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Recent literature: DNA alkylating
Date Journal Article title
2020 Jan Sci Rep Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity.
2020 Jan Genes Cells MLH1-mediated recruitment of FAN1 to chromatin for the induction of apoptosis triggered by O6 -methylguanine.
2020 Jan DNA Repair (Amst) Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.
2020 Jan Genes Cells Involvement of Rev1 in alkylating agent-induced loss of heterozygosity in Oryzias latipes.
2020 Jan J Am Chem Soc Conjugating Aptamer and Mitomycin C with Reductant-Responsive Linker Leading to Synergistically Enhanced Anticancer Effect.
2020 Jan G3 (Bethesda) Mutational Analysis of N-Ethyl-N-Nitrosourea (ENU) in the Fission Yeast iSchizosaccharomyces pombei.
2020 Jan Clin Cancer Res Restoration of Temozolomide Sensitivity by Poly(ADP-Ribose) Polymerase inhibitors in Mismatch Repair Deficient Glioblastoma is Independent of Base Excision Repair.
2019 PLoS One Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: A pilot study on the impact of age and type of treatment.
2019 Dec Int J Mol Sci Reductive Activity and Mechanism of Hypoxia- Targeted AGT Inhibitors: An Experimental and Theoretical Investigation.
2020 Jan J Biol Chem SMARCAD1-mediated recruitment of the DNA mismatch repair protein MutLα to MutSα on damaged chromatin induces apoptosis in human cells.
2020 Cancer Treat Rev Biomarker-guided implementation of the old drug temozolomide as a novel treatment option for patients with metastatic colorectal cancer.
2019 Anticancer Res Temozolomide-resistant Glioblastoma Depends on HDAC6 Activity Through Regulation of DNA Mismatch Repair.
2019 Ann Saudi Med O6-methylguanine-DNA methyltransferase promoter methylation and isocitrate dehydrogenase mutation as prognostic factors in a cohort of Saudi patients with glioblastoma.
2019 Nov Oncotarget Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models.
2019 Genes Cancer HDAC8 affects MGMT levels in glioblastoma cell lines iviai interaction with the proteasome receptor ADRM1.
2020 Jan Virus Res Persistent HCMV infection of a glioblastoma cell line contributes to the development of resistance to temozolomide.
2019 Nov Cancer Res Gain-of-Function Mutant p53 R273H Interacts with Replicating DNA and PARP1 in Breast Cancer.
2020 Jan ChemMedChem Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy.
2019 Nov J Cancer Res Clin Oncol Bevacizumab versus alkylating chemotherapy in recurrent glioblastoma.
2019 Nov Cell Death Dis BET and Aurora Kinase A inhibitors synergize against MYCN-positive human glioblastoma cells.
2019 Nature Longitudinal molecular trajectories of diffuse glioma in adults.
2020 Jan Bioconjug Chem Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody-Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation.
2019 Nov Biomed Chromatogr An LC-MSMS method for determination of O6 -benzylguanine and its metabolite O6 -benzyl-8-oxoguanine in human plasma.
2019 Nov J Neurol Intravenous cyclophosphamide monthly pulses in refractory myasthenia gravis.
2019 Nov Biomedicines Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. iBiomedicinesi 2019, i7i, 69.
2020 J Chem Neuroanat Maternal exposure to busulfan reduces the cell number in the somatosensory cortex associated with delayed somatic and reflex maturation in neonatal rats.
2019 Dec Bioorg Med Chem The adduct formation between the thioguanine-polyamine ligands and DNA with the AP site under UVA irradiated and non-irradiated conditions.
2019 Oct Molecules Bypass of the Major Alkylative DNA Lesion by Human DNA Polymerase η.
2019 Nov Mol Cancer Res An Emerging Regulatory Role for the Tumor Microenvironment in the DNA Damage Response to Double-Strand Breaks.
2019 Oct Biochem Cell Biol Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumor stem cells (BTSCs).
2019 Oct Invest New Drugs Veliparib in ovarian cancer: a new synthetically lethal therapeutic approach.
2019 Oct Nat Commun Occurrence and repair of alkylating stress in the intracellular pathogen Brucella abortus.
2012 LiverTox: Clinical and Re... Platinum Coordination Complexes
2012 LiverTox: Clinical and Re... Alkylating Agents
2019 Nov ACS Appl Mater Interfaces Enhanced Copper-Temozolomide Interactions by Protein for Chemotherapy against Glioblastoma Multiforme.
2019 Dec Nucleic Acids Res Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase.
2019 Oct BMC Infect Dis Disseminated cytomegalovirus disease after bendamustine: a case report and analysis of circulating B- and T-cell sets.
2019 Ther Adv Med Oncol Novel multi-drugs incorporating hybrid-structured nanofibers enhance alkylating agent activity in malignant gliomas.
2019 Oct ACS Appl Mater Interfaces Enhanced Efficacy of Temozolomide Loaded by a Tetrahedral Framework DNA Nanoparticle in the Therapy for Glioblastoma.
2019 Oct Cancers (Basel) Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia.
2019 Oct Sci Rep Extracellular Vesicles Shedding Promotes Melanoma Growth in Response to Chemotherapy.
2019 Oct Curr Cancer Drug Targets Natural DNA Intercalators as Promising Therapeutics for Cancer and Infectious Diseases.
2019 An Acad Bras Cienc Deoxyribonucleic acid damage and repair response in the chemotherapy of lung cancer: cross-sectional study.
2020 Methods Mol Biol Methods for Evaluation of a Snake Venom-Derived Disintegrin in Animal Models of Human Cancer.
2019 Sep Haematologica Characterization and genotype-phenotype correlation of patients with Fanconi anemia in a multi-ethnic population.
2019 Sep Int J Mol Sci Platelet-Derived Growth Factor Receptor and Ionizing Radiation in High Grade Glioma Cell Lines.
2019 Bioorg Chem Synthesis of Mitomycin C and decarbamoylmitomycin C N6 deoxyadenosine-adducts.
2019 Aquat Toxicol Anticancer agents found in environment affect Daphnia at population, individual and molecular levels.
2019 Sep Biomedicines Temozolomide and Other Alkylating Agents in Glioblastoma Therapy.
2019 Nov Cancer Lett MicroRNA-1 presses glioblastoma in preclinical models by targeting fibronectin.
2019 Sep Invest New Drugs Radiosensitizing effects of trabectedin on human A549 lung cancer cells and HT-29 colon cancer cells.
2019 DNA Repair (Amst) Modification of the base excision repair enzyme MBD4 by the small ubiquitin-like molecule SUMO1.
2019 Sep Biophys J A Quantitative Model Explains Single-Cell Dynamics of the Adaptive Response in Escherichia coli.
2019 Food Chem Toxicol Evaluation of mutagenic activity of platinum complexes in somatic cells of Drosophila melanogaster.
2019 Aug Nat Commun Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy.
2019 Nov Brain Res Temozolomide has anti-tumor effects through the phosphorylation of cPLA2 on glioblastoma cells.
2019 Aug Pathol Oncol Res Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes.
2019 Sep J Nat Prod Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.
2019 Jul - Mutat Res Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.
2019 Aug ACS Med Chem Lett Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).
2019 Sep J Chromatogr B Analyt Tec... Measurement of the DNA alkylating agents busulfan and melphalan in human plasma by mass spectrometry.
2019 Aug Sci Rep A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51.
2019 Aug Med Oncol A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.
2019 Jul Oncotarget Polyphenols enhance the activity of alkylating agents in leukaemia cell lines.
2019 Drug Metab Dispos Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
2019 Sep Bioorg Med Chem Lett Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
2019 Aug Hum Reprod The impact of chemo- and radiotherapy treatments on selfish de novo FGFR2 mutations in sperm of cancer survivors.
2019 Sep Chemistry A Chemical Proteomic Analysis of Illudin-Interacting Proteins.
2019 Jul Sci Rep PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner.
2020 Neuroendocrinology Multiple Assays to Determine Methylguanine-Methyltransferase Status in Lung Carcinoids and Correlation with Clinical and Pathological Features.
2019 Atlas Genet Cytogenet Onc... XRCC2 (X-ray repair cross complementing 2).
2019 EMBO Mol Med Chlorambucil targets BRCA12-deficient tumours and counteracts PARP inhibitor resistance.
2019 Sep Cancer Res Temozolomide Sensitizes MGMT-Deficient Tumor Cells to ATR Inhibitors.
2019 Methods Mol Biol G2 Premature Chromosome CondensationChromosome Aberration Assay: Drug-Induced Premature Chromosome Condensation (PCC) Protocols and Cytogenetic Approaches in Mitotic Chromosome and Interphase Chromatin for Radiation Biology.
2019 Sep Clin Cancer Res Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas.