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Recent literature: Xanthine oxidase inhibitor
Date Journal Article title
2019 Jan Eur J Med Chem Pharmacological urate-lowering approaches in chronic kidney disease.
2019 Feb Rheumatol Ther Reassessing the Safety Profile of Lesinurad in Combination with Xanthine Oxidase Inhibitor Therapy.
2019 Feb Clin Pharmacol Drug Dev Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.
2019 Feb Clin Pharmacol Drug Dev Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor.
2012 Medical Genetics Summaries Lesinurad Therapy and iCYP2C9i Genotype
2019 Feb ChemMedChem Inhibitors of xanthine oxidase: scaffold diversity and structure-based drug design.
2019 Feb Biosci Biotechnol Biochem New xanthine oxidase inhibitors from the fruiting bodies of Tyromyces fissilis.
2019 Feb Life Sci Protective effects of febuxostat against paraquat-induced lung toxicity in rats: Impact on RAGEPI3KAkt pathway and downstream inflammatory cascades.
2019 Jan Cancer Prev Res (Phila) Alpha-blockers as colorectal cancer chemopreventatives: findings from a case-control study, human cell cultures, and in vivo preclinical testing.
2019 Jan Clin Pharmacol Ther Hypersensitivity and cardiovascular risks related to allopurinol and febuxostat therapy in Asians: A population-based cohort study and meta-analysis.
2019 Jan Infect Disord Drug Targets Allopurinol and loss of consciousness in a 78-old year man suffering from gout.
2019 Jan Int J Clin Pract Risk of Cutaneous Adverse Reactions Associated with Allopurinol or Febuxostat in Real-World Patients: A Nationwide Study.
2019 Jan J Biol Chem Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.
2019 Feb Bioorg Med Chem Lett Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.
2019 Mol Med Rep Febuxostat inhibits TGF‑β1‑induced epithelial‑mesenchymal transition via downregulation of USAG‑1 expression in Madin‑Darby canine kidney cells in vitro.
2019 Jan Nat Prod Res Isolation, characterization, and xanthine oxidase inhibitory activities of flavonoids from the leaves of Perilla frutescens.
2018 Oxid Med Cell Longev Uric Acid Protects against Focal Cerebral IschemiaReperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression.
2018 Dec Am J Physiol Renal Physiol Blockade of Enhancer of Zeste Homolog 2 alleviates renal injury associated with hyperuricemia.
2019 Jan Proc Natl Acad Sci U S A AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis.
2018 Acta Sci Pol Technol Aliment Antioxidant and xanthine oxidase inhibitory properties and LC-MSMS identification of compoundsof ethanolic extract from Mulberry leaves.
2018 Dec Molecules Optimization of the Extraction Conditions and Biological Evaluation of iDendropanax morbiferai H. Lev as an Anti-Hyperuricemic Source.
2019 Biomed Pharmacother Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by pressing uric acid.
2018 Dec Molecules Effects of Toona sinensis Leaf Extract and Its Chemical Constituents on Xanthine Oxidase Activity and Serum Uric Acid Levels in Potassium Oxonate-Induced Hyperuricemic Rats.
2018 Dec Int J Mol Sci The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.
2018 Dec Molecules iSalvia elegansi, iSalvia greggiii and iSalvia officinalisi Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes.
2018 Nov Brain Sci Augmentation of 5-Aminolevulinic Acid Treatment of Glioblastoma by Adding Ciprofloxacin, Deferiprone, 5-Fluorouracil and Febuxostat: The CAALA Regimen.
2018 Curr Top Med Chem Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress.
2018 Nov Nat Prod Res Neocucurbitacin D, a novel lactone-type norcucurbitacin as xanthine oxidase inhibitor from Herpetospermum pedunculosum.
2018 Oct Cell Mol Biol (Noisy-le-g... Inhibitory effects of various solvent extracts from Rhamnus frangula leaves on some inflammatory and metabolic enzymes.
2018 Nov Nutrients The Immunomodulatory and Anti-Inflammatory Role of Polyphenols.
2018 J Alzheimers Dis A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B.
2019 Free Radic Biol Med Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects.
2018 Oct Molecules Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (iMelilotus albusi) and Its Distribution in Selected Gramineae Species.
2018 Hypertension Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy.
2019 Feb Am J Hypertens Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis.
2018 Zhongguo Zhong Yao Za Zhi [Research on XOD captured components in Lagotis brevituba based on UPLC-Q-TOF-MS and molecular docking technology].
2018 Atherosclerosis Hyperuricemia and endothelial function: From molecular background to clinical perspectives.
2018 PLoS One Accumulation of uric acid in the epidermis forms the white integument of Samia ricini larvae.
2018 Free Radic Biol Med Xanthine oxidase is hyper-active in Duchenne muscular dystrophy.
2019 Jan Food Chem In vivo anti-hyperuricemic and xanthine oxidase inhibitory properties of tuna protein hydrolysates and its isolated fractions.
2018 Oct Clin Exp Nephrol The urate-lowering efficacy and safety of febuxostat versus allopurinol in Chinese patients with asymptomatic hyperuricemia and with chronic kidney disease stages 3-5.
2019 Jan Am J Hypertens Xanthine Oxidase Inhibitor, Febuxostat Ameliorates the High Salt Intake-Induced Cardiac Hypertrophy and Fibrosis in Dahl Salt-Sensitive Rats.
2019 J Cell Physiol BI1 alleviates cardiac microvascular ischemia-reperfusion injury via modifying mitochondrial fission and inhibiting XOROSF-actin pathways.
2018 Pharmacotherapy Efficacy and Safety of Lesinurad in Patients with Hyperuricemia Associated with Gout: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
2018 Eur Stroke J Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) - Protocol for a randomised double blind placebo-controlled clinical trial.
2018 Clin Rheumatol International position paper on the appropriate use of uricosurics with the introduction of lesinurad.
2018 Sep Molecules The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension.
2018 Drug Metab Dispos Metabolism of c-Met Kinase Inhibitors Containing Quinoline by Aldehyde Oxidase, Electron Donating, and Steric Hindrance Effect.
2018 Int J Biol Macromol Coumarin derivatives as promising xanthine oxidase inhibitors.
2018 Am J Kidney Dis Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.
2018 Rev Alerg Mex [De-sensitization to allopurinol in a patient with tophi gout].
2018 Arch Pharm (Weinheim) Xanthine oxidase inhibitory activity of new pyrrole carboxamide derivatives: In vitro and in silico studies.
2018 Sep Int Heart J Antiremodeling Effect of Xanthine Oxidase Inhibition in a Canine Model of Atrial Fibrillation.
2018 Patient Relat Outcome Meas Patient considerations in the management of gout and role of combination treatment with lesinurad.
2019 Jan Rheumatology (Oxford) Integrated safety studies of the urate reabsorption inhibitor lesinurad in treatment of gout.
2018 Sep Analyst Innovative HPTLC method with fluorescence detection for assessment of febuxostat-montelukast combination and study of their protective effects against gouty arthritis.
2018 Sep Int Heart J Randomized Trial of Effect of Urate-Lowering Agent Febuxostat in Chronic Heart Failure Patients with Hyperuricemia (LEAF-CHF).
2018 Jun Semin Arthritis Rheum Combination urate-lowering therapy in the treatment of gout: What is the evidence?
2018 J Investig Med Metabolic and cardiovascular effects of chronic mild hyperuricemia in rodents.
2018 Expert Opin Pharmacother Febuxostat for the treatment of hyperuricaemia in gout.
2018 Biomed Res Int Selected Enzyme Inhibitory Effects of iEuphorbia characiasi Extracts.
2018 Jul BMC Cardiovasc Disord A meta-analysis of the efficacy of allopurinol in reducing the incidence of myocardial infarction following coronary artery bypass grafting.
2019 J Diabetes Investig Brown rice-specific γ-oryzanol as a promising prophylactic avenue to protect against diabetes mellitus and obesity in humans.
2018 J Biol Regul Homeost Agents The involvement and mechanism of febuxostat in non-alcoholic fatty liver disease cells.
2018 Jul Eur J Med Chem Design, synthesis and bioevaluation of 2-mercapto-6-phenylpyrimidine-4-carboxylic acid derivatives as potent xanthine oxidase inhibitors.
2018 Jun Clin Exp Nephrol The effects of xanthine oxidase inhibitor in patients with chronic heart failure complicated with hyperuricemia: a prospective randomized controlled clinical trial of topiroxostat vs allopurinol-study protocol.
2018 Comput Biol Chem Identification of new drug-like compounds from millets as Xanthine oxidoreductase inhibitors for treatment of Hyperuricemia: A molecular docking and simulation study.
2018 Clin Med Insights Cardiol Effect of Xanthine Oxidase Inhibition on Arterial Stiffness in Patients With Chronic Heart Failure.
2018 J Trace Elem Med Biol Compounds containing trace element copper or zinc exhibit as potent hyperuricemia inhibitors via xanthine oxidase inactivation.
2018 Br J Clin Pharmacol Evaluation of a pharmacokinetic-pharmacodynamic model for hypouricaemic effects of febuxostat using datasets obtained from real-world patients.
2018 Oct Spectrochim Acta A Mol Bi... Spectroscopic and molecular structure (monomeric and dimeric model) investigation of Febuxostat: A combined experimental and theoretical study.
2018 May Arthritis Res Ther Efficacy and safety of febuxostat extended release and immediate release in patients with gout and moderate renal impairment: phase II placebo-controlled study.
2018 Biochem Pharmacol Jacareubin inhibits FcεRI-induced extracellular calcium entry and production of reactive oxygen species required for anaphylactic degranulation of mast cells.
2018 May Pharmaceuticals (Basel) Side Effects and Interactions of the Xanthine Oxidase Inhibitor Febuxostat.
2018 Iran J Basic Med Sci DNA protection, antioxidant and xanthine oxidase inhibition activities of polyphenol-enriched fraction of iBerberis integerrimai Bunge fruits.