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Recent literature: Signal transduction inhibitor
Date Journal Article title
2019 Jun Oncotarget Regression of iBRAFi V600E mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases.
2019 Jun Cancer Discov PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
2019 Jun Antimicrob Agents Chemother Identification of small molecules exhibiting oxacillin synergy through a novel assay for inhibition of ivraTSRi expression in methicillin resistant iStaphylococcus aureusi.
2019 Jun Autophagy Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation.
2019 Jun Int J Parasitol Plasmodium berghei serinethreonine protein phosphatase PP5 plays a critical role in male gamete fertility.
2019 Jun J Biomol Struct Dyn Binding modes and conformational changes of FK506-binding protein 51 induced by inhibitor bindings: insight into molecular mechanisms based on multiple simulation technologies.
2019 Jun J Mol Model Discovery of SBF1 as an allosteric inhibitor targeting the PIF-pocket of 3-phosphoinositide-dependent protein kinase-1.
2019 Jun Leukemia Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia.
2019 Jun World J Pediatr Forkhead box M1 transcription factor: a novel target for pulmonary arterial hypertension therapy.
2019 Jun Mol Cell Proteomics Phosphoproteome Analysis Reveals Estrogen-ER pathway as a modulator of mTOR activity via DEPTOR.
2019 Jun Int J Cancer ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.
2019 Oncol Lett High expression of PIM2 induces HSC proliferation in myelodysplastic syndromes via the IDH1HIF1-α signaling pathway.
2019 Jun Vet Clin North Am Small A... Targeted Therapies in Veterinary Oncology.
2019 Jun Int J Pharm Effect of surfactant on the size and stability of PLGA nanoparticles encapsulating a protein kinase C inhibitor.
2019 Jun Clin Transl Oncol The effect of fenofibrate, a PPARα activator on toll-like receptor-4 signal transduction in melanoma both in vitro and in vivo.
2019 Cell Mol Biol Lett The role of different SIRT1-mediated signaling pathways in toxic injury.
2019 May J Dairy Sci Establishing a model of primary bovine hepatocytes with responsive growth hormone receptor expression.
2019 Pestic Biochem Physiol Uncovering malathion (an organophosphate insecticide) action on Ca2+ signal transduction and investigating the effects of BAPTA-AM (a cell-permeant Ca2+ chelator) on protective responses in glial cells.
2019 Methods Mol Biol Monitoring RhoGDI Extraction of Lipid-Modified Rho GTPases from Membranes Using Click Chemistry.
2019 Sep Sci Total Environ Fluoxetine presses the immune responses of blood clams by reducing haemocyte viability, disturbing signal transduction and imposing physiological stress.
2019 Wei Sheng Yan Jiu [Role of p53p21 signal transduction pathway in the malignant transformation of human embryonic lung fibroblasts induced by quartz].
2019 May Toxicol Sci The TGFβ1 receptor antagonist GW788388 reduces JNK activation and protects against acetaminophen hepatotoxicity in mice.
2019 Theranostics Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α.
2019 Aug Life Sci Protective role of AGK2 on thioacetamide-induced acute liver failure in mice.
2019 Aug Life Sci Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver.
2019 May Asian Pac J Cancer Prev Targeting the BRAF Signaling Pathway in CD133pos Cancer Stem Cells of Anaplastic Thyroid Carcinoma
2019 May BMC Complement Altern Med Lancemaside A, a major triterpene saponin of Codonopsis lanceolata enhances regulation of nitric oxide synthesis via eNOS activation.
2019 Aug Life Sci P120-catenin regulates pulmonary fibrosis and TGF-β induced lung fibroblast differentiation.
2019 May Neurogastroenterol Motil Hemin reduces postoperative ileus in a heme oxygenase 1-dependent manner while dimethyl fumarate does without heme oxygenase 1-induction.
2019 May Autoimmunity Crystalline silica activates the T-cell and the B-cell antigen receptor complexes and induces T-cell and B-cell proliferation.
2019 J Enzyme Inhib Med Chem Design and synthesis of novel pyrazolo[4,3-idi]pyrimidines as potential therapeutic agents for acute lung injury.
2019 Mol Med Rep Formaldehyde induces the apoptosis of BMCs of BALBc mice via the PTENPI3KAkt signal transduction pathway.
2019 Apr Zhong Nan Da Xue Xue Bao ... [Research progress in the role of FBXW7 in drug resistance against non-small cell lung cancer].
2019 May J Bacteriol The two chemotaxis clusters in iCaulobacter crescentusi play different roles in chemotaxis and biofilm regulation.
2019 Cancer Genet A familial germline mutation in KIT associated with achalasia, mastocytosis and gastrointestinal stromal tumors shows response to kinase inhibitors.
2019 Aug Life Sci MiR-223 regulates proliferation and apoptosis of IL-22-stimulated HaCat human keratinocyte cell lines via the PTENAkt pathway.
2019 May J Exp Clin Cancer Res The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells.
2019 May J Cell Physiol The small molecule SI113 hinders epithelial-to-mesenchymal transition and verts cytoskeletal organization in human cancer cells.
2019 Anticancer Res Perfluorooctanoic Acid Enhances Invasion of Follicular Thyroid Carcinoma Cells Through NF-κB and Matrix Metalloproteinase-2 Activation.
2019 May BMC Cancer Major vault protein presses lung cancer cell proliferation by inhibiting STAT3 signaling pathway.
2019 May Ann Oncol Whole-genome sequencing reveals clinically relevant insights into the aetiology of familial breast cancers.
2019 Cell Physiol Biochem Regulation of Plasma Membrane Localization of the Na⁺-Taurocholate Co-Transporting Polypeptide by Glycochenodeoxycholate and Tauroursodeoxycholate.
2019 May J Clin Invest Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance.
2019 May Cell Syst Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming.
2019 Jul Gene Down-regulation of microRNA-98 promoted apoptosis of TNF-α stimulated human fibroblast-like synoviocytes via up-regulating IL-10.
2019 May Br J Pharmacol Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models.
2019 Jun J Biomed Nanotechnol Effects of VCP979 Novel p38 Mitogen Activated Protein Kinase Inhibitor on Progression of Pancreatic Cancer in Mouse Model with Diabetic Conditions.
2019 Oncogene Correction: DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor Geminin: molecular characterization and associations with breast cancer.
2019 Jun Chem Biol Interact Protection of the myocardium against ischemiareperfusion injury by punicalagin through an SIRT1-NRF-2-HO-1-dependent mechanism.
2019 Chem Pharm Bull (Tokyo) 2,4,5-Trichloro-6-((2,4,6-trichlorophenyl)amino)isophthalonitrile, Exerts Anti-bladder Activities through IGF-1RSTAT3 Signaling.
2019 May Cancers (Basel) Antitumor Activity of DFX117 by Dual Inhibition of c-Met and PI3Kα in Non-Small Cell Lung Cancer.
2019 May New Phytol Endosymbiotic Sinorhizobium meliloti modulate Medicago root susceptibility to secondary infection via ethylene.
2019 May Curr Pharm Des The function of RAS mutation in cancer and advances in its drug research.
2019 Sep Toxicol Lett Endoplasmic reticulum stress and autophagy contribute to cadmium-induced cytotoxicity in retinal pigment epithelial cells.
2019 Microb Pathog The ubiquitin-proteasome system is necessary for the replication of duck Tembusu virus.
2019 Cell Physiol Biochem ROS Generated by Upconversion Nanoparticle-Mediated Photodynamic Therapy Induces Autophagy via PI3KAKT mTOR Signaling Pathway in M1 Peritoneal Macrophage.
2019 May Biosci Biotechnol Biochem A novel Ca2+-signal transduction inhibitor, kujigamberol C, isolated from Kuji amber.
2019 May Oncogene Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer.
2019 May Nat Commun High mitogenic stimulation arrests angiogenesis.
2019 Jul Gene Evaluation of the diagnostic and therapeutic roles of non-coding RNA and cell proliferation related gene association in hepatocellular carcinoma.
2019 May J Med Chem Consideration of Binding Kinetics in the Design of Stapled Peptide Mimics of the Disordered Proteins Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 and Eukaryotic Translation Initiation Factor 4G.
2018 Jun Zhongguo Ying Yong Sheng ... [Baicalein inhibits the proliferation and invasion of oral squamous cell carcinoma and its possible signaling pathway].
2019 Prog Mol Biol Transl Sci The clinical use of Fondaparinux: A synthetic heparin pentasaccharide.
2019 Sep Toxicol Lett Therapeutic effects of scavenger receptor MARCO ligand on silica-induced pulmonary fibrosis in rats.
2019 Jun J Biol Chem Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation.
2019 Jul Gene miR-412-5p targets Xpo1 to regulate angiogenesis in hemorrhoid tissue.
2019 Sep Toxicol Lett Nontoxic concentrations of OTA aggravate DON-induced intestinal barrier dysfunction in IPEC-J2 cells via activation of NF-κB signaling pathway.
2019 Cell Physiol Biochem Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate-Induced Cell Invasion by Targeting AKTNF-κB via Matrix Metalloproteinase-2-9 Expression in Human Cervical Cancer Cells.
2019 Front Pharmacol Hydroxysafflor Yellow A Alleviates Ovalbumin-Induced Asthma in a Guinea Pig Model by Attenuateing the Expression of Inflammatory Cytokines and Signal Transduction.
2019 Apr BMC Complement Altern Med Differences in anti-inflammatory effect of immature and mature of Rubus coreanus fruits on LPS-induced RAW 264.7 macrophages via NF-κB signal pathways.
2019 Jul Eur J Med Chem The identification of naturally occurring labdane diterpenoid calcaratarin D as a potential anti-inflammatory agent.
2019 PLoS One A negative role for the interleukin-2-inducible T-cell kinase (ITK) in human Foxp3+ TREG differentiation.
2019 Toxicol Lett Inhibition of Rac1 activity alleviates PM2.5-induced pulmonary inflammation via the AKT signaling pathway.
2019 Apr Circulation Targeting Filamin A Reduces Macrophage Activity and Atherosclerosis.
2019 Apr Molecules Postharvest UV-B Irradiation Stimulated Ginsenoside Rg1 Biosynthesis through Nitric Oxide (NO) and Jasmonic Acid (JA) in iPanax quinquefoliusi Roots.