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Recent literature: Ergosterol synthesis inhibitor
Date Journal Article title
2019 Jan - Rev Iberoam Micol Simvastatin and other inhibitors of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase of Ustilago maydis (Um-Hmgr) affect the viability of the fungus, its synthesis of sterols and mating.
2019 Feb J Biotechnol Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by α-asarone-based synthetic compounds as antifungal agents.
2019 Jan Front Biosci (Landmark Ed) Withaferin A attenuates ovalbumin induced airway inflammation.
2018 Mol Biochem Parasitol The steroid derivative 6-aminocholestanol inhibits the DEAD-box helicase eIF4A (LieIF4A) from the Trypanosomatid parasite Leishmania by perturbing the RNA and ATP binding sites.
2018 Nov Org Biomol Chem Studies of 4-arylthiazolylhydrazones derived from 1-indanones as Trypanosoma cruzi squalene epoxidase inhibitors by molecular simulations.
2018 Oct Life Sci Withaferin A inhibits apoptosis via activated Akt-mediated inhibition of oxidative stress.
2018 Plant Dis Baseline Sensitivity and Toxic Actions of Prochloraz to Sclerotinia sclerotiorum.
2018 Jul Medchemcomm Structure-based virtual screening and ADMET-based prediction analysis for the discovery of novel antifungal CYP51 inhibitors.
2018 Biochim Biophys Acta Mol ... Functional importance for developmental regulation of sterol biosynthesis in Acanthamoeba castellanii.
2018 PLoS Negl Trop Dis Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery.
2018 Apr Molecules Synthesis and Anticandidal Activity of New Imidazole-Chalcones.
2018 Apr Eur J Med Chem Identification of Pyrazolo[3,4-e][1,4]thiazepin based CYP51 inhibitors as potential Chagas disease therapeutic alternative: In vitro and in vivo evaluation, binding mode prediction and SAR exploration.
2018 Antimicrob Agents Chemother iIn Vitroi and iIn Vivoi Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.
2017 J Biosci Cholesterol-lowering drug, in combination with chromium chloride, induces early apoptotic signals in intracellular L. donovani amastigotes, leading to death.
2018 Appl Microbiol Biotechnol Knockout of the SREBP system increases production of the polyketide FR901512 in filamentous fungal sp. No. 14919 and lovastatin in Aspergillus terreus ATCC20542.
2017 Nov Int J Mol Sci Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase.
2017 Dec Bioorg Med Chem Selenium-containing analogues of WC-9 are extremely potent inhibitors of Trypanosoma cruzi proliferation.
2018 Pest Manag Sci Synergistic interactions between a variety of insecticides and an ergosterol biosynthesis inhibitor fungicide in dietary exposures of bumble bees (Bombus terrestris L.).
2017 Oct Bioorg Med Chem Eudesmane sesquiterpenes from Chinese liverwort are strates of Cdrs and display antifungal activity by targeting Erg6 and Erg11 of Candida albicans.
2017 Antimicrob Agents Chemother Novel Cell-Killing Mechanisms of Hydroxyurea and the Implication toward Combination Therapy for the Treatment of Fungal Infections.
2017 Oct Chembiochem Antifungal Activity of the Lipophilic Antioxidant Ferrostatin-1.
2017 Nov Biochem Pharmacol Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells.
2017 Biochim Biophys Acta Mol ... Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor CEBPβ.
2017 Jul Colloids Surf B Biointerf... Effect of the presence of cholesterol in the interfacial microenvironment on the modulation of the alkaline phosphatase activity during in vitro mineralization.
2017 Cancer Sci Glucose metabolism-targeted therapy and withaferin A are effective for epidermal growth factor receptor tyrosine kinase inhibitor-induced drug-tolerant persisters.
2017 Dev Neurobiol Upregulation of matrix metalloproteinase triggers transdifferentiation of retinal pigmented epithelial cells in Xenopus laevis: A Link between inflammatory response and regeneration.
2017 Redox Biol Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B.
2017 World J Microbiol Biotechnol α-Bisabolol inhibits Aspergillus fumigatus Af239 growth via affecting microsomal ∆24-sterol methyltransferase as a crucial enzyme in ergosterol biosynthesis pathway.
2017 Feb Proc Natl Acad Sci U S A Synergistic antileukemic therapies in iNOTCH1i-induced T-ALL.
2017 Mar Bioorg Med Chem Lett Physapubescin, a natural withanolide as a kidney-type glutaminase (KGA) inhibitor.
2017 Appl Biochem Biotechnol Recombinant 3-Hydroxy 3-Methyl Glutaryl-CoA Reductase from Candida glabrata (Rec-CgHMGR) Obtained by Heterologous Expression, as a Novel Therapeutic Target Model for Testing Synthetic Drugs.
2017 Chem Pharm Bull (Tokyo) Trialkylamine Derivatives Containing a Triazole Moiety as Promising Ergosterol Biosynthesis Inhibitor: Design, Synthesis, and Antifungal Activity.
2016 PLoS One Withaferin A Induces ROS-Mediated Paraptosis in Human Breast Cancer Cell-Lines MCF-7 and MDA-MB-231.
2017 Biochim Biophys Acta Mol ... 24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei.
2017 Mol Immunol Lipopolysaccharides-stimulated macrophage products enhance Withaferin A-induced apoptosis via activation of caspases and inhibition of NF-κB pathway in human cancer cells.
2016 Recent Pat Antiinfect Dru... Targets and Patented Drugs for Chemotherapy of Chagas Disease in the Last 15 Years-Period.
2016 Sep Cell Death Dis Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis.
2016 PLoS Genet Chemogenetic E-MAP in Saccharomyces cerevisiae for Identification of Membrane Transporters Operating Lipid Flip Flop.
2017 J Gastroenterol A small molecule inhibitor of NFκB blocks ER stress and the NLRP3 inflammasome and prevents progression of pancreatitis.
2016 Cancer Sci Withaferin A presses the growth of myelodysplasia and leukemia cell lines by inhibiting cell cycle progression.
2016 Jun Sci Rep Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through pression of oxidative stress and inflammation.
2016 Antimicrob Agents Chemother The Investigational Drug VT-1129 Is a Highly Potent Inhibitor of Cryptococcus Species CYP51 but Only Weakly Inhibits the Human Enzyme.
2016 Front Microbiol Δ(24)-Sterol Methyltransferase Plays an Important Role in the Growth and Development of Sporothrix schenckii and Sporothrix brasiliensis.
2016 Mol Nutr Food Res Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4β-hydroxywithanolide E isolated from Physalis peruviana.
2016 Mol Cell Biochem Physalin A induces G2M phase cell cycle arrest in human non-small cell lung cancer cells: involvement of the p38 MAPKROS pathway.
2016 Feb Sci Rep A common mechanism involving the TORC1 pathway can lead to amphotericin B-persistence in biofilm and planktonic Saccharomyces cerevisiae populations.
2016 Int J Oncol Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.
2016 Mycoses Cross-resistance to fluconazole induced by exposure to the agricultural azole tetraconazole: an environmental resistance school?
2016 Feb Oncotarget Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by pressing JAKSTAT3 signaling.
2015 Sci Pharm Synthesis and Antifungal Evaluation of Novel N-Alkyl Tetra- and Perhydroquinoline Derivatives.
2015 Neurosignals Lithium-Sensitive Store-Operated Ca2+ Entry in the Regulation of FGF23 Release.
2015 Oct Chem Biol Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei.
2015 Dec Toxicol Appl Pharmacol Thiol dependent NF-κB pression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A.
2015 Comp Biochem Physiol A Mo... The small heat shock protein, HSP30, is associated with aggresome-like inclusion bodies in proteasomal inhibitor-, arsenite-, and cadmium-treated Xenopus kidney cells.
2015 PLoS One Vimentin Phosphorylation Underlies Myofibroblast Sensitivity to Withaferin A In Vitro and during Corneal Fibrosis.
2015 Parasitol Res Antileishmanial effect of mevastatin is due to interference with sterol metabolism.
2015 Sep Bioorg Med Chem Lett Hedgehog inhibitors from Withania somnifera.
2015 Steroids Fungal sterol C22-desaturase is not an antimycotic target as shown by selective inhibitors and testing on clinical isolates.
2015 Aug ACS Chem Biol Withaferin A Analogs That Target the AAA+ Chaperone p97.
2015 Curr Aging Sci Withaferin A Regulates LRRK2 Levels by Interfering with the Hsp90- Cdc37 Chaperone Complex.
2016 Mol Carcinog Par-4 dependent modulation of cellular β-catenin by medicinal plant natural product derivative 3-azido Withaferin A.
2015 Lett Appl Microbiol Production of squalene by lactose-fermenting yeast Kluyveromyces lactis with reduced squalene epoxidase activity.
2015 J Physiol Sci A protein tyrosine kinase receptor, c-RET signaling pathway contributes to the enteric neurogenesis induced by a 5-HT4 receptor agonist at an anastomosis after transection of the gut in rodents.
2015 Feb Cell Death Dis Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.
2015 J Biomol Struct Dyn Binding pattern analysis and structural insight into the inhibition mechanism of Sterol 24-C methyltransferase by docking and molecular dynamics approach.
2015 J Appl Microbiol Synergistic activity of magnolol with azoles and its possible antifungal mechanism against Candida albicans.
2015 J Lipid Res Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth.
2014 PLoS One Tumor necrosis factor-α sensitizes breast cancer cells to natural products with proteasome-inhibitory activity leading to apoptosis.
2015 Expert Opin Drug Saf Drug safety assessment of oral formulations of ketoconazole.
2015 Int J Mol Med Withaferin A induces apoptosis through the generation of thiol oxidation in human head and neck cancer cells.
2014 Oct Cell Death Dis JNK-NQO1 axis drives TAp73-mediated tumor pression upon oxidative and proteasomal stress.
2015 Feb Exp Cell Res Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling.
2014 Sep Oncotarget Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell.
2014 Antimicrob Agents Chemother The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.
2014 Eukaryot Cell Ascorbic acid inhibition of Candida albicans Hsp90-mediated morphogenesis occurs via the transcriptional regulator Upc2.