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Recent literature: μ-opioid receptor agonist
Date Journal Article title
2019 May Eur J Med Chem Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
2019 Jun J Forensic Sci Loperamide as a Potential Drug of Abuse and Misuse: Fatal Overdoses at the Medical University of South Carolina.
2019 Jun J Addict Med Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance.
2019 Jun J Pain A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy with Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.
2019 Jun J Psychopharmacol Salvindolin elicits opioid system-mediated antinociceptive and antidepressant-like activities.
2019 J Pain Res Pharmacological rationale for tapentadol therapy: a review of new evidence.
2019 Jun Mol Pharmacol A biased view of µ opioid receptors?
2019 Jun Pain Med Dilemma of Addiction and Respiratory Depression in the Treatment of Pain: A Prototypical Endomorphin as a New Approach.
2019 Jun Pain Pract APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.
2019 Aug Bioorg Med Chem Lett Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.
2019 May Proteins Stabilization of μ-opioid receptor facilitates its cellular translocation and signaling.
2019 Front Pharmacol Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene.
2019 Front Mol Neurosci GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization.
2019 May Neurogastroenterol Motil Radiographic dose-dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea-like behavior.
2019 Sep Neuropharmacology Voluntary wheel running effects on intra-accumbens opioid driven diet preferences in male and female rats.
2019 Apr Forensic Sci Int Postmortem concentrations of the synthetic opioid U-47700 in 26 fatalities associated with the drug.
2019 Jun Org Biomol Chem Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.
2019 May Am J Physiol Gastrointest... Clathrin and GRK23 inhibitors block delta opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.
2019 May Sci Rep Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking.
2019 May Br J Pharmacol The G protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signaling to ion channels.
2019 May Neuroscience Sex Differences in Neuroplasticity- and Stress-Related Gene Expression and Protein Levels in the Rat Hippocampus Following Oxycodone Conditioned Place Preference.
2019 Front Pharmacol A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists.
2019 Jul Neurosci Lett μ-Opioid receptor in the CA1 involves in tramadol and morphine cross state-dependent memory.
2019 Front Pharmacol Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats.
2019 Anesthesiology Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats.
2019 Apr Exp Clin Psychopharmacol Effects of repeated kappa-opioid receptor agonist U-50488 treatment and sequent termination on intracranial self-stimulation in male and female rats.
2019 Apr Pain Med Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.
2019 Jun Neuroscience μ-Opioid Receptor Activation Directly Modulates Intrinsically Photosensitive Retinal Ganglion Cells.
2019 Apr J Neuroinflammation Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10β-endorphin pathway.
2019 Neuropsychopharmacology Effects of stimulation of mu opioid and nociceptinorphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.
2019 Apr Neuropharmacology The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward.
2019 Jun Am J Physiol Regul Integr... Stimulation of spinal δ-opioid receptors attenuates the exercise pressor reflex in decerebrate rats.
2019 Apr Sci Signal TRPV1 promotes opioid analgesia during inflammation.
2019 Mar Int J Mol Sci Effects of Motilin Receptor Agonists and Ghrelin in Human imotilin receptori Transgenic Mice.
2019 Apr J Med Chem Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonistδ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability.
2019 Mar Chem Biol Drug Des Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site.
2019 Apr J Med Chem Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design.
2019 Br J Anaesth BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
2019 Br J Anaesth The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target.
2019 Alcohol Clin Exp Res Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice.
2019 Mar Cell Mol Life Sci Agonist-dependent development of delta opioid receptor tolerance in the colon.
2019 Mar Curr Pain Headache Rep The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects.
2019 Neuropharmacology Role of agonist efficacy in exposure-induced enhancement of mu opioid reward in rats.
2019 Mar Handb Exp Pharmacol Effects of NOP-Related Ligands in Nonhuman Primates.
2019 Jun Eur J Pharmacol D2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat.
2019 Mar Neuropsychopharmacology Intranasal naloxone rapidly occupies brain mu-opioid receptors in human jects.
2019 Expert Opin Ther Targets Current strategies toward safer mu opioid receptor drugs for pain management.
2019 Pept Sci (Hoboken) Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor.
2019 Feb Neuromodulation Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat.
2019 Jun J Anal Toxicol Analysis of Acetyl Fentanyl in Postmortem Specimens by Gas Chromatography-Mass Spectrometry (GC-MS): Method Validation and Case Report.
2019 Feb Sci Rep Indispensable role of β-arrestin2 in the protection of remifentanil preconditioning against hepatic ischemic reperfusion injury.
2019 PLoS One Evaluating the pharmacological response in fluorescence microscopy images: The Δm algorithm.
2019 May Am J Physiol Cell Physiol The HECT ubiquitin E3 ligase Smurf2 degrades μ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells.
2019 May ACS Chem Neurosci Characterization of 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment.
2019 Semin Perinatol Pharmacological treatment of opioid use disorder in pregnancy.
2019 Pain SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain.
2019 Apr Mol Pharm Novel Kappa Opioid Receptor Agonist as Improved PET Radiotracer: Development and in Vivo Evaluation.
2018 J Physiol Pharmacol The effect of selective agonists of opioid receptors on in vitro secretion of steroid hormones by porcine endometrium during the estrous cycle and early pregnancy.
2019 Jan Neuropharmacology Pharmacological activation of dopamine D4 receptor modulates morphine-induced changes in the expression of GAD6567 and GABAB receptors in the basal ganglia.
2019 Mar Pain Manag Perspectives on cannabis as a stitute for opioid analgesics.
2019 PLoS Comput Biol Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis.
2019 Can J Anaesth Carfentanil: a narrative review of its pharmacology and public health concerns.
2019 J Urol Re: Mechanisms of Inhibitory Action of TRK-130 (Naltalimide), a μ-Opioid Receptor Partial Agonist, on the Micturition Reflex.
2018 Neuro Endocrinol Lett Mu Opioid Receptor Regulation of Gonadotropin-Releasing Hormone-Luteinizing Hormone Axis during Short-Term Food Deprivation: Role of Alpha1-Adrenoreceptor Signaling.
2019 Jan Bioanalysis Simultaneous quantification of high-dose naloxone and naloxone-3-β-d-glucuronide in human plasma by UHPLC-MSMS.
2019 May Neuropharmacology Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.
2019 Exp Neurol Opioid receptors inhibit the spinal AMPA receptor Ca2+ permeability that mediates latent pain sensitization.
2019 Jan Molecules Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists.
2019 Feb J Chem Inf Model Microswitches for the Activation of the Nociceptin Receptor Induced by Cebranopadol: Hints from Microsecond Molecular Dynamics.
2019 Feb Bioorg Med Chem Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation.
2019 Expert Opin Pharmacother The role of oxycodonenaloxone in the management of patients with pain and opioid-induced constipation.
2018 Front Pharmacol Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons - Effects of Nerve Injury.
2019 Biomed Pharmacother An overview of tramadol and its usage in pain management and future perspective.
2018 Dec Neuron Pain Wars: A New Hope.
2019 Mar Neuropharmacology Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats.