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Recent literature: Muscarinic receptor antagonist
Date Journal Article title
2019 Ther Adv Respir Dis The once-daily fixed-dose combination of olodaterol and tiotropium in the management of COPD: current evidence and future prospects.
2019 Apr Mol Med Inhibition of HMGB1RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists presses inflammation.
2019 Apr Sci Rep Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.
2019 Apr Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 Mar Int J Mol Sci Effects of Motilin Receptor Agonists and Ghrelin in Human imotilin receptori Transgenic Mice.
2019 Jun Toxicol Lett The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM).
2019 PLoS One TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.
2019 Mar Neurobiol Learn Mem Estrous cycle stage gates sex differences in prefrontal muscarinic control of fear memory formation.
2019 Apr Life Sci Role of ambrisentan (selective endothelin-A receptor antagonist) on cigarette smoke exposure induced cognitive impairment in Danio rerio.
2019 Mar Cochrane Database Syst Rev Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease.
2019 J Enzyme Inhib Med Chem Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase.
2019 Expert Rev Clin Pharmacol Revefenacin for the treatment of chronic obstructive pulmonary disease.
2019 Feb Neurobiol Dis Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy.
2019 Apr Life Sci Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling.
2019 Pharmacol Rep The muscarinic antagonist gallamine induces proliferation of airway smooth muscle cells regardless of the cell phenotype.
2019 Feb Sci Rep Phencynonate S-isomer as a eutomer is a novel central anticholinergic drug for anti-motion sickness.
2019 Jun Brain Res Layer-specific involvement of endocannabinoid signaling in muscarinic-induced long-term depression in layer 23 pyramidal neurons of rat visual cortex.
2019 Feb Nutrients Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System.
2019 Neurotox Res Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor.
2018 eNeuro Cell Type- and Layer-Specific Muscarinic Potentiation of Excitatory Synaptic Drive onto Parvalbumin Neurons in Mouse Prefrontal Cortex.
2019 Drug Dev Ind Pharm Nicotine-like discriminative stimulus effects of acetylcholinesterase inhibitors and a muscarinic receptor agonist in Rhesus monkeys.
2019 Apr Neuroscience Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition.
2019 Neurobiol Dis Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.
2018 Pestic Biochem Physiol Pharmacology of central octopaminergic and muscarinic pathways in Drosophila melanogaster larvae: Assessing the target potential of GPCRs.
2019 Jun Brain Res Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and sequent epileptogenesis in two rat models of temporal lobe epilepsy.
2019 Jan Clin Exp Optom Alpha2 -adrenoceptor agonists inhibit form-deprivation myopia in the chick.
2019 Jan Pharmaceuticals (Basel) On the Absolute Stereochemistry of Tolterodine: A Circular Dichroism Study.
2019 Jan mSphere Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections.
2019 Int J Chron Obstruct Pulm... A randomized trial to determine the impact of indacaterolglycopyrronium on nighttime oxygenation and symptoms in patients with moderate-to-severe COPD: the DuoSleep study.
2019 Chest Adding a LAMA to ICSLABA Therapy: A Meta-analysis of Triple Combination Therapy in COPD.
2019 Eur Rev Med Pharmacol Sci Aclidinium bromide inhibits proliferation of osteosarcoma cells through regulation of PI3KAkt pathway.
2019 Jan Int J Mol Sci The Effect of Dexamethasone, Adrenergic and Cholinergic Receptor Agonists on Phospholipid Metabolism in Human Osteoarthritic Synoviocytes.
2019 Expert Rev Clin Pharmacol Green tobacco sickness: mecamylamine, varenicline, and nicotine vaccine as clinical research tools and potential therapeutics.
2019 Apr Neurosci Lett Acetylcholine presses the increase of glia fibrillary acidic protein expression via acetylcholine receptors in cAMP-induced astrocytic differentiation of rat C6 glioma cells.
2019 PLoS One In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients.
2018 Int J Chron Obstruct Pulm... Triple therapy (ICSLABALAMA) in COPD: time for a reappraisal.
2019 Biomed Pharmacother Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: An in vitro and in vivo approach.
2019 Jan Food Funct Theanine attenuates memory impairments induced by klotho gene depletion in mice.
2019 Tuberc Respir Dis (Seoul) Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma.
2018 Dec BMC Anesthesiol Tramadol for the treatment of catheter-related bladder discomfort: a randomized controlled trial.
2019 Cancer Chemother Pharmacol Prophylactic effect of scopolamine butylbromide, a competitive antagonist of muscarinic acetylcholine receptor, on irinotecan-related cholinergic syndrome.
2019 Feb Bioorg Med Chem Lett Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low type selectivity for human M1 - M5 muscarinic acetylcholine receptors.
2018 Dec Respir Res Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial.
2018 Dec Cochrane Database Syst Rev Combined aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD).
2019 Psychiatry Res BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1.
2019 J Psychopharmacol Overnight transdermal scopolamine patch administration has no clear effect on cognition and emotional processing in healthy volunteers.
2018 Dec Cochrane Database Syst Rev Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis.
2019 Jan Eur J Pharmacol Pharmacological characterization of DA-8010, a novel muscarinic receptor antagonist selective for urinary bladder over salivary gland.
2019 J Mol Neurosci Thrombin and the Protease-Activated Receptor-1 in Organophosphate-Induced Status Epilepticus.
2019 Psychiatry Res Electro convulsive therapy: Modification of its effect on the autonomic nervous system using anti-cholinergic drugs.
2019 Neuropsychopharmacology Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation.
2019 Jan Eur J Pharmacol Nicotine modulates the facial stimulation-evoked responses in cerebellar granule cell layer in vivo in mice.
2018 Medicine (Baltimore) Treatment of chronic obstructive pulmonary disease in patients with different fractional exhaled nitric oxide levels.
2018 Nov Oncogenesis Muscarinic acetylcholine receptor 3 mediates vagus nerve-induced gastric cancer.
2018 Cancer Cell Int M3 muscarinic acetylcholine receptors regulate epithelial-mesenchymal transition, perineural invasion, and migrationmetastasis in cholangiocarcinoma through the AKT pathway.
2019 Pharmacol Biochem Behav The role of dopamine D1- and D2-like receptors related to muscarinic M1 receptors in impulsive choice in high-impulsive and low-impulsive rats.
2018 Nat Chem Biol Structural insights into the type-selective antagonist binding to the M2 muscarinic receptor.
2019 Jan Biomol Ther (Seoul) The Inhibitory Mechanism on Acetylcholine-Induced Contraction of Bladder Smooth Muscle in the Streptozotocin-Induced Diabetic Rat.
2019 Feb Behav Brain Res Kappa opioid receptors mediate yohimbine-induced increases in impulsivity in the 5-choice serial reaction time task.
2018 Nov Proc Natl Acad Sci U S A Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists.
2018 Nov BMJ Triple therapy in the management of chronic obstructive pulmonary disease: systematic review and meta-analysis.
2018 Dec Drug Alcohol Depend An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic α6β2* antagonist r-bPiDI.
2018 Aug Nan Fang Yi Ke Da Xue Xue... [Low-intensity pulsed ultrasound pretreatment inhibits HMGB1 expression and attenuates lung ischemia-reperfusion injury in rats iviai the cholinergic anti-inflammatory pathway].
2018 Biomed Pharmacother Protective effect of α-asarone against nicotine-induced seizures in mice, but not by its interaction with nicotinic acetylcholine receptors.
2018 Biomed Pharmacother Diosmin is neuroprotective in a rat model of scopolamine-induced cognitive impairment.
2019 Neuropharmacology Amphetamine enantiomers inhibit homomeric α7 nicotinic receptor through a competitive mechanism and within the intoxication levels in humans.
2018 Peptides BJ-PRO-7A and BJ-PRO-10C induce vasodilatation and inotropic effects in normotensive and hypertensive rats: Role of nitric oxide and muscarinic receptors.
2018 Int J Chron Obstruct Pulm... Effects of a single long-acting muscarinic antagonist agent and a long-acting muscarinic antagonistlong-acting β2-adrenoceptor agonist combination on lung function and symptoms in untreated COPD patients in Japan.
2019 Feb Brain Res Stimulating muscarinic M1 receptors in the anterior cingulate cortex reduces mechanical hypersensitivity via GABAergic transmission in nerve injury rats.
2018 Int J Chron Obstruct Pulm... LABALAMA fixed-dose combinations in patients with COPD: a systematic review.
2018 Int J Chron Obstruct Pulm... Current appraisal of single inhaler triple therapy in COPD.
2018 Oct Disaster Med Public Healt... Contingency Medical Countermeasures for Mass Nerve-Agent Exposure: Use of Pharmaceutical Alternatives to Community Stockpiled Antidotes.
2018 Dec Eur J Med Chem Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.
2018 Oct Braz J Med Biol Res Acute exercise inhibits gastric emptying of liquids in rats: influence of the NO-cGMP pathway.
2018 Oct Int J Mol Sci Prostaglandin D₂ Induces Ca2+ Sensitization of Contraction without Affecting Cytosolic Ca2+ Level in Bronchial Smooth Muscle.