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Recent literature: DNA alkylating
Date Journal Article title
2019 Apr Angew Chem Int Ed Engl Nanopore sequencing accurately identifies the mutagenic DNA lesion O6-carboxymethyl guanine and reveals its behavior in replication.
2019 Epigenet Insights Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors: Small Steps Toward Personalized Medicine?
2019 Apr Clin Cancer Res OBI-3424, a novel AKR1C3-activated prodrug, exhibits potent efficacy against preclinical models of T-ALL.
2019 Apr Arch Pharm (Weinheim) Investigation of the molecular reactivity of bioactive oxiranylmethyloxy anthraquinones.
2019 Sci Adv Targeting dePARylation selectively presses DNA repair-defective and PARP inhibitor-resistant malignancies.
2019 Trends Pharmacol Sci Rethinking Alkylating(-Like) Agents for Solid Tumor Management.
2019 Apr Am J Chin Med Curcumin Promotes Connexin 43 Degradation and Temozolomide-Induced Apoptosis in Glioblastoma Cells.
2019 Apr Res Microbiol The bifunctional protein GlmU is a key factor in biofilm formation induced by alkylating stress in Mycobacterium smegmatis.
2019 J Toxicol Sci Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin.
2019 Jun Eur J Med Chem Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability.
2019 Apr Brain Tumor Pathol Overview of DNA methylation in adult diffuse gliomas.
2019 Mar Curr Top Med Chem Nitrogen Mustards As Anticancer Chemotherapies: Historic Perspective, Current Developments, And Future Trends.
2019 Mar Int J Mol Sci Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?
2019 PLoS One Dose-dependent spatiotemporal responses of mammalian cells to an alkylating agent.
2019 Apr Anal Chem Quantification of a Novel DNA-Protein Cross-Link Product Formed by Reacting ApurinicApyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method.
2019 Mar Toxics Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke.
2019 Mar Sci Rep DNA polymerase ι is acetylated in response to SN2 alkylating agents.
2019 Mar Sci Rep CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.
2019 Mutat Res The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.
2019 Mar Cancers (Basel) Glioblastoma in Elderly Patients: Current Management and Future Perspectives.
2019 Mar Anticancer Agents Med Chem Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs.
2019 Mar Sci Rep PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.
2019 Dig Liver Dis O6-methylguanine-DNA methyltransferase (MGMT) status in neuroendocrine tumors: a randomized phase II study (MGMT-NET).
2019 PLoS One Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.
2019 Apr Exp Cell Res Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing.
2019 Feb Sci Signal Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.
2019 Jan J Vis Exp Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy.
2019 Feb Haematologica The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity than SAR3419 in CD19-positive lymphoma and leukemia models.
2019 Pharmacol Res Perspect pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study.
2019 Mar Cancer Res A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications.
2019 Mar J Biol Chem DNA replication studies of iNi-nitroso compound-induced iOi 6-alkyl-2'-deoxyguanosine lesions in iEscherichia colii.
2019 Feb J Med Chem Discovery of Macrocyclic Inhibitors of ApurinicApyrimidinic Endonuclease 1.
2018 Dec Oncotarget NEO412: A temozolomide analog with transdermal activity in melanoma iin vitroi and iin vivoi.
2019 Jan Cell Rep Mapping the Human Kinome in Response to DNA Damage.
2019 Clin Genitourin Cancer Metronomic Oral Cyclophosphamide in 2 Heavily Pretreated Patients With Metastatic Castration-resistant Prostate Cancer With Homologous Recombination Deficiency (HRD): A Case Report.
2019 Jan Dalton Trans Modulation of the reactivity of nitrogen mustards by metal complexation: approaches to modify their therapeutic properties.
2018 Dec Oncotarget Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent.
2019 Feb Biochem Biophys Res Commun Heteroexpression of Mycobacterium leprae hypothetical protein ML0190 provides protection against DNA-alkylating agent methyl methanesulfonate.
2019 Jan Clin Epigenetics Preferential MGMT methylation could predispose a set of KITPDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents.
2019 Jan Biol Blood Marrow Transplant Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms.
2019 Mar J Am Chem Soc Molecular Characteristics of DNA-Alkylating PI Polyamides Targeting RUNX Transcription Factors.
2019 Jan Bioconjug Chem Size-Dependent Transport and Cytotoxicity of Mitomycin-Gold Nanoparticle Conjugates in 2D and 3D Mammalian Cell Models.
2018 Neurol India Basic principles of mathematical growth modeling applied to high-grade gliomas: A brief clinical review for clinicians.
2018 Dec BMC Cancer EGFEGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence.
2019 Jan J Neuropathol Exp Neurol MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.
2019 DNA Repair (Amst) The DNA damage response is developmentally regulated in the African trypanosome.
2019 Curr Drug Targets Investigational Hypoxia-Activated Prodrugs: Making Sense of Future Development.
2019 DNA Repair (Amst) Repair pathway for PARP-1 DNA-protein crosslinks.
2018 Cell Physiol Biochem 4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients.
2019 Arch Toxicol Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.
2019 Cancer Sci 20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.
2018 Nov Proc Natl Acad Sci U S A Histone tails decrease N7-methyl-2'-deoxyguanosine depurination and yield DNA-protein cross-links in nucleosome core particles and cells.
2018 Nov BMC Cancer Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line.
2018 Nov Molecules A Novel Venom-Derived Peptide for Brachytherapy of Glioblastoma: Preclinical Studies in Mice.
2018 Nov Molecules In Silico Prediction of O⁶-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods.
2019 Biomed Pharmacother Studies examining the synergy between Dihydrotanshinone and Temozolomide against MGMT+ glioblastoma cells in vitro: Predicting interactions with the blood-brain barrier.
2019 Haematologica CD123 expression patterns and selective targeting with a CD123-targeted antibody-drug conjugate (IMGN632) in acute lymphoblastic leukemia.
2019 Oncogene Loss of Stat6 affects chromatin condensation in intestinal epithelial cells causing diverse outcome in murine models of inflammation-associated and sporadic colon carcinogenesis.
2019 Feb Biochemistry RNA Modifications: Reversal Mechanisms and Cancer.
2019 Cancer Chemother Pharmacol Clinical and in vitro studies of the correlation between MGMT and the effect of streptozocin in pancreatic NET.
2018 Cancer Manag Res An intronic genetic variation of iMGMTi affects enhancer activity and is associated with glioma susceptibility.
2018 Nov Nucleic Acids Res MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
2018 An Acad Bras Cienc Hibiscus acetosella extract protects against alkylating agent-induced DNA damage in mice.
2019 Jan Int J Cancer Short half-life of HPV16 E6 and E7 mRNAs sensitizes HPV16-positive tonsillar cancer cell line HN26 to DNA-damaging drugs.
2018 Sep Blood Cancer J Role of apurinicapyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance.
2018 Oct Nat Commun ATRChk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.
2018 Nov ACS Chem Biol Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma.
2019 Mol Oncol HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.
2019 Jan Neuro Oncol N2M2 (NOA-20) phase III trial of molecularly matched targeted therapies plus radiotherapy in patients with newly diagnosed non-MGMT hypermethylated glioblastoma.
2019 Clin Breast Cancer Potential Novel Therapy Targets in Neuroendocrine Carcinomas of the Breast.
2018 Gynecol Oncol Incidence of secondary myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) in patients with ovarian or breast cancer in a real-world setting in the United States.
2018 World Neurosurg Extensive Leptomeningeal Intracranial and Spinal Metastases in a Patient with a Supratentorial Glioblastoma Multiforme, IDH-Wildtype.
2018 Oct Neurol Med Chir (Tokyo) Potential Strategies Overcoming the Temozolomide Resistance for Glioblastoma.
2018 Mutat Res DNA damaging agents trigger the expression of the HML silent mating type locus in Saccharomyces cerevisiae.
2018 Endocrine Tumoral MGMT content predicts survival in patients with aggressive pituitary tumors and pituitary carcinomas given treatment with temozolomide.