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Recent literature: μ-opioid receptor agonist
Date Journal Article title
2019 Aug Neuropsychopharmacology A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal.
2019 Aug J Pharmacol Exp Ther Methocinnamox (MCAM) produces long-lasting antagonism of the behavioral effects of µ opioid receptor agonists but not prolonged precipitated withdrawal in rats.
2019 Aug QJM Non-medical use of loperamide in the UK and USA.
2019 Aug Neurochem Int Activation of MORs in the VTA induces changes on cFos expression in different projecting regions: Effect of inflammatory pain.
2019 Aug Biomolecules Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor.
2019 Aug J Pharmacol Exp Ther Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment.
2019 Aug Mol Pharmacol Separation of acute desensitization and long-term tolerance of mu-opioid receptors is determined by the degree of C-terminal phosphorylation.
2019 Jul Pain Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury.
2019 Jul Pain Med Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS).
2019 Jul ChemMedChem Discovery of Novel Biased Opioid Receptor Ligands through Structure-Based Pharmacophore Virtual Screening and Experiment.
2019 Jul Eur J Pharm Sci Biosensor-based kinetic and thermodynamic characterization of opioids interaction with human μ-opioid receptor.
2019 Jul Mol Reprod Dev Implication of mu opioid receptor in the in vitro maturation of oocytes and its effects on sequent fertilization and embryo development in mice.
2019 Jul Neuropharmacology Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.
2019 Jul Br J Pharmacol Functional characterization of a novel opioid, PZM21, and its influence on behavioural responses to morphine.
2019 Anesthesiology Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.
2019 Jul Br J Pharmacol Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
2019 J Pharmacol Sci Possible biased analgesic of hydromorphone through the G protein-over β-arrestin-mediated pathway: cAMP, CellKey™, and receptor internalization analyses.
2019 Front Cell Neurosci Neuropathic Pain Induced Alterations in the Opioidergic Modulation of a Descending Pain Facilitatory Area of the Brain.
2019 Jul Neuropharmacology Effects of mu opioid receptors in paraventricular nucleus on ejaculation through mediating sympathetic nerve system activity.
2019 Jul J Pharmacol Exp Ther Opioid-induced signaling and antinociception are modulated by the recently deorphanized receptor, GPR171.
2019 Jul Drug Dev Res Effectiveness of nalbuphine, a κ-opioid receptor agonist and μ-opioid receptor antagonist, in the inhibition of INa , IK(M) , and IK(erg) unlinked to interaction with opioid receptors.
2019 Sep Drug Alcohol Depend Effects of the synthetic cannabinoid receptor agonist JWH-018 on abuse-related effects of opioids in rhesus monkeys.
2019 Jul Neuropharmacology BPR1M97, a dual mu opioid receptornociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine.
2019 Jun Eur J Med Chem Endomorphin-2 analogs containing modified tyrosines: Biological and theoretical investigation of the influence on conformation and pharmacological profile.
2019 Jun ACS Cent Sci 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.
2019 Aug ACS Chem Neurosci Computational Systems Pharmacology-Target Mapping for Fentanyl-Laced Cocaine Overdose.
2019 Sep Eur J Med Chem Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
2019 Jun J Forensic Sci Loperamide as a Potential Drug of Abuse and Misuse: Fatal Overdoses at the Medical University of South Carolina.
2019 Jun J Addict Med Opioid Toxidrome Following Grapefruit Juice Consumption in the Setting of Methadone Maintenance.
2019 Jun J Pain A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy With Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models.
2019 J Psychopharmacol Salvindolin elicits opioid system-mediated antinociceptive and antidepressant-like activities.
2019 J Pain Res Pharmacological rationale for tapentadol therapy: a review of new evidence.
2019 Jun Mol Pharmacol A biased view of µ opioid receptors?
2019 Jun Pain Med Dilemma of Addiction and Respiratory Depression in the Treatment of Pain: A Prototypical Endomorphin as a New Approach.
2019 Jun Pain Pract APOLLO-2: A Randomized, Placebo and Active-Controlled Phase III Study Investigating Oliceridine (TRV130), a G Protein-Biased Ligand at the μ-Opioid Receptor, for Management of Moderate to Severe Acute Pain Following Abdominoplasty.
2019 Aug Bioorg Med Chem Lett Discovery of conolidine derivative DS39201083 as a potent novel analgesic without mu opioid agonist activity.
2019 May Proteins Stabilization of μ-opioid receptor facilitates its cellular translocation and signaling.
2019 Front Pharmacol Drinking Levels and Profiles of Alcohol Addicted Rats Predict Response to Nalmefene.
2019 Front Mol Neurosci GRK Mediates μ-Opioid Receptor Plasma Membrane Reorganization.
2019 Neurogastroenterol Motil Radiographic dose-dependency study of loperamide effects on gastrointestinal motor function in the rat. Temporal relationship with nausea-like behavior.
2019 Sep Neuropharmacology Voluntary wheel running effects on intra-accumbens opioid driven diet preferences in male and female rats.
2019 Forensic Sci Int Postmortem concentrations of the synthetic opioid U-47700 in 26 fatalities associated with the drug.
2019 Jun Org Biomol Chem Antinociceptive activity of thiazole-containing cyclized DAMGO and Leu-(Met) enkephalin analogs.
2019 Aug Am J Physiol Gastrointest... Clathrin and GRK23 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.
2019 May Sci Rep Temporal dependence of shifts in mu opioid receptor mobility at the cell surface after agonist binding observed by single-particle tracking.
2019 Br J Pharmacol The G-protein-biased agents PZM21 and TRV130 are partial agonists of μ-opioid receptor-mediated signalling to ion channels.
2019 Jul Neuroscience Sex Differences in Neuroplasticity- and Stress-Related Gene Expression and Protein Levels in the Rat Hippocampus Following Oxycodone Conditioned Place Preference.
2019 Front Pharmacol A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists.
2019 Jul Neurosci Lett μ-Opioid receptor in the CA1 involves in tramadol and morphine cross state-dependent memory.
2019 Front Pharmacol Efficacy-Based Perspective to Overcome Reduced Opioid Analgesia of Advanced Painful Diabetic Neuropathy in Rats.
2019 Anesthesiology Activating α4β2 Nicotinic Acetylcholine Receptors Alleviates Fentanyl-induced Respiratory Depression in Rats.
2019 Apr Exp Clin Psychopharmacol Effects of repeated kappa-opioid receptor agonist U-50488 treatment and sequent termination on intracranial self-stimulation in male and female rats.
2019 Apr Pain Med Pharmacokinetics and Abuse Potential of Asalhydromorphone, a Novel Prodrug of Hydromorphone, After Intranasal Administration in Recreational Drug Users.
2019 Jun Neuroscience μ-Opioid Receptor Activation Directly Modulates Intrinsically Photosensitive Retinal Ganglion Cells.
2019 Apr J Neuroinflammation Activation of GPR40 produces mechanical antiallodynia via the spinal glial interleukin-10β-endorphin pathway.
2019 Neuropsychopharmacology Effects of stimulation of mu opioid and nociceptinorphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.
2019 Apr Neuropharmacology The bivalent ligand MCC22 potently attenuates hyperalgesia in a mouse model of cisplatin-evoked neuropathic pain without tolerance or reward.
2019 Jun Am J Physiol Regul Integr... Stimulation of spinal δ-opioid receptors attenuates the exercise pressor reflex in decerebrate rats.
2019 Apr Sci Signal TRPV1 promotes opioid analgesia during inflammation.
2019 Mar Int J Mol Sci Effects of Motilin Receptor Agonists and Ghrelin in Human imotilin receptori Transgenic Mice.
2019 Apr J Med Chem Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonistδ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability.
2019 Chem Biol Drug Des Molecular modeling of salsolinol, a full Gi protein agonist of the μ-opioid receptor, within the receptor binding site.
2019 Apr J Med Chem Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design.
2019 Br J Anaesth BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
2019 Br J Anaesth The mu-opioid receptor is a molecular marker for poor prognosis in hepatocellular carcinoma and represents a potential therapeutic target.
2019 Alcohol Clin Exp Res Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice.
2019 Cell Mol Life Sci Agonist-dependent development of delta opioid receptor tolerance in the colon.
2019 Mar Curr Pain Headache Rep The Utilization of Mu-Opioid Receptor Biased Agonists: Oliceridine, an Opioid Analgesic with Reduced Adverse Effects.
2019 Neuropharmacology Role of agonist efficacy in exposure-induced enhancement of mu opioid reward in rats.
2019 Handb Exp Pharmacol Effects of NOP-Related Ligands in Nonhuman Primates.
2019 Jun Eur J Pharmacol D2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat.
2019 Neuropsychopharmacology Intranasal naloxone rapidly occupies brain mu-opioid receptors in human jects.
2019 Expert Opin Ther Targets Current strategies toward safer mu opioid receptor drugs for pain management.
2019 Pept Sci (Hoboken) Equipotent enantiomers of cyclic opioid peptides at μ opioid receptor.
2019 Feb Neuromodulation Characterization of Analgesic Actions of the Chronic Intrathecal Infusion of H-Dmt-D-Arg-Phe-Lys-NH2 in Rat.