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Recent literature: Protease inhibitor
Date Journal Article title
2019 Aug Biochimie Antithrombin is incorporated into exosomes produced by antithrombin non-expressing cells.
2019 Aug Acta Pharmacol Sin Cathepsin L induced PC-12 cell apoptosis via activation of B-Myb and regulation of cell cycle proteins.
2019 Aug J Biotechnol Cathepsin D: removal strategy on Protein A chromatography, near real time monitoring and characterisation during monoclonal antibody production.
2019 Aug Contraception A phase I randomized safety study of a single-size silicone rubber diaphragm used with or without a lactic-acid-containing diaphragm gel.
2019 J Int AIDS Soc Multisystem impairment in South African adolescents with Perinatally acquired HIV on antiretroviral therapy (ART).
2019 Aug Int J Cardiol Circulating Serpina3 levels predict the major adverse cardiac events in patients with myocardial infarction.
2019 Aug Cells Fisetin Suppresses the Proliferation and Metastasis of Renal Cell Carcinoma through Upregulation of MEKERK-Targeting CTSS and ADAM9.
2019 Aug JAMA Oncol Clinical Outcomes of the HIV Protease Inhibitor Nelfinavir With Concurrent Chemoradiotherapy for Unresectable Stage IIIAIIIB Non-Small Cell Lung Cancer: A Phase 12 Trial.
2019 Aug Mol Carcinog Macrophage HIF-2α regulates tumor-pressive Spint1 in the tumor microenvironment.
2019 Aug Protein J Properties of a Non-canonical Complex Formed Between a Tepary Bean (Phaseolus acutifolius) Protease Inhibitor and α-Chymotrypsin.
2019 Aug Blood Tissue factor pathway inhibitor primes monocytes for antiphospholipid antibody-induced thrombosis.
2019 Aug Int J Cosmet Sci The importance of 12R-lipoxygenase and transglutaminase activities in the hydration-dependent ex vivo maturation of corneocyte envelopes.
2019 Aug J Alzheimers Dis Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PF-06751979, a Potent and Selective Oral BACE1 Inhibitor: Results from Phase I Studies in Healthy Adults and Healthy Older Subjects.
2019 Aug J Orthop Res Transcriptomic analysis of cellular pathways in healing flexor tendons of plasminogen activator inhibitor 1 (PAI-1Serpine1) null mice.
2019 Aug J Thromb Haemost Engineering a protein Z-dependent protease inhibitor (ZPI) mutant as a novel antagonist of ZPI anticoagulant function for hemophilia treatment.
2019 Aug Curr Issues Mol Biol Progress in the Discovery of Small Molecule Modulators of DeSUMOylation.
2019 Aug J Microbiol Immunol Infect Dual therapy with ritonavir-boosted protease inhibitor (PI) plus lamivudine versus triple therapy with ritonavir-boosted PI plus two nucleos(t)ide reverse-transcriptase inhibitor in HIV-infected patients with viral pression.
2019 Aug BMC Pediatr Impact of antiretroviral treatment on height evolution of HIV infected children.
2019 Aug Acta Biomater Regulation of chitosan-mediated differentiation of human olfactory receptor neurons by insulin-like growth factor binding protein-2.
2019 Aug FEBS J The N-terminal peptide of the transglutaminase-activating metalloprotease inhibitor from Streptomyces mobaraensis accommodates both inhibition and glutamine cross-linking sites.
2019 PLoS One Batroxobin accelerated tissue repair via neutrophil extracellular trap regulation and defibrinogenation in a murine ischemic hindlimb model.
2019 Neurobiol Stress Altered fibrinolytic system in rat models of depression and patients with first-episode depression.
2019 Aug Alzheimers Dement Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life.
2019 Aug Bioorg Med Chem Lett Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation.
2019 Aug ACS Med Chem Lett Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3.
2019 Aug ACS Med Chem Lett Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP).
2019 Infect Drug Resist Profile of sofosbuvirvelpatasvirvoxilaprevir in the treatment of hepatitis C.
2019 Aug Trials A phase 12 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC).
2019 Aug Cell Rep Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis.
2019 Aug Hum Mol Genet Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin deficient muscles through matrix metalloproteinases.
2019 J Enzyme Inhib Med Chem Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 type C protease.
2019 Aug Allergy Exonic mutations associated with atopic dermatitis disrupt LEKTI action and enhance its degradation.
2019 Heliyon A model to study the inhibition of nsP2B-nsP3 protease of dengue virus with imidazole, oxazole, triazole thiadiazole, and thiazolidine based scaffolds.
2019 Aug Sci Rep Plasmid DNA nicking- a Novel Activity of Soybean Trypsin Inhibitor and Bovine Aprotinin.
2019 Aug Molecules Psoromic Acid, a Lichen-Derived Molecule, Inhibits the Replication of HSV-1 and HSV-2, and Inactivates HSV-1 DNA Polymerase: Shedding Light on Antiherpetic Properties.
2019 PeerJ Binding interactions of epididymal protease inhibitor and semenogelin-1: a homology modeling, docking and molecular dynamics simulation study.
2019 Aug J Cell Mol Med Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation.
2019 Aug Allergol Int Eosinophilic chronic rhinosinusitis.
2019 Aug Braz J Microbiol Protein-mediated degradation of aflatoxin B1 by Pseudomonas putida.
2019 Aug Clin Drug Investig Individualized Protease Inhibitor Monotherapy: The Role of Pharmacokinetics and Pharmacogenetics in an Aged and Heavily Treated HIV-Infected Patient.
2019 Aug J Proteomics An integrated transcriptomic and proteomic analysis reveals toxin arsenal of a novel Antarctic jellyfish Cyanea sp.
2019 Aug Gastroenterology Efficacy of Glecaprevir and Pibrentasvir in Patients with Genotype 1 Hepatitis C Virus Infection with Treatment Failure after NS5A Inhibitor Plus Sofosbuvir Therapy.
2019 Aug Fish Shellfish Immunol Characterization, expression, enzymatic activity, and functional identification of cathepsin S from black rockfish Sebastes schlegelii.
2019 Aug Mar Drugs Purification, Characterization and Evaluation of Inhibitory Mechanism of ACE Inhibitory Peptides from Pearl Oyster (iPinctada fucata martensiii) Meat Protein Hydrolysate.
2019 Aug Acta Crystallogr F Struct... Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.
2019 Jul Bioorg Med Chem Structure-activity analysis of peptidic Chlamydia HtrA inhibitors.
2019 Aug AIDS Care Factors associated with erectile dysfunction among men living with HIV: a systematic review.
2019 Aug Neuroscience Chronic Cerebral Hypoperfusion Activates the Coagulation and Complement Cascades in Alzheimer's Disease Mice.
2019 Expert Rev Gastroenterol ... Management of HCV patients in cases of direct-acting antiviral failure.
2019 Aug Cell Mol Life Sci Glutamate controls vessel-associated migration of GABA interneurons from the pial migratory route via NMDA receptors and endothelial protease activation.
2019 Aug Sci Rep A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases.
2019 Jul Pancreatology Cinacalcet sustainedly prevents pancreatitis in a child with a compound heterozygous SPINK1AP2S1 mutation.
2019 Eur Rev Med Pharmacol Sci MiR-126 promotes endothelial cell apoptosis by targeting PI3KAkt in rats with lower limb arteriosclerosis obliterans.
2019 Aug Int J Mol Sci SUSD2 Proteolytic Cleavage Requires the GDPH Sequence and Inter-Fragment Disulfide Bonds for Surface Presentation of Galectin-1 on Breast Cancer Cells.
2019 Oct Virus Res Serine protease inhibitor AEBSF reduces dengue virus infection via decreased cholesterol synthesis.
2019 Aug J Med Chem HIV-1 Protease Inhibitors Incorporating Stereochemically Defined P2' Ligands To Optimize Hydrogen Bonding in the Substrate Envelope.
2019 Aug Biochemistry Molecular Determinants of Epistasis in HIV-1 Protease: Elucidating the Interdependence of L89V and L90M Mutations in Resistance.
2019 Aug Proc Natl Acad Sci U S A Spatial domain organization in the HIV-1 reverse transcriptase p66 homodimer precursor probed by double electron-electron resonance EPR.
2019 Aug Blood Targeting Protease Nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia.
2019 Aug Pharmaceutics AlginateChitosan Particle-Based Drug Delivery Systems for Pulmonary Applications.
2019 Aug J Chem Inf Model Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
2019 Jul Biochim Biophys Acta Prot... Novel applications of modification of thiol enzymes and redox-regulated proteins using S-methyl methanethiosulfonate (MMTS).
2019 Jul Biochim Biophys Acta Biom... ClTI, a Kunitz trypsin inhibitor purified from Cassia leiandra Benth. seeds, exerts a candidicidal effect on Candida albicans by inducing oxidative stress and necrosis.
2019 Aug Cardiovasc Res Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischemia-reperfusion injury.
2019 Drug Des Devel Ther Durability of INI-containing regimens after switching from PI-containing regimens: a single-centre cohort of drug-experienced HIV-infected jects.
2019 Aug Sci Rep Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice.
2019 Aug Nat Commun Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations.
2019 Aug Genes Dev Activator of one protease transforms into inhibitor of another in response to nutritional signals.
2019 Jul Lancet HIV Third-line antiretroviral therapy in low-income and middle-income countries (ACTG A5288): a prospective strategy study.
2019 Jul Eye Contact Lens Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease.
2019 Anal Bioanal Chem Characterization of AEBSF-antibody modifications for a protease inhibitor plementation strategy.
2019 Aug Med Sci Monit The Protective Effects of Protease Inhibitor MG-132 on Sepsis-Induced Acute Lung Rats and Its Possible Mechanisms.
2019 Aug J Phys Chem B Prediction of Noncompetitive Inhibitor Binding Mode Reveals Promising Site for Allosteric Modulation of Falcipain-2.
2019 Jul Ann Pharmacother The Incidence and Severity of Drug Interactions Before and After Antiretroviral Therapy Simplification in Treatment-Experienced Patients With HIV Infection.
2019 Aug Proc Natl Acad Sci U S A Functional selection of protease inhibitory antibodies.