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Recent literature: D2 receptor antagonist
Date Journal Article title
2019 Nov Arch Biochem Biophys 15-Deoxy-Δ12,14-prostaglandin J2 ameliorates dextran sulfate sodium-induced colitis in mice through heme oxygenase-1 induction.
2019 Nov Neuro Oncol Biological activity of weekly ONC201 in adult recurrent glioblastoma patients.
2019 Nov Sci Rep Differential effects of D-cycloserine and amantadine on motor behavior and D23 receptor binding in the nigrostriatal and mesolimbic system of the adult rat.
2019 Nov Int J Neuropsychopharmacol Balanced activation of striatal output pathways by faster off-rate PDE10A inhibitors elicits not only antipsychotic-like effects but also procognitive effects in rodents.
2019 Nov J Clin Psychopharmacol Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
2019 JBMR Plus Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus.
2019 Oct Clin Exp Allergy A Phase 2 Study to Evaluate the Safety, Efficacy and Pharmacokinetics of DP2 Antagonist GB001 and to Explore Biomarkers of Airway Inflammation in Mild to Moderate Asthma.
2019 Aug EJNMMI Radiopharm Chem Improved synthesis of [18F] fallypride and characterization of a Huntington's disease mouse model, zQ175DN KI, using longitudinal PET imaging of D2D3 receptors.
2019 Oct Neuropharmacology Neuromedin U induces self-grooming in socially-stimulated mice.
2019 Oct J Cell Mol Med Effect and mechanisms of sacral nerve stimulation on visceral hypersensitivity mediated by nerve growth factor.
2019 Oct Comp Biochem Physiol A Mo... Daily variation of D2 dopamine receptor transcription in the brain of the Japanese eel Anguilla japonica and its regulation with dopamine and melatonin.
2019 PLoS One Dopamine receptor antagonists effects on low-dimensional attractors of local field potentials in optogenetic mice.
2019 Oct Exp Physiol The effect of dopamine on pulmonary diffusing capacity and capillary blood volume responses to exercise in young healthy humans.
2019 Oct J Med Chem Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor.
2019 J Pharmacol Exp Ther Newly Developed Dopamine D3 Receptor Antagonists, iRi-VK4-40 and iRi-VK4-116, Do Not Potentiate Cardiovascular Effects of Cocaine or Oxycodone in Rats.
2019 Oct Stress Involvement of D2 receptor in the NAc in chronic unpredictable stress-induced depression-like behaviors.
2019 Nov Bioorg Med Chem Lett Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives.
2019 Sep Int J Mol Sci Risperidone Treatment after Transient Ischemia Induces Hypothermia and Provides Neuroprotection in the Gerbil Hippocampus by Decreasing Oxidative Stress.
2019 Nov Biochem Biophys Res Commun Dopaminergic mechanisms in the lateral hypothalamus regulate feeding behavior in association with neuropeptides.
2019 J Pharmacol Exp Ther The Role of Dopamine D3 Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens.
2019 CNS Spectr Keeping up with the therapeutic advances in schizophrenia: a review of novel and emerging pharmacological entities.
2019 Nov Neuroimage Validity and reliability of extrastriatal [11C]raclopride binding quantification in the living human brain.
2019 Oct Am J Physiol Gastrointest... Roles of the noradrenergic nucleus locus coeruleus and dopaminergic nucleus A11 region as raspinal defecation centers in rats.
2019 J Neurooncol Pediatric and adult H3 K27M-mutant diffuse midline glioma treated with the selective DRD2 antagonist ONC201.
2019 Aug Behav Neurosci Involvement of D1- and D2-like dopamine receptors within the rat nucleus accumbens in the maintenance of morphine rewarding properties in the rats.
2019 Oct Bioorg Med Chem Lett Rasagiline derivatives combined with histamine H3 receptor properties.
2019 Prog Neurobiol Role of homeostatic feedback mechanisms in modulating methylphenidate actions on phasic dopamine signaling in the striatum of awake behaving rats.
2019 Aug Naunyn Schmiedebergs Arch... Dopamine D1 receptor antagonist reduces stimulant-induced conditioned place preferences and dopamine receptor ersensitivity.
2019 Ann Clin Psychiatry Ecopipam as a pharmacologic treatment of stuttering.
2019 Jul Eur J Neurosci The priming effect of food persists following blockade of dopamine receptors.
2019 Sep Eur J Pharmacol Dopamine D1 and D2 receptors mediate neuropeptide S-induced antinociception in the mouse formalin test.
2019 Psychopharmacology (Berl) Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D23 receptor agents.
2019 Jul Neurosci Res Methylenedioxypyrovalerone (MDPV) impairs working memory and alters patterns of dopamine signaling in mesocorticolimbic strates.
2019 Nov Neuropharmacology AMP-activated protein kinase slows D2 dopamine autoreceptor desensitization in stantia nigra neurons.
2019 FEBS Open Bio Dopamine receptor D2 activation presses the radiosensitizing effect of aripiprazole via activation of AMPK.
2020 Jan J Comp Neurol Dopaminergic modulation of olfactory-evoked motor output in sea lampreys (Petromyzon marinus L.).
2019 J Pharmacol Exp Ther Revisiting the Pharmacodynamic Uroselectivity of iαi 1-Adrenergic Receptor Antagonists.
2019 Jul Psychopharmacology (Berl) Role of dopamine D1-like and D2-like receptors in the activation of ingestive behaviour in thirsty rats licking for water.
2019 Jul Allergy Evidence for the induction of Th2 inflammation by group 2 innate lymphoid cells in response to prostaglandin D2 and cysteinyl leukotrienes in allergic rhinitis.
2019 Mol Pharmacol Innovative Bioluminescence Resonance Energy Transfer Assay Reveals Differential Agonist-Induced D2 Receptor Intracellular Trafficking and Arrestin-3 Recruitment.
2019 Neuropharmacology Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites.
2019 Jun Int J Mol Sci A Free-Operant Reward-Tracking Paradigm to Study Neural Mechanisms and Neurochemical Modulation of Adaptive Behavior in Rats.
2019 Neuropharmacology D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
2019 Oct Eur J Med Chem 2-Aminoimidazole-based antagonists of the 5-HT6 receptor - A new concept in aminergic GPCR ligand design.
2019 Sep Eur J Med Chem Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HT6.
2019 Psychoneuroendocrinology Allopregnanolone is required for prepulse inhibition deficits induced by D1 dopamine receptor activation.
2019 J Recept Signal Transduct... Dopamine-induced functional activation of Gαq mediated by dopamine D1-like receptor in rat cerebral cortical membranes.
2019 Front Pharmacol Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Signaling Downstream of the Dopamine D2 Receptor.
2019 Pulm Pharmacol Ther Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.
2019 Neurogastroenterol Motil Regulation of stress-induced gastric ulcers via central oxytocin and a potential mechanism through the VTA-NAc dopamine pathway.
2019 Psychopharmacology (Berl) Dopamine D1 and D2 receptors mediate analgesic and hypnotic effects of l-tetrahydropalmatine in a mouse neuropathic pain model.
2019 Jun Acta Pharmacol Sin Preclinical PKPD model for the combinatorial use of dexamethasone and sulpiride in the treatment of breast cancer.
2019 Jun J Psychopharmacol Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats.
2019 May Nat Prod Res Study on antidepressant-like effect of protoilludane sesquiterpenoid aromatic esters from iArmillaria Melleai.
2019 Biochem Pharmacol A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes.
2019 Sep Neuropharmacology Optogenetic control of alcohol-seeking behavior via the dorsomedial striatal circuit.
2019 Case Rep Psychiatry Accidental Overdose of Paliperidone Palmitate.
2019 CNS Neurosci Ther Procognitive impact of ciproxifan (a histaminergic H3 receptor antagonist) on contextual memory retrieval after acute stress.
2019 Iran J Pharm Res The Involvement of Intra-Hippocampal Dopamine Receptors in the Conditioned Place Preference Induced By Orexin Administration into the Rat Ventral Tegmental Area.
2019 Brain Struct Funct Dissociable effects of dopamine D1 and D2 receptors on compulsive ingestion and pivoting movements elicited by disinhibiting the ventral pallidum.
2019 J Psychopharmacol Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system.
2019 Psychopharmacology (Berl) Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain.
2019 Mar Arch Iran Med The Involvement of D1 and D2 Dopamine Receptors in the Restoration Effect of Left Frontal Anodal, but not Cathodal, tDCS on Streptozocin-Induced Amnesia.
2019 Front Neurosci Voluntary Wheel Running Reverses Deficits in Social Behavior Induced by Chronic Social Defeat Stress in Mice: Involvement of the Dopamine System.
2019 Apr CNS Spectr The role of dopamine D3 receptors in the mechanism of action of cariprazine.
2019 J Neurochem Differential regulation of phasic dopamine release in the forebrain by the VTA noradrenergic receptor signaling.
2019 Neurochem Int Blonanserin ameliorates social deficit through dopamine-D3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.
2019 Apr Int J Mol Sci Distinct Dopamine D₂ Receptor Antagonists Differentially Impact D₂ Receptor Oligomerization.
2019 May Bioorg Med Chem Chemical synthesis, microbial transformation and biological evaluation of tetrahydroprotoberberines as dopamine D1D2 receptor ligands.
2019 Front Neurosci GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact.
2019 Curr Pharm Des Therapeutic Effect of Novel Antidepressant Drugs Acting at Specific Receptors of Neurotransmitters and Neuropeptides.
2019 Cogn Neurodyn L-menthol exhibits antidepressive-like effects mediated by the modification of 5-HTergic, GABAergic and DAergic systems.
2019 Apr J Neurosurg Pediatr First clinical experience with DRD23 antagonist ONC201 in H3 K27M-mutant pediatric diffuse intrinsic pontine glioma: a case report.
2019 Jul Eur J Pharmacol A CRTH2 antagonist, CT-133, presses NF-κB signalling to relieve lipopolysaccharide-induced acute lung injury.