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Recent literature: DNA alkylating
Date Journal Article title
2019 Aug Brain Res Temozolomide has anti-tumor effects through the phosphorylation of cPLA2 on glioblastoma cells.
2019 Aug Pathol Oncol Res Mcl-1 Inhibitor Induces Cells Death in BRAF-Mutant Amelanotic Melanoma Trough GSH Depletion, DNA Damage and Cell Cycle Changes.
2019 Aug J Nat Prod Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.
2019 Jul - Mutat Res Meta-analysis of chromosomal aberrations as a biomarker of exposure in healthcare workers occupationally exposed to antineoplastic drugs.
2019 Aug ACS Med Chem Lett Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs).
2019 Sep J Chromatogr B Analyt Tec... Measurement of the DNA alkylating agents busulfan and melphalan in human plasma by mass spectrometry.
2019 Aug Sci Rep A Novel Cell-Penetrating Antibody Fragment Inhibits the DNA Repair Protein RAD51.
2019 Aug Med Oncol A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.
2019 Jul Oncotarget Polyphenols enhance the activity of alkylating agents in leukaemia cell lines.
2019 Jul Drug Metab Dispos Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues.
2019 Sep Bioorg Med Chem Lett Design, synthesis and evaluation of novel, potent DNA alkylating agents and their antibody-drug conjugates (ADCs).
2019 Jul Hum Reprod The impact of chemo- and radiotherapy treatments on selfish de novo FGFR2 mutations in sperm of cancer survivors.
2019 Jul Chemistry A chemical proteomic analysis of illudin-interacting proteins.
2019 Jul Sci Rep PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner.
2019 Jun Neuroendocrinology Multiple Assays to Determine Methylguanine-Methyltransferase Status in Lung Carcinoids and Correlation with Clinical and Pathological Features.
2019 Atlas Genet Cytogenet Onc... XRCC2 (X-ray repair cross complementing 2).
2019 EMBO Mol Med Chlorambucil targets BRCA12-deficient tumours and counteracts PARP inhibitor resistance.
2019 Jul Cancer Res Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors.
2019 Jul Clin Cancer Res Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas.
2019 Anticancer Res Broad-spectrum Cross-resistance to Anticancer Drugs Mediated by Epidermal Growth Factor Receptor.
2019 Anticancer Res Schlafen11 Expression Is Associated With the Antitumor Activity of Trabectedin in Human Sarcoma Cell Lines.
2019 Cancer Discov Lymphoma Chemotherapy: Hungry Macrophages Strike the Final Blow.
2019 Jun Eur J Med Chem Human constitutive androstane receptor agonist DL5016: A novel sensitizer for cyclophosphamide-based chemotherapies.
2019 Jun Mol Cancer Ther Encapsulation of temozolomide in a calixarene nanocapsule improves its stability and enhances its therapeutic efficacy against glioblastoma.
2019 Jun Nucleic Acids Res Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.
2019 Heliyon Potential antigenotoxicity assessment of iZiziphus jujubai fruit.
2019 Jul Nucleic Acids Res Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids.
2019 Biochem Pharmacol Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells.
2019 Jun Acta Neuropathol Commun Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients.
2019 May Cancers (Basel) PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma.
2019 Front Plant Sci The XPF-ERCC1 Complex Is Essential for Genome Stability and Is Involved in the Mechanism of Gene Targeting in iPhyscomitrella patensi.
2019 Aug Cancer Res Dysfunction of Poly (ADP-Ribose) Glycohydrolase Induces a Synthetic Lethal Effect in Dual Specificity Phosphatase 22-Deficient Lung Cancer Cells.
2019 J Toxicol Environ Health A Identification of DNA and glutathione adducts in male Sprague-Dawley rats exposed to 1-bromopropane.
2019 Daru Protective effect of Echinacea purpurea (Immulant) against cisplatin-induced immunotoxicity in rats.
2019 Front Physiol PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells.
2019 May EMBO Mol Med Chlorambucil targets BRCA12-deficient tumours and counteracts PARP inhibitor resistance.
2019 Jul Bioorg Med Chem Lett Generation of C5-desoxy analogs of tetrahydroisoquinoline alkaloids exhibiting potent DNA alkylating ability.
2019 Jun ACS Chem Biol Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms.
2019 Cancer Biol Ther Glioblastoma vs temozolomide: can the red queen race be won?
2019 May Sci Rep The DNA Alkylguanine DNA Alkyltransferase-2 (AGT-2) Of Caenorhabditis Elegans Is Involved In Meiosis And Early Development Under Physiological Conditions.
2019 May Nat Commun Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p.
2019 DNA Repair (Amst) DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas.
2019 Curr Protoc Nucleic Acid ... Immobilization of DNA on Biosensing Devices with Nitrogen Mustard-Modified Linkers.
2019 Epigenet Insights Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors: Small Steps Toward Personalized Medicine?
2019 Jul Clin Cancer Res OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL.
2019 Arch Pharm (Weinheim) Investigation of the molecular reactivity of bioactive oxiranylmethyloxy anthraquinones.
2019 Sci Adv Targeting dePARylation selectively presses DNA repair-defective and PARP inhibitor-resistant malignancies.
2019 Trends Pharmacol Sci Rethinking Alkylating(-Like) Agents for Solid Tumor Management.
2019 Am J Chin Med Curcumin Promotes Connexin 43 Degradation and Temozolomide-Induced Apoptosis in Glioblastoma Cells.
2019 Jun - Res Microbiol The bifunctional protein GlmU is a key factor in biofilm formation induced by alkylating stress in Mycobacterium smegmatis.
2019 J Toxicol Sci Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin.
2019 Jun Eur J Med Chem Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability.
2019 Brain Tumor Pathol Overview of DNA methylation in adult diffuse gliomas.
2019 Curr Top Med Chem Nitrogen Mustards as Anticancer Chemotherapies: Historic Perspective, Current Developments and Future Trends.
2019 Mar Int J Mol Sci Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?
2019 PLoS One Dose-dependent spatiotemporal responses of mammalian cells to an alkylating agent.
2019 Methods Mol Biol Unbiased Forward Genetic Screening with Chemical Mutagenesis to Uncover Drug-Target Interactions.
2019 J Cancer Res Ther Integrating systemic module inference with attract method excavates attractor modules for cyclophosphamide contributing to prostate cancer.
2019 Apr Anal Chem Quantification of a Novel DNA-Protein Cross-Link Product Formed by Reacting ApurinicApyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method.
2019 Mar Toxics Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke.
2019 Mar Sci Rep DNA polymerase ι is acetylated in response to SN2 alkylating agents.
2019 Mar Sci Rep CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.
2019 Mutat Res Genet Toxicol E... The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.
2019 Mar Cancers (Basel) Glioblastoma in Elderly Patients: Current Management and Future Perspectives.
2019 Mar Anticancer Agents Med Chem Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs.
2019 Mar BMC Cancer Phase IIIa study of concomitant radiotherapy with olaparib and temozolomide in unresectable or partially resectable glioblastoma: OLA-TMZ-RTE-01 trial protocol.
2019 Mar Sci Rep PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.
2019 Dig Liver Dis O6-methylguanine-DNA methyltransferase (MGMT) status in neuroendocrine tumors: a randomized phase II study (MGMT-NET).
2019 PLoS One Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.
2019 Apr Exp Cell Res Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing.
2019 Feb Cancer Commun (Lond) Carbon ion radiotherapy boost in the treatment of glioblastoma: a randomized phase IIII clinical trial.
2019 Feb Science The human gut bacterial genotoxin colibactin alkylates DNA.
2019 Feb Sci Signal Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.
2019 Jan J Vis Exp Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy.
2019 Haematologica The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models.