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Recent literature: DNA alkylating
Date Journal Article title
2019 Jun Mol Cancer Ther Encapsulation of temozolomide in a calixarene nanocapsule improves its stability and enhances its therapeutic efficacy against glioblastoma.
2019 Jun Nucleic Acids Res Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.
2019 Heliyon Potential antigenotoxicity assessment of iZiziphus jujubai fruit.
2019 Jun Nucleic Acids Res Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids.
2019 Jun Biochem Pharmacol Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells.
2019 Jun Acta Neuropathol Commun Predictive MGMT status in a homogeneous cohort of IDH wildtype glioblastoma patients.
2019 May Cancers (Basel) PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma.
2019 Front Plant Sci The XPF-ERCC1 Complex Is Essential for Genome Stability and Is Involved in the Mechanism of Gene Targeting in iPhyscomitrella patensi.
2019 May Cancer Res Dysfunction of poly(ADP-ribose) glycohydrolase induces a synthetic lethal effect in dual specificity phosphatase 22-deficient lung cancer cells.
2019 J Toxicol Environ Health A Identification of DNA and glutathione adducts in male Sprague-Dawley rats exposed to 1-bromopropane.
2019 May Daru Protective effect of Echinacea purpurea (Immulant) against cisplatin-induced immunotoxicity in rats.
2019 Front Physiol PARP Inhibitor PJ34 Protects Mitochondria and Induces DNA-Damage Mediated Apoptosis in Combination With Cisplatin or Temozolomide in B16F10 Melanoma Cells.
2019 May EMBO Mol Med Chlorambucil targets BRCA12-deficient tumours and counteracts PARP inhibitor resistance.
2019 Jul Bioorg Med Chem Lett Generation of C5-desoxy analogs of tetrahydroisoquinoline alkaloids exhibiting potent DNA alkylating ability.
2019 May ACS Chem Biol Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms.
2019 May Cancer Biol Ther Glioblastoma vs temozolomide: can the red queen race be won?
2019 May Sci Rep The DNA Alkylguanine DNA Alkyltransferase-2 (AGT-2) Of Caenorhabditis Elegans Is Involved In Meiosis And Early Development Under Physiological Conditions.
2019 May Nat Commun Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p.
2019 DNA Repair (Amst) DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas.
2019 Curr Protoc Nucleic Acid ... Immobilization of DNA on Biosensing Devices with Nitrogen Mustard-Modified Linkers.
2019 Epigenet Insights Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors: Small Steps Toward Personalized Medicine?
2019 Apr Clin Cancer Res OBI-3424, a Novel AKR1C3-Activated Prodrug, Exhibits Potent Efficacy against Preclinical Models of T-ALL.
2019 Arch Pharm (Weinheim) Investigation of the molecular reactivity of bioactive oxiranylmethyloxy anthraquinones.
2019 Sci Adv Targeting dePARylation selectively presses DNA repair-defective and PARP inhibitor-resistant malignancies.
2019 Trends Pharmacol Sci Rethinking Alkylating(-Like) Agents for Solid Tumor Management.
2019 Am J Chin Med Curcumin Promotes Connexin 43 Degradation and Temozolomide-Induced Apoptosis in Glioblastoma Cells.
2019 Apr Res Microbiol The bifunctional protein GlmU is a key factor in biofilm formation induced by alkylating stress in Mycobacterium smegmatis.
2019 J Toxicol Sci Dosage time affects alkylating agents induced micronuclei in mouse peripheral blood reticulocytes through the function of erythropoietin.
2019 Jun Eur J Med Chem Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability.
2019 Brain Tumor Pathol Overview of DNA methylation in adult diffuse gliomas.
2019 Mar Curr Top Med Chem Nitrogen Mustards As Anticancer Chemotherapies: Historic Perspective, Current Developments, And Future Trends.
2019 Mar Int J Mol Sci Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?
2019 PLoS One Dose-dependent spatiotemporal responses of mammalian cells to an alkylating agent.
2019 Apr Anal Chem Quantification of a Novel DNA-Protein Cross-Link Product Formed by Reacting ApurinicApyrimidinic Sites in DNA with Cysteine Residues in Protein by Liquid Chromatography-Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method.
2019 Mar Toxics Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke.
2019 Mar Sci Rep DNA polymerase ι is acetylated in response to SN2 alkylating agents.
2019 Mar Sci Rep CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma.
2019 Mutat Res Genet Toxicol E... The response of Escherichia coli to the alkylating agents chloroacetaldehyde and styrene oxide.
2019 Mar Cancers (Basel) Glioblastoma in Elderly Patients: Current Management and Future Perspectives.
2019 Mar Anticancer Agents Med Chem Nitrogen Mustards as Alkylating Agents: A Review on Chemistry, Mechanism of Action and Current USFDA Status of Drugs.
2019 Mar Sci Rep PARP1 rs1805407 Increases Sensitivity to PARP1 Inhibitors in Cancer Cells Suggesting an Improved Therapeutic Strategy.
2019 Dig Liver Dis O6-methylguanine-DNA methyltransferase (MGMT) status in neuroendocrine tumors: a randomized phase II study (MGMT-NET).
2019 PLoS One Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.
2019 Apr Exp Cell Res Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing.
2019 Feb Sci Signal Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.
2019 Jan J Vis Exp Assessing Stem Cell DNA Integrity for Cardiac Cell Therapy.
2019 Feb Haematologica The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity than SAR3419 in CD19-positive lymphoma and leukemia models.
2019 Pharmacol Res Perspect pH as a potential therapeutic target to improve temozolomide antitumor efficacy : A mechanistic modeling study.
2019 Mar Cancer Res A DNA Repair and Cell-Cycle Gene Expression Signature in Primary and Recurrent Glioblastoma: Prognostic Value and Clinical Implications.
2019 Mar J Biol Chem DNA replication studies of iNi-nitroso compound-induced iOi 6-alkyl-2'-deoxyguanosine lesions in iEscherichia colii.
2019 Feb J Med Chem Discovery of Macrocyclic Inhibitors of ApurinicApyrimidinic Endonuclease 1.
2018 Dec Oncotarget NEO412: A temozolomide analog with transdermal activity in melanoma iin vitroi and iin vivoi.
2019 Jan Cell Rep Mapping the Human Kinome in Response to DNA Damage.
2019 Clin Genitourin Cancer Metronomic Oral Cyclophosphamide in 2 Heavily Pretreated Patients With Metastatic Castration-resistant Prostate Cancer With Homologous Recombination Deficiency (HRD): A Case Report.
2019 Jan Dalton Trans Modulation of the reactivity of nitrogen mustards by metal complexation: approaches to modify their therapeutic properties.
2018 Dec Oncotarget Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent.
2019 Feb Biochem Biophys Res Commun Heteroexpression of Mycobacterium leprae hypothetical protein ML0190 provides protection against DNA-alkylating agent methyl methanesulfonate.
2019 Jan Clin Epigenetics Preferential MGMT methylation could predispose a set of KITPDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents.
2019 Biol Blood Marrow Transplant Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms.
2019 Mar J Am Chem Soc Molecular Characteristics of DNA-Alkylating PI Polyamides Targeting RUNX Transcription Factors.
2019 Jan Bioconjug Chem Size-Dependent Transport and Cytotoxicity of Mitomycin-Gold Nanoparticle Conjugates in 2D and 3D Mammalian Cell Models.
2018 Neurol India Basic principles of mathematical growth modeling applied to high-grade gliomas: A brief clinical review for clinicians.
2018 Dec BMC Cancer EGFEGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence.
2019 Jan J Neuropathol Exp Neurol MGMT: Immunohistochemical Detection in High-Grade Astrocytomas.
2019 DNA Repair (Amst) The DNA damage response is developmentally regulated in the African trypanosome.
2019 Curr Drug Targets Investigational Hypoxia-Activated Prodrugs: Making Sense of Future Development.
2019 DNA Repair (Amst) Repair pathway for PARP-1 DNA-protein crosslinks.
2018 Cell Physiol Biochem 4-Octyl Itaconate Activates Nrf2 Signaling to Inhibit Pro-Inflammatory Cytokine Production in Peripheral Blood Mononuclear Cells of Systemic Lupus Erythematosus Patients.
2018 Biochem Pharmacol Ubiquitin-conjugating enzyme E2 B regulates the ubiquitination of O6-methylguanine-DNA methyltransferase and BCNU sensitivity in human nasopharyngeal carcinoma cells.
2019 Appl Microbiol Biotechnol Triptolide modulates tumour-colonisation and anti-tumour effect of attenuated Salmonella encoding DNase I.
2019 Arch Toxicol Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo.
2019 Cancer Sci 20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.
2018 Nov Proc Natl Acad Sci U S A Histone tails decrease N7-methyl-2'-deoxyguanosine depurination and yield DNA-protein cross-links in nucleosome core particles and cells.
2018 Nov BMC Cancer Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line.
2018 Nov Molecules A Novel Venom-Derived Peptide for Brachytherapy of Glioblastoma: Preclinical Studies in Mice.