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Recent literature: DNA alkylating
Date Journal Article title
2019 Feb Sci Signal Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.
2019 Jan J Vis Exp Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy.
2019 Feb Haematologica The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity than SAR3419 in CD19-positive lymphoma and leukemia models.
2019 Jan Cancer Res A DNA repair and cell cycle gene expression signature in primary and recurrent glioblastoma: prognostic value and clinical implications.
2019 Jan J Biol Chem DNA replication studies of iNi-nitroso compound-induced iOi 6-alkyl-2'-deoxyguanosine lesions in iEscherichia colii.
2019 Feb J Med Chem Discovery of Macrocyclic Inhibitors of ApurinicApyrimidinic Endonuclease 1.
2018 Dec Oncotarget NEO412: A temozolomide analog with transdermal activity in melanoma iin vitroi and iin vivoi.
2019 Jan Cell Rep Mapping the Human Kinome in Response to DNA Damage.
2018 Dec Clin Genitourin Cancer Metronomic Oral Cyclophosphamide in 2 Heavily Pretreated Patients With Metastatic Castration-resistant Prostate Cancer With Homologous Recombination Deficiency (HRD): A Case Report.
2019 Jan Dalton Trans Modulation of the reactivity of nitrogen mustards by metal complexation: approaches to modify their therapeutic properties.
2018 Dec Oncotarget Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent.
2019 Feb Biochem Biophys Res Commun Heteroexpression of Mycobacterium leprae hypothetical protein ML0190 provides protection against DNA-alkylating agent methyl methanesulfonate.
2019 Jan Clin Epigenetics Preferential MGMT methylation could predispose a set of KITPDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents.
2019 Jan Biol Blood Marrow Transplant Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms.
2019 Jan J Am Chem Soc Molecular characteristics of DNA-alkylating PI polyamides targeting RUNX transcription factors.
2018 Dec Bioconjug Chem Size-dependent transport and cytotoxicity of mitomycin-gold nano-particle conjugates in 2D and 3D mammalian cell models.
2018 Neurol India Basic principles of mathematical growth modeling applied to high-grade gliomas: A brief clinical review for clinicians.
2018 Dec BMC Cancer EGFEGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence.
2019 Jan J Neuropathol Exp Neurol MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.
2019 DNA Repair (Amst) The DNA damage response is developmentally regulated in the African trypanosome.
2018 Nov Curr Drug Targets Investigational Hypoxia-Activated Prodrugs: Making Sense of Future Development.
2019 DNA Repair (Amst) Repair pathway for PARP-1 DNA-protein crosslinks.
2018 Cell Physiol Biochem 4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients.
2019 Arch Toxicol Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.
2019 Cancer Sci 20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.
2018 Nov Proc Natl Acad Sci U S A Histone tails decrease N7-methyl-2'-deoxyguanosine depurination and yield DNA-protein cross-links in nucleosome core particles and cells.
2018 Nov BMC Cancer Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line.
2018 Nov Molecules A Novel Venom-Derived Peptide for Brachytherapy of Glioblastoma: Preclinical Studies in Mice.
2018 Nov Molecules In Silico Prediction of O⁶-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods.
2018 Oct Haematologica CD123 expression patterns and selective targeting with a CD123-specific antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia.
2018 Oct Oncogene Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis.
2019 Feb Biochemistry RNA Modifications: Reversal Mechanisms and Cancer.
2019 Cancer Chemother Pharmacol Clinical and in vitro studies of the correlation between MGMT and the effect of streptozocin in pancreatic NET.
2018 Cancer Manag Res An intronic genetic variation of iMGMTi affects enhancer activity and is associated with glioma susceptibility.
2018 Nov Nucleic Acids Res MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
2018 An Acad Bras Cienc Hibiscus acetosella extract protects against alkylating agent-induced DNA damage in mice.
2019 Jan Int J Cancer Short half-life of HPV16 E6 and E7 mRNAs sensitizes HPV16-positive tonsillar cancer cell line HN26 to DNA-damaging drugs.
2018 Oct Nat Commun ATRChk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.
2018 Nov ACS Chem Biol Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma.
2019 Mol Oncol HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.
2019 Jan Neuro Oncol N2M2 (NOA-20) phase III trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma.
2018 Sep Clin Breast Cancer Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast.
2018 Gynecol Oncol Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
2018 World Neurosurg Extensive Leptomeningeal Intracranial and Spinal Metastases in a Patient with a Supratentorial Glioblastoma Multiforme, IDH-Wildtype.
2018 Oct Neurol Med Chir (Tokyo) Potential Strategies Overcoming the Temozolomide Resistance for Glioblastoma.
2018 Mutat Res DNA damaging agents trigger the expression of the HML silent mating type locus in Saccharomyces cerevisiae.
2018 Environ Res Genotoxicity of intermediate frequency magnetic fields in vitro and in vivo.
2018 Mol Cancer Ther PLK1 Inhibition Targets Myc-Activated Malignant Glioma Cells Irrespective of Mismatch Repair Deficiency-Mediated Acquired Resistance to Temozolomide.
2018 Lancet Oncol Trabectedin and olaparib in patients with advanced and non-resectable bone and soft-tissue sarcomas (TOMAS): an open-label, phase 1b study from the Italian Sarcoma Group.
2018 Cancer Cell Int Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis.
2019 Jan Clin Cancer Res Dual PAK4-NAMPT Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldenström Macroglobulinemia.
2018 Sep Phytomedicine Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review.
2018 Cancer Genomics Proteomics Pyrosequencing Analysis of iMGMTi Promoter Methylation in Meningioma.
2018 Oct Toxicol Appl Pharmacol Integration of sperm DNA damage assessment into OECD test guidelines for genotoxicity testing using the MutaMouse model.
2018 Kidney Int Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis.
2018 Arch Toxicol Next-generation sequencing approaches for the study of genome and epigenome toxicity induced by sulfur mustard.
2018 Plant Cell APURINICAPYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability.
2018 Toxicol In Vitro MIM1, the Mcl-1 - specific BH3 mimetic induces apoptosis in human U87MG glioblastoma cells.
2018 PLoS One Characterization of biochemical properties of an apurinicapyrimidinic endonuclease from Helicobacter pylori.
2018 Exp Hematol Epigenetic modification enhances the cytotoxicity of busulfan and4-hydroperoxycyclophosphamide in AML cells.
2018 Chem Biol Drug Des Involvement of Akt in mitomycin C and its analog triggered cytotoxicity in MCF-7 and K562 cancer cells.
2018 Ther Adv Neurol Disord Treatment of glioblastoma in adults.
2018 Oct Cancer Lett β-catenin contributes to cordycepin-induced MGMT inhibition and reduction of temozolomide resistance in glioma cells by increasing intracellular reactive oxygen species.
2018 Clin Dermatol (Wilmington) Expression of Laminin 332 in Vesicant Skin Injury and Wound Repair.
2018 Biomed Res Int Caffeine Sensitizes U87-MG Human Glioblastoma Cells to Temozolomide through Mitotic Catastrophe by Impeding G2 Arrest.
2018 Nov Colloids Surf B Biointerf... Coaxial extrusion bioprinted shell-core hydrogel microfibers mimic glioma microenvironment and enhance the drug resistance of cancer cells.
2018 Aug Bioorg Med Chem Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3.
2018 Mol Med Rep Triptolide exhibits antitumor effects by reversing hypermethylation of WIF‑1 in lung cancer cells.
2018 Aug Future Med Chem The specific role of O6-methylguanine-DNA methyltransferase inhibitors in cancer chemotherapy.
2018 Jul Biomed Microdevices A low cost PS based microfluidic platform to investigate cell cycle towards developing a therapeutic strategy for cancer.
2018 Jul Sci Transl Med iBCL3i expression promotes resistance to alkylating chemotherapy in gliomas.
2018 Front Endocrinol (Lausanne) Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions.
2018 Aug Biochemistry Structural and Kinetic Studies of the Effect of Guanine N7 Alkylation and Metal Cofactors on DNA Replication.
2018 Mol Oncol C1qTNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma.
2018 Jun Sci Rep A genome-wide mutation analysis method enabling high-throughput identification of chemical mutagen signatures.