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Recent literature: Topoisomerase inhibitor
Date Journal Article title
2020 Jan Environ Mol Mutagen Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds.
2020 Jan Cancer Sci ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.
2020 Jan Int J Mol Sci Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors.
2020 Jan J Chem Inf Model Molecular Insight into the Interaction between Camptothecin and Acyclic Cucurbit[4]urils as Efficient Nanocontainers in Comparison with Cucurbit[7]uril: Molecular Docking and Molecular Dynamics Simulation.
2019 Dec J Pharm Biomed Anal Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma.
2019 Dec Cells Transcriptional Suppression of the NLRP3 Inflammasome and Cytokine Release in Primary Macrophages by Low-Dose Anthracyclines.
2020 Feb Bioorg Med Chem Lett Synthesis and biological evaluation of novel indole-pyrazoline hybrid derivatives as potential topoisomerase 1 inhibitors.
2020 Jan Thorac Cancer Clinical significance of topoisomerase-II expression in patients with advanced non-small cell lung cancer treated with amrubicin.
2019 J Pharm Anal Nuclear magnetic resonance based structure of the protoberberine alkaloid coralyne and its self-association by spectroscopy techniques.
2019 Dec Int J Mol Sci Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.
2019 Dec DNA Repair (Amst) Genotoxic effects of topoisomerase poisoning and PARP inhibition on zebrafish embryos.
2019 Front Oncol The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37-Targeted Radioimmunotherapy in Activated B Cell Like Diffuse Large B Cell Lymphoma Cell Lines.
2019 Dec Sci Rep The DNA topoisomerase II inhibitor amsacrine as a novel candidate adjuvant in a model of glaucoma filtration surgery.
2019 Dec Daru Benzoxazines as new human topoisomerase I inhibitors and potential poisons.
2019 Dec Sci Rep Activity of M3814, an Oral DNA-PK Inhibitor, In Combination with Topoisomerase II Inhibitors in Ovarian Cancer Models.
2019 Dec N Engl J Med Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer.
2019 Dec Cancers (Basel) (S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity.
2020 Bioorg Chem Synthesis of novel 2-aminobenzothiazole derivatives as potential antimicrobial agents with dual DNA gyrasetopoisomerase IV inhibition.
2020 DNA Repair (Amst) Novel deazaflavin tyrosyl-DNA phosphodiesterase 2 (TDP2) inhibitors.
2019 Dec ACS Synth Biol Enzymatic iOi-Glycosylation of Etoposide Aglycone by Exploration of the Substrate Promiscuity for Glycosyltransferases.
2019 Nov Cardiovasc Toxicol The Role of Topoisomerase IIβ in the Mechanisms of Action of the Doxorubicin Cardioprotective Agent Dexrazoxane.
2019 Nov Pathol Oncol Res PARP inhibitor Olaparib Enhances the Apoptotic Potentiality of Curcumin by Increasing the DNA Damage in Oral Cancer Cells through Inhibition of BER Cascade.
2019 Nov Anticancer Agents Med Chem Synthesis, Biological Evaluation and Molecular Docking Study of Cyclic Diarylheptanoids as Potential Anticancer Therapeutics.
2020 Mater Sci Eng C Mater Bio... Advanced nanoscale carrier-based approaches to overcome biopharmaceutical issues associated with anticancer drug 'Etoposide'.
2020 Biochem Pharmacol NG2-glia cell proliferation and differentiation by glial growth factor 2 (GGF2), a strategy to promote functional recovery after ischemic stroke.
2019 Nov ACS Omega Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching.
2019 Nov J Inorg Biochem Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand.
2019 Dec Anal Chem Personalized Drug Efficacy Monitoring Chip.
2019 Nov Cancer Chemother Pharmacol PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.
2019 Nat Med Chromatin regulators mediate anthracycline sensitivity in breast cancer.
2019 Nov Sci Rep Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.
2019 Nov J Magn Reson Imaging Pretreatment MR-Based Radiomics Signature as Potential Imaging Biomarker for Assessing the Expression of Topoisomerase II alpha (TOPO-IIα) in Rectal Cancer.
2019 Nov Dalton Trans Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.
2019 Oct ACS Omega Synthesis of New Cu Complex Based on Natural 5iZi,9iZi-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line.
2019 Oct Molecules New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
2019 Nov Biochemistry Bimodal Actions of a NaphthyridoneAminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.
2019 Oct Nucleosides Nucleotides N... Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms.
2019 Nov Chem Commun (Camb) A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform.
2019 PLoS Genet Histone deposition promotes recombination-dependent replication at arrested forks.
2020 Mol Biol Rep Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
2020 Jan J Clin Invest Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
2019 Oct Sci Rep Gram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles.
2019 PLoS One [Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti-CTLA-4 antibody in a mouse model.
2019 Lung Cancer Phase II trial of single agent amrubicin in patients with previously treated advanced thymic malignancies.
2019 Oct Dalton Trans Non-mutagenic Ru(ii) complexes: cytotoxicity, topoisomerase IB inhibition, DNA and HSA binding.
2019 Nov J Org Chem Three-Component Approach to Pyridine-Stabilized Ketenimines for the Synthesis of Diverse Heterocycles.
2019 PLoS One Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines.
2019 Sep Sci Rep Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery.
2019 Nov Int J Pharm Formulation of injectable glycyrrhizic acid-hydroxycamptothecin micelles as new generation of DNA topoisomerase I inhibitor for enhanced antitumor activity.
2019 Mol Pharmacol The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison.
2019 Cell Death Discov Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress.
2019 Sep Int J Cancer Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients.
2019 Dec Clin Cancer Res A Novel HER3-Targeting Antibody-Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization.
2019 Aug Molecules Antibacterial Evaluation, In Silico Characters and Molecular Docking of Schiff Bases Derived from 5-aminopyrazoles.
2018 Aug ACS Omega Activity of CoII-Quinalizarin: A Novel Analogue of Anthracycline-Based Anticancer Agents Targets Human DNA Topoisomerase, Whereas Quinalizarin Itself Acts via Formation of Semiquinone on Acute Lymphoblastic Leukemia MOLT-4 and HCT 116 Cells.
2019 Aug Curr Comput Aided Drug Des Molecular Docking based analysis to elucidate the DNA Topoisomerase IIβ as the potential target for the Ganoderic acid, A natural therapeutic agent in cancer therapy.
2019 Pharmacol Res Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production.
2019 Aug J Clin Invest cGASSTING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
2019 Mol Cancer Ther U3-1402, a Novel HER3-Targeting Antibody-Drug Conjugate, for the Treatment of Colorectal Cancer.
2019 Oncologist A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer.
2019 Front Immunol Daurinol Attenuates Autoimmune Arthritis via Stabilization of Nrp1-PTEN-Foxp3 Signaling in Regulatory T Cells.
2019 Bioorg Chem Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors.
2019 Aug Diagnostics (Basel) Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review.
2019 J Inorg Biochem Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-IIα.
2019 Transl Oncol DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas.
2019 Front Microbiol Transcriptional Response of iStreptomyces coelicolori to Rapid Chromosome Relaxation or Long-Term Supercoiling Imbalance.
2019 Expert Opin Investig Drugs Etirinotecan pegol in women with recurrent platinum-resistant or refractory ovarian cancer.
2019 J Pharm Sci αVβ3-Targeted Delivery of Camptothecin-Encapsulated Carbon Nanotube-Cyclic RGD in 2D and 3D Cancer Cell Culture.
2020 FEBS J Complex genetic interactions between DNA polymerase β and the NHEJ ligase.
2019 Oct Eur J Med Chem Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
2019 Jul Sci Rep PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner.
2019 Jul BMC Plant Biol Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb.
2019 Arch Toxicol Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6.
2019 Immun Ageing Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections.
2019 Mol Oncol Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology.