Purchases through the above links give commission which helps fund this website
Recent literature: Signal transduction inhibitor
Date Journal Article title
2019 Nov BMB Rep Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages.
2019 Nov Mol Cancer Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma.
2019 Nov Biochem Biophys Res Commun Mechanotransduction via the Piezo1-Akt pathway underlies Sost pression in osteocytes.
2019 Hortic Res Auxin regulation involved in gynoecium morphogenesis of papaya flowers.
2019 Nov Int J Mol Sci Acute Liver Injury after CCl4 Administration is Independent of Smad7 Expression in Myeloid Cells.
2019 Heliyon Yokukansan, a Kampo medicine, enhances the level of neuronal lineage markers in differentiated P19 embryonic carcinoma cells.
2019 Nov J Lipid Res Inhibition of sphingosine 1phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice.
2019 Nov Aging (Albany NY) Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms.
2019 PLoS One Retinoic acid-stimulated ERK12 pathway regulates meiotic initiation in cultured fetal germ cells.
2019 Oct J Ethnopharmacol Sargassum horneri (Turner) inhibit urban particulate matter-induced inflammation in MH-S lung macrophages via blocking TLRs mediated NF-κB and MAPK activation.
2019 Oct Life Sci Salvianolic acid B exerts anti-liver fibrosis effects via inhibition of MAPK-mediated phospho-Smad23 at linker regions in vivo and in vitro.
2019 Oct Biochim Biophys Acta Mol ... Therapeutic targeting of RAS: New hope for drugging the "undruggable".
2019 Oct Basic Res Cardiol Glucocorticoids preserve the t-tubular system in ventricular cardiomyocytes by upregulation of autophagic flux.
2019 Mol Metab miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease.
2019 Oct Cells Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling.
2019 Oct JCI Insight ER stress and Rho kinase activation underlie the vasculopathy of CADASIL.
2019 Nov ACS Infect Dis Identification of Small Molecules Disrupting the Ubiquitin Proteasome System in Malaria.
2019 Oct Cells PTPN11 (SHP2) Is Indispensable for Growth Factors and Cytokine Signal Transduction During Bovine Oocyte Maturation and Blastocyst Development.
2019 Oct Int J Mol Sci Novel Pituitary Actions of Epidermal Growth Factor: Receptor Specificity and Signal Transduction for iUTS1i, iEGR1i, and iMMP13i Regulation by EGF.
2019 Sichuan Da Xue Xue Bao Yi... [Bortezomib Inhibits Extranodal Natural KillerT Cell Lymphoma, Nasal Type by Targeting NF-κB Signaling Pathway].
2019 Oct Arch Oral Biol Rutin protects human periodontal ligament stem cells from TNF-α induced damage to osteogenic differentiation through pressing mTOR signaling pathway in inflammatory environment.
2019 Oct Plant J Natural variation in the promoter of Awn Length Inhibitor 1 (ALI-1) is associated with awn elongation and grain length in common wheat.
2019 Adv Exp Med Biol NF-κB, IκB, and IKK: Integral Components of Immune System Signaling.
2019 Oct Cell Commun Signal Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and AktVEGFR2 pathway in hepatocellular carcinoma.
2019 Acta Cir Bras Effect of miR-134 against myocardial hypoxiareoxygenation injury by directly targeting NOS3 and regulating PI3KAkt pathway.
2019 Front Plant Sci Hypocotyl Elongation Inhibition of Melatonin Is Involved in Repressing Brassinosteroid Biosynthesis in iArabidopsisi.
2019 Oct J Biol Chem Cytoplasmic dsRNA induces the expression of iOCT34i and iNANOGi mRNAs in differentiated human cells.
2019 Nov Life Sci Amphiregulin promotes trophoblast invasion and increases MMP9TIMP1 ratio through ERK12 and Akt signal pathways.
2019 Oct Antimicrob Agents Chemother Quinazoline-based anti-virulence compounds selectively target iSalmonellai PhoPPhoQ signal transduction system.
2019 Nov Life Sci Inhibition of ovalbumin-induced allergic rhinitis by sumatriptan through the nitric oxide pathway in mice.
2019 Nov Life Sci The role of Wntβ-catenin pathway in the protection process by dexmedetomidine against cerebral ischemiareperfusion injury in rats.
2019 Dec Chem Biol Interact Multiple cytotoxic effects of gamabufotalin against human glioblastoma cell line U-87.
2019 Oct Hepatology Overriding adaptive resistance to sorafenib via combination therapy with SHP2 blockade in hepatocellular carcinoma.
2019 Oct Genes Cells AMPK activity is required for the induction of anhydrobiosis in a tardigrade Hypsibius exemplaris, and its potential up-regulator is PP2A.
2019 Sep Oncotarget Dual-Targeting AKT2 and ERK in cancer stem-like cells in neuroblastoma.
2019 Front Cell Neurosci The ATP-P2X7 Signaling Pathway Participates in the Regulation of Slit1 Expression in Satellite Glial Cells.
2019 Oct Adv Biol Regul Mice lacking DGKε show increased beige adipogenesis in visceral white adipose tissue after long-term high fat diet in a COX-2- dependent manner.
2019 Dec Chem Biol Interact MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFRAktGSK3ββ-catenin pathway: Amelioration by fisetin.
2019 Nov Life Sci Ginsenoside Rg1 defenses PC-12 cells against hydrogen peroxide-caused damage via up-regulation of miR-216a-5p.
2019 Biochem Pharmacol Genipin, a natural AKT inhibitor, targets the PH domain to affect downstream signaling and alleviates inflammation.
2019 Zhongguo Zhong Yao Za Zhi [Shenxiong Glucose Injection inhibits H_2O_2-induced apoptosis of H9c2 cells by activating PI3KAKT pathway].
2019 Zhongguo Zhong Yao Za Zhi [Triptolide induces autophagy of ovarian granulosa cells via PI3KAKTm TOR pathway].
2019 Zhongguo Zhong Yao Za Zhi [Modulation effect of Acanthopanax senticosus polysaccharides through inflammatory cytokines in protecting immunological liver-injured mice].
2019 Oct Clin Drug Investig Comparative Efficacy and Safety of Peficitinib 25, 50, 100, and 150 mg in Patients with Active Rheumatoid Arthritis: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.
2019 Oct Mar Drugs Kinase-Based Screening of Marine Natural Extracts Leads to the Identification of a Cytotoxic High Molecular Weight Metabolite from the Mediterranean Sponge iCrambe tailliezii.
2019 Fish Shellfish Immunol SpBAG1 promotes the WSSV infection by inhibiting apoptosis in mud crab (Scylla paramamosain).
2019 Oct Biochemistry Development of a Cell-Based Ligand-Screening System for Identifying Hsp90 Inhibitors.
2019 J Clin Biochem Nutr 5-Aminolevulinic acid induced apoptosis via oxidative stress in normal gastric epithelial cells.
2019 Oct Environ Toxicol Benzyl isothiocyanate promotes miR-99a expression through ERKAP-1-dependent pathway in bladder cancer cells.
2019 Oct J Biol Chem Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion.
2019 Oct J Biol Chem A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine erfamily member, inhibits MIF-2 biological activity.
2019 Oct J Pharmacol Exp Ther A Novel Phosphodiesterase 1 Inhibitor DSR-141562 Exhibits Efficacies in Animal Models for Positive, Negative, and Cognitive Symptoms Associated with Schizophrenia.
2019 Sep ACS Omega Residue Network Involved in the Allosteric Regulation of Cystathionine β-Synthase Domain-Containing Pyrophosphatase by Adenine Nucleotides.
2019 Dec Chem Biol Interact Famotidine has a neuroprotective effect on MK-801 induced toxicity via the AktGSK-3ββ-catenin signaling pathway in the SH-SY5Y cell line.
2019 Sep Semin Cancer Biol Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer.
2019 Sep Sheng Wu Gong Cheng Xue Bao [Research progress in melanogenesis signaling pathway].
2019 PLoS One MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells.
2019 Neurochem Res TGF-β2Smad3 Signaling Pathway Activation Through Enhancing VEGF and CD34 Ameliorates Cerebral IschemiaReperfusion Injury After Isoflurane Post-conditioning in Rats.
2019 Sep Asian Pac J Cancer Prev Signal Transduction of Improving Effects of Ibudilast on Methamphetamine Induced Cell Death.
2019 Sep Mol Oncol Metallopeptidase inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer.
2019 Int J Oncol Genome profiling revealed the activation of IL2RGJAK3STAT5 in peripheral T‑cell lymphoma expressing the ITK‑SYK fusion gene.
2020 Jan J Endocrinol eEF1A2 exacerbated insulin resistance in male skeletal muscle via PKCβ and ER stress.
2019 Eur Rev Med Pharmacol Sci Influence of mesenchymal stem cells on respiratory distress syndrome in newborn swines via the JAK-STAT signaling pathway.
2019 Nat Metab miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma.
2019 Sep Intern Med Long-term Effects of the Janus Kinase 12 Inhibitor Ruxolitinib on Pulmonary Hypertension and the Cardiac Function in a Patient with Myelofibrosis.
2019 Nov J Neurosci β-Secretase BACE1 Is Required for Normal Cochlear Function.
2019 Aug Redox Biol Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma.
2019 Oct Life Sci Dimethyl fumarate attenuates lipopolysaccharide-induced mitochondrial injury by activating Nrf2 pathway in cardiomyocytes.
2019 Oct Life Sci Chronic central miR-29b antagonism alleviates angiotensin II-induced hypertension and vascular endothelial dysfunction.
2019 Expert Opin Investig Drugs Tie-2Angiopoietin pathway modulation as a therapeutic strategy for retinal disease.
2019 Sep Sci Rep Atomoxetine produces oxidative stress and alters mitochondrial function in human neuron-like cells.
2019 Nov J Exp Med Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.
2019 J Biosci 5-Azacytidine and trichostatin A enhance the osteogenic differentiation of bone marrow mesenchymal stem cells isolated from steroid-induced avascular necrosis of the femoral head in rabbit.
2019 Dec Biochim Biophys Acta Mol ... mTORC1 inhibition attenuates necroptosis through RIP1 inhibition-mediated TFEB activation.
2019 Aug Oncotarget DS-1205b, a novel selective inhibitor of AXL kinase, blocks resistance to EGFR-tyrosine kinase inhibitors in a non-small cell lung cancer xenograft model.