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Recent literature: Topoisomerase inhibitor
Date Journal Article title
2019 Jun Clin Cancer Res Targeting Topoisomerase I in the Era of Precision Medicine.
2019 Jun Mol Pharmacol T-cell protein tyrosine phosphatase (TCPTP) is irreversibly inhibited by etoposide-quinone, a reactive metabolite of the chemotherapy drug etoposide.
2019 Jun Proc Natl Acad Sci U S A SIPCacyBP promotes autophagy by regulating levels of BRUCEApollon, which stimulates LC3-I degradation.
2019 Jun Molecules Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.
2019 Jun BMC Cancer Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene.
2019 Oxid Med Cell Longev p53-Mediated PI3KAKTmTOR Pathway Played a Role in PtoxDpt-Induced EMT Inhibition in Liver Cancer Cell Lines.
2019 Jun Phytochemistry Repurposing of ginseng extract as topoisomerase I inhibitor based on the comparative analysis of gene expression patterns.
2019 May Eur J Med Chem Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
2019 Jun Molecules Machine Learning Models Combined with Virtual Screening and Molecular Docking to Predict Human Topoisomerase I Inhibitors.
2019 May Molecules Potent Anti-Ovarian Cancer with Inhibitor Activities on both Topoisomerase II and V600EBRAF of Synthesized Substituted Estrone Candidates.
2019 May Biochim Biophys Acta Gen ... PPEF: A bisbenzimdazole potent antimicrobial agent interacts at acidic triad of catalytic domain of E. coli topoisomerase IA.
2019 May Mol Med CKD-602, a topoisomerase I inhibitor, induces apoptosis and cell-cycle arrest and inhibits invasion in cervical cancer.
2019 Jul Bioorg Med Chem Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid.
2019 May Target Oncol Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
2019 May Nucleic Acids Res RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.
2019 Apr Oncotarget A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs.
2019 May Int J Cancer [fam-] trastuzumab deruxtecan, antitumor activity is dependent on HER2 expression level rather than on HER2 amplification.
2019 May Future Oncol ATTAIN: Phase III study of etirinotecan pegol versus treatment of physician's choice in patients with metastatic breast cancer and brain metastases.
2019 Front Oncol Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives.
2019 Jun Biochem Biophys Res Commun A novel mechanism of irinotecan targeting MDM2 and Bcl-xL.
2019 Lancet Oncol Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive gastric cancer: a dose-expansion, phase 1 study.
2019 Lancet Oncol Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study.
2019 Curr Oncol Second-line systemic therapies for metastatic urothelial carcinoma: a population-based cohort analysis.
2019 Apr Environ Mol Mutagen Epigallocatechin-3-gallate induces telomere shortening and clastogenic damage in glioblastoma cells.
2019 Apr Medicines (Basel) Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells.
2019 Apr Mol Biol Rep Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
2019 Apr Cancer Chemother Pharmacol SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4.
2019 May J Med Chem Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.
2019 Apr Mol Imaging Biol Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23.
2019 Sci Adv Targeting dePARylation selectively presses DNA repair-defective and PARP inhibitor-resistant malignancies.
2019 Apr Molecules Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents.
2019 Anticancer Drugs Ethyl-2-amino-pyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo.
2019 Int J Oncol Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
2019 Jun Eur J Med Chem Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.
2019 May J Chromatogr B Analyt Tec... In-vitro metabolic profiling study of potential topoisomerase inhibitors 'pyrazolines' in RLMs by mass spectrometry.
2019 Apr Curr Pharm Des Synthetic optimization of ellipticine and antitumor activity of novel hexacyclic derivatives of ellipticine.
2019 Jun Eur J Med Chem A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade.
2019 J Enzyme Inhib Med Chem The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor.
2019 Food Chem Toxicol Camptothecin induces mitotic arrest through Mad2-Cdc20 complex by activating the JNK-mediated Sp1 pathway.
2019 Comput Struct Biotechnol J Ligand-based Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Discovery of Potential Topoisomerase I Inhibitors.
2019 Jun J Virol Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA.
2019 Mar Anticancer Agents Med Chem Recent Development in Indole Derivatives as Anticancer Agents for Breast Cancer.
2019 Jun Exp Cell Res Simultaneous induction of distinct protein phase separation events in multiple cellular compartments of a single cell.
2019 May Chem Res Toxicol Idarubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells.
2019 Biochem Biophys Rep 15-deoxy-Δ12, 14-prostaglandin J2 enhances anticancer activities independently of VHL status in renal cell carcinomas.
2019 Int J Biochem Cell Biol Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines.
2018 Ecancermedicalscience The cardioprotective effect of dexrazoxane (Cardioxane) is consistent with sequestration of poly(ADP-ribose) by self-assembly and not depletion of topoisomerase 2B.
2019 Feb Molecules Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A.
2019 Apr Eur J Med Chem An optimised series of stituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
2019 Stem Cell Res Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.
2019 FEBS Open Bio Genotoxic stress causes the accumulation of DNA-dependent protein kinase catalytic unit phosphorylated at serine 2056 at nuclear speckles and alters pre-mRNA alternative splicing.
2019 Apr ACS Infect Dis Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
2018 J BUON ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma.
2018 Front Oncol Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.
2019 J Surg Res Topotecan Alleviates Lipopolysaccharide-Mediated Acute Lung Injury Via the NF-κB Signaling Pathway.
2019 Mar Eur J Med Chem Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitro and in vivo.
2019 Mol Cancer Ther A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia.
2019 Jan Anticancer Agents Med Chem Synthesis of Dual Target CPT-Ala-Nor Conjugates and Their Biological Activity Evaluation.
2019 Feb Mol Cell Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.
2019 Mar J Biol Chem DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
2019 Jan Leukemia The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia.
2019 Mar J Biol Chem Casein kinase II-dependent phosphorylation of DNA topoisomerase II presses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast.
2019 PLoS One Towards an understanding of C9orf82 proteinCAAP1 function.
2019 Feb Biochemistry Benzimidazoles: Selective Inhibitors of Topoisomerase I with Differential Modes of Action.
2019 Jan Nat Commun ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
2019 Jan Molecules Antiproliferative and Enzyme Docking Analysis of Engleromycin from iEngleromyces goetzeii.
2019 Feb Life Sci Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative.
2018 Dec Molecules MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells.
2019 Am J Rhinol Allergy Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa.
2019 Leukemia Dasatinib and navitoclax act synergistically to target NUP98-NSD1+FLT3-ITD+ acute myeloid leukemia.
2019 Feb Nucleic Acids Res Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation.
2018 R Soc Open Sci Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining.
2018 Dec Invest New Drugs Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
2019 Jan Bioorg Med Chem Lett Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
2019 Biometals Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors.