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Recent literature: 5-HT2A and D2 antagonism
Date Journal Article title
2019 Sep Innov Clin Neurosci Brexpiprazole as a New Serotonin-Dopamine Receptor Modulator: Considering the Clinical Relevance for Metabolic Parameters and Prolactin Levels.
2020 Arch Pharm (Weinheim) G protein-coupled receptor binding and pharmacological evaluation of indole-derived thiourea compounds.
2019 Dec ChemMedChem Synthesis and Biological Evaluation of Five-Atom-Linker-Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile.
2019 Nihon Yakurigaku Zasshi [Preclinical pharmacological profiles and clinical efficacy of the novel antipsychotic drug brexpiprazole (REXULTI® Tablets 1 mg, 2 mg)].
2019 J Pharmacol Exp Ther The Role of Dopamine D3 Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens.
2019 Expert Opin Pharmacother Brexpiprazole for treatment-resistant major depressive disorder.
2019 Nov Neuropharmacology Serotonin 5-HT1A, 5-HT2A and dopamine D2 receptors strongly influence prefronto-hippocampal neural networks in alert mice: Contribution to the actions of risperidone.
2019 Neurochem Int Blonanserin ameliorates social deficit through dopamine-D3 receptor antagonism in mice administered phencyclidine as an animal model of schizophrenia.
2019 Pharmacology Evaluation of Antidepressant Effects on Recovery of Electrical Field Stimulation-Induced Contractions that have been Suppressed by Clonidine in Isolated Rat Vas Deferens.
2019 May ACS Chem Neurosci Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.
2018 Drugs Today (Barc) Lumateperone: a new treatment approach for neuropsychiatric disorders.
2019 Exp Clin Psychopharmacol Does antagonism at 5-HT2A receptors potentiate D₂ blockade-induced disruption of conditioned avoidance response?
2018 Mol Pharmacol Involvement of 5-HT1A and 5-HT2A Receptors but Not iαi 2-Adrenoceptors in the Acute Electrophysiological Effects of Cariprazine in the Rat Brain In Vivo.
2018 Jan Can J Psychiatry Movement Disorders Associated With Antipsychotic Medication in People With Schizophrenia: An Overview of Cochrane Reviews and Meta-Analysis.
2018 Jun Bioorg Med Chem Lett Synthesis and activity of di- or tristituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system.
2018 May Sci Rep In Vitro and In Vivo Characterization of PCC0104005, a Novel Modulator of Serotonin-Dopamine Activity, as an Atypical Antipsychotic Drug.
2018 Jul ACS Chem Neurosci Classics in Chemical Neuroscience: Risperidone.
2018 Feb Eur J Med Chem Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
2017 Neurol Clin Pract Pimavanserin: A novel therapeutic option for Parkinson disease psychosis.
2017 Eur Neuropsychopharmacol The antipsychotic drug brexpiprazole reverses phencyclidine-induced disruptions of thalamocortical networks.
2017 Aug Behav Brain Res RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia.
2017 Pharmacol Biochem Behav Involvement of presynaptic 5-HT1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats.
2016 Int J Health Sci (Qassim) Histamine H3 receptors and its antagonism as a novel mechanism for antipsychotic effect: a current preclinical amp; clinical perspective.
2016 J Ocul Pharmacol Ther Effects of Antipsychotic Drugs Haloperidol and Clozapine on Visual Responses of Retinal Ganglion Cells in a Rat Model of Retinitis Pigmentosa.
2017 Pharmacology Inhibitory Effects of Antidepressants on Acetylcholine-Induced Contractions in Isolated Guinea Pig Urinary Bladder Smooth Muscle.
2016 Aug Psychopharmacol Bull An Open Label Pilot Study of Adjunctive Asenapine for the Treatment of Posttraumatic Stress Disorder.
2017 Clin Pharmacokinet Pharmacokinetics and Pharmacodynamics of Lurasidone Hydrochloride, a Second-Generation Antipsychotic: A Systematic Review of the Published Literature.
2016 Sep Bioorg Med Chem Synthesis and biological investigation of new equatorial (β) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile.
2016 Expert Rev Neurother ITI-007 in the treatment of schizophrenia: from novel pharmacology to clinical outcomes.
2016 May Behav Brain Res The atypical antipsychotic blonanserin reverses (+)-PD-128907- and ketamine-induced deficit in executive function in common marmosets.
2016 Ther Adv Psychopharmacol Brexpiprazole: so far so good.
2016 Curr Pharm Des Serotonergic Drugs: AgonistsAntagonists at Specific Serotonergic Subreceptors for the Treatment of Cognitive, Depressant and Psychotic Symptoms in Alzheimer's Disease.
2015 Neuropsychiatr Dis Treat Lurasidone for the treatment of bipolar depression: an evidence-based review.
2015 Psychopharmacology (Berl) Preclinical characterization of toluene as a non-classical hallucinogen drug in rats: participation of 5-HT, dopamine and glutamate systems.
2015 Neuropharmacology Neuropharmacology of light-induced locomotor activation.
2015 J Pharmacol Sci Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range.
2015 Mini Rev Med Chem Benzo- and thienobenzo- diazepines: multi-target drugs for CNS disorders.
2015 May Behav Brain Res Combined serotonin (5-HT)1A agonism, 5-HT(2A) and dopamine D₂ receptor antagonism reproduces atypical antipsychotic drug effects on phencyclidine-impaired novel object recognition in rats.
2014 Noro Psikiyatr Ars A Case of Risperidone Induced Stuttering as a Paradox.
2014 Nov Bioorg Med Chem Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles.
2014 J Pharmacol Exp Ther Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization.
2014 PLoS One Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis.
2014 J Pharmacol Exp Ther Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator.
2014 Apr Prog Neuropsychopharmacol... Anatomical specificity in the modulation of activity-regulated genes after acute or chronic lurasidone treatment.
2013 Psychiatriki [Aggressive behavior: theoretical and biological aspects].
2014 J Neurochem Comparative effect of lurasidone and blonanserin on cortical glutamate, dopamine, and acetylcholine efflux: role of relative serotonin (5-HT)2A and DA D2 antagonism and 5-HT1A partial agonism.
2013 Sep J Neurosci Short-term quetiapine treatment alters the use of reinforcement signals during risky decision-making and promotes the choice of negative expected values in healthy adult males.
2013 Psychiatr Danub Clinical potential of cariprazine in the treatment of acute mania.
2014 CNS Neurol Disord Drug Ta... Blockade of MK-801-induced heat shock protein 7273 in rat brain by antipsychotic and monoaminergic agents targeting D2, 5-HT1A, 5-HT2A and α1-adrenergic receptors.
2013 Nihon Rinsho [Paliperidone, risperidone].
2013 May Behav Brain Res The role of 5-HT7 receptor antagonism in the amelioration of MK-801-induced learning and memory deficits by the novel atypical antipsychotic drug lurasidone.
2012 Clin Schizophr Relat Psyc... New serotonindopamine antagonists for the treatment of schizophrenia: are we making real progress?
2012 May CNS Drugs Quetiapine: a review of its use in the management of bipolar depression.
2011 Med Arh Risperidone in the treatment of schizophrenia.
2011 Ther Adv Psychopharmacol Receptor mechanisms of antipsychotic drug action in bipolar disorder - focus on asenapine.
2012 Naunyn Schmiedebergs Arch... Discovery of potential antipsychotic agents possessing pro-cognitive properties.
2012 Rev Recent Clin Trials Clinical pharmacology of paliperidone palmitate a parenteral long-acting formulation for the treatment of schizophrenia.
2011 Przegl Lek [The clinical picture of acute olanzapine poisonings].
2011 Schizophr Res Atypical antipsychotics and effects of muscarinic, serotonergic, dopaminergic and histaminergic receptor binding on insulin secretion in vivo: an animal model.
2012 J Affect Disord Receptor targets for antidepressant therapy in bipolar disorder: an overview.
2011 J Cent Nerv Syst Dis Sertindole in the management of schizophrenia.
2011 J Enzyme Inhib Med Chem Design, synthesis, and preliminary in vitro and in vivo pharmacological evaluation of 2-{4-[4-(2,5-distituted thiazol-4-yl)phenylethyl]piperazin-1-yl}-1,8-naphthyridine-3-carbonitriles as atypical antipsychotic agents.
2011 Feb Eur J Pharmacol Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex.
2009 Int J Clin Pract Asenapine for schizophrenia and bipolar disorder: a review of the efficacy and safety profile for this newly approved lingually absorbed second-generation antipsychotic.
2009 Eur J Clin Pharmacol Association between the use of anticholinergic antiparkinson drugs and safety and receptor drug-binding profiles of antipsychotic agents.
2009 J Neural Transm (Vienna) Aripiprazole in L-dopa-induced dyskinesias: a one-year open-label pilot study.
2009 Expert Opin Drug Saf A review of the safety and tolerability of aripiprazole.
2008 Behav Pharmacol A comparison of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in DBA2 and C57BL6 inbred mice.
2008 Psychopharmacology (Berl) Modulation of striatal dopamine release by 5-HT2A and 5-HT2C receptor antagonists: [11C]raclopride PET studies in the rat.
2007 Pharmacopsychiatry Dopamine and serotonin interactions in the prefrontal cortex: insights on antipsychotic drugs and their mechanism of action.
2000 CNS Spectr The universal field hypothesis of catatonia and neuroleptic malignant syndrome.
2008 Curr Opin Investig Drugs Evolution of schizophrenia drugs: a focus on dopaminergic systems.
2008 Feb Prog Neuropsychopharmacol... Long-term perospirone treatment with a single dose at bedtime in schizophrenia: relevant to intermittent dopamine D2 receptor antagonism.
2007 Aug J Med Chem Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
2007 Expert Opin Investig Drugs Aripiprazole acts as a selective dopamine D2 receptor partial agonist.