BlueBrainBoost
freedom-pharmacy
Purchases through the above links give commission which helps fund this website
Recent literature: Signal transduction inhibitor
Date Journal Article title
2019 Feb Clin Exp Rheumatol The effect of JAK1JAK2 inhibition in rheumatoid arthritis: efficacy and safety of baricitinib.
2019 Hepatol Commun An Inhibitor of Arginine-Glycine-Aspartate-Binding Integrins Reverses Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis.
2019 Feb Rice (N Y) Mutation in a putative glycosyltransferase-like gene causes programmed cell death and early leaf senescence in rice.
2019 Int J Biol Sci Exosomal transfer of obesity adipose tissue for decreased miR-141-3p mediate insulin resistance of hepatocytes.
2019 Feb J Biol Chem Melanocortin type 4 receptor-mediated inhibition of A-type K+ current enhances sensory neuronal excitability and mechanical pain sensitivity in rats.
2019 Feb J Biol Chem Rational design of a heterotrimeric G protein α unit with artificial inhibitor sensitivity.
2019 Feb Mol Cell Biochem Phospho-strate profiling of Epac-dependent protein kinase C activity.
2019 Feb Plant Physiol Identification of novel inhibitors of auxin-induced Ca2+ signaling via a plant-based chemical screen.
2019 Cell Biosci Growth inhibition and apoptosis in colorectal cancer cells induced by Vitamin D-Nanoemulsion (NVD): involvement of Wntβ-catenin and other signal transduction pathways.
2019 Feb Environ Toxicol Nickel-induced VEGF expression via regulation of Akt, ERK12, NFκB, and AMPK pathways in H460 cells.
2019 Feb J Cell Physiol The basics of epithelial-mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective.
2019 Feb Biol Pharm Bull Effect of selective serotonin (5-HT)2B receptor agonist BW723C86 on epidermal growth factortransforming growth factor-α receptor tyrosine kinase and ribosomal p70 S6 kinase activities in primary cultures of adult rat hepatocytes.
2019 Jan Cancer Lett C-terminal HSP90 inhibitor L80 elicits anti-metastatic effects in triple-negative breast cancer via STAT3 inhibition.
2019 Jan ACS Cent Sci A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after HypoxiaReoxygenation Injury.
2019 ScientificWorldJournal RASGRP2 Suppresses Apoptosis via Inhibition of ROS Production in Vascular Endothelial Cells.
2019 Jan Sci Rep Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures.
2019 J Surg Res MMP-12-Induced Pro-osteogenic Responses in Human Aortic Valve Interstitial Cells.
2019 Mar Life Sci Distinct role of 4E-BP1 and S6K1 in regulating autophagy and hepatitis B virus (HBV) replication.
2019 Mar Biochem Biophys Res Commun Conversion of Ca2+ oscillation into propagative electrical signals by Ca2+-activated ion channels and connexin as a reconstituted Ca2+ clock model for the pacemaker activity.
2019 Jan Nat Commun IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
2019 Jan J Biol Chem Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4).
2019 Oncol Lett Correlation of ERKMAPK signaling pathway with proliferation and apoptosis of colon cancer cells.
2019 Jan J Neurotrauma Bisperoxovanadium mediates neuronal protection through inhibition of PTEN and activation of PI3KAKT-mTOR signaling following traumatic spinal injuries.
2019 Cell Mol Neurobiol Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4PI3KAktJNK1214-3-3εNF-κBMMP9 Signal Transduction Pathway.
2019 Jan Am J Pathol SpexinNPQ Induces Fos and Produces Antinociceptive Effect against Inflammatory Pain in the Mouse Model.
2019 Jan J Diabetes Investig Canagliflozin, an SGLT2 inhibitor, normalizes renal susceptibility to type 1 cardiorenal syndrome through reduction of renal oxidative stress in diabetic rats.
2018 Oxid Med Cell Longev Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications.
2019 Jan Biochim Biophys Acta Gen ... Regulation of Ca2+calmodulin-dependent protein kinase kinase β by cAMP signaling.
2019 Feb Chem Biol Interact SIRT6 protects retinal ganglion cells against hydrogen peroxide-induced apoptosis and oxidative stress by promoting Nrf2ARE signaling via inhibition of Bach1.
2019 Jan Nat Commun An evolutionarily-conserved Wnt3β-cateninSp5 feedback loop restricts head organizer activity in Hydra.
2019 Jan BMC Ophthalmol All-trans retinoic acid stimulates the secretion of TGF-β2 via the phospholipase C but not the adenylyl cyclase signaling pathway in retinal pigment epithelium cells.
2019 Oncol Lett Enhanced cytotoxicity of human hepatocellular carcinoma cells following pretreatment with sorafenib combined with trichostatin A.
2019 Jan Reprod Biomed Online C-type natriuretic peptide regulates sperm capacitation by the cGMPPKG signalling pathway via Ca2+ influx and tyrosine phosphorylation.
2019 Jan EBioMedicine Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression.
2019 Jan Curr Genet Disturbance in biosynthesis of arachidonic acid impairs the sexual development of the onion blight pathogen Stemphylium eturmiunum.
2019 Feb J Cell Sci TIMP-1 promotes hypermigration of iToxoplasmai-infected primary dendritic cells via CD63-ITGB1-FAK signaling.
2019 Jan J Med Chem Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
2018 JACC Basic Transl Sci The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE-- and LDLr-- Mice by a Mechanism That Includes Inflammatory Pathways.
2018 Dec World J Gastroenterol Role of cenicriviroc in the management of nonalcoholic fatty liver disease.
2019 Neoplasia MicroRNA-503-5p Inhibits the CD97-Mediated JAK2STAT3 Pathway in Metastatic or Paclitaxel-Resistant Ovarian Cancer Cells.
2019 Expert Opin Ther Pat Selective Tyk2 inhibitors as potential therapeutic agents: a patent review (2015-2018).
2018 Front Cell Infect Microbiol High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors.
2019 Jan J Cell Physiol YAP1 influences differentiation of osteoblastic MC3T3-E1 cells through the regulation of ID1.
2019 Feb Chem Biol Interact Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3KAktmTOR pathway.
2019 Feb Eur J Med Chem Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.
2019 Feb Toxicol Appl Pharmacol Triptonide inhibits lung cancer cell tumorigenicity by selectively attenuating the Shh-Gli1 signaling pathway.
2019 Jan Cell Rep WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop.
2019 Jan Curr Pharm Biotechnol Extracellular RNA, a Potential Drug Target for Alleviating Atherosclerosis, IschemiaReperfusion Injury and Organ Transplantation.
2019 Jan Leuk Lymphoma Dose reductions in ibrutinib therapy are not associated with inferior outcomes in patients with chronic lymphocytic leukemia (CLL).
2018 Ann Pediatr Endocrinol Metab The role of p21CIP1WAF1 (p21) in the negative regulation of the growth hormonegrowth hormone receptor and epidermal growth factorepidermal growth factor receptor pathways, in growth hormone transduction defect.
2019 Nat Plants Algal photoprotection is regulated by the E3 ligase CUL4-DDB1DET1.
2019 Feb Chem Biol Interact The ion channel activator CyPPA inhibits melanogenesis via the GSK3ββ-catenin pathway.
2018 Dec J Biol Chem A high-throughput chemical-genetics screen in murine adipocytes identifies insulin-regulatory pathways.
2018 Dec N Engl J Med Tofacitinib Treatment and Molecular Analysis of Cutaneous Sarcoidosis.
2018 Int J Nanomedicine Transferrin receptor-targeted HMSN for sorafenib delivery in refractory differentiated thyroid cancer therapy.
2018 Dec Asian Pac J Cancer Prev Molecular Targeting of Notch Signaling Pathway by DAPT in Human Ovarian Cancer: Possible Anti Metastatic Effects
2018 Dec J Exp Clin Cancer Res Arsenic trioxide reverses the chemoresistance in hepatocellular carcinoma: a targeted intervention of 14-3-3ηNF-κB feedback loop.
2019 Pharmacol Res Perspect MDM2 inhibitor ameliorates cisplatin-induced nephropathy via NFκΒ signal inhibition.
2019 Jan J Med Chem Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.
2018 Cell Physiol Biochem MACROD1LRP16 Enhances LPS-Stimulated Inflammatory Responses by Up-Regulating a Rac1-Dependent Pathway in Adipocytes.
2019 Feb Eur J Med Chem Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.
2019 Cancer Sci Nuclear factor (erythroid-derived 2)-like 2 antioxidative response mitigates cytoplasmic radiation-induced DNA double-strand breaks.
2018 Dec Arch Toxicol A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes.
2018 Dec J Formos Med Assoc IL-1β-induced ICAM-1 and IL-8 expressionsecretion of dental pulp cells is differentially regulated by IRAK and p38.
2018 Dec BMC Plant Biol Ozone-induced inhibition of kiwifruit ripening is amplified by 1-methylcyclopropene and reversed by exogenous ethylene.
2018 Front Physiol Comparative Transcriptome Analysis Between Resistant and Susceptible Rice Cultivars Responding to Striped Stem Borer (SSB), iChilo pressalisi (Walker) Infestation.
2019 Mar Gene FH535 inhibits proliferation and migration of colorectal cancer cells by regulating CyclinA2 and Claudin1 gene expression.
2019 Cancer Sci Sine oculis homeobox 1 promotes proliferation and migration of human colorectal cancer cells through activation of Wntβ-catenin signaling.
2018 Dec Int J Mol Sci Topical Application of JAK1JAK2 Inhibitor Momelotinib Exhibits Significant Anti-Inflammatory Responses in DNCB-Induced Atopic Dermatitis Model Mice.
2019 Oncol Rep sFRP1 exerts effects on gastric cancer cells through GSK3βRac1‑mediated restraint of TGFβSmad3 signaling.
2019 Oncol Rep PI3Kβ inhibitor AZD6482 exerts antiproliferative activity and induces apoptosis in human glioblastoma cells.
2019 Oncol Rep Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via pression of the ERK and AKT pathways.
2019 Oncol Rep Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
2018 J Biosci Down-regulation of microRNA-216a confers protection against yttrium aluminium garnet laser-induced retinal injury iviai the GDNF-mediated GDNFGFRα1RET signalling pathway.
2018 J Biosci Ursolic acid stimulates UCP2 expression and protects H9c2 cells from hypoxia-reoxygenation injury via p38 signaling.