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Recent literature: Reverse transcriptase inhibitor
Date Journal Article title
2019 Feb PLoS Pathog A high rate of polymerization during synthesis of mouse mammary tumor virus DNA alleviates hypermutation by APOBEC3 proteins.
2019 Feb Curr Drug Discov Technol Using PBPK Modeling to Predict Drug Exposure and Support Dosage Adjustments in Patients With Renal Impairment: An Example With Lamivudine.
2019 Feb J Virol HIV-1 type C with PYxE insertion has enhanced binding of Gag-p6 to host cell protein ALIX and increased replication fitness.
2019 Feb Curr HIV Res Real World Patient-Reported Outcomes In Hiv-Infected Adults Switching To Eviplera®, Because Of A Previous Intolerance To Cart. Pro-Str Stu.
2019 Feb J Antimicrob Chemother Stable prevalence of transmitted drug resistance mutations and increased circulation of non-B types in antiretroviral-naive chronically HIV-infected patients in 20152016 in France.
2019 Feb J Neurovirol Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes.
2019 Feb Antimicrob Agents Chemother In Vitro Evaluation of the Drug Interaction Potential of Doravirine.
2019 Feb Antimicrob Agents Chemother Population Pharmacokinetics of Doravirine and Exposure-Response in Individuals with HIV-1.
2019 Feb AIDS Predictors of faster virological pression in early treated infants with perinatal HIV from Europe and Thailand.
2019 Feb Antivir Ther Provincial and national prevalence estimates of transmitted HIV-1 drug resistance in South Africa measured using two WHO-recommended methods.
2018 Front Immunol Do Antiretroviral Drugs Protect From Multiple Sclerosis by Inhibiting Expression of MS-Associated Retrovirus?
2019 Feb Toxicol Appl Pharmacol The inhibitory effect of antiretroviral drugs on the L-carnitine uptake in human placenta.
2019 Feb Lancet Infect Dis Dolutegravir versus ritonavir-boosted lopinavir both with dual nucleoside reverse transcriptase inhibitor therapy in adults with HIV-1 infection in whom first-line therapy has failed (DAWNING): an open-label, non-inferiority, phase 3b trial.
2019 Nature L1 drives IFN in senescent cells and promotes age-associated inflammation.
2019 Feb Pharmacotherapy Effectiveness of Once-Daily Dolutegravir plus Boosted Darunavir as a Switch Strategy in Human Immunodeficiency Virus-Infected, Heavily Treated Patients.
2019 Lancet HIV Incidence of switching to second-line antiretroviral therapy and associated factors in children with HIV: an international cohort collaboration.
2019 Feb J Med Chem Exploiting the Tolerant Region I of Non-nucleoside Reverse Transcriptase Inhibitor Binding Pocket (NNIBP): Discovery of Potent Diarylpyrimidine (DAPY)-typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.
2019 Jan Cardiovasc J Afr Cardiovascular risk factors among people living with HIV in rural Kenya: a clinic-based study.
2019 Feb Curr HIV Res Molecular antiretroviral resistance markers of Human Immunodeficiency Virus-1 of CRF01_AE type in Bali, Indonesia.
2019 Feb Drug Metab Rev Singularities of nevirapine metabolism: from sex-dependent differences to of idiosyncratic toxicity.
2019 Jan J Med Virol Viral evolution in the cell-associated HIV-1 DNA during early ART can lead to drug resistance and virological failure in children.
2019 PLoS One Body composition and adipokines changes after initial treatment with darunavir-ritonavir plus either raltegravir or tenofovir disoproxil fumarate-emtricitabine: A study of the NEAT001ANRS143 randomised trial.
2019 Jan J Hepatol Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis.
2019 Jan Phytother Res Nigella sativa essential oil and its bioactive compounds as resistance modifiers against Staphylococcus aureus.
2019 Jan J Antimicrob Chemother Detection of pretreatment minority HIV-1 reverse transcriptase inhibitor-resistant variants by ultra-deep sequencing has a limited impact on virological outcomes.
2018 Sep Phytomedicine The anti-inflammatory and anti-nociceptive effects of Korean black ginseng.
2018 Oct Phytomedicine Chidamide-induced ROS accumulation and miR-129-3p-dependent cell cycle arrest in non-small lung cancer cells.
2019 Jan AIDS Minority and majority pre-treatment HIV-1 drug resistance associated with failure of 1st-line NNRTI ART in Kenyan women.
2019 Future Med Chem Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases.
2019 Feb Biochem Biophys Res Commun Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid stitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors.
2019 Open Forum Infect Dis Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance.
2018 Jun Pharmacoeconomic Review R...
2019 Pharmacogenomics Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir.
2019 Jan Environ Toxicol Epithelial growth factor receptor tyrosine kinase inhibitors alleviate house dust mite allergen Der p2-induced IL-6 and IL-8.
2019 Jan J Biol Chem HIV-1 envelope proteins up-regulate iNi 6-methyladenosine levels of cellular RNA independently of viral replication.
2018 Dec S Afr Med J Treatment outcomes in perinatally infected HIV-positive adolescents and young adults after ≥10 years on antiretroviral therapy.
2019 Anticancer Res Combined Applications of Repurposed Drugs and Their Detrimental Effects on Glioblastoma Cells.
2018 Jun Sheng Wu Yi Xue Gong Chen... [Andrographolide-releasing collagen scaffold enhance the ability of chondrocytes to maintain their specific phenotype under inflammatory environment iin vitroi].
2018 Dec Br J Clin Pharmacol Atrial fibrillation and human immunodeficiency virus type-1 infection: a systematic review. Implications for anticoagulant and antiarrhythmic therapy.
2019 Rev Esp Quimioter Influence of pharmacist intervention, based on CMO model, to improve activation in HIV patients.
2018 Dec Arch Virol Prevalence of HIV-1 transmitted drug resistance and viral pression among recently diagnosed adults in São Paulo, Brazil.
2018 Dec BMC Ophthalmol UVB-mediated down-regulation of proteasome in cultured human primary pterygium fibroblasts.
2018 Dec Int J Mol Sci Butyrate Stimulates Histone H3 Acetylation, 8-Isoprostane Production, RANKL Expression, and Regulated Osteoprotegerin ExpressionSecretion in MG-63 Osteoblastic Cells.
2019 Feb AIDS Nucleoside reverse transcriptase inhibitor backbones and pregnancy outcomes.
2019 AIDS Res Hum Retroviruses Pretreatment HIV Drug Resistance and Virologic Outcomes to First-Line Antiretroviral Therapy in Peru.
2019 J Cell Biochem Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA CILinc02.
2018 Dec Int Forum Allergy Rhinol Alternaria-induced barrier dysfunction of nasal epithelial cells: role of serine protease and reactive oxygen species.
2018 Dec Hum Exp Toxicol Toxicity and genotoxicity induced by abacavir antiretroviral medication alone or in combination with zidovudine andor lamivudine in Drosophila melanogaster.
2019 Feb Poult Sci Joint treatment with azidothymidine and antiserum for eradication of avian leukosis virus group a contamination in vaccine virus seeds.
2018 Front Oncol Revitalizing the AZT Through of the Selenium: An Approach in Human Triple Negative Breast Cancer Cell Line.
2018 Front Immunol Myeloid Cells in Intact Human Cervical Explants Capture HIV and Can Transmit It to CD4 T Cells.
2019 Feb Eur J Pharmacol Tenofovir disoproxil fumarate induces pheochromocytoma cells apoptosis.
2018 Cell Physiol Biochem miR-122 Targets X-Linked Inhibitor of Apoptosis Protein to Sensitize Oxaliplatin-Resistant Colorectal Cancer Cells to Oxaliplatin-Mediated Cytotoxicity.
2018 PLoS Med Raltegravir-intensified initial antiretroviral therapy in advanced HIV disease in Africa: A randomised controlled trial.
2018 Dec Curr Eye Res TGF-β1 Induces Human Tenon's Fibroblasts Fibrosis via miR-200b and Its Suppression of PTEN Signaling.
2018 PLoS One AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase.
2018 Nov Genes Chromosomes Cancer Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform.
2018 Nov J Invest Dermatol A MicroRNA-29 Mimic (Remlarsen) Represses Extracellular Matrix Expression and Fibroplasia in the Skin.
2019 J Cell Physiol Roles of miRNA-1 and miRNA-133 in the proliferation and differentiation of myoblasts in duck skeletal muscle.
2018 Drug Discov Ther Is there a need for shifting patients on long term nevirapine based regimens to efavirenz based regimens: a cross-sectional study?
2018 Nov Braz J Med Biol Res Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function.
2018 J Exp Zool B Mol Dev Evol Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells.
2018 Drugs BictegravirEmtricitabineTenofovir Alafenamide: A Review in HIV-1 Infection.
2019 J Mol Graph Model Torsional flexibility of undecorated catechol diether compound as potent NNRTI targeting HIV-1 reverse transcriptase.
2018 Nov BMC Infect Dis Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.
2019 AIDS Res Hum Retroviruses Moderate-to-High Levels of Pretreatment HIV Drug Resistance in KwaZulu-Natal Province, South Africa.
2019 Jan ChemMedChem Recent Advances in the Design and Development of Non-nucleoside Reverse Transcriptase Inhibitor Scaffolds.
2018 Medicine (Baltimore) Integrase inhibitor-based regimens result in more rapid virologic pression rates among treatment-naïve human immunodeficiency virus-infected patients compared to non-nucleoside and protease inhibitor-based regimens in a real-world clinical setting: A retrospective cohort study.
2018 Nov Med Mal Infect Which antiretrovirals should be prescribed as first-line treatments? Changes over the past 10 years in France.
2018 Drugs DolutegravirRilpivirine: A Review in HIV-1 Infection.
2018 Mediators Inflamm Placental Ras Regulates Inflammation Associated with Maternal Obesity.
2019 Feb J Antimicrob Chemother Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.
2018 Open Forum Infect Dis Hepatitis B Virus (HBV) Infection and Re-activation During Nucleos(t)ide Reverse Transcriptase Inhibitor-Sparing Antiretroviral Therapy in a High-HBV Endemicity Setting.
2018 Western Pac Surveill Resp... Viral load pression and acquired HIV drug resistance in adults receiving antiretroviral therapy in Viet Nam: results from a nationally representative survey.
2018 Oct J Cell Biochem Investigation of the effect of telomerase inhibitor BIBR1532 on breast cancer and breast cancer stem cells.