Purchases through the above links give commission which helps fund this website
Recent literature: μ-opioid receptor agonist
Date Journal Article title
2019 Nov Reprod Fertil Dev Mu opioid receptor expression and localisation in murine spermatozoa and its role in IVF.
2019 Oct Molecules Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening.
2019 Nov Addict Biol Potent and selective NOP receptor activation reduces cocaine self-administration in rats by lowering hedonic set point.
2019 Nov Br J Pharmacol G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder.
2019 Nov Neurochem Int Agonist binding of human mu opioid receptors expressed in the yeast Pichia pastoris: Effect of cholesterol complementation.
2019 Dec Bioorg Med Chem Lett Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity.
2019 Oct Biophys J Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation.
2019 Aug Cureus A Unique Case Report on Methadone Used for Treatment of Opioid-induced Hyperalgesia in a Cancer Patient at the End of Life.
2019 Oct Int J Neuropsychopharmacol Behavioral pharmacology of novel kappa opioid receptor antagonists in rats.
2019 Oct Proc Natl Acad Sci U S A A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.
2019 Oct Handb Exp Pharmacol Emerging Insights into Mu Opioid Pharmacology.
2019 Dec Eur J Pharmacol Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
2019 Oct Behav Pharmacol Impact of order of fixed-ratio presentation on demand for self-administered remifentanil in male rats.
2019 Nov J Biol Chem Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation.
2019 Mol Pharmacol Homologous Regulation of Mu Opioid Receptor Recycling by G iβγi , Protein Kinase C, and Receptor Phosphorylation.
2019 Dec Eur J Pharmacol Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis.
2019 Sep Pain Med Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study.
2019 Nov Life Sci Intrathecally injected tramadol reduces articular incapacitation and edema in a rat model of lipopolysaccharide (LPS)-induced reactive arthritis.
2019 J Psychopharmacol Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats.
2019 Pharmacol Biochem Behav Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone.
2019 J Pharmacol Exp Ther Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.
2019 Nov Eur J Med Chem Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.
2019 Dec Brain Res Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice.
2019 Aug Neuropsychopharmacology A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal.
2019 Aug QJM Non-medical use of loperamide in the UK and USA.
2019 Neurochem Int Activation of MORs in the VTA induces changes on cFos expression in different projecting regions: Effect of inflammatory pain.
2019 Aug Biomolecules Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor.
2019 J Pharmacol Exp Ther Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment.
2019 Mol Pharmacol Separation of Acute Desensitization and Long-Term Tolerance of iµi-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation.
2019 Pain Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury.
2019 Jul Pain Med Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS).
2019 Oct ChemMedChem Discovery of Novel Biased Opioid Receptor Ligands through Structure-Based Pharmacophore Virtual Screening and Experiment.
2019 Oct Eur J Pharm Sci Biosensor-based kinetic and thermodynamic characterization of opioids interaction with human μ-opioid receptor.
2019 Mol Reprod Dev Implication of mu opioid receptor in the in vitro maturation of oocytes and its effects on sequent fertilization and embryo development in mice.
2019 Jul Neuropharmacology Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.
2019 Jul Br J Pharmacol Functional characterization of a novel opioid, PZM21, and its influence on behavioural responses to morphine.
2019 Anesthesiology Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.
2019 Br J Pharmacol Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
2019 J Pharmacol Sci Possible biased analgesic of hydromorphone through the G protein-over β-arrestin-mediated pathway: cAMP, CellKey™, and receptor internalization analyses.
2019 Front Cell Neurosci Neuropathic Pain Induced Alterations in the Opioidergic Modulation of a Descending Pain Facilitatory Area of the Brain.
2019 Nov Neuropharmacology Effects of mu opioid receptors in paraventricular nucleus on ejaculation through mediating sympathetic nerve system activity.
2019 J Pharmacol Exp Ther Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171.
2019 Drug Dev Res Effectiveness of nalbuphine, a κ-opioid receptor agonist and μ-opioid receptor antagonist, in the inhibition of INa , IK(M) , and IK(erg) unlinked to interaction with opioid receptors.
2019 Sep Drug Alcohol Depend Effects of the synthetic cannabinoid receptor agonist JWH-018 on abuse-related effects of opioids in rhesus monkeys.
2019 Jul Neuropharmacology BPR1M97, a dual mu opioid receptornociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.
2019 Oct Eur J Med Chem Endomorphin-2 analogs containing modified tyrosines: Biological and theoretical investigation of the influence on conformation and pharmacological profile.
2019 Jun ACS Cent Sci 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.
2019 Aug ACS Chem Neurosci Computational Systems Pharmacology-Target Mapping for Fentanyl-Laced Cocaine Overdose.
2019 Sep Eur J Med Chem Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
2019 J Forensic Sci Loperamide as a Potential Drug of Abuse and Misuse: Fatal Overdoses at the Medical University of South Carolina.
2019 Jun J Addict Med Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance.
2019 Jun J Pain A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.
2019 J Psychopharmacol Salvindolin elicits opioid system-mediated antinociceptive and antidepressant-like activities.
2019 J Pain Res Pharmacological rationale for tapentadol therapy: a review of new evidence.
2019 Mol Pharmacol A Biased View of iμi-Opioid Receptors?
2019 Jun Pain Med Dilemma of Addiction and Respiratory Depression in the Treatment of Pain: A Prototypical Endomorphin as a New Approach.
2019 Pain Pract APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.
2019 Aug Bioorg Med Chem Lett Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.
2019 Proteins Stabilization of μ-opioid receptor facilitates its cellular translocation and signaling.
2019 Front Pharmacol Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene.
2019 Front Mol Neurosci GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization.
2019 Neurogastroenterol Motil Radiographic dose-dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea-like behavior.
2019 Sep Neuropharmacology Voluntary wheel running effects on intra-accumbens opioid driven diet preferences in male and female rats.
2019 Forensic Sci Int Postmortem concentrations of the synthetic opioid U-47700 in 26 fatalities associated with the drug.
2019 Jun Org Biomol Chem Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.
2019 Aug Am J Physiol Gastrointest... Clathrin and GRK23 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.
2019 May Sci Rep Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking.
2019 Br J Pharmacol The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels.
2019 Jul Neuroscience Sex Differences in Neuroplasticity- and Stress-Related Gene Expression and Protein Levels in the Rat Hippocampus Following Oxycodone Conditioned Place Preference.
2019 Front Pharmacol A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists.
2019 Jul Neurosci Lett μ-Opioid receptor in the CA1 involves in tramadol and morphine cross state-dependent memory.
2019 Front Pharmacol Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats.
2019 Apr Exp Clin Psychopharmacol Effects of repeated kappa-opioid receptor agonist U-50488 treatment and sequent termination on intracranial self-stimulation in male and female rats.
2019 Apr Pain Med Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.
2019 Jun Neuroscience μ-Opioid Receptor Activation Directly Modulates Intrinsically Photosensitive Retinal Ganglion Cells.