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Recent literature: Na+ channel blocker
Date Journal Article title
2019 Aug Oncology Epidermal Growth Factor Potentiates Migration of MDA-MB 231 Breast Cancer Cells by Increasing NaV1.5 Channel Expression.
2019 Jul J Neurophysiol Molecular determinants of afferent sensitization in a rat model of cystitis with urothelial barrier dysfunction.
2019 Jun J Pharmacol Toxicol Methods Recording of multiple ion current components and action potentials in human induced pluripotent stem cell-derived cardiomyocytes via automated patch-clamp.
2019 PeerJ Capsazepine prolongation of the duration of lidocaine block of sensory transmission in mice may be mediated by modulation of HCN channel currents.
2019 Jun Fundam Clin Pharmacol ARC 118925XX stimulates cation influx in bEND.3 endothelial cells.
2019 May Heart Rhythm Enhancement of β-cateninT-cell factor 4 signaling causes susceptibility to cardiac arrhythmia by pressing NaV1.5 expression in mice.
2019 F1000Res Recent advances in understandingmanaging trigeminal neuralgia.
2019 Basic Clin Neurosci Characterization of Functional Effects of Two New Active Fractions Isolated From Scorpion Venom on Neuronal Ca2+ Spikes: A Possible Action on Ca2+-Dependent Dependent K+ Channels.
2019 Apr Sci Rep In vivo synaptic activity-independent co-uptakes of amyloid β1-42 and Zn2+ into dentate granule cells in the normal brain.
2019 Biosci Biotechnol Biochem Flagellum-mediated motility in iPelotomaculum thermopropionicumi SI.
2019 Arch Med Sci Neuroprotective effects of the new Na channel blocker rs100642 in global ischemic brain injury.
2019 Jun Am J Physiol Heart Circ P... Conduction in the right and left ventricle is differentially regulated by protein kinases and phosphatases: implications for arrhythmogenesis.
2019 Cell Calcium Persistent Na+ influx drives L-type channel resting Ca2+ entry in rat melanotrophs.
2019 Mar Science Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA.
2018 eNeuro Cell Type- and Layer-Specific Muscarinic Potentiation of Excitatory Synaptic Drive onto Parvalbumin Neurons in Mouse Prefrontal Cortex.
2019 Mar Adv Physiol Educ Anesthetic MS-222 eliminates nerve and muscle activity in frogs used for physiology teaching laboratories.
2019 Biomed Pharmacother Polysaccharides from Portulaca oleracea L. regulated insulin secretion in INS-1 cells through voltage-gated Na+ channel.
2019 Jan Bioorg Med Chem The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain.
2019 Apr Ecotoxicol Environ Saf Cardiotoxicity of Consolida rugulosa, a poisonous weed in Western China.
2019 Feb Eur J Pharmacol Parecoxib, a selective blocker of cyclooxygenase-2, directly inhibits neuronal delayed-rectifier K+ current, M-type K+ current and Na+ current.
2018 Dec Curr Biol Control of Xenopus Tadpole Locomotion via Selective Expression of Ih in Excitatory Interneurons.
2019 J Comp Physiol B Mechanisms of Ca2+ uptake in freshwater and seawater-acclimated killifish, Fundulus heteroclitus, and their response to acute salinity transfer.
2018 Front Cell Neurosci Regional and Developmental Differences in Na+ Currents in Vestibular Primary Afferent Neurons.
2018 Nov Int J Mol Sci Daidzein-Stimulated Increase in the Ciliary Beating Amplitude via an [Cl-]i Decrease in Ciliated Human Nasal Epithelial Cells.
2018 Nov Molecules 8-Oxo-9-Dihydromakomakine Isolated from iAristotelia chilensisi Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx.
2018 Nov Acta Biochim Pol Aquaporins in human platelets: intracellular localization and possible role in granule and lysosome secretion.
2018 Nov Sci Rep Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells.
2019 Jan J Vet Med Sci Eukaryotic elongation factor 2 kinase inhibitor, A484954 inhibits noradrenaline-induced acute increase of blood pressure in rats.
2018 Daru New mechanisms of phenytoin in calcium homeostasis: competitive inhibition of CD38 in hippocampal cells.
2019 Jan Neurosci Lett Effects of lidocaine on adult zebrafish behavior and brain acetylcholinesterase following peripheral and systemic administration.
2019 Feb Toxicol Sci Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation.
2019 J Cell Physiol Colorectal cancer invasiveness in vitro: Predominant contribution of neonatal Nav1.5 under normoxia and hypoxia.
2019 Feb Brain Res The cytosolic Ca2+ concentration in acutely dissociated fornical organ (SFO) neurons of rats: Spontaneous Ca2+ oscillations and Ca2+ oscillations induced by picomolar concentrations of angiotensin II.
2018 Front Plant Sci Hydrogen Sulfide Mediates K+ and Na+ Homeostasis in the Roots of Salt-Resistant and Salt-Sensitive Poplar Species Subjected to NaCl Stress.
2018 J Neural Transm (Vienna) Projection length stimulated by oxytocin is modulated by the inhibition of calcium signaling in U-87MG cells.
2018 J Pharmacol Sci Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers.
2018 J Toxicol Sci Conduction and contraction properties of human iPS cell-derived cardiomyocytes: analysis by motion field imaging compared with the guinea-pig isolated heart model.
2018 Clin Exp Pharmacol Physiol Inhibition of the voltage-dependent K+ current by the class Ic antiarrhythmic drug flecainide in rabbit coronary arterial smooth muscle cells.
2018 Oncol Lett Functional cardiac Na+ channels are expressed in human melanoma cells.
2018 Aug J Gen Physiol The N terminus of α-ENaC mediates ENaC cleavage and activation by furin.
2018 Exp Physiol Determinants of slowed conduction in premature ventricular beats induced during programmed stimulations in perfused guinea-pig heart.
2018 Eur Rev Med Pharmacol Sci Lercanidipine and T-type calcium current.
2018 J Pharmacol Sci Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
2018 Oct Am J Physiol Heart Circ P... CaMKII-dependent late Na+ current increases electrical dispersion and arrhythmia in ischemia-reperfusion.
2018 Comp Biochem Physiol A Mo... Assessing the role of the acid-sensing ion channel ASIC4b in sodium uptake by larval zebrafish.
2018 J Dent Res Defective NaCl Reabsorption in Salivary Glands of Eda-Null X-LHED Mice.
2018 Aug Neuroscience Gain-of-function KCNJ6 Mutation in a Severe Hyperkinetic Movement Disorder Phenotype.
2018 May J Biomed Sci Differential regulation of nimodipine-sensitive and -insensitive Ca2+ influx by the Na+Ca2+ exchanger and mitochondria in the rat rachiasmatic nucleus neurons.
2018 J Pharmacol Sci Mechanisms underlying the relaxation by A484954, a eukaryotic elongation factor 2 kinase inhibitor, in rat isolated mesenteric artery.
2018 Jun J Neurosci A Critical Neurodevelopmental Role for L-Type Voltage-Gated Calcium Channels in Neurite Extension and Radial Migration.
2018 Jul Neuroscience Orexin B Modulates Spontaneous Excitatory and Inhibitory Transmission in Lamina II Neurons of Adult Rat Spinal Cord.
2018 Jul Bioorg Med Chem Lett Discovery of a bicyclo[4.3.0]nonane derivative DS88790512 as a potent, selective, and orally bioavailable blocker of transient receptor potential canonical 6 (TRPC6).
2018 Cell Calcium The effects of mitochondrial inhibitors on Ca2+ signalling and electrical conductances required for pacemaking in interstitial cells of Cajal in the mouse small intestine.
2018 Apr Phytomedicine Mechanism of resveratrol-induced relaxation of the guinea pig fundus.
2018 PLoS One Voltage-dependent inward currents in smooth muscle cells of skeletal muscle arterioles.
2018 Mar Oncotarget Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps.
2018 Front Physiol Dynamic Action Potential Restitution Contributes to Mechanical Restitution in Right Ventricular Myocytes From Pulmonary Hypertensive Rats.
2018 Jun ACS Chem Neurosci Heteroarylguanidines as Allosteric Modulators of ASIC1a and ASIC3 Channels.
2018 May Eur J Pharmacol Paeonol promotes hippocampal synaptic transmission: The role of the Kv2.1 potassium channel.
2018 Biomed Pharmacother Effects of polysaccharide from Portulaca oleracea L. on voltage-gated Na+ channel of INS-1 cells.
2018 Apr J Neurosci β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses.
2018 Brain Res Bull Mechanism of noradrenaline-induced α1-adrenoceptor mediated regulation of Na-K ATPase unit expression in Neuro-2a cells.
2018 May Neuropharmacology Direct evidence for high affinity blockade of NaV1.6 channel type by huwentoxin-IV spider peptide, using multiscale functional approaches.
2018 eNeuro Transient Receptor Potential Channels TRPM4 and TRPC3 Critically Contribute to Respiratory Motor Pattern Formation but not Rhythmogenesis in Rodent Brainstem Circuits.
2018 Mar Chem Biol Interact Hyperpolarization by N-(3-oxododecanoyl)-l-homoserine-lactone, a quorum sensing molecule, in rat thymic lymphocytes.
2018 Cell Physiol Biochem Voltage-Gated Na+ Channels are Modulated by Glucose and Involved in Regulating Cellular Insulin Content of INS-1 Cells.
2018 Drug Deliv Nano-engineered microcapsules boost the treatment of persistent pain.
2018 Feb Chin J Physiol Stimulatory Action of Telmisartan, an Antagonist of Angiotensin II Receptor, on Voltage-Gated Na⁺ Current: Experimental and Theoretical Studies.
2018 May Am J Physiol Cell Physiol P2Y receptor regulation of K2P channels that facilitate K+ secretion by human mammary epithelial cells.
2017 Dec J Appl Physiol (1985) Enhanced basal late sodium current appears to underlie the age-related prolongation of action potential duration in guinea pig ventricular myocytes.
2018 Mar Toxicol Lett Differential regulation of tefluthrin and telmisartan on the gating charges of INa activation and inactivation as well as on resurgent and persistent INa in a pituitary cell line (GH3).
2018 Jan J Gen Physiol Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation.
2017 Front Physiol Synergistic Anti-arrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin.
2017 Acta Virol Calcium signaling involved in bovine herpesvirus 1 replication in MDBK cells.
2018 J Ocul Pharmacol Ther Inhibitory Effect of Amitriptyline on the Impulse Activity of Cold Thermoreceptor Terminals of Intact and Tear-Deficient Guinea Pig Corneas.