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Recent literature: Muscarinic receptor antagonist
Date Journal Article title
2020 Expert Opin Pharmacother The pharmacological management of asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS).
2020 Jan Inflammation Anti-arthritic Effect of the Spirocyclopiperazinium Salt Compound LXM-15 in Rats and Its Underlying Mechanism.
2020 Jan Int J Mol Sci PIP2 Mediated Inhibition of TREK Potassium Currents by Bradykinin in Mouse Sympathetic Neurons.
2020 Jan Eur J Pharmacol The muscarinic receptor antagonist tolterodine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells.
2019 Dec Respir Med One-year follow up of asthmatic patients newly initiated on treatment with medium- or high-dose inhaled corticosteroid-long-acting β2-agonist in UK primary care settings.
2019 Dec Behav Pharmacol The contribution of orexin receptors within the ventral tegmental area to modulation of antinociception induced by chemical stimulation of the lateral hypothalamus in the animal model of orofacial pain in the rats.
2020 Pflugers Arch Modulation of hypercapnic respiratory response by cholinergic transmission in the commissural nucleus of the solitary tract.
2019 Dec Toxicol Sci Characterization of Cholinesterases from Multiple Large Animal Species for Medical Countermeasure Development against Chemical Warfare Nerve Agents.
2020 Jan Neuroreport Possible interaction between the ventral hippocampal cannabinoid CB2 and muscarinic acetylcholine receptors on the modulation of memory consolidation in mice.
2019 Bratisl Lek Listy The effects and mechanisms of the action of galangin on spatial memory in rats.
2020 Jan ACS Chem Neurosci Discovery of Procognitive Antipsychotics by Combining Muscarinic M1 Receptor Structure-Activity Relationship with Systems Response Profiles in Zebrafish Larvae.
2019 Front Pharmacol Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M3 Muscarinic Acetylcholine Receptor.
2020 J Pharmacol Sci Muscarinic M1 receptors stimulated by intracerebroventricular administration of McN-A-343 reduces the nerve injury-induced mechanical hypersensitivity via GABAB receptors rather than GABAA receptors in mice.
2019 Dec Neurosci Res Dopamine D1 and muscarinic acetylcholine receptors in dorsal striatum are required for high speed running.
2019 Dec Drugs Real World Outcomes Comparative Causal Analysis of the Effects of Long-Acting Muscarinic Antagonist Versus No Long-Acting Bronchodilator Use on Readmission or Mortality After Hospitalization for Chronic Obstructive Pulmonary Disease.
2020 Jan Brain Res Loss of endogenous analgesia leads to delayed recovery from incisional pain in a rat model of chronic neuropathic pain.
2019 Nov Sci Rep Zn2+ stimulates salivary secretions via metabotropic zinc receptor ZnRGPR39 in human salivary gland cells.
2019 Nov Low Urin Tract Symptoms Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies.
2019 Nov Int J Clin Pharmacol Ther Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy jects: A phase 1 randomized, double-blind, single-dose escalation study
2019 FP Essent Respiratory Conditions: Chronic Obstructive Pulmonary Disease.
2019 Evodevo Characterization of nAChRs in iNematostella vectensisi ports neuronal and non-neuronal roles in the cnidarian-bilaterian common ancestor.
2019 Nov Sci Rep The beneficial effects of a muscarinic agonist on pancreatic β-cells.
2019 Nov Exp Clin Endocrinol Diabetes 3-Iodothyronamine Induces Diverse Signaling Effects at Different Aminergic and Non-Aminergic G-Protein Coupled Receptors.
2020 Feb Behav Brain Res Rewarding effects of M4 but not M3 muscarinic cholinergic receptor antagonism in the rostromedial tegmental nucleus.
2019 Nov Basic Clin Pharmacol Toxicol Pre-clinical evidence of safety and protective effect of isatin and oxime derivatives against malathion-induced toxicity.
2019 Neurochem Res Antinociceptive Effect of Spirocyclopiperazinium Salt Compound DXL-A-24 and the Underlying Mechanism.
2020 Feb Behav Brain Res Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus).
2019 Pharmacol Biochem Behav d-Cycloserine reverses scopolamine-induced object and place memory deficits in a spontaneous recognition paradigm in rats.
2019 Pharmacol Rep Muscarinic M1 and M2 receptor types play opposite roles in LPS-induced septic shock.
2019 J Asthma Allergy Characterizing Real-World Use Of Tiotropium In Asthma In The USA.
2019 Oct Eur J Neurosci Dorsal hippocampus cholinergic and nitrergic neurotransmission modulates the cardiac baroreflex function in rats.
2019 Oct JCI Insight Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish.
2019 Dec Toxicol Appl Pharmacol Tiotropium bromide, a long acting muscarinic receptor antagonist triggers intracellular calcium signalling in the heart.
2019 Neurochem Res A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice.
2019 Dec J Neurophysiol Muscarinic acetylcholine receptor-dependent persistent activity of layer 5 intrinsic-bursting and regular-spiking neurons in primary auditory cortex.
2019 Pharmacol Biochem Behav Strain differences in muscarinic cholinergic receptor antagonism of fat intake and acquisition and expression of fat-conditioned flavor preferences in male BALBc, C57BL6 and SWR mice.
2019 Cell Physiol Biochem JAK2STAT3 Pathway is Required for α7nAChR-Dependent Expression of POMC and AGRP Neuropeptides in Male Mice.
2019 J Pharm Pharmacol Effects of myricetin-3-O-α-rhamnoside (myricitrin) treatment on urinary parameters of Wistar rats.
2019 Int J Chron Obstruct Pulm... Imidafenacin, An Orally Active Muscarinic Receptor Antagonist, Improves Pulmonary Function In Patients With Chronic Obstructive Pulmonary Disease: A Multicenter, Randomized, Double-Blind, Placebo-Controlled 3×3 Crossover Phase II Trial.
2019 Sep Sci Rep M1 muscarinic receptor is a key target of neuroprotection, neuroregeneration and memory recovery by i-Extract from Withania somnifera.
2019 Sep Sci Transl Med Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors.
2019 Front Pharmacol Pharmacological Modulation of Endotoxin-Induced Release of IL-26 in Human Primary Lung Fibroblasts.
2019 Surg Oncol Acetylcholine receptors: Key players in cancer development.
2019 Sep Peptides Islet adaptation in GIP receptor knockout mice.
2019 J Cardiovasc Pharmacol Intrinsic Adaptation of SHR Right Atrium Reduces Heart Rate.
2020 Int J Neurosci Central muscarinic receptor types (M1 and M3) involved in carbacol-induced hypophagia in neonatal broiler chicken.
2019 Sep Cereb Cortex A Key Role for Prefrontocortical Small Conductance Calcium-Activated Potassium Channels in Stress Adaptation and Rapid Antidepressant Response.
2019 Oct Bioorg Med Chem Lett Discovery of novel steroidal histamine H3 receptor antagonistsinverse agonists. Part 2. Versatile steroidal carboxamide derivatives.
2019 Pharmacol Rep Cryptostrobin and catechin isolated from Eugenia mattosii D. Legrand leaves induce endothelium-dependent and independent relaxation in spontaneously hypertensive rat aorta.
2019 Oct J Neurosci Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits.
2019 Biochem Pharmacol M3 muscarinic receptor activation reduces hepatocyte lipid accumulation via CaMKKβAMPK pathway.
2019 Heliyon Evaluation of antiamnesic activity of iSalvia multicaulisi essential oil on scopolamine-induced amnesia in rats: iin vivoi and iin silicoi approaches.
2019 Dec J Ethnopharmacol Elucidation of the possible mechanism of analgesic action of methanol stem bark extract of Uapaca togoensis pax in mice.
2019 Nov Am J Physiol Gastrointest... Optogenetic analysis of neuromuscular transmission in the colon of ChAT-ChR2-YFP BAC transgenic mice.
2019 Int Immunopharmacol Cholinergic system is involved in the therapeutic effect of madecassoside on collagen-induced arthritis in rats.
2019 Oct Life Sci R2-8018 reduces the proliferation and migration of non-small cell lung cancer cells by disturbing transactivation between M3R and EGFR.
2019 J Oral Biosci Novel effects of rooibos extract on tear and saliva secretion mediated by the muscarinic acetylcholine receptor 3 in mice.
2019 Neurobiol Learn Mem Corticolimbic analysis of microRNAs and protein expressions in scopolamine-induced memory loss under stress.
2019 Hypertension Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice.
2019 Oct Chem Biol Interact The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice.
2019 Oct Eur J Med Chem A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
2019 Aug Neuroscience Scopolamine and Medial Frontal Stimulus-Processing during Interval Timing.
2019 Herz Pulmonary and cardiac drugs: clinically relevant interactions.
2019 Jul Sci Rep Role of corticotropin-releasing factor on bladder function in rats with psychological stress.
2019 Aug Neuroscience Cholinergic Receptor Blockade in the VTA Attenuates Cue-Induced Cocaine-Seeking and Reverses the Anxiogenic Effects of Forced Abstinence.
2019 Aug Psychiatry Res Neuroimaging Influence of muscarinic M1 receptor antagonism on brain choline levels and functional connectivity in medication-free jects with psychosis: A placebo controlled, cross-over study.
2019 Front Cell Neurosci Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms.
2019 Behav Neurosci Development of an "object category recognition" task for mice: Involvement of muscarinic acetylcholine receptors.
2019 Apr Cureus The Role of Revefenacin in Chronic Obstructive Pulmonary Disease.
2019 Oct Eur J Med Chem 2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
2019 Aug Biochem Biophys Res Commun Muscarinic acetylcholine receptors regulate the dephosphorylation of eukaryotic translation elongation factor 2 in SNU-407 colon cancer cells.
2019 Br J Anaesth A systematic review of rescue analgesic strategies in acute exacerbations of primary trigeminal neuralgia.
2019 Aug Bioorg Med Chem Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.
2019 Jun Digestion The Traditional Medicine Banhasasim-Tang Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through M3 Muscarinic and 5-HT3 Receptors in Murine Small Intestine.