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Recent literature: Signal transduction inhibitor
Date Journal Article title
2019 Apr Stem Cell Res Cyclic tensile stress promotes osteogenic differentiation of adipose stem cells via ERK and p38 pathways.
2019 Apr Biomed Pharmacother Hypoxia-induced microRNA-141 regulates trophoblast apoptosis, invasion, and vascularization by blocking CXCL12βCXCR24 signal transduction.
2019 Mar Eur J Med Chem Discovery of 7H-pyrrolo[2,3-d]pyrimidine derivatives as selective covalent irreversible inhibitors of interleukin-2-inducible T-cell kinase (Itk).
2019 Apr JCI Insight High-throughput screening discovers antifibrotic properties of haloperidol by hindering myofibroblast activation.
2019 Apr J Biol Chem Smoothened-dependent and independent pathways in mammalian non-canonical Hedgehog signaling.
2019 Apr J Exp Bot Modeling of aluminum-induced malate secretion by pharmacological approach in Arabidopsis: involvement of lipid signaling.
2019 Front Cell Infect Microbiol iLutzomyia longipalpisi TGF-β Has a Role in iLeishmania infantum chagasii Survival in the Vector.
2019 Apr Cell Rep High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
2019 Feb Int J Oncol Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
2019 Apr J Biol Chem H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bounded retrograde trafficking mechanism.
2019 Apr Antioxidants (Basel) Juglone in Oxidative Stress and Cell Signaling.
2019 Apr Curr Drug Targets Anti-tumor drug targets analysis: current insight and future prospect.
2019 Mar Bioorg Chem Discovery of new inhibitors against both NF-κB and osteoclastogenesis from in-house library with α, β-unsaturated-enone fragment.
2019 Cell Physiol Biochem Specific Features of Fibrotic Lung Fibroblasts Highly Sensitive to Fibrotic Processes Mediated via TGF-β-ERK5 Interaction.
2019 Apr JCI Insight Alteration of myocardial GRK2 produces a global metabolic phenotype.
2019 Apr Int J Cancer Claudin7-dependent exosome-promoted reprogramming of non-metastasizing tumor cells.
2019 Apr Br J Pharmacol Bradykinin increases blood pressure in endotoxemic rats: functional and biochemical evidence of angiotensin II type 1bradykinin B2 receptor heterodimerization.
2019 Apr Oncol Rep Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells.
2019 Mar Molecules Smoke-Isolated Karrikins Stimulated Tanshinones Biosynthesis in iSalvia miltiorrhizai through Endogenous Nitric Oxide and Jasmonic Acid.
2019 Cell Physiol Biochem Dual PI3K-BRD4 Inhibitor SF1126 Inhibits Colorectal Cancer Cell Growth in Vitro and in Vivo.
2019 Apr Nat Commun YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells.
2019 Mar Gastroenterology Interactions Between Commensal Bacteria and Enteric Neurons, via FPR1 Induction of ROS, Increase Gastrointestinal Motility in Mice.
2019 Mar RNA Biol Systematic evaluation of the microRNAome through miR-CATCHv2.0 identifies positive and negative regulators of BRAF-X1 mRNA.
2019 Oxid Med Cell Longev Regulation of Skeletal Muscle DRP-1 and FIS-1 Protein Expression by IL-6 Signaling.
2019 Mar J Histochem Cytochem Rho-kinase and PKCα Inhibition Induces Primary Cilia Elongation and Alters the Behavior of Undifferentiated and Differentiated Temperature-sensitive Mouse Cochlear Cells.
2019 Oxid Med Cell Longev The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network.
2019 Oxid Med Cell Longev Increased Thioredoxin-1 Expression Promotes Cancer Progression and Predicts Poor Prognosis in Patients with Gastric Cancer.
2019 Int J Med Sci PM2.5 Upregulates MicroRNA-146a-3p and Induces M1 Polarization in RAW264.7 Cells by Targeting Sirtuin1.
2019 Cell Physiol Biochem miR-106b Promotes Metastasis of Early Gastric Cancer by Targeting ALEX1 in Vitro and in Vivo.
2019 Mar J Am Soc Nephrol Protein Phosphatase 1 Inhibitor-1 Mediates the cAMP-Dependent Stimulation of the Renal NaCl Cotransporter.
2019 Mar Cancer Biol Ther Discovery and mechanisms of host defense to oncogenesis: targeting the β-defensin-1 peptide as a natural tumor inhibitor.
2019 Mar Nat Commun Targeting glutamine-addiction and overcoming CDK46 inhibitor resistance in human esophageal squamous cell carcinoma.
2019 Mar Adv Biol Regul Effects of the MDM-2 inhibitor Nutlin-3a on PDAC cells containing and lacking WT-TP53 on sensitivity to chemotherapy, signal transduction inhibitors and nutraceuticals.
2019 PLoS Comput Biol ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion.
2019 Mar BMC Ophthalmol Cyclic stretch induced oxidative stress by mitochondrial and NADPH oxidase in retinal pigment epithelial cells.
2019 Ren Fail Hirudin ameliorates immunoglobulin A nephropathy by inhibition of fibrosis and inflammatory response.
2019 Apr Life Sci Pro-angiogenic activity of isoliquiritin on HUVECs in vitro and zebrafish in vivo through RafMEK signaling pathway.
2019 Apr Life Sci Histone deacetylase inhibitor LMK-235-mediated HO-1 expression induces apoptosis in multiple myeloma cells via the JNKAP-1 signaling pathway.
2019 Apr Life Sci TLR3 is involved in paraquat-induced acute renal injury.
2019 Mar Biol Res IRF2-INPP4B-mediated autophagy presses apoptosis in acute myeloid leukemia cells.
2019 Mar Int J Mol Sci The Selection of NFκB Inhibitors to Block Inflammation and Induce Sensitisation to FasL-Induced Apoptosis in HNSCC Cell Lines Is Critical for Their Use as a Prospective Cancer Therapy.
2019 Mol Immunol The inhibitor of interleukin-3 receptor protects against sepsis in a rat model of cecal ligation and puncture.
2019 Mar Hum Exp Toxicol Aβ1-42 increases the expression of neural KATP units Kir6.2SUR1 via the NF-κB, p38 MAPK and PKC signal pathways in rat primary cholinergic neurons.
2018 Dec Cureus Malignant Sarcomatous Transformation of Benign Giant Cell Tumor of Bone after Treatment with Denosumab Therapy: A Literature Review of Reported Cases.
2019 Mar Biosci Rep Resveratrol inhibits IL-1β-mediated nucleus pulposus cell apoptosis through regulating the PI3KAkt pathway.
2019 Mar J Immunol Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation.
2019 Mar Anticancer Agents Med Chem Recent Development in Indole Derivatives as Anticancer Agents for Breast Cancer.
2019 Mar Arch Dermatol Res From pathogenesis of acne vulgaris to anti-acne agents.
2019 Apr Life Sci Phosphodiestrase-1 and 4 inhibitors ameliorate liver fibrosis in rats: Modulation of cAMPCREBTLR4 inflammatory and fibrogenic pathways.
2019 Apr J Phys Chem Lett The Subtle Trade-Off between Evolutionary and Energetic Constraints in Protein-Protein Interactions.
2019 Apr Cell Stem Cell MAP4K4 Inhibition Promotes Survival of Human Stem Cell-Derived Cardiomyocytes and Reduces Infarct Size In Vivo.
2019 Mar Gynecol Oncol Therapeutic potential of the new TRIB3-mediated cell autophagy anticancer drug ABTL0812 in endometrial cancer.
2019 Mar Cell Syst Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos.
2019 Apr Life Sci β-Hydroxybutyrate, a ketone body, reduces the cytotoxic effect of cisplatin via activation of HDAC5 in human renal cortical epithelial cells.
2019 Mar Cell Death Differ TAK1 presses RIPK1-dependent cell death and is associated with disease progression in melanoma.
2019 Apr Life Sci Cardioprotective effect of a moderate and prolonged exercise training involves sirtuin pathway.
2019 Mar Haematologica Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma.
2019 Mar Cell Prolif C-type lectin domain family 5, member A (CLEC5A, MDL-1) promotes brain glioblastoma tumorigenesis by regulating PI3KAkt signalling.
2019 Mar J Agric Food Chem Glycyrrhizin Attenuates the Process of Epithelial-to-Mesenchymal Transition by Modulating HMGB1 Initiated Novel Signaling Pathway in Prostate Cancer Cells.
2019 Mar Fitoterapia Isolation of a spirolactone norditerpenoid as a yeast Ca2+ signal transduction inhibitor from Kuji amber and evaluation of its effects on PPM1A activity.
2019 J Inflamm (Lond) Extracellular acidification-induced CXCL8 production through a proton-sensing receptor OGR1 in human airway smooth muscle cells: a response inhibited by dexamethasone.
2019 Mar Br J Pharmacol Identification of TAK-632 and its analogues as potent inhibitors of necroptosis by targeting RIPK1 and RIPK3.
2019 Plant Sci The role of SIPK signaling pathway in antioxidant activity and programmed cell death of tobacco cells after exposure to cadmium.
2019 Plant Sci The p38-like MAP kinase modulated H2O2 accumulation in wounding signaling pathways of sweet potato.
2019 Plant Sci Microtubule dynamics modulate sensing during cold acclimation in grapevine suspension cells.
2019 Environ Pollut Di-(2-ethylhexyl) phthalate induced an increase in blood pressure via activation of ACE and inhibition of the bradykinin-NO pathway.
2019 Comp Biochem Physiol C To... Oxibendazole induces apoptotic cell death in proliferating porcine trophectoderm and uterine luminal epithelial cells via mitochondria-mediated calcium disruption and breakdown of mitochondrial membrane potential.
2019 Feb Zhonghua Yi Xue Za Zhi [Effect of RKIP on proliferation and migration of malignant melanoma cells and potential mechanism].
2019 Apr Toxicology Inhibition of double-stranded RNA-dependent protein kinase prevents oxytosis and ferroptosis in mouse hippocampal HT22 cells.
2019 Mar Reproduction Inhibition of DNA repair protein RAD51 affects porcine preimplantation embryo development.
2019 Cell Physiol Biochem The Regulation of Trophoblastic p53 Homeostasis by the p38-Wip1 Feedback Loop is Disturbed in Placentas from Pregnancies Complicated by Preeclampsia.
2019 May Gene Hsp-27 and NF-κB pathway is associated with ARAR-V7 expression in prostate cancer cells.
2019 Apr Life Sci Myocardial caspase-3 and NF-κB activation promotes calpain-induced septic apoptosis: The role of AkteNOSNO pathway.
2019 J Parasitol In Vitro and in Vivo Effect of MAPK Signal Transduction Pathway Inhibitors on Echinococcus multilocularis.
2019 Feb Med Sci Monit Cyclopamine Suppresses Human Esophageal Carcinoma Cell Growth by Inhibiting Glioma-Associated Oncogene Protein-1, a Marker of Human Esophageal Carcinoma Progression.