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Recent literature: DNA alkylating
Date Journal Article title
2019 Nov J Neurol Intravenous cyclophosphamide monthly pulses in refractory myasthenia gravis.
2019 Nov Biomedicines Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. iBiomedicinesi 2019, i7i, 69.
2019 Nov J Chem Neuroanat Maternal exposure to busulfan reduces the cell number in the somatosensory cortex associated with delayed somatic and reflex maturation in neonatal rats.
2019 Oct Bioorg Med Chem The adduct formation between the thioguanine-polyamine ligands and DNA with the AP site under UVA irradiated and non-irradiated conditions.
2019 Oct Molecules Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η.
2019 Nov Mol Cancer Res An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks.
2019 Oct Biochem Cell Biol Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs).
2019 Oct Clin Pharmacol Ther A novel AKR1C3 specific prodrug TH3424 with potent anti-tumor activity in liver cancer.
2019 Oct Invest New Drugs Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach.
2019 Oct Nat Commun Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus.
2012 LiverTox: Clinical and Re... Platinum Coordination Complexes
2012 LiverTox: Clinical and Re... Alkylating Agents
2019 Nov ACS Appl Mater Interfaces Enhanced Copper-Temozolomide Interactions by Protein for Chemotherapy against Glioblastoma Multiforme.
2019 Oct Nucleic Acids Res Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase.
2019 Ther Adv Med Oncol Novel multi-drugs incorporating hybrid-structured nanofibers enhance alkylating agent activity in malignant gliomas.
2019 Oct ACS Appl Mater Interfaces Enhanced Efficacy of Temozolomide Loaded by a Tetrahedral Framework DNA Nanoparticle in the Therapy for Glioblastoma.
2019 Oct Cancers (Basel) Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia.
2019 Oct Sci Rep Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy.
2019 Oct Curr Cancer Drug Targets Natural DNA Intercalators as Promising Therapeutics for Cancer and Infectious Diseases.
2019 An Acad Bras Cienc Deoxyribonucleic acid damage and repair response in the chemotherapy of lung cancer: cross-sectional study.
2020 Methods Mol Biol Methods for Evaluation of a Snake Venom-Derived Disintegrin in Animal Models of Human Cancer.
2019 Sep Haematologica Characterization and genotype-phenotype correlation of patients with Fanconi anemia in a multi-ethnic population.
2019 Sep Int J Mol Sci Platelet-Derived Growth Factor Receptor and Ionizing Radiation in High Grade Glioma Cell Lines.
2019 Bioorg Chem Synthesis of Mitomycin C and decarbamoylmitomycin C N6 deoxyadenosine-adducts.
2019 Aquat Toxicol Anticancer agents found in environment affect Daphnia at population, individual and molecular levels.
2019 Sep Biomedicines Temozolomide and Other Alkylating Agents in Glioblastoma Therapy.
2019 Nov Cancer Lett MicroRNA-1 presses glioblastoma in preclinical models by targeting fibronectin.
2019 Sep Invest New Drugs Radiosensitizing effects of trabectedin on human A549 lung cancer cells and HT-29 colon cancer cells.
2019 DNA Repair (Amst) Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1.
2019 Sep Biophys J A Quantitative Model Explains Single-Cell Dynamics of the Adaptive Response in Escherichia coli.
2019 Food Chem Toxicol Evaluation of mutagenic activity of platinum complexes in somatic cells of Drosophila melanogaster.
2019 Aug Nat Commun Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy.
2019 Nov Brain Res Temozolomide has anti-tumor effects through the phosphorylation of cPLA2 on glioblastoma cells.
2019 Aug Pathol Oncol Res Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes.
2019 Sep J Nat Prod Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.
2019 Jul - Mutat Res Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.
2019 Aug ACS Med Chem Lett Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).
2019 Sep J Chromatogr B Analyt Tec... Measurement of the DNA alkylating agents busulfan and melphalan in human plasma by mass spectrometry.
2019 Aug Sci Rep A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51.
2019 Aug Med Oncol A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.
2019 Jul Oncotarget Polyphenols enhance the activity of alkylating agents in leukaemia cell lines.
2019 Drug Metab Dispos Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
2019 Sep Bioorg Med Chem Lett Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
2019 Aug Hum Reprod The impact of chemo- and radiotherapy treatments on selfish de novo FGFR2 mutations in sperm of cancer survivors.
2019 Sep Chemistry A Chemical Proteomic Analysis of Illudin-Interacting Proteins.
2019 Jul Sci Rep PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner.
2019 Jun Neuroendocrinology Multiple Assays to Determine Methylguanine-Methyltransferase Status in Lung Carcinoids and Correlation with Clinical and Pathological Features.
2019 Atlas Genet Cytogenet Onc... XRCC2 (X-ray repair cross complementing 2).
2019 EMBO Mol Med Chlorambucil targets BRCA12-deficient tumours and counteracts PARP inhibitor resistance.
2019 Sep Cancer Res Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors.
2019 Sep Clin Cancer Res Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas.
2019 Anticancer Res Broad-spectrum Cross-resistance to Anticancer Drugs Mediated by Epidermal Growth Factor Receptor.
2019 Anticancer Res Schlafen11 Expression Is Associated With the Antitumor Activity of Trabectedin in Human Sarcoma Cell Lines.
2019 Cancer Discov Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow.
2019 Oct Eur J Med Chem Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.
2019 Mol Cancer Ther Encapsulation of Temozolomide in a Calixarene Nanocapsule Improves Its Stability and Enhances Its Therapeutic Efficacy against Glioblastoma.
2019 Nov Nucleic Acids Res Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.
2019 Heliyon Potential antigenotoxicity assessment of iZiziphus jujubai fruit.
2019 Jul Nucleic Acids Res Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids.
2019 Biochem Pharmacol Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells.
2019 Jun Acta Neuropathol Commun Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients.
2019 May Cancers (Basel) PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma.
2019 Front Plant Sci The XPF-ERCC1 Complex Is Essential for Genome Stability and Is Involved in the Mechanism of Gene Targeting in iPhyscomitrella patensi.
2019 Aug Cancer Res Dysfunction of Poly (ADP-Ribose) Glycohydrolase Induces a Synthetic Lethal Effect in Dual Specificity Phosphatase 22-Deficient Lung Cancer Cells.
2019 J Toxicol Environ Health A Identification of DNA and glutathione adducts in male Sprague-Dawley rats exposed to 1-bromopropane.
2019 Daru Protective effect of Echinacea purpurea (Immulant) against cisplatin-induced immunotoxicity in rats.
2019 Front Physiol PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells.
2019 Jul Bioorg Med Chem Lett Generation of C5-desoxy analogs of tetrahydroisoquinoline alkaloids exhibiting potent DNA alkylating ability.
2019 Jun ACS Chem Biol Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms.
2019 Cancer Biol Ther Glioblastoma vs temozolomide: can the red queen race be won?
2019 May Sci Rep The DNA Alkylguanine DNA Alkyltransferase-2 (AGT-2) Of Caenorhabditis Elegans Is Involved In Meiosis And Early Development Under Physiological Conditions.
2019 May Nat Commun Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p.
2019 DNA Repair (Amst) DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas.
2019 Curr Protoc Nucleic Acid ... Immobilization of DNA on Biosensing Devices with Nitrogen Mustard-Modified Linkers.
2019 Epigenet Insights Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors: Small Steps Toward Personalized Medicine?