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Recent literature: Peptidoglycan synthesis inhibitor
Date Journal Article title
2020 Mar J Mol Biol Structures of Bacterial MraY and Human GPT Provide Insights into Rational Antibiotic Design.
2020 Bioorg Chem Hydrophobic stituents on isatin derivatives enhance their inhibition against bacterial peptidoglycan glycosyltransferase activity.
2020 Mar J Biol Chem Glycolytic reprogramming of macrophages activated by NOD1 and TLR4 agonists: No association with proinflammatory cytokine production in normoxia.
2020 Feb Nucleic Acids Res Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes.
2020 Int J Antimicrob Agents Characterisation of the β-lactam resistance enzyme in Acanthamoeba castellanii.
2019 PLoS Pathog Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.
2019 J Antibiot (Tokyo) Liposidomycin, the first reported nucleoside antibiotic inhibitor of peptidoglycan biosynthesis translocase I: The discovery of liposidomycin and related compounds with a perspective on their application to new antibiotics.
2019 Curr Pharm Biotechnol Identification of a Potential Inhibitor Targeting MurC Ligase of the Drug Resistant Pseudomonas aeruginosa Strain through Structure-Based Virtual Screening Approach and In Vitro Assay.
2019 Jun Nat Commun In situ structure and assembly of the multidrug efflux pump AcrAB-TolC.
2019 Infect Immun PhiA, a Peptidoglycan Hydrolase Inhibitor of iBrucellai Involved in the Virulence Process.
2019 J Recept Signal Transduct... An explorative study on iStaphylococcus aureusi MurE inhibitor: induced fit docking, binding free energy calculation, and molecular dynamics.
2019 J Enzyme Inhib Med Chem Evaluation of the published kinase inhibitor set to identify multiple inhibitors of bacterial ATP-dependent mur ligases.
2019 Jun J Proteomics Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics.
2019 May J Biol Chem Trace levels of peptidoglycan in serum underlie the NOD-dependent cytokine response to endoplasmic reticulum stress.
2019 Mol Microbiol Sodium-powered stators of the bacterial flagellar motor can generate torque in the presence of phenamil with mutations near the peptidoglycan-binding region.
2019 Fish Shellfish Immunol Lipid droplets participate in modulating innate immune genes in Ctenopharyngodon idella kidney cells.
2019 Mol Microbiol Structural basis for interaction of DivIVAGpsB proteins with their ligands.
2019 Antimicrob Agents Chemother Select β-Lactam Combinations Exhibit Synergy against iMycobacterium abscessus In Vitroi.
2019 PLoS Pathog Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM.
2019 Mar Biol Pharm Bull Curcumin Down-Regulates Toll-Like Receptor-2 Gene Expression and Function in Human Cystic Fibrosis Bronchial Epithelial Cells.
2019 Feb ACS Chem Biol Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics.
2019 Appl Microbiol Biotechnol Morphology engineering for enhanced production of medium-chain-length polyhydroxyalkanoates in Pseudomonas mendocina NK-01.
2018 Tuberculosis (Edinb) The catalytic role of water in the binding site of l,d-transpeptidase 2 within acylation mechanism: A QMMM (ONIOM) modelling.
2018 Dec Acta Crystallogr F Struct... Structure of undecaprenyl pyrophosphate synthase from Acinetobacter baumannii.
2019 Appl Microbiol Biotechnol Ethambutol targets the glutamate racemase of Mycobacterium tuberculosis-an enzyme involved in peptidoglycan biosynthesis.
2019 Mar J Biol Chem Phage single-gene lysis: Finding the weak spot in the bacterial cell wall.
2019 SAR QSAR Environ Res Combining molecular docking and molecular dynamics studies for modelling Staphylococcus aureus MurD inhibitory activity.
2019 Biochim Biophys Acta Mol ... Nod1-mediated lipolysis promotes diacylglycerol accumulation and successive inflammation via PKCδ-IRAK axis in adipocytes.
2018 Nov Bioorg Med Chem Monosaccharide inhibitors targeting carbohydrate esterase family 4 de-N-acetylases.
2018 Nov Eur J Med Chem 1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio.
2018 Curr Opin Struct Biol Enzyme targets for drug design of new anti-virulence therapeutics.
2018 Front Microbiol Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst.
2018 Aug Sci Rep Structural basis of cell wall peptidoglycan amidation by the GatDMurT complex of Staphylococcus aureus.
2019 Curr Drug Discov Technol Antibacterial Flavonoids Against Oral Bacteria of Enterococcus Faecalis ATCC 29212 from Sarang Semut (Myrmecodia pendans) and Its Inhibitor Activity Against Enzyme MurA.
2018 Cell Surf Coupling of polymerase and carrier lipid phosphatase prevents product inhibition in peptidoglycan synthesis.
2018 Oct Chemistry Synthesis of Lipid-Carbohydrate-Peptidyl-RNA Conjugates to Explore the Limits Imposed by the Substrate Specificity of Cell Wall Enzymes on the Acquisition of Drug Resistance.
2018 Mol Microbiol Aspartate deficiency limits peptidoglycan synthesis and sensitizes cells to antibiotics targeting cell wall synthesis in Bacillus tilis.
2018 Jul Bioorg Med Chem Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus.
2018 PLoS Pathog SliC is a surface-displayed lipoprotein that is required for the anti-lysozyme strategy during Neisseria gonorrhoeae infection.
2018 Jun Proc Natl Acad Sci U S A Structure and mutagenic analysis of the lipid II flippase MurJ from iEscherichia colii.
2018 Insect Biochem Mol Biol Manduca sexta serpin-12 controls the prophenoloxidase activation system in larval hemolymph.
2018 Drug Discov Today Structural basis for selective inhibition of antibacterial target MraY, a membrane-bound enzyme involved in peptidoglycan synthesis.
2018 Front Immunol Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain.
2018 Apr Zhonghua Nei Ke Za Zhi [Role of Rac1 signaling pathway of azathioprine and peptidoglycan in the regulation of monocyte-macrophage apoptosis in Crohn's disease].
2018 J Cell Physiol Peptidoglycan induces bradykinin receptor 1 expression through Toll-like receptor 2 and NF-κB signaling pathway in human nasal mucosa-derived fibroblasts of chronic rhinosinusitis patients.
2018 Apr Eur J Med Chem Structure-based design of bacterial transglycosylase inhibitors incorporating biphenyl, amine linker and 2-alkoxy-3-phosphorylpropanoate moieties.
2019 J Biomol Struct Dyn Molecular insights into strate binding mechanism of undecaprenyl pyrophosphate with membrane integrated phosphatidyl glycerophosphate phosphatase B (PgpB) using molecular dynamics simulation approach.
2018 Mar AAPS J Structure and Inhibitor Specificity of L,D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation.
2018 Int J Mycobacteriol Identification and development of novel indazole derivatives as potent bacterial peptidoglycan synthesis inhibitors.
2018 Mar mBio Multisystem Analysis of iMycobacterium tuberculosisi Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface.
2018 Mar Biochemistry Kinetic Evidence for a Second Ligand Binding Site on Streptococcus pneumoniae Penicillin-Binding Protein 2x.
2018 Feb Molecules The Biological Properties and Potential Interacting Proteins of d-Alanyl-d-alanine Ligase A from Mycobacterium tuberculosis.
2018 Biochem Pharmacol Syk and Src-targeted anti-inflammatory activity of aripiprazole, an atypical antipsychotic.
2017 Dec Nat Commun Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.
2017 Nov Sci Rep Penicillin induces alterations in glutamine metabolism in Streptococcus pneumoniae.
2017 J Antibiot (Tokyo) Modified tunicamycins with reduced eukaryotic toxicity that enhance the antibacterial activity of β-lactams.
2017 Nov Eur J Pharmacol KATP channel block inhibits the Toll-like receptor 2-mediated stimulation of NF-κB by pressing the activation of Akt, mTOR, JNK and p38-MAPK.
2017 Aug BMC Microbiol IL-8 and IP-10 expression from human bronchial epithelial cells BEAS-2B are promoted by Streptococcus pneumoniae endopeptidase O (PepO).
2018 J Vet Pharmacol Ther Effects of polymyxin-B on TNF-α production in equine whole blood stimulated with three different bacterial toxins.
2017 J Dermatol Involvement of adenosine triphosphate-binding cassette family B member 1 in the augmentation of triacylglycerol excretion by Propionibacterium acnes in differentiated hamster sebocytes.
2017 May Elife Efficacy of β-lactamβ-lactamase inhibitor combination is linked to WhiB4-mediated changes in redox physiology of iMycobacterium tuberculosisi.
2017 Apr Oncotarget Sodium butyrate improves porcine host defense peptide expression and relieves the inflammatory response upon Toll-like receptor 2 activation and histone deacetylase inhibition in porcine kidney cells.
2017 Jun ACS Infect Dis Diamide Inhibitors of the Bacillus tilis N-Acetylglucosaminidase LytG That Exhibit Antibacterial Activity.
2017 May J Biol Chem Innate immune signaling in iDrosophilai is regulated by transforming growth factor β (TGFβ)-activated kinase (Tak1)-triggered ubiquitin editing.
2017 Antimicrob Agents Chemother Antibiotic Effects on Methicillin-Resistant Staphylococcus aureus Cytoplasmic Peptidoglycan Intermediate Levels and Evidence for Potential Metabolite Level Regulatory Loops.
2017 Feb Antibiotics (Basel) Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases.
2017 Mar Biochemistry Desleucyl-Oritavancin with a Damaged d-Ala-d-Ala Binding Site Inhibits the Transpeptidation Step of Cell-Wall Biosynthesis in Whole Cells of Staphylococcus aureus.
2017 Feb Nat Commun Infection-derived lipids elicit an immune deficiency circuit in arthropods.
2017 PLoS Genet Inhibition of a NF-κBDiap1 Pathway by PGRP-LF Is Required for Proper Apoptosis during Drosophila Development.
2017 Feb Cold Spring Harb Perspect... Fosfomycin: Mechanism and Resistance.
2017 Jan Chem Commun (Camb) Effect of the lipid II sugar moiety on bacterial transglycosylase: the 4-hydroxy epimer of lipid II is a TGase inhibitor.
2017 J Antimicrob Chemother Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa.
2017 Inflammation Brain-Derived Neurotrophic Factor Inhibits Peptidoglycan-Induced Inflammatory Cytokine Expression in Human Dental Pulp Cells.
2017 Mol Microbiol Caught between two proteins: a mycobacterial inhibitor challenges the mold.
2017 Curr Comput Aided Drug Des Screening of Potential Lead Molecule as Novel MurE Inhibitor: Virtual Screening, Molecular Dynamics and In Vitro Studies.