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Recent literature: Xanthine oxidase inhibitor
Date Journal Article title
2019 Jun Drug Metab Dispos Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
2019 Jun Mol Pain [EXPRESS] Involvement of inflammasome activation via elevation of uric acid level in nociception in a mouse model of muscle pain.
2019 J Pharmacol Sci A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain.
2019 Front Neurol Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia.
2019 May J Oncol Pharm Pract A retrospective analysis of tumor lysis syndrome management in a quaternary care hospital.
2019 Aug Nitric Oxide NADPH oxidase is a primary target for antioxidant effects by inorganic nitrite in lipopolysaccharide-induced oxidative stress in mice and in macrophage cells.
2019 Apr Brain Res Assessment of anti-nociceptive effect of allopurinol in a neuropathic pain model.
2019 J Enzyme Inhib Med Chem Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach.
2019 Apr Eur J Drug Metab Pharmaco... In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
2019 Apr Arthritis Rheumatol Excess deaths upon cessation of xanthine oxidase inhibitor treatment-data from the Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities trial: comment on the article by Choi et al.
2019 Apr Int J Clin Pharmacol Ther Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
2019 Apr Med Chem Synthesis and biological evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole derivatives as xanthine oxidase inhibitors.
2019 Apr Folia Morphol (Warsz) Neuroprotective effects of allopurinol on spinal cord injury in rats: a biochemical and immunohistochemical study.
2019 Mar Clin Pharmacol Ther Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
2019 Apr J Chromatogr B Analyt Tec... A novel xanthine oxidase inhibitor WSJ-557 study on pharmacokinetics and tissue distribution in rats by UPLC-MSMS.
2019 Mar Intern Emerg Med Effects of allopurinol and febuxostat on cardiovascular mortality in elderly heart failure patients.
2019 FASEB J The emerging role of xanthine oxidase inhibition for pression of breast cancer cell migration and metastasis associated with hypercholesterolemia.
2019 Bioorg Chem Synthesis and characterization of CAPE derivatives as xanthine oxidase inhibitors with radical scavenging properties.
2019 Mar Can J Physiol Pharmacol Effect of febuxostat on biochemical parameters of hyperlipidemia induced by a high-fat diet in rabbits.
2019 Apr Am J Physiol Heart Circ P... Reactive oxygen species modulate Na+-coupled neutral amino acid transporter 1 expression in piglet pulmonary arterial endothelial cells.
2019 Mar Eur J Med Chem Pharmacological urate-lowering approaches in chronic kidney disease.
2019 Rheumatol Ther Reassessing the Safety Profile of Lesinurad in Combination with Xanthine Oxidase Inhibitor Therapy.
2019 Feb Clin Pharmacol Drug Dev Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.
2019 Feb Clin Pharmacol Drug Dev Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor.
2012 Medical Genetics Summaries Lesinurad Therapy and iCYP2C9i Genotype
2019 Apr ChemMedChem Inhibitors of Xanthine Oxidase: Scaffold Diversity and Structure-Based Drug Design.
2019 Biosci Biotechnol Biochem New xanthine oxidase inhibitors from the fruiting bodies of Tyromyces fissilis.
2019 Mar Life Sci Protective effects of febuxostat against paraquat-induced lung toxicity in rats: Impact on RAGEPI3KAkt pathway and downstream inflammatory cascades.
2019 Cancer Prev Res (Phila) Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and iIn Vivoi Preclinical Testing.
2019 Jan Clin Pharmacol Ther Hypersensitivity and Cardiovascular Risks Related to Allopurinol and Febuxostat Therapy in Asians: A Population-Based Cohort Study and Meta-Analysis.
2019 Jan Infect Disord Drug Targets Allopurinol and loss of consciousness in a 78-old year man suffering from gout.
2019 Int J Clin Pract Risk of cutaneous adverse reactions associated with allopurinol or febuxostat in real-world patients: A nationwide study.
2019 Mar J Biol Chem Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.
2019 Feb Bioorg Med Chem Lett Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.
2019 Mol Med Rep Febuxostat inhibits TGF‑β1‑induced epithelial‑mesenchymal transition via downregulation of USAG‑1 expression in Madin‑Darby canine kidney cells in vitro.
2019 ESC Heart Fail Plasma xanthine oxidoreductase activity in patients with decompensated acute heart failure requiring intensive care.
2019 Jan Nat Prod Res Isolation, characterization, and xanthine oxidase inhibitory activities of flavonoids from the leaves of Perilla frutescens.
2018 Oxid Med Cell Longev Uric Acid Protects against Focal Cerebral IschemiaReperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression.
2019 Mar Am J Physiol Renal Physiol Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia.
2019 Jan Proc Natl Acad Sci U S A AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis.
2018 Acta Sci Pol Technol Aliment Antioxidant and xanthine oxidase inhibitory properties and LC-MSMS identification of compoundsof ethanolic extract from Mulberry leaves.
2018 Dec Molecules Optimization of the Extraction Conditions and Biological Evaluation of iDendropanax morbiferai H. Lev as an Anti-Hyperuricemic Source.
2019 Biomed Pharmacother Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by pressing uric acid.
2018 Dec Molecules Effects of Toona sinensis Leaf Extract and Its Chemical Constituents on Xanthine Oxidase Activity and Serum Uric Acid Levels in Potassium Oxonate-Induced Hyperuricemic Rats.
2018 Dec Int J Mol Sci The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.
2019 Mar Toxicol Lett Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.
2018 Biol Pharm Bull Endogenous Nitric Oxide Inhibits, Whereas Awakening Stimuli Increase, the Activity of a Subset of Orexin Neurons.
2019 Jan Biochem Biophys Res Commun Blockage of macrophage migration inhibitory factor (MIF) pressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling.
2018 Dec Molecules iSalvia elegansi, iSalvia greggiii and iSalvia officinalisi Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes.
2018 Nov Brain Sci Augmentation of 5-Aminolevulinic Acid Treatment of Glioblastoma by Adding Ciprofloxacin, Deferiprone, 5-Fluorouracil and Febuxostat: The CAALA Regimen.
2018 Curr Top Med Chem Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress.
2018 Nov Nat Prod Res Neocucurbitacin D, a novel lactone-type norcucurbitacin as xanthine oxidase inhibitor from Herpetospermum pedunculosum.
2018 Oct Cell Mol Biol (Noisy-le-g... Inhibitory effects of various solvent extracts from Rhamnus frangula leaves on some inflammatory and metabolic enzymes.
2018 Nov Nutrients The Immunomodulatory and Anti-Inflammatory Role of Polyphenols.
2018 J Alzheimers Dis A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B.
2019 Free Radic Biol Med Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects.
2018 Oct Molecules Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (iMelilotus albusi) and Its Distribution in Selected Gramineae Species.
2018 Hypertension Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy.
2019 Feb Am J Hypertens Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis.
2018 Zhongguo Zhong Yao Za Zhi [Research on XOD captured components in Lagotis brevituba based on UPLC-Q-TOF-MS and molecular docking technology].
2018 Atherosclerosis Hyperuricemia and endothelial function: From molecular background to clinical perspectives.
2018 PLoS One Accumulation of uric acid in the epidermis forms the white integument of Samia ricini larvae.
2018 Free Radic Biol Med Xanthine oxidase is hyper-active in Duchenne muscular dystrophy.
2019 Jan Food Chem In vivo anti-hyperuricemic and xanthine oxidase inhibitory properties of tuna protein hydrolysates and its isolated fractions.
2019 Clin Exp Nephrol The urate-lowering efficacy and safety of febuxostat versus allopurinol in Chinese patients with asymptomatic hyperuricemia and with chronic kidney disease stages 3-5.
2019 Jan Am J Hypertens Xanthine Oxidase Inhibitor, Febuxostat Ameliorates the High Salt Intake-Induced Cardiac Hypertrophy and Fibrosis in Dahl Salt-Sensitive Rats.
2019 J Cell Physiol BI1 alleviates cardiac microvascular ischemia-reperfusion injury via modifying mitochondrial fission and inhibiting XOROSF-actin pathways.
2018 Pharmacotherapy Efficacy and Safety of Lesinurad in Patients with Hyperuricemia Associated with Gout: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
2018 Eur Stroke J Xanthine oxidase inhibition for the improvement of long-term outcomes following ischaemic stroke and transient ischaemic attack (XILO-FIST) - Protocol for a randomised double blind placebo-controlled clinical trial.
2018 Clin Rheumatol International position paper on the appropriate use of uricosurics with the introduction of lesinurad.
2018 Sep Molecules The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension.
2018 Drug Metab Dispos Metabolism of c-Met Kinase Inhibitors Containing Quinoline by Aldehyde Oxidase, Electron Donating, and Steric Hindrance Effect.
2018 Int J Biol Macromol Coumarin derivatives as promising xanthine oxidase inhibitors.
2018 Am J Kidney Dis Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.
2018 Rev Alerg Mex [De-sensitization to allopurinol in a patient with tophi gout].