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Recent literature: Topoisomerase inhibitor
Date Journal Article title
2019 Nov ACS Omega Kinetic Study of DNA Topoisomerases by Supercoiling-Dependent Fluorescence Quenching.
2019 Nov J Inorg Biochem Synthesis, characterization, DNA binding, topoisomerase inhibition, and apoptosis induction studies of a novel cobalt(III) complex with a thiosemicarbazone ligand.
2019 Nov Anal Chem Personalized Drug Efficacy Monitoring Chip.
2019 Nov Cancer Chemother Pharmacol PLX038: a PEGylated prodrug of SN-38 independent of UGT1A1 activity.
2019 Nat Med Chromatin regulators mediate anthracycline sensitivity in breast cancer.
2019 Nov Sci Rep Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures.
2019 Nov J Magn Reson Imaging Pretreatment MR-Based Radiomics Signature as Potential Imaging Biomarker for Assessing the Expression of Topoisomerase II alpha (TOPO-IIα) in Rectal Cancer.
2019 Nov Dalton Trans Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors.
2019 Oct ACS Omega Synthesis of New Cu Complex Based on Natural 5iZi,9iZi-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line.
2019 Oct Molecules New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
2019 Nov Biochemistry Bimodal Actions of a NaphthyridoneAminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.
2019 Oct Nucleosides Nucleotides N... Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms.
2019 Nov Chem Commun (Camb) A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform.
2019 PLoS Genet Histone deposition promotes recombination-dependent replication at arrested forks.
2019 Oct Mol Biol Rep Inhibition of DNA-PK potentiates the synergistic effect of NK314 and etoposide combination on human glioblastoma cells.
2019 Oct J Clin Invest Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
2019 Oct Sci Rep Gram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles.
2019 PLoS One [Fam-] trastuzumab deruxtecan (DS-8201a)-induced antitumor immunity is facilitated by the anti-CTLA-4 antibody in a mouse model.
2019 Lung Cancer Phase II trial of single agent amrubicin in patients with previously treated advanced thymic malignancies.
2019 Oct Dalton Trans Non-mutagenic Ru(ii) complexes: cytotoxicity, topoisomerase IB inhibition, DNA and HSA binding.
2019 Nov J Org Chem Three-Component Approach to Pyridine-Stabilized Ketenimines for the Synthesis of Diverse Heterocycles.
2019 PLoS One Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines.
2019 Sep Sci Rep Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery.
2019 Nov Int J Pharm Formulation of injectable glycyrrhizic acid-hydroxycamptothecin micelles as new generation of DNA topoisomerase I inhibitor for enhanced antitumor activity.
2019 Mol Pharmacol The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison.
2019 Cell Death Discov Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress.
2019 Sep Int J Cancer Relationship between protein biomarkers of chemotherapy response and microsatellite status, tumor mutational burden and PD-L1 expression in cancer patients.
2019 Aug Clin Cancer Res A Novel HER3-Targeting Antibody-Drug Conjugate, U3-1402, Exhibits Potent Therapeutic Efficacy through the Delivery of Cytotoxic Payload by Efficient Internalization.
2018 Aug ACS Omega Activity of CoII-Quinalizarin: A Novel Analogue of Anthracycline-Based Anticancer Agents Targets Human DNA Topoisomerase, Whereas Quinalizarin Itself Acts via Formation of Semiquinone on Acute Lymphoblastic Leukemia MOLT-4 and HCT 116 Cells.
2019 Aug Curr Comput Aided Drug Des Molecular Docking based analysis to elucidate the DNA Topoisomerase IIβ as the potential target for the Ganoderic acid, A natural therapeutic agent in cancer therapy.
2019 Pharmacol Res Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production.
2019 Aug J Clin Invest cGASSTING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
2019 Mol Cancer Ther U3-1402, a Novel HER3-Targeting Antibody-Drug Conjugate, for the Treatment of Colorectal Cancer.
2019 Aug Oncologist A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer.
2019 Front Immunol Daurinol Attenuates Autoimmune Arthritis via Stabilization of Nrp1-PTEN-Foxp3 Signaling in Regulatory T Cells.
2019 Bioorg Chem Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors.
2019 Aug Diagnostics (Basel) Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review.
2019 J Inorg Biochem Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-IIα.
2019 Transl Oncol DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas.
2019 Front Microbiol Transcriptional Response of iStreptomyces coelicolori to Rapid Chromosome Relaxation or Long-Term Supercoiling Imbalance.
2019 Expert Opin Investig Drugs Etirinotecan pegol in women with recurrent platinum-resistant or refractory ovarian cancer.
2019 J Pharm Sci αVβ3-Targeted Delivery of Camptothecin-Encapsulated Carbon Nanotube-Cyclic RGD in 2D and 3D Cancer Cell Culture.
2019 Jul FEBS J Complex genetic interactions between DNA polymerase β and the NHEJ ligase.
2019 Oct Eur J Med Chem Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
2019 Jul Sci Rep PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner.
2019 Jul BMC Plant Biol Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb.
2019 Arch Toxicol Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6.
2019 Immun Ageing Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections.
2019 Mol Oncol Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology.
2019 Antimicrob Agents Chemother Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations.
2019 Nov Clin Cancer Res Targeting Topoisomerase I in the Era of Precision Medicine.
2019 Mol Pharmacol T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide.
2019 Nature Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.
2019 Jul Proc Natl Acad Sci U S A SIPCacyBP promotes autophagy by regulating levels of BRUCEApollon, which stimulates LC3-I degradation.
2019 Jun Molecules Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.
2019 Jun BMC Cancer Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene.
2019 Oxid Med Cell Longev p53-Mediated PI3KAKTmTOR Pathway Played a Role in PtoxDpt-Induced EMT Inhibition in Liver Cancer Cell Lines.
2019 Phytochemistry Repurposing of ginseng extract as topoisomerase I inhibitor based on the comparative analysis of gene expression patterns.
2019 Sep Eur J Med Chem Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
2019 Jun Molecules Machine Learning Models Combined with Virtual Screening and Molecular Docking to Predict Human Topoisomerase I Inhibitors.
2019 May Molecules Potent Anti-Ovarian Cancer with Inhibitor Activities on both Topoisomerase II and V600EBRAF of Synthesized Substituted Estrone Candidates.
2019 Biochim Biophys Acta Gen ... PPEF: A bisbenzimdazole potent antimicrobial agent interacts at acidic triad of catalytic domain of E. coli topoisomerase IA.
2019 May Mol Med CKD-602, a topoisomerase I inhibitor, induces apoptosis and cell-cycle arrest and inhibits invasion in cervical cancer.
2019 Jul Bioorg Med Chem Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid.
2019 Target Oncol Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
2019 Jul Nucleic Acids Res RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.
2019 Apr Oncotarget A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs.
2019 Dec Int J Cancer [fam-] trastuzumab deruxtecan, antitumor activity is dependent on HER2 expression level rather than on HER2 amplification.
2019 Future Oncol ATTAIN: Phase III study of etirinotecan pegol versus treatment of physician's choice in patients with metastatic breast cancer and brain metastases.
2019 Front Oncol Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives.
2019 Jun Biochem Biophys Res Commun A novel mechanism of irinotecan targeting MDM2 and Bcl-xL.
2019 Lancet Oncol Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive gastric cancer: a dose-expansion, phase 1 study.
2019 Lancet Oncol Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study.
2019 Curr Oncol Second-line systemic therapies for metastatic urothelial carcinoma: a population-based cohort analysis.
2019 Environ Mol Mutagen Epigallocatechin-3-gallate induces telomere shortening and clastogenic damage in glioblastoma cells.