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Recent literature: DNA alkylating
Date Journal Article title
2020 Mar BMC Biol DDX39B interacts with the pattern recognition receptor pathway to inhibit NF-κB and sensitize to alkylating chemotherapy.
2019 Interdiscip Toxicol Genotoxicity of cisplatin and carboplatin in cultured human lymphocytes: a comparative study.
2020 Apr Eur J Med Chem Comparative analysis of the dual EGFR-DNA targeting and growth inhibitory properties of 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline-based type II combi-molecules.
2020 Mar Biosci Rep Association between MGMT status and response to alkylating agents in patients with neuroendocrine neoplasms: a systematic review and meta-analysis.
2020 Mar J Am Soc Mass Spectrom Collision-Induced Dissociation Studies of Protonated Ions of Alkylated Thymidine and 2'-Deoxyguanosine.
2020 Mar Nucleic Acids Res Mutation signatures specific to DNA alkylating agents in yeast and cancers.
2020 Feb Oncotarget MAGE-A inhibit apoptosis and promote proliferation in multiple myeloma through regulation of BIM and p21Cip1.
2020 Feb Exp Mol Pathol Antioxidantstress response in mouse epidermis following exposure to nitrogen mustard.
2020 Feb Cancers (Basel) A "Clickable" Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT.
2020 Feb Oncologist Maximizing Breast Cancer Therapy with Awareness of Potential Treatment-Related Blood Disorders.
2020 J Clin Neurosci Immunohistochemistry for O6-methylguanin-DNA methyltransferase in glioblastomas defined by WHO2016: Correlation with promoter methylation status and patients' progression-free survival with the cut-off value determined by ROC analysis.
2020 Feb Oncogene EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma.
2020 Feb Neuro Oncol Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter-methylated malignant astrocytoma.
2020 Feb Org Biomol Chem Migratory ability of quinone methide-generating acridine conjugates in DNA.
2020 Feb Acta Neuropathol Commun The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas.
2020 Feb Mitochondrion Mitochondrial-associated impairments of temozolomide on neural stemprogenitor cells and hippocampal neurons.
2020 Feb Anticancer Drugs Causes and possibilities to circumvent cyclophosphamide toxicity.
2020 Feb Sci Rep Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition.
2019 Front Oncol O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy.
2020 Biomed Pharmacother Inhibition of MGMT-mediated autophagy pression decreases cisplatin chemosensitivity in gastric cancer.
2020 Mar J Biol Chem The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites.
2019 Front Oncol N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression.
2020 Jan Sci Rep Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity.
2020 Genes Cells MLH1-mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O6 -methylguanine.
2020 DNA Repair (Amst) Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.
2020 Genes Cells Involvement of Rev1 in alkylating agent-induced loss of heterozygosity in Oryzias latipes.
2020 Feb J Am Chem Soc Conjugating Aptamer and Mitomycin C with Reductant-Responsive Linker Leading to Synergistically Enhanced Anticancer Effect.
2020 Mar G3 (Bethesda) Mutational Analysis of N-Ethyl-N-Nitrosourea (ENU) in the Fission Yeast iSchizosaccharomyces pombei.
2020 Jan Clin Cancer Res Restoration of Temozolomide Sensitivity by PARP Inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair.
2020 Feb Life Sci Revisiting the development of small molecular inhibitors that directly target the signal transducer and activator of transcription 3 (STAT3) domains.
2019 PLoS One Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: A pilot study on the impact of age and type of treatment.
2019 Dec Int J Mol Sci Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation.
2020 Jan J Biol Chem SMARCAD1-mediated recruitment of the DNA mismatch repair protein MutLα to MutSα on damaged chromatin induces apoptosis in human cells.
2020 Cancer Treat Rev Biomarker-guided implementation of the old drug temozolomide as a novel treatment option for patients with metastatic colorectal cancer.
2019 Dec Nat Commun Oxidation and alkylation stresses activate ribosome-quality control.
2019 Anticancer Res Temozolomide-resistant Glioblastoma Depends on HDAC6 Activity Through Regulation of DNA Mismatch Repair.
2019 Ann Saudi Med O6-methylguanine-DNA methyltransferase promoter methylation and isocitrate dehydrogenase mutation as prognostic factors in a cohort of Saudi patients with glioblastoma.
2019 Nov Oncotarget Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models.
2019 Genes Cancer HDAC8 affects MGMT levels in glioblastoma cell lines iviai interaction with the proteasome receptor ADRM1.
2020 Jan Virus Res Persistent HCMV infection of a glioblastoma cell line contributes to the development of resistance to temozolomide.
2019 PLoS One Effect of anti-epileptic drugs on the survival of patients with glioblastoma multiforme: A retrospective, single-center study.
2020 Feb Cancer Res Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer.
2020 Jan ChemMedChem Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy.
2020 Jan Chem Biol Interact In vitro metabolism of naphthalene and its alkylated congeners by human and rat liver microsomes via alkyl side chain or aromatic oxidation.
2020 J Cancer Res Clin Oncol Bevacizumab versus alkylating chemotherapy in recurrent glioblastoma.
2019 Nov Cell Death Dis BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells.
2019 Nature Longitudinal molecular trajectories of diffuse glioma in adults.
2020 Jan Bioconjug Chem Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
2020 Biomed Chromatogr An LC-MSMS method for determination of O6 -benzylguanine and its metabolite O6 -benzyl-8-oxoguanine in human plasma.
2020 J Neurol Intravenous cyclophosphamide monthly pulses in refractory myasthenia gravis.
2019 Nov Biomedicines Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. iBiomedicinesi 2019, i7i, 69.
2020 J Chem Neuroanat Maternal exposure to busulfan reduces the cell number in the somatosensory cortex associated with delayed somatic and reflex maturation in neonatal rats.
2019 Dec Bioorg Med Chem The adduct formation between the thioguanine-polyamine ligands and DNA with the AP site under UVA irradiated and non-irradiated conditions.
2019 Oct Molecules Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η.
2020 Mol Cancer Res An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks.
2019 Oct Biochem Cell Biol Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs).
2020 Invest New Drugs Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach.
2019 Oct Nat Commun Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus.
2012 LiverTox: Clinical and Re... Platinum Coordination Complexes
2012 LiverTox: Clinical and Re... Alkylating Agents
2019 Nov ACS Appl Mater Interfaces Enhanced Copper-Temozolomide Interactions by Protein for Chemotherapy against Glioblastoma Multiforme.
2019 Dec Nucleic Acids Res Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase.
2019 Oct BMC Infect Dis Disseminated cytomegalovirus disease after bendamustine: a case report and analysis of circulating B- and T-cell sets.
2019 Oct J Exp Clin Cancer Res The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment.
2019 Ther Adv Med Oncol Novel multi-drugs incorporating hybrid-structured nanofibers enhance alkylating agent activity in malignant gliomas.
2019 Oct ACS Appl Mater Interfaces Enhanced Efficacy of Temozolomide Loaded by a Tetrahedral Framework DNA Nanoparticle in the Therapy for Glioblastoma.
2019 Oct Cancers (Basel) Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia.
2019 Oct Sci Rep Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy.
2020 Curr Cancer Drug Targets Natural DNA Intercalators as Promising Therapeutics for Cancer and Infectious Diseases.
2019 Mutat Res Combined treatment with cisplatin and the tankyrase inhibitor XAV-939 increases cytotoxicity, abrogates cancer-stem-like cell phenotype and increases chemosensitivity of head-and-neck squamous-cell carcinoma cells.
2019 An Acad Bras Cienc Deoxyribonucleic acid damage and repair response in the chemotherapy of lung cancer: cross-sectional study.
2020 Methods Mol Biol Methods for Evaluation of a Snake Venom-Derived Disintegrin in Animal Models of Human Cancer.
2019 Mutat Res The enzyme-modified comet assay: Enzyme incubation step in 2 vs 12-gelsslide systems.
2019 Sep Haematologica Characterization and genotype-phenotype correlation of patients with Fanconi anemia in a multi-ethnic population.
2019 Sep Int J Mol Sci Platelet-Derived Growth Factor Receptor and Ionizing Radiation in High Grade Glioma Cell Lines.