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Recent literature: Xanthine oxidase inhibitor
Date Journal Article title
2018 Best Pract Res Clin Rheum... Management of complex gout in clinical practice: Update on therapeutic approaches.
2019 J Clin Med Res Renoprotective Effect of Xanthine Oxidase Inhibitor, Topiroxostat.
2019 Aug Am J Physiol Renal Physiol Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload.
2019 Aug Arthritis Rheumatol Xanthine oxidase inhibitor withdrawal syndrome?
2019 Jul Eur J Med Chem Targeting the pocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-[4-alkoxy-3-(1H-tetrazol-1-yl) phenyl]-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.
2019 Jul Eur J Med Chem Design, synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives as novel xanthine oxidase inhibitors.
2019 Aug Int Urol Nephrol Effect of febuxostat on oxidative stress in hemodialysis patients with endothelial dysfunction: a randomized, placebo-controlled, double-blinded study.
2019 Jul Am J Physiol Renal Physiol Targeted renal knockdown of Na+H+ exchanger regulatory factor iSip1i produces uric acid nephrolithiasis in iDrosophilai.
2019 J Food Biochem Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase.
2019 Jul Molecules Screening and Evaluation of Xanthine Oxidase Inhibitors from iGnetum parvifoliumi in China.
2019 Jan StatPearls Febuxostat
2019 Jul Phytochemistry Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.
2019 Mayo Clin Proc Comparing Cardiovascular Safety of Febuxostat and Allopurinol in the Real World: A Population-Based Cohort Study.
2019 Jul - Transplant Proc Gout Severity in Recipients of Kidney Transplant.
2019 Jun BMC Pediatr Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for eriority (phase III).
2019 Neuropsychiatr Dis Treat HO-1 protects the nerves of rats with cerebral hemorrhage by regulating the PI3KAKT signaling pathway.
2019 Drug Metab Dispos Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
2019 J Pharmacol Sci A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain.
2019 Front Neurol Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia.
2019 May J Oncol Pharm Pract A retrospective analysis of tumor lysis syndrome management in a quaternary care hospital.
2019 Aug Nitric Oxide NADPH oxidase is a primary target for antioxidant effects by inorganic nitrite in lipopolysaccharide-induced oxidative stress in mice and in macrophage cells.
2019 Oct Brain Res Assessment of anti-nociceptive effect of allopurinol in a neuropathic pain model.
2019 J Enzyme Inhib Med Chem Evaluation of caffeine as inhibitor against collagenase, elastase and tyrosinase using in silico and in vitro approach.
2019 Apr Eur J Drug Metab Pharmaco... In Vitro Metabolism by Aldehyde Oxidase Leads to Poor Pharmacokinetic Profile in Rats for c-Met Inhibitor MET401.
2019 Arthritis Rheumatol Excess Deaths Upon Cessation of Xanthine Oxidase Inhibitor Treatment-Data From the Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Morbidities Trial: Comment on the Article by Choi et al.
2019 Biomed Res Int Telmisartan Attenuates Uric Acid-Induced Epithelial-Mesenchymal Transition in Renal Tubular Cells.
2019 Int J Clin Pharmacol Ther Comparative efficacy and safety of lesinurad 200 mg and 400 mg combined with a xanthine oxidase inhibitor in hyperuricemic patients with gout: A Bayesian network meta-analysis of randomized controlled trials
2019 Apr Med Chem Synthesis and biological evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole derivatives as xanthine oxidase inhibitors.
2019 Apr Folia Morphol (Warsz) Neuroprotective effects of allopurinol on spinal cord injury in rats: a biochemical and immunohistochemical study.
2019 Clin Pharmacol Ther Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol.
2019 Apr J Chromatogr B Analyt Tec... A novel xanthine oxidase inhibitor WSJ-557 study on pharmacokinetics and tissue distribution in rats by UPLC-MSMS.
2019 Mar Intern Emerg Med Effects of allopurinol and febuxostat on cardiovascular mortality in elderly heart failure patients.
2019 FASEB J The emerging role of xanthine oxidase inhibition for pression of breast cancer cell migration and metastasis associated with hypercholesterolemia.
2019 Bioorg Chem Synthesis and characterization of CAPE derivatives as xanthine oxidase inhibitors with radical scavenging properties.
2019 Can J Physiol Pharmacol Effect of febuxostat on biochemical parameters of hyperlipidemia induced by a high-fat diet in rabbits.
2019 Apr Am J Physiol Heart Circ P... Reactive oxygen species modulate Na+-coupled neutral amino acid transporter 1 expression in piglet pulmonary arterial endothelial cells.
2019 Mar Eur J Med Chem Pharmacological urate-lowering approaches in chronic kidney disease.
2019 Rheumatol Ther Reassessing the Safety Profile of Lesinurad in Combination with Xanthine Oxidase Inhibitor Therapy.
2019 Clin Pharmacol Drug Dev Lesinurad: Evaluation of Pharmacokinetic and Pharmacodynamic Interactions With Warfarin in Healthy Volunteers.
2019 Clin Pharmacol Drug Dev Effects of Food and Antacids on Pharmacokinetics and Pharmacodynamics of Lesinurad, a Selective Urate Reabsorption Inhibitor.
2012 Medical Genetics Summaries Lesinurad Therapy and iCYP2C9i Genotype
2019 Apr ChemMedChem Inhibitors of Xanthine Oxidase: Scaffold Diversity and Structure-Based Drug Design.
2019 Biosci Biotechnol Biochem New xanthine oxidase inhibitors from the fruiting bodies of Tyromyces fissilis.
2019 Mar Life Sci Protective effects of febuxostat against paraquat-induced lung toxicity in rats: Impact on RAGEPI3KAkt pathway and downstream inflammatory cascades.
2019 Cancer Prev Res (Phila) Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and iIn Vivoi Preclinical Testing.
2019 Clin Pharmacol Ther Hypersensitivity and Cardiovascular Risks Related to Allopurinol and Febuxostat Therapy in Asians: A Population-Based Cohort Study and Meta-Analysis.
2019 Jan Infect Disord Drug Targets Allopurinol and loss of consciousness in a 78-old year man suffering from gout.
2019 Int J Clin Pract Risk of cutaneous adverse reactions associated with allopurinol or febuxostat in real-world patients: A nationwide study.
2019 Mar J Biol Chem Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats.
2019 Feb Bioorg Med Chem Lett Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.
2019 Mol Med Rep Febuxostat inhibits TGF‑β1‑induced epithelial‑mesenchymal transition via downregulation of USAG‑1 expression in Madin‑Darby canine kidney cells in vitro.
2019 ESC Heart Fail Plasma xanthine oxidoreductase activity in patients with decompensated acute heart failure requiring intensive care.
2019 Jan Nat Prod Res Isolation, characterization, and xanthine oxidase inhibitory activities of flavonoids from the leaves of Perilla frutescens.
2018 Oxid Med Cell Longev Uric Acid Protects against Focal Cerebral IschemiaReperfusion-Induced Oxidative Stress via Activating Nrf2 and Regulating Neurotrophic Factor Expression.
2019 Mar Am J Physiol Renal Physiol Blockade of enhancer of zeste homolog 2 alleviates renal injury associated with hyperuricemia.
2019 Jan Proc Natl Acad Sci U S A AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis.
2018 Acta Sci Pol Technol Aliment Antioxidant and xanthine oxidase inhibitory properties and LC-MSMS identification of compoundsof ethanolic extract from Mulberry leaves.
2018 Dec Molecules Optimization of the Extraction Conditions and Biological Evaluation of iDendropanax morbiferai H. Lev as an Anti-Hyperuricemic Source.
2019 Biomed Pharmacother Dipeptidyl peptidase-4 inhibition protects the liver of insulin-resistant female rats against triglyceride accumulation by pressing uric acid.
2018 Dec Molecules Effects of Toona sinensis Leaf Extract and Its Chemical Constituents on Xanthine Oxidase Activity and Serum Uric Acid Levels in Potassium Oxonate-Induced Hyperuricemic Rats.
2018 Dec Int J Mol Sci The Xanthine Oxidase Inhibitor Febuxostat Suppresses the Progression of IgA Nephropathy, Possibly via Its Anti-Inflammatory and Anti-Fibrotic Effects in the gddY Mouse Model.
2019 Mar Toxicol Lett Glucocorticoid-activation system mediated glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis programming alteration of adrenal dysfunction induced by prenatal caffeine exposure.
2018 Biol Pharm Bull Endogenous Nitric Oxide Inhibits, Whereas Awakening Stimuli Increase, the Activity of a Subset of Orexin Neurons.
2019 Jan Biochem Biophys Res Commun Blockage of macrophage migration inhibitory factor (MIF) pressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling.
2018 Dec Molecules iSalvia elegansi, iSalvia greggiii and iSalvia officinalisi Decoctions: Antioxidant Activities and Inhibition of Carbohydrate and Lipid Metabolic Enzymes.
2018 Nov Brain Sci Augmentation of 5-Aminolevulinic Acid Treatment of Glioblastoma by Adding Ciprofloxacin, Deferiprone, 5-Fluorouracil and Febuxostat: The CAALA Regimen.
2018 Curr Top Med Chem Flavonoids and Anthranquinones as Xanthine Oxidase and Monoamine Oxidase Inhibitors: A New Approach Towards Inflammation and Oxidative Stress.
2018 Nov Nat Prod Res Neocucurbitacin D, a novel lactone-type norcucurbitacin as xanthine oxidase inhibitor from Herpetospermum pedunculosum.
2018 Oct Cell Mol Biol (Noisy-le-g... Inhibitory effects of various solvent extracts from Rhamnus frangula leaves on some inflammatory and metabolic enzymes.
2018 Nov Nutrients The Immunomodulatory and Anti-Inflammatory Role of Polyphenols.
2018 J Alzheimers Dis A Free Radical-Generating System Regulates Amyloid Oligomers: Involvement of Cathepsin B.
2019 Free Radic Biol Med Nitrite treatment downregulates vascular MMP-2 activity and inhibits vascular remodeling in hypertension independently of its antihypertensive effects.
2018 Oct Molecules Isolation of Tricin as a Xanthine Oxidase Inhibitor from Sweet White Clover (iMelilotus albusi) and Its Distribution in Selected Gramineae Species.
2018 Hypertension Maternal Allopurinol Prevents Cardiac Dysfunction in Adult Male Offspring Programmed by Chronic Hypoxia During Pregnancy.
2019 Feb Am J Hypertens Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis.