Purchases through the above links give commission which helps fund this website
Recent literature: Signal transduction inhibitor
Date Journal Article title
2019 Aug Cells Pathogenic and Therapeutic Relevance of JAKSTAT Signaling in Systemic Lupus Erythematosus: Integration of Distinct Inflammatory Pathways and the Prospect of Their Inhibition with an Oral Agent.
2019 Aug J Cachexia Sarcopenia Muscle Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.
2019 Aug Antioxidants (Basel) Induction of G2M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3kAkt Signal Transduction Pathway.
2019 Bioinformation Design of novel JAK3 Inhibitors towards Rheumatoid Arthritis using molecular docking analysis.
2019 Jun Food Chem X Ca2+ involved in GABA signal transduction for phenolics accumulation in germinated hulless barley under NaCl stress.
2019 Aug Carcinogenesis Truncation of MYH8 tail in AML: a Novel prognostic marker with increase cell migration and epithelial-mesenchymal transition utilizing RAFMAPK pathway.
2019 Front Oncol SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC.
2019 Aug J Immunol Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes.
2019 Aug BMC Plant Biol Integrative omics analysis on phytohormones involved in oil palm seed germination.
2019 Exp Ther Med Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemiareperfusion injury in non-obese type 2 diabetic Goto-Kakizaki rats.
2019 Exp Ther Med Effects of iAchyranthes bidentatai alcohol on proliferation capacity of osteoblasts and miRNA in Runx2.
2019 Aug Cell Death Dis mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma.
2019 PeerJ miRDRN-miRNA disease regulatory network: a tool for exploring disease and tissue-specific microRNA regulatory networks.
2019 Aug Pathol Res Pract NTRK-Fusions - A new kid on the block.
2019 FASEB Bioadv 1,25(OH)2D3 regulates the proangiogenic activity of pericyte through VDR-mediated modulation of VEGF production and signaling of VEGF and PDGF receptors.
2019 Rinsho Ketsueki [Efficacy of Hedgehog inhibitors in acute myeloid leukemia and establishment of valid biomarkers].
2019 Aug Arch Dermatol Res Association between sphingosine-1-phosphate-induced signal transduction via mitogen-activated protein kinase pathways and keloid formation.
2019 Aug Cell Signal Analysis of the FLVR motif of SHIP1 and its importance for the protein stability of SH2 containing signaling proteins.
2019 Jul Int J Antimicrob Agents Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.
2019 Jul Zhen Ci Yan Jiu [Electroacupuncture at "Zusanli"(ST36) promotes gastrointestinal motility possibly by pres-sing excessive autophagy via AMPKULK1 signaling in rats with functional dyspepsia].
2019 Jul Fish Shellfish Immunol IKKε-like plays an important role in the innate immune signaling of the Pacific oyster (Crassostrea gigas).
2019 Cell Physiol Biochem Small Molecule Glycomimetics Inhibit Vascular Calcification via c-MetNotch3HES1 Signalling.
2019 Sep Biochem Biophys Res Commun Anti-inflammatory and anti-osteoarthritis effects of Cm-02 and Ck-02.
2019 Int Rev Neurobiol 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology.
2019 Jul Food Chem Toxicol Thyroid hormone-induced expression of inflammatory cytokines interfere with resveratrol-induced anti-proliferation of oral cancer cells.
2019 PLoS One CRLF2 rearrangement in Ph-like acute lymphoblastic leukemia predicts relative glucocorticoid resistance that is overcome with MEK or Akt inhibition.
2019 PLoS One Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment.
2019 Biochem Biophys Rep Effects of purine-scaffold inhibitors on HUVECs: Involvement of the purinergic pathway and interference with ATP. Implications for preventing the adverse effects of extracellular Grp94.
2019 Zhongguo Dang Dai Er Ke Z... [Research advances in the role of mTOR signaling pathway in autism spectrum disorder].
2019 Onco Targets Ther Rhein sensitizes human colorectal cancer cells to EGFR inhibitors by inhibiting STAT3 pathway.
2019 Jul BMC Plant Biol ABA mediates development-dependent anthocyanin biosynthesis and fruit coloration in Lycium plants.
2019 Anticancer Drugs ADAM8 promotes chondrosarcoma cell migration and invasion by activating the NF-κBMMP-13 signaling axis.
2019 Jul J Agric Food Chem Neuroprotective Effects of Ginsenoside Rg1 against Hyperphosphorylated Tau-Induced Diabetic Retinal Neurodegeneration via Activation of IRS-1AktGSK3β Signaling.
2019 Xi Bao Yu Fen Zi Mian Yi ... [IL-17 regulates the expression of RANKL and OPG in human periodontal ligament fibroblasts by activating p38MAPK signaling pathway].
2019 Theranostics Suppression of YAPTAZ-Notch1-NICD axis by bromodomain and extraterminal protein inhibition impairs liver regeneration.
2019 Sep Gene Low dose of indomethacin and Hedgehog signaling inhibitor administration synergistically attenuates cartilage damage in osteoarthritis by controlling chondrocytes pyroptosis.
2019 APMIS Notch signaling presses CD14+ monocytes cells activity in patients with chronic hepatitis C.
2019 Jul Biomol Ther (Seoul) G0G1 Switch 2 Induces Cell Survival and Metastasis through Integrin-Mediated Signal Transduction in Human Invasive Breast Cancer Cells.
2019 Sep Gene Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.
2019 Int J Oncol Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer.
2019 Jul Cell Commun Signal Minocycline impairs TNF-α-induced cell fusion of M13SV1-Cre cells with MDA-MB-435-pFDR1 cells by pressing NF-κB transcriptional activity and its induction of target-gene expression of fusion-relevant factors.
2019 Jul J Med Chem Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[idi]thiazol-5-ylamino)-6-(iterti-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
2019 Anticancer Res Virtual Screening of 1,4-Naphthoquinone Derivatives for Inhibition of a Key Cancer Signaling Protein, AKT1 Kinase.
2019 Anticancer Res Suppression of ERKNF-κB Activation Is Associated With Amentoflavone-Inhibited Osteosarcoma Progression iIn Vivoi.
2019 Anticancer Res Cetrimonium Bromide Inhibits Cell Migration and Invasion of Human Hepatic SK-HEP-1 Cells Through Modulating the Canonical and Non-canonical TGF-β Signaling Pathways.
2019 Mol Cancer Ther Differences in Signaling Patterns on PI3K Inhibition Reveal Context Specificity in iKRASi-Mutant Cancers.
2019 Jul Breast Cancer Res A kinase inhibitor screen identifies a dual cdc7CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.
2019 Jun Zhonghua Lao Dong Wei She... [Preliminary study of exon sequence in pneumoconiosis using high-throughput and intervention of EGFR-TKIs on silicosis rats].
2019 Jun Microb Pathog Panning using a phage-displayed random peptide library to identify peptides that antagonize the Helicobacter pylori ArsS acid-sensing domain.
2019 Aug J Biol Chem Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event.
2019 Jun Int J Mol Sci Biphasic Effect of Sildenafil on Energy Sensing is Mediated by Phosphodiesterases 2 and 3 in Adipocytes and Hepatocytes.
2019 Jun Cell Commun Signal Intragenic regulation of SOCS3 isoforms.
2019 Jun J Clin Med Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo.
2019 Cell Physiol Biochem Enhancement of Histone Deacetylase Inhibitor Sensitivity in Combination with Cyclin-Dependent Kinase Inhibition for the Treatment of Oral Squamous Cell Carcinoma.
2019 Jun Medicina (Kaunas) Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.
2019 Jun Nat Commun Reduced cutaneous adipogenesis in human hypertrophic obesity is linked to senescent precursor cells.
2019 Oct Toxicol Lett Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro.
2019 Oct Toxicol Lett Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
2019 Jun Sheng Li Xue Bao [Wnt5a modulates vincristine resistance through PI3KAktGSK3β signaling pathway in human ovarian carcinoma SKOV3VCR cells].
2019 Jun Oncotarget Regression of iBRAFi V600E mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases.
2019 Jun Cancer Discov PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.
2019 Cancer Sci Stromal iodothyronine deiodinase 2 (DIO2) promotes the growth of intestinal tumors in ApcΔ716 mutant mice.
2019 Antimicrob Agents Chemother Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of ivraTSRi Expression in Methicillin-Resistant Staphylococcus aureus.
2019 Zhongguo Shi Yan Xue Ye X... [Effect of PI3KmTOR Signal Pathway Inhibitor XL765 on Human Leukemic KG-1 Cells].
2019 Zhongguo Shi Yan Xue Ye X... [Bmi-1-siRNA Regulates the Proliferation of K562 Leukemia Cells in vitro and in vivo by PTENpAKT Pathway].
2019 Jun Autophagy Inactivation of MTOR promotes autophagy-mediated epithelial injury in particulate matter-induced airway inflammation.
2019 Int J Parasitol Plasmodium berghei serinethreonine protein phosphatase PP5 plays a critical role in male gamete fertility.
2019 Jun J Biomol Struct Dyn Binding modes and conformational changes of FK506-binding protein 51 induced by inhibitor bindings: insight into molecular mechanisms based on multiple simulation technologies.
2019 Jun J Mol Model Discovery of SBF1 as an allosteric inhibitor targeting the PIF-pocket of 3-phosphoinositide-dependent protein kinase-1.
2019 Jun Leukemia Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia.
2019 Jun World J Pediatr Forkhead box M1 transcription factor: a novel target for pulmonary arterial hypertension therapy.
2019 Jun Nat Commun LncRNA-p21 alters the antiandrogen enzalutamide-induced prostate cancer neuroendocrine differentiation via modulating the EZH2STAT3 signaling.
2019 Mol Cell Proteomics Phosphoproteome Analysis Reveals Estrogen-ER Pathway as a Modulator of mTOR Activity Via DEPTOR.
2019 Jun Int J Cancer ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.
2019 Oncol Lett High expression of PIM2 induces HSC proliferation in myelodysplastic syndromes via the IDH1HIF1-α signaling pathway.