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Recent literature: Muscarinic receptor antagonist
Date Journal Article title
2019 Jun Biochem Biophys Res Commun Muscarinic acetylcholine receptors regulate the dephosphorylation of eukaryotic translation elongation factor 2 in SNU-407 colon cancer cells.
2019 Jun Br J Dermatol Safety and efficacy of topical formulations containing 0.5, 1 and 2% glycopyrronium bromide in patients with primary axillary hyperhidrosis: a randomised, double-blind, placebo-controlled study.
2019 Jun Bioorg Med Chem Chemical modification-mediated optimisation of bronchodilatory activity of mepenzolate, a muscarinic receptor antagonist with anti-inflammatory activity.
2019 Jun Digestion The Traditional Medicine Banhasasim-Tang Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through M3 Muscarinic and 5-HT3 Receptors in Murine Small Intestine.
2019 Jun Aging (Albany NY) Real-world effectiveness of medications on survival in patients with COPD-heart failure overlap.
2019 Apr Biol Psychiatry Cholinergic Modulation of Exposure Disrupts Hippocampal Processes and Augments Extinction: Proof-of-Concept Study With Social Anxiety Disorder.
2019 Jun ChemMedChem Novel BQCA and TBPB derived M1 Receptor Hybrid-Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism.
2019 Jun J Labelled Comp Radiopharm A convenient synthesis of the muscarinic cholinergic antagonist (R)-[N-methyl-3 H]quinuclidinyl benzilate methiodide.
2019 Jun J Chem Inf Model Heterogeneous Dielectric Implicit Membrane Model for the Calculation of MMPBSA Binding Free Energies.
2019 Front Cell Neurosci Spontaneous and Acetylcholine Evoked Calcium Transients in the Developing Mouse Utricle.
2019 J BUON Aclidinium Bromide holds promising inhibitory effects in A549 lung cancer cells potentials by regulating PI3K AKT signaling pathway.
2019 Ther Adv Respir Dis Aclidinium bromide in fixed-dose combination with formoterol fumarate in the management of COPD: an update on the evidence base.
2019 May Hippocampus Place cell assemblies remain intact, despite reduced phase precession, after cholinergic disruption.
2019 J Pharmacol Exp Ther Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonistiβi 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile.
2018 Pharm Biol Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats.
2019 May Psychopharmacology (Berl) Matured hop bitter acids improve spatial working and object recognition memory via nicotinic acetylcholine receptors.
2019 May Naunyn Schmiedebergs Arch... Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
2019 Neuropeptides Excitatory effect of bradykinin on intrinsic neurons of the rat heart.
2019 Jun Neuroscience Effects of Muscarinic Acetylcholine m1 and m4 Receptor Blockade on Dyskinesia in the Hemi-Parkinsonian Rat.
2019 Ther Adv Respir Dis The once-daily fixed-dose combination of olodaterol and tiotropium in the management of COPD: current evidence and future prospects.
2019 Apr Mol Med Inhibition of HMGB1RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists presses inflammation.
2019 Apr Sci Rep Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 Mar Int J Mol Sci Effects of Motilin Receptor Agonists and Ghrelin in Human imotilin receptori Transgenic Mice.
2019 Jun Toxicol Lett The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM).
2019 PLoS One TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.
2019 Neurobiol Learn Mem Estrous cycle stage gates sex differences in prefrontal muscarinic control of fear memory formation.
2019 Apr Life Sci Role of ambrisentan (selective endothelin-A receptor antagonist) on cigarette smoke exposure induced cognitive impairment in Danio rerio.
2019 Mar Cochrane Database Syst Rev Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease.
2019 Pharmacol Rep Orexin type-2 receptor blockade prevents the nicotine-induced excitation of nucleus accumbens core neurons in rats: An electrophysiological perspective.
2019 J Enzyme Inhib Med Chem Exploring the activity of polyamine analogues on polyamine and spermine oxidase: methoctramine, a potent and selective inhibitor of polyamine oxidase.
2019 Expert Rev Clin Pharmacol Revefenacin for the treatment of chronic obstructive pulmonary disease.
2019 Feb Neurobiol Dis Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy.
2019 Apr Life Sci Cholinergic drugs ameliorate endothelial dysfunction by decreasing O-GlcNAcylation via M3 AChR-AMPK-ER stress signaling.
2019 Pharmacol Rep The muscarinic antagonist gallamine induces proliferation of airway smooth muscle cells regardless of the cell phenotype.
2019 Feb Sci Rep Phencynonate S-isomer as a eutomer is a novel central anticholinergic drug for anti-motion sickness.
2019 Jun Brain Res Layer-specific involvement of endocannabinoid signaling in muscarinic-induced long-term depression in layer 23 pyramidal neurons of rat visual cortex.
2019 Feb Nutrients Tryptophan-Tyrosine Dipeptide, the Core Sequence of β-Lactolin, Improves Memory by Modulating the Dopamine System.
2019 Neurotox Res Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor.
2018 eNeuro Cell Type- and Layer-Specific Muscarinic Potentiation of Excitatory Synaptic Drive onto Parvalbumin Neurons in Mouse Prefrontal Cortex.
2019 Drug Dev Ind Pharm Nicotine-like discriminative stimulus effects of acetylcholinesterase inhibitors and a muscarinic receptor agonist in Rhesus monkeys.
2019 Apr Neuroscience Augmentation of Endogenous Acetylcholine Uptake and Cholinergic Facilitation of Hippocampal Long-Term Potentiation by Acetylcholinesterase Inhibition.
2019 Neurobiol Dis Trihexyphenidyl rescues the deficit in dopamine neurotransmission in a mouse model of DYT1 dystonia.
2018 Pestic Biochem Physiol Pharmacology of central octopaminergic and muscarinic pathways in Drosophila melanogaster larvae: Assessing the target potential of GPCRs.
2019 Dtsch Med Wochenschr [Antidementia Drug Therapy of Alzheimer's Dementia: Status 2018 and Outlook].
2019 Jun Brain Res Commonalities and differences in extracellular levels of hippocampal acetylcholine and amino acid neurotransmitters during status epilepticus and sequent epileptogenesis in two rat models of temporal lobe epilepsy.
2019 Jan Clin Exp Optom Alpha2 -adrenoceptor agonists inhibit form-deprivation myopia in the chick.
2019 Jan Pharmaceuticals (Basel) On the Absolute Stereochemistry of Tolterodine: A Circular Dichroism Study.
2019 Jan mSphere Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections.
2019 Int J Chron Obstruct Pulm... A randomized trial to determine the impact of indacaterolglycopyrronium on nighttime oxygenation and symptoms in patients with moderate-to-severe COPD: the DuoSleep study.
2019 Chest Adding a LAMA to ICSLABA Therapy: A Meta-analysis of Triple Combination Therapy in COPD.
2019 Eur Rev Med Pharmacol Sci Aclidinium bromide inhibits proliferation of osteosarcoma cells through regulation of PI3KAkt pathway.
2019 Jan Int J Mol Sci The Effect of Dexamethasone, Adrenergic and Cholinergic Receptor Agonists on Phospholipid Metabolism in Human Osteoarthritic Synoviocytes.
2019 Expert Rev Clin Pharmacol Green tobacco sickness: mecamylamine, varenicline, and nicotine vaccine as clinical research tools and potential therapeutics.
2019 Apr Neurosci Lett Acetylcholine presses the increase of glia fibrillary acidic protein expression via acetylcholine receptors in cAMP-induced astrocytic differentiation of rat C6 glioma cells.
2019 PLoS One In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients.
2019 J Physiol Sci Effects of nicotine on odor-induced increases in regional blood flow in the olfactory bulb in rats.
2019 Biomed Pharmacother Decreased α7nAChR mRNA levels in peripheral blood monocytes are associated with enhanced inflammatory cytokine production in patients with lupus nephritis.
2018 Int J Chron Obstruct Pulm... Triple therapy (ICSLABALAMA) in COPD: time for a reappraisal.
2019 Biomed Pharmacother Vasorelaxant and antihypertensive effects of Tianshu Capsule on rats: An in vitro and in vivo approach.
2019 Jan Food Funct Theanine attenuates memory impairments induced by klotho gene depletion in mice.
2019 Tuberc Respir Dis (Seoul) Expression of Muscarinic Receptors and the Effect of Tiotropium Bromide in Aged Mouse Model of Chronic Asthma.
2018 Dec BMC Anesthesiol Tramadol for the treatment of catheter-related bladder discomfort: a randomized controlled trial.
2019 Cancer Chemother Pharmacol Prophylactic effect of scopolamine butylbromide, a competitive antagonist of muscarinic acetylcholine receptor, on irinotecan-related cholinergic syndrome.
2018 PLoS One Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors.
2019 Feb Bioorg Med Chem Lett Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low type selectivity for human M1 - M5 muscarinic acetylcholine receptors.
2019 Mar Behav Brain Res Blockade of nicotinic acetylcholine receptor enhances the responsiveness to bupropion in the mouse forced swim test.
2018 Dec Respir Res Spirometric changes during exacerbations of COPD: a post hoc analysis of the WISDOM trial.
2018 Dec Cochrane Database Syst Rev Combined aclidinium bromide and long-acting beta2-agonist for chronic obstructive pulmonary disease (COPD).
2019 Mar Behav Brain Res Cholinergic M4 receptors are involved in morphine-induced expression of behavioral sensitization by regulating dopamine function in the nucleus accumbens of rats.
2019 Psychiatry Res BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1.
2019 J Psychopharmacol Overnight transdermal scopolamine patch administration has no clear effect on cognition and emotional processing in healthy volunteers.
2018 Dec Cochrane Database Syst Rev Dual combination therapy versus long-acting bronchodilators alone for chronic obstructive pulmonary disease (COPD): a systematic review and network meta-analysis.
2019 Jan Toxicology Alternariol induced proliferation in primary mouse keratinocytes and inflammation in mouse skin is regulated via PGE2EP2cAMPp-CREB signaling pathway.
2019 Jan Eur J Pharmacol Pharmacological characterization of DA-8010, a novel muscarinic receptor antagonist selective for urinary bladder over salivary gland.