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Recent literature: Topoisomerase inhibitor
Date Journal Article title
2019 Feb Stem Cell Res Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.
2019 FEBS Open Bio Genotoxic stress causes the accumulation of DNA-dependent protein kinase catalytic unit phosphorylated at serine 2056 at nuclear speckles and alters pre-mRNA alternative splicing.
2019 Feb ACS Infect Dis Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
2018 J BUON ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma.
2018 Front Oncol Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.
2019 J Surg Res Topotecan Alleviates Lipopolysaccharide-Mediated Acute Lung Injury Via the NF-κB Signaling Pathway.
2019 Mar Eur J Med Chem Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitro and in vivo.
2019 Jan Mol Cancer Ther A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent towards acute myeloid leukemia.
2019 Jan Anticancer Agents Med Chem Synthesis of Dual Target CPT-Ala-Nor Conjugates and Their Biological Activity Evaluation.
2019 Jan Mol Cell Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.
2019 Jan J Biol Chem DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
2019 Jan Leukemia The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia.
2019 Jan J Biol Chem Casein kinase II-dependent phosphorylation of DNA topoisomerase II presses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast.
2019 PLoS One Towards an understanding of C9orf82 proteinCAAP1 function.
2019 Feb Biochemistry Benzimidazoles: Selective Inhibitors of Topoisomerase I with Differential Modes of Action.
2019 Jan Nat Commun ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
2019 Jan Molecules Antiproliferative and Enzyme Docking Analysis of Engleromycin from iEngleromyces goetzeii.
2019 Feb Life Sci Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative.
2018 Dec Molecules MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells.
2018 Dec Am J Rhinol Allergy Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa.
2018 Dec Leukemia Dasatinib and navitoclax act synergistically to target NUP98-NSD1+FLT3-ITD+ acute myeloid leukemia.
2018 Dec Nucleic Acids Res Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation.
2018 R Soc Open Sci Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining.
2018 Dec Invest New Drugs Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
2019 Jan Bioorg Med Chem Lett Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
2019 Biometals Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors.
2018 Biochim Biophys Acta Gene... Sensory domain of the cell cycle kinase CckA regulates the differential DNA binding of the master regulator CtrA in Caulobacter crescentus.
2018 Front Pharmacol Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction.
2018 Dec Food Funct Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture.
2018 Anim Cells Syst (Seoul) VIG-1 is required for maintenance of genome stability in iCaenorhabditis elegansi.
2018 Nov Cytometry A Concurrent detection of lysosome and tissue transglutaminase activation in relation to cell cycle position during apoptosis induced by different anticancer drugs.
2019 Jan Eur J Med Chem Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
2019 J Enzyme Inhib Med Chem Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines.
2019 Environ Mol Mutagen Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks.
2018 Oct Int J Mol Sci Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy.
2018 Arterioscler Thromb Vasc ... Inhibition of Vascular Calcification.
2018 Oct Xenobiotica Comprehensive Preclinical Pharmacokinetic Evaluations of Trastuzumab Deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in Cynomolgus Monkeys.
2018 Dec ChemMedChem Inhibition of Human Topoisomerase II by N,N,N-Trimethylethanammonium Iodide Alkylcarbazole Derivatives.
2018 Int J Nanomedicine Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy.
2019 Oncogene An HER3-targeting antibody-drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC.
2018 Oct Sci Rep Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
2018 Sep Cancers (Basel) Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules.
2018 J Photochem Photobiol B Monitoring of topoisomerase (I) inhibitor camptothecin release from endogenous redox-stimulated GO-polymer hybrid carrier.
2018 Oct Bioorg Med Chem A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships.
2018 Sep Molecules A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2iHi-chromen-4-ol Scaffold.
2018 Plasmid Plasmids for making multiple knockouts in a radioresistant bacterium Deinococcus radiodurans.
2018 Small Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy.
2019 Mol Inform HToPred: A Tool for Human Topoisomerase II Inhibitor Prediction.
2018 Sep Cell Death Dis PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin.
2018 Tuberculosis (Edinb) The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.
2018 Cell Cycle P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage.
2018 Biomed Pharmacother The telomerase inhibitor MST-312 synergistically enhances the apoptotic effect of doxorubicin in pre-B acute lymphoblastic leukemia cells.
2018 Mol Cancer Ther Targeted Inhibition of ULK1 Promotes Apoptosis and Suppresses Tumor Growth and Metastasis in Neuroblastoma.
2018 Mol Autism Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant iUbe3ai gene associated with Angelman syndrome.
2018 Jul Oncotarget Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a ra-additive antitumor effect when combined with anti-PD-L1 antibodies.
2018 Aug Nanoscale Tobacco mosaic virus delivery of mitoxantrone for cancer therapy.
2018 Adv Sci (Weinh) A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia.
2018 Oct Eur J Pharm Sci Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo.
2018 Biomed Pharmacother Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence.
2018 Aug Molecules Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs.
2018 Aug Sci Rep Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites.
2018 Front Microbiol Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of iMycobacterium tuberculosisi.
2018 Int J Oncol Radiosensitization by irinotecan is attributed to G2M phase arrest, followed by enhanced apoptosis, probably through the ATMChkCdc25CCdc2 pathway in p53-mutant colorectal cancer cells.
2018 Orv Hetil [Epigenetic effects affecting etoposide distribution and metabolism in the human body].
2018 Eur J Cancer Contribution of genotoxic anticancer treatments to the development of multiple primary tumours in the context of germline TP53 mutations.
2018 Sep Mol Pharm Liposomal Irinotecan Achieves Significant Survival and Tumor Burden Control in a Triple Negative Breast Cancer Model of Spontaneous Metastasis.
2019 J Clin Pharmacol Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients.
2018 Sep JAMA Surg Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice.
2018 Aug Eur J Med Chem Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line.
2018 Aug Eur J Med Chem Novel indolo-sophoridinic scaffold as Topo I inhibitors: Design, synthesis and biological evaluation as anticancer agents.
2018 Front Mol Biosci New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy.
2018 Nature CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions.
2018 Anticancer Res Preclinical Evaluation of Combined Topoisomerase and Proteasome Inhibition Against Pediatric Malignancies.
2018 Int J Oncol Identification of cisplatin sensitizers through high-throughput combinatorial screening.
2018 Aug Bioorg Med Chem Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors.