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Recent literature: Xanthine oxidase inhibitor
Date Journal Article title
2019 Lett Drug Des Discov Challenges in the Discovery and Optimization of mGlu24 Heterodimer Positive Allosteric Modulators.
2020 Mar Free Radic Biol Med Neopterin formation through radical scavenging of eroxide by the macrophage synthesised antioxidant 7,8-dihydroneopterin.
2020 Feb Medicina (Kaunas) Predictors of Hyperuricemia after Kidney Transplantation: Association with Graft Function.
2020 Mar - J Pharmacol Toxicol Methods A natural complex product Yaocha reduces uric acid level in a live zebrafish model.
2020 May Talanta Electrochemical sensor based on magnetite graphene oxideordered mesoporous carbon hybrid to detection of allopurinol in clinical samples.
2020 Feb Hum Exp Toxicol Protective effect of febuxostat in sepsis-induced liver and kidney injuries after cecal ligation and puncture with the impact of xanthine oxidase, interleukin 1iβi, and c-Jun N-terminal kinases.
2020 Jan Redox Biol Hydrogen sulfide stimulates xanthine oxidoreductase conversion to nitrite reductase and formation of NO.
2020 Mar Eur J Med Chem Design, synthesis and biological evaluation of 1-alkyl-56-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)-1H-indole-3-carbonitriles as novel xanthine oxidase inhibitors.
2020 Arterioscler Thromb Vasc ... Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation.
2020 Mar Nitric Oxide Supplementation of dietary nitrate attenuated oxidative stress and endothelial dysfunction in diabetic vasculature through inhibition of NADPH oxidase.
2020 Jan Clin Rheumatol Evaluation of urate-lowering therapy in hyperuricemia patients: a systematic review and Bayesian network meta-analysis of randomized controlled trials.
2020 Jan Hypertens Res Pretreatment with cilnidipine attenuates hypoxiareoxygenation injury in HL-1 cardiomyocytes through enhanced NO production and action potential shortening.
2019 Saudi J Kidney Dis Transpl Superior protective effects of febuxostat plus alpha-lipoic acid on renal ischemiareperfusion-induced hepatorenal injury in rats.
2020 Int Immunopharmacol Uric acid increases IL-1β secretion and Caspase-1 activation in PBMCs of Behçet's disease patients: The in vitro immunomodulatory effect of xanthine oxidase inhibitor Allopurinol.
2020 Bioorg Chem Novel 3-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-1,2,4-oxadiazol-5(4H)-ones as promising xanthine oxidase inhibitors: Design, synthesis and biological evaluation.
2020 Pharmacotherapy Drug Interaction Between Febuxostat and Thiopurine Antimetabolites: A Review of the FDA Adverse Event Reporting System and Medical Literature.
2019 Dec Recent Pat Drug Deliv Formul Formulation and in vitro evaluation of fast dissolving tablets of Febuxostat using co-processed excipients.
2020 Jan Biomol Ther (Seoul) Function of NADPH Oxidases in Diabetic Nephropathy and Development of Nox Inhibitors.
2019 Dec Rheumatology (Oxford) Comparative cardiovascular risk in users versus non-users of xanthine oxidase inhibitors and febuxostat versus allopurinol users.
2019 Dec Int J Mol Sci Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation.
2019 Dec Clin Exp Nephrol Efficacy of xanthine oxidase inhibitor for chronic kidney disease patients with hyperuricemia.
2019 Nov Semin Arthritis Rheum Beyond urate lowering: Analgesic and anti-inflammatory properties of allopurinol.
2019 Vasc Health Risk Manag Effect of Long-Term Allopurinol Therapy on Left Ventricular Mass Index in Patients with Ischemic Heart Disease; A Cross-Sectional Study.
2020 Methods Mol Biol Enzymatic Bioautographic Methods.
2019 Dec J Am Heart Assoc Severe Hypouricemia Impairs Endothelium-Dependent Vasodilatation and Reduces Blood Pressure in Healthy Young Men: A Randomized, Placebo-Controlled, and Crossover Study.
2019 Nov Nat Prod Res Lignans and phenylpropanoids from the liquid juice of iphyllostachys edulisi.
2020 Clin Exp Nephrol The effect for hyperuricemia inpatient of uric acid overproduction type or in combination with topiroxostat on the pharmacokinetics, pharmacodynamics and safety of dotinurad, a selective urate reabsorption inhibitor.
2019 Oct Biomolecules Interactions of 7,8-Dihydroxyflavone with Serum Albumin as well as with CYP2C9, CYP2C19, CYP3A4, and Xanthine Oxidase Biotransformation Enzymes.
2020 Clin Exp Nephrol Intensive uric acid-lowering therapy in CKD patients: the protocol for a randomized controlled trial.
2019 Nov JCI Insight Xanthine oxidase inhibitor ameliorates postischemic renal injury in mice by promoting resynthesis of adenine nucleotides.
2020 Reproduction Allopurinol inhibits excess glucose-induced trophoblast IL-1β and ROS production.
2020 Pharmacol Res Hydralazine improves ischemia-induced neovasculogenesis via xanthine-oxidase inhibition in chronic renal insufficiency.
2020 Clin Exp Nephrol Febuxostat, a novel inhibitor of xanthine oxidase, reduces ER stress through upregulation of SIRT1-AMPK-HO-1thioredoxin expression.
2019 Nov J Agric Food Chem Identification and Characterization of the Tyrosinase Inhibitory Activity of Caffeine from Camellia Pollen.
2020 Int J Clin Pharmacol Ther Comparison of long-term efficacy and renal safety of febuxostat and allopurinol in patients with chronic kidney diseases
2020 Biomed Chromatogr Anti-hyperuricemia activity and toxicity prediction of a novel xanthine oxidoreductase inhibitor.
2012 LiverTox: Clinical and Re... Benzbromarone
2012 LiverTox: Clinical and Re... Febuxostat
2012 LiverTox: Clinical and Re... Allopurinol
2019 Comput Biol Chem Xanthine oxidase inhibitory activity of isoflavonoids from Apios americana.
2019 Expert Opin Ther Pat Novel urate transporter 1 (URAT1) inhibitors: a review of recent patent literature (2016-2019).
2019 Dec Eur J Med Chem Design, synthesis and biological evaluation of N-(3-(1H-tetrazol-1-yl)phenyl)isonicotinamide derivatives as novel xanthine oxidase inhibitors.
2019 Sep Int J Mol Sci Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice.
2019 Rheumatol Ther A Randomized, Double-Blind, Non-Inferiority Study of Febuxostat Versus Allopurinol in Hyperuricemic Chinese Subjects With or Without Gout.
2019 Complement Ther Med CaffeineAngelica dahurica and caffeineSalvia miltiorrhiza metabolic inhibition in humans: In vitro and in vivo studies.
2019 Int Immunopharmacol Febuxostat attenuates ulcerative colitis by the inhibition of NF-κB, proinflammatory cytokines, and oxidative stress in mice.
2019 J Geriatr Cardiol Effects of febuxostat on atrial remodeling in a rabbit model of atrial fibrillation induced by rapid atrial pacing.
2018 Best Pract Res Clin Rheum... Management of complex gout in clinical practice: Update on therapeutic approaches.
2019 J Clin Med Res Renoprotective Effect of Xanthine Oxidase Inhibitor, Topiroxostat.
2019 Oct Am J Physiol Renal Physiol Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload.
2019 Arthritis Rheumatol Xanthine Oxidase Inhibitor Withdrawal Syndrome? Comment on the Article by Choi et al.
2019 Nov Eur J Med Chem Targeting the pocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
2019 Nov Eur J Med Chem Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.
2019 Int Urol Nephrol Effect of febuxostat on oxidative stress in hemodialysis patients with endothelial dysfunction: a randomized, placebo-controlled, double-blinded study.
2019 Jul Molecules Interspecies Variation in NCMNi-O-iDemethylation in Liver Microsomes from Various Species.
2019 Oct Am J Physiol Renal Physiol Targeted renal knockdown of Na+H+ exchanger regulatory factor iSip1i produces uric acid nephrolithiasis in iDrosophilai.
2019 J Food Biochem Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase.
2019 Jul Molecules Screening and Evaluation of Xanthine Oxidase Inhibitors from iGnetum parvifoliumi in China.
2020 Jan StatPearls Febuxostat
2019 Phytochemistry Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.
2019 Mayo Clin Proc Comparing Cardiovascular Safety of Febuxostat and Allopurinol in the Real World: A Population-Based Cohort Study.
2019 Jul - Transplant Proc Gout Severity in Recipients of Kidney Transplant.
2019 Jun BMC Pediatr Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for eriority (phase III).
2019 Neuropsychiatr Dis Treat HO-1 protects the nerves of rats with cerebral hemorrhage by regulating the PI3KAKT signaling pathway.
2019 Drug Metab Dispos Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
2019 J Pharmacol Sci A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain.
2019 PLoS One Molecular mechanisms involved in drug-induced liver injury caused by urate-lowering Chinese herbs: A network pharmacology study and biology experiments.
2019 Front Neurol Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia.
2020 J Oncol Pharm Pract A retrospective analysis of tumor lysis syndrome management in a quaternary care hospital.
2019 Aug Nitric Oxide NADPH oxidase is a primary target for antioxidant effects by inorganic nitrite in lipopolysaccharide-induced oxidative stress in mice and in macrophage cells.
2019 Oct Brain Res Assessment of anti-nociceptive effect of allopurinol in a neuropathic pain model.
2019 J Enzyme Inhib Med Chem Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach.
2019 Eur J Drug Metab Pharmaco... In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
2019 Arthritis Rheumatol Excess Deaths Upon Cessation of Xanthine Oxidase Inhibitor Treatment-Data From the Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities Trial: Comment on the Article by Choi et al.
2019 Biomed Res Int Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells.