BlueBrainBoost
freedom-pharmacy
Purchases through the above links give commission which helps fund this website
Recent literature: Topoisomerase inhibitor
Date Journal Article title
2020 Mar Molecules 'Acridines' as New Horizons in Antifungal Treatment.
2020 Mar Cell Rep Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress.
2020 Mar Cell Death Dis Inhibition of topoisomerase IIA (Top2α) induces telomeric DNA damage and T cell dysfunction during chronic viral infection.
2020 Mar Arch Toxicol Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action.
2020 Ann Transl Med A novel topoisomerase I inhibitor DIA-001 induces DNA damage mediated cell cycle arrest and apoptosis in cancer cell.
2020 Mar J Biomol Struct Dyn Molecular docking, DFT and antimicrobial studies of Cu(II) complex as topoisomerase I inhibitor.
2020 Feb Mutat Res Targeting DNA-PK in cancer.
2020 Drugs Trastuzumab Deruxtecan: First Approval.
2020 Jan StatPearls Irinotecan
2020 Mutat Res Bioflavonoids cause DNA double-strand breaks and chromosomal translocations through topoisomerase II-dependent and -independent mechanisms.
2020 Feb Sci Transl Med BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers.
2020 Feb Mar Drugs Antitumor Activity of Asperphenin A, a Lipopeptidyl Benzophenone from Marine-Derived iAspergillusi sp. Fungus, by Inhibiting Tubulin Polymerization in Colon Cancer Cells.
2020 Feb Mol Neurobiol Context-Dependent Functions of E2F1: Cell Cycle, Cell Death, and DNA Damage Repair in Cortical Neurons.
2020 Feb J Clin Oncol Antitumor Activity and Safety of Trastuzumab Deruxtecan in Patients With HER2-Low-Expressing Advanced Breast Cancer: Results From a Phase Ib Study.
2020 Feb Elife Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity.
2020 Mar Eur J Med Chem Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases.
2020 Future Med Chem Second-generation 4,5,6,7-tetrahydrobenzo[idi]thiazoles as novel DNA gyrase inhibitors.
2020 Feb Proc Natl Acad Sci U S A The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.
2020 Feb J Control Release PEAMOtecan, a novel chronotherapeutic polymeric drug for brain cancer.
2020 Feb Planta Med Destabilization of FoxM1 and Inhibition of Topoisomerase I Contribute to Cytotoxicity of Prenylated Xanthones Isolated from Metaxya rostrata.
2020 Pancreas Real-World Dosing Patterns and Outcomes of Patients With Metastatic Pancreatic Cancer Treated With a Liposomal Irinotecan Regimen in the United States.
2020 Jan Environ Mol Mutagen Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds.
2020 Cancer Sci ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.
2020 Jan Int J Mol Sci Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors.
2020 Mar J Chem Inf Model Molecular Insight into the Interaction between Camptothecin and Acyclic Cucurbit[4]urils as Efficient Nanocontainers in Comparison with Cucurbit[7]uril: Molecular Docking and Molecular Dynamics Simulation.
2020 Mar J Pharm Biomed Anal Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma.
2019 Dec Cells Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines.
2020 Feb Bioorg Med Chem Lett Synthesis and biological evaluation of novel indole-pyrazoline hybrid derivatives as potential topoisomerase 1 inhibitors.
2020 Thorac Cancer Clinical significance of topoisomerase-II expression in patients with advanced non-small cell lung cancer treated with amrubicin.
2019 J Pharm Anal Nuclear magnetic resonance based structure of the protoberberine alkaloid coralyne and its self-association by spectroscopy techniques.
2019 Dec Int J Mol Sci Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.
2020 DNA Repair (Amst) Genotoxic effects of topoisomerase poisoning and PARP inhibition on zebrafish embryos.
2019 Front Oncol The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37-Targeted Radioimmunotherapy in Activated B Cell Like Diffuse Large B Cell Lymphoma Cell Lines.
2019 Dec Sci Rep The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery.
2019 Dec Daru Benzoxazines as new human topoisomerase I inhibitors and potential poisons.
2019 Dec Sci Rep Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models.
2020 Feb N Engl J Med Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer.
2019 Dec Cancers (Basel) (S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity.
2020 Bioorg Chem Synthesis of novel 2-aminobenzothiazole derivatives as potential antimicrobial agents with dual DNA gyrasetopoisomerase IV inhibition.
2020 DNA Repair (Amst) Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
2019 Dec ACS Synth Biol Enzymatic iOi-Glycosylation of Etoposide Aglycone by Exploration of the Substrate Promiscuity for Glycosyltransferases.
2019 Nov Cardiovasc Toxicol The Role of Topoisomerase IIβ in the Mechanisms of Action of the Doxorubicin Cardioprotective Agent Dexrazoxane.
2019 Nov Pathol Oncol Res PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade.
2019 Nov Anticancer Agents Med Chem Synthesis, Biological Evaluation and Molecular Docking Study of Cyclic Diarylheptanoids as Potential Anticancer Therapeutics.
2020 Mater Sci Eng C Mater Bio... Advanced nanoscale carrier-based approaches to overcome biopharmaceutical issues associated with anticancer drug 'Etoposide'.
2020 Biochem Pharmacol NG2-glia cell proliferation and differentiation by glial growth factor 2 (GGF2), a strategy to promote functional recovery after ischemic stroke.
2019 Nov ACS Omega Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching.
2020 J Inorg Biochem Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand.
2019 Dec Anal Chem Personalized Drug Efficacy Monitoring Chip.
2020 Cancer Chemother Pharmacol PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.
2019 Nat Med Chromatin regulators mediate anthracycline sensitivity in breast cancer.
2019 Nov Sci Rep Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.
2019 Nov J Magn Reson Imaging Pretreatment MR-Based Radiomics Signature as Potential Imaging Biomarker for Assessing the Expression of Topoisomerase II alpha (TOPO-IIα) in Rectal Cancer.
2019 Nov Dalton Trans Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.
2019 Oct Molecules Synthesis, Docking Studies, and In Vitro Evaluation of Some Novel Thienopyridines and Fused Thienopyridine-Quinolines as Antibacterial Agents and DNA Gyrase Inhibitors.
2019 Oct ACS Omega Synthesis of New Cu Complex Based on Natural 5iZi,9iZi-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line.
2019 Oct Molecules New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
2019 Nov Biochemistry Bimodal Actions of a NaphthyridoneAminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.
2019 Oct Nucleosides Nucleotides N... Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms.
2019 Nov Chem Commun (Camb) A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform.
2019 PLoS Genet Histone deposition promotes recombination-dependent replication at arrested forks.
2020 Mol Biol Rep Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
2020 Jan J Clin Invest Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
2019 Oct Sci Rep Gram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles.
2019 PLoS One [Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti-CTLA-4 antibody in a mouse model.
2019 Lung Cancer Phase II trial of single agent amrubicin in patients with previously treated advanced thymic malignancies.
2019 Oct Dalton Trans Non-mutagenic Ru(ii) complexes: cytotoxicity, topoisomerase IB inhibition, DNA and HSA binding.
2019 Nov J Org Chem Three-Component Approach to Pyridine-Stabilized Ketenimines for the Synthesis of Diverse Heterocycles.
2019 PLoS One Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines.
2019 Sep Sci Rep Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery.
2019 Nov Int J Pharm Formulation of injectable glycyrrhizic acid-hydroxycamptothecin micelles as new generation of DNA topoisomerase I inhibitor for enhanced antitumor activity.
2019 Mol Pharmacol The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison.
2019 Cell Death Discov Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress.
2019 Sep Int J Cancer Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients.
2019 Dec Clin Cancer Res A Novel HER3-Targeting Antibody-Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization.