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Recent literature: Peptidyl transferase inhibitor
Date Journal Article title
2019 J Antibiot (Tokyo) Liposidomycin, the first reported nucleoside antibiotic inhibitor of peptidoglycan biosynthesis translocase I: The discovery of liposidomycin and related compounds with a perspective on their application to new antibiotics.
2019 Aug Chem Commun (Camb) Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen.
2019 Sep Arch Biochem Biophys Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPKmTOR signaling.
2019 Biochimie Oridonin enhances TRAIL-induced apoptosis through GALNT14-mediated DR5 glycosylation.
2019 Peptides Genetic disruption of guanylyl cyclasenatriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice.
2019 Jun Am J Physiol Renal Physiol Peptidyl arginine deiminase-4 exacerbates ischemic AKI by finding NEMO.
2019 Int J Mol Med Imbalance of angiotensin-converting enzymes affects myocardial apoptosis during cardiac arrest induced by acute pulmonary embolism in a porcine model.
2019 Clin Exp Hypertens Angiotensin-converting enzyme 2 activation presses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension.
2019 Antimicrob Agents Chemother Select β-Lactam Combinations Exhibit Synergy against iMycobacterium abscessus In Vitroi.
2019 Oncogene A novel proteotoxic combination therapy for EGFR+ and HER2+ cancers.
2019 Apr J Biol Chem Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics.
2018 Tuberculosis (Edinb) The catalytic role of water in the binding site of l,d-transpeptidase 2 within acylation mechanism: A QMMM (ONIOM) modelling.
2018 Nov Cell Rep Promotion of Myoblast Differentiation by Fkbp5 via Cdk4 Isomerization.
2019 J Ind Microbiol Biotechnol Discovery, properties, and biosynthesis of pseudouridimycin, an antibacterial nucleoside-analog inhibitor of bacterial RNA polymerase.
2019 J Enzyme Inhib Med Chem Phosphonate inhibitors of West Nile virus NS2BNS3 protease.
2018 Curr Opin Struct Biol Enzyme targets for drug design of new anti-virulence therapeutics.
2018 Sep J Am Chem Soc Cell-Permeable Bicyclic Peptidyl Inhibitors against NEMO-IκB Kinase Interaction Directly from a Combinatorial Library.
2018 J Cell Physiol Peptidyl-prolyl cis-trans isomerase NIMA interacting 1 regulates skeletal muscle fusion through structural modification of Smad3 in the linker region.
2018 Nov Hum Mol Genet PIN1 is a new therapeutic target of craniosynostosis.
2018 Aug Stem Cells Dev Somatic Angiotensin I-Converting Enzyme Regulates Self-Renewal of Mouse Spermatogonial Stem Cells Through the Mitogen-Activated Protein Kinase Signaling Pathway.
2018 Antimicrob Agents Chemother Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order.
2018 Mar AAPS J Structure and Inhibitor Specificity of L,D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation.
2018 J Am Soc Nephrol Blood HER2 and Uromodulin as Causal Mediators of CKD.
2018 Feb Nutrients Bovine α-Lactalbumin Hydrolysates (α-LAH) Ameliorate Adipose Insulin Resistance and Inflammation in High-Fat Diet-Fed C57BL6J Mice.
2018 Mar J Mol Biol Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
2018 Mar J Mol Biol Mechanism of Inhibition of Translation Termination by Blasticidin S.
2018 Mar J Biol Chem Mycolyltransferase from iMycobacterium tuberculosisi in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis.
2017 Dec Mol Cell Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding.
2018 Jan Biochem Biophys Res Commun Trametinib presses HIV-1 replication by interfering with the disassembly of human immunodeficiency virus type 1 capsid core.
2018 Int J Mol Med Angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinasenuclear factor-κB pathway.
2017 Dec J Biol Chem The peptidyl-prolyl isomerase PIN1 relieves cyclin-dependent kinase 2 (CDK2) inhibition by the CDK inhibitor p27.
2018 Clin Exp Hypertens Early short-term treatment with exogenous hydrogen sulfide postpones the transition from prehypertension to hypertension in spontaneously hypertensive rat.
2017 Am J Chin Med Evodiamine Prevents Glioma Growth, Induces Glioblastoma Cell Apoptosis and Cell Cycle Arrest through JNK Activation.
2017 Jul Nucleic Acids Res Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
2017 Int J Mol Med A heptameric peptide purified from Spirulina sp. gastrointestinal hydrolysate inhibits angiotensin I-converting enzyme- and angiotensin II-induced vascular dysfunction in human endothelial cells.
2017 Jan Cereb Cortex Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.
2017 Amino Acids Dual effect of chloramphenicol peptides on ribosome inhibition.
2017 Mar Biochemistry Desleucyl-Oritavancin with a Damaged d-Ala-d-Ala Binding Site Inhibits the Transpeptidation Step of Cell-Wall Biosynthesis in Whole Cells of Staphylococcus aureus.
2018 Nephrology (Carlton) N-acetyl-seryl-aspartyl-lysyl-proline mediates the anti-fibrotic properties of captopril in unilateral ureteric obstructed BALBC mice.
2017 Feb Angew Chem Int Ed Engl Enhancing the Cell Permeability and Metabolic Stability of Peptidyl Drugs by Reversible Bicyclization.
2016 Dec World J Gastroenterol Understanding the role of PIN1 in hepatocellular carcinoma.
2017 Innate Immun The angiotensin-converting enzyme inhibitor captopril rescues mice from endotoxin-induced lethal hepatitis.
2016 Nov Proc Natl Acad Sci U S A Ligand-induced and small-molecule control of strate loading in a hexameric helicase.
2016 Oct Am J Physiol Heart Circ P... Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure.
2016 May J Neurosci Pin1 Modulates the Synaptic Content of NMDA Receptors via Prolyl-Isomerization of PSD-95.
2016 Jul Int J Cardiol Simultaneous Rho kinase inhibition in circulating leukocytes and in cardiovascular tissue in rats with high angiotensin converting enzyme levels.
2016 FEBS J Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance.
2016 Peptides Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTORERK signaling in apolipoprotein E-deficient mice.
2016 Apr J Med Chem Routes of Synthesis of Carbapenems for Optimizing Both the Inactivation of L,D-Transpeptidase LdtMt1 of Mycobacterium tuberculosis and the Stability toward Hydrolysis by β-Lactamase BlaC.
2017 Arch Physiol Biochem Activation of cardiac renin-angiotensin system and plasminogen activator inhibitor-1 gene expressions in oral contraceptive-induced cardiometabolic disorder.
2016 May J Mol Biol Crystal Structures of the uL3 Mutant Ribosome: Illustration of the Importance of Ribosomal Proteins for Translation Efficiency.
2015 Cell Biochem Funct Cyclophilin A as a downstream effector of PI3KAkt signalling pathway in multiple myeloma cells.
2016 Mar Mol Cell Endocrinol Up-regulation of the Ang IIAT1 receptor may compensate for the loss of gastric antrum ICC via the PI3kAkt signaling pathway in STZ-induced diabetic mice.
2016 Eur J Nutr Vinegar decreases blood pressure by down-regulating AT1R expression via the AMPKPGC-1αPPARγ pathway in spontaneously hypertensive rats.
2016 J Enzyme Inhib Med Chem Nitrobenzoxadiazole-based GSTP1-1 inhibitors containing the full peptidyl moiety of (pseudo)glutathione.
2015 PLoS One Local Augmented Angiotensinogen Secreted from Apoptotic Vascular Endothelial Cells Is a Vital Mediator of Vascular Remodelling.
2015 May Mol Cell Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.
2016 J Biomol Struct Dyn Targeting the cell wall of Mycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.
2015 FEMS Microbiol Lett Helicobacter pylori FKBP-type PPIase promotes gastric epithelial cell proliferation and anchorage-independent growth through activation of ERK-mediated mitogenic signaling pathway.
2015 Feb Sci Rep Angiotensin-converting enzyme 2angiotensin-(1-7)Mas axis prevents lipopolysaccharide-induced apoptosis of pulmonary microvascular endothelial cells by inhibiting JNKNF-κB pathways.
2014 Int J Clin Exp Pathol PI3KAKT signaling pathway plays a role in enhancement of eNOS activity by recombinant human angiotensin converting enzyme 2 in human umbilical vein endothelial cells.
2014 Cell Cycle Inhibition of CDK-mediated phosphorylation of Smad3 results in decreased oncogenesis in triple negative breast cancer cells.
2015 Antimicrob Agents Chemother Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.
2014 Sep Nature Structural basis for the inhibition of the eukaryotic ribosome.
2014 Aug BMC Microbiol Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors.
2014 Methods Mol Biol Pharmacogenomics of heart failure.
2014 Jul Biochem Biophys Res Commun A microplate assay for the coupled transglycosylase-transpeptidase activity of the penicillin binding proteins; a vancomycin-neutralizing tripeptide combination prevents penicillin inhibition of peptidoglycan synthesis.
2014 J Gen Virol Phosphorylation of human immunodeficiency virus type 1 capsid protein at serine 16, required for peptidyl-prolyl isomerase-dependent uncoating, is mediated by virion-incorporated extracellular signal-regulated kinase 2.
2015 Mol Carcinog COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancer.
2014 Appl Environ Microbiol GouR, a TetR family transcriptional regulator, coordinates the biosynthesis and export of gougerotin in Streptomyces graminearus.
2014 Am J Respir Cell Mol Biol Angiotensin-converting enzyme 2angiotensin-(1-7)Mas axis protects against lung fibrosis by inhibiting the MAPKNF-κB pathway.
2013 Circ J Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.
2013 Oct Cardiovasc Diabetol Arg972 Insulin receptor strate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence.
2013 Mol Cell Biol Molecular insights revealing interaction of Tim23 and channel units of presequence translocase.
2013 Antimicrob Agents Chemother In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.