHPLC-MSMS.
2019 May Neuropharmacology Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.
2019 Exp Neurol Opioid receptors inhibit the spinal AMPA receptor Ca2+ permeability that mediates latent pain sensitization.
2019 Jan Molecules Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists.
2019 Feb J Chem Inf Model Microswitches for the Activation of the Nociceptin Receptor Induced by Cebranopadol: Hints from Microsecond Molecular Dynamics.
2019 Feb Bioorg Med Chem Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation.
2019 Expert Opin Pharmacother The role of oxycodonenaloxone in the management of patients with pain and opioid-induced constipation.
2018 Front Pharmacol Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons - Effects of Nerve Injury.
2019 Biomed Pharmacother An overview of tramadol and its usage in pain management and future perspective.
2018 Dec Neuron Pain Wars: A New Hope.
2019 Mar Neuropharmacology Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats.
2019 Feb Eur J Pharmacol Role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist Ro 64-6198 in rhesus monkeys.
2019 Biomed Pharmacother Involvement of opioid system in behavioral despair induced by social isolation stress in mice.
2019 J Addict Med Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations.
2019 J Clin Psychopharmacol Assessment of the Abuse Potential of Cebranopadol in Nondependent Recreational Opioid Users: A Phase 1 Randomized Controlled Study.
2018 Dec Basic Clin Pharmacol Toxicol Optimization and pharmacological characterization of receptor-mediated Gio activation in postmortem human prefrontal cortex.
2018 Laeknabladid [Loperamide abuse - constipation or heart attack?]
2019 Mar ACS Chem Neurosci Analgesic Effects of the GIRK Activator, VU0466551, Alone and in Combination with Morphine in Acute and Persistent Pain Models.
2018 Drugs Tapentadol Prolonged Release: A Review in Pain Management.
2018 Trends Pharmacol Sci Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.
2018 Nov J Neuroinflammation Anti-inflammatory effects induced by pharmaceutical stances on inflammatory active brain astrocytes-promising treatment of neuroinflammation.
2018 Br J Anaesth Remifentanil as an adjunct to anaesthesia for electroconvulsive therapy fails to confer long-term benefits.
2018 Nov Exp Mol Med Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via pressing PI3KAkt-MAPK signaling in a MOR-dependent manner.
2019 J Pharmacol Exp Ther Long-Lasting Effects of Methocinnamox on Opioid Self-Administration in Rhesus Monkeys.
2019 Peptides Determinants of opioid abuse potential: Insights using intracranial self-stimulation.
2018 Peptides Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain.
2019 Jan Chem Res Toxicol Lateral Flow Assessment and Unanticipated Toxicity of Kratom.
2019 Phytother Res Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking.
2019 Jan Scand J Pain Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery.
2019 Am J Emerg Med Approach to buprenorphine use for opioid withdrawal treatment in the emergency setting.
2018 Nov Life Sci Remifentanil attenuates lipopolysaccharide-induced oxidative injury by downregulating PKCβ2 activation and inhibiting autophagy in H9C2 cardiomyocytes.
2019 Methods Mol Biol Quantitation of Tapentadol by Liquid Chromatography: Tandem Mass Spectrometry.
2018 Trends Pharmacol Sci Abuse Potential of Biased Mu Opioid Receptor Agonists.
2018 Dec Neuroscience Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat.
2018 Oct Sci Rep Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation.
2018 Oct Behav Pharmacol Punishment and reinforcement by opioid receptor agonists in a choice procedure in rats.