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Recent literature: Topoisomerase inhibitor
Date Journal Article title
2019 Apr Mol Biol Rep Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
2019 Apr Cancer Chemother Pharmacol SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4.
2019 Apr J Med Chem Novel deazaflavin analogues potently inhibited tyrosyl DNA phosphodiesterase 2 (TDP2) and strongly sensitized cancer cells toward treatment with topoisomerase II (TOP2) poison etoposide.
2019 Apr Mol Imaging Biol Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23.
2019 Sci Adv Targeting dePARylation selectively presses DNA repair-defective and PARP inhibitor-resistant malignancies.
2019 Apr Molecules Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents.
2019 Anticancer Drugs Ethyl-2-amino-pyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo.
2019 Int J Oncol Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
2019 Jun Eur J Med Chem Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.
2019 May J Chromatogr B Analyt Tec... In-vitro metabolic profiling study of potential topoisomerase inhibitors 'pyrazolines' in RLMs by mass spectrometry.
2019 Apr Curr Pharm Des Synthetic optimization of ellipticine and antitumor activity of novel hexacyclic derivatives of ellipticine.
2019 Jun Eur J Med Chem A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade.
2019 J Enzyme Inhib Med Chem The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor.
2019 Food Chem Toxicol Camptothecin induces mitotic arrest through Mad2-Cdc20 complex by activating the JNK-mediated Sp1 pathway.
2019 Comput Struct Biotechnol J Ligand-based Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Discovery of Potential Topoisomerase I Inhibitors.
2019 Mar J Virol Cellular DNA topoisomerases are required for the synthesis of hepatitis B virus covalently closed circular DNA.
2019 Mar Anticancer Agents Med Chem Recent Development in Indole Derivatives as Anticancer Agents for Breast Cancer.
2019 Jun Exp Cell Res Simultaneous induction of distinct protein phase separation events in multiple cellular compartments of a single cell.
2019 Mar Chem Res Toxicol Idarubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells.
2019 Biochem Biophys Rep 15-deoxy-Δ12, 14-prostaglandin J2 enhances anticancer activities independently of VHL status in renal cell carcinomas.
2019 Feb Int J Biochem Cell Biol Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines.
2018 Ecancermedicalscience The cardioprotective effect of dexrazoxane (Cardioxane) is consistent with sequestration of poly(ADP-ribose) by self-assembly and not depletion of topoisomerase 2B.
2019 Feb Molecules Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A.
2019 Apr Eur J Med Chem An optimised series of stituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
2019 Stem Cell Res Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.
2019 FEBS Open Bio Genotoxic stress causes the accumulation of DNA-dependent protein kinase catalytic unit phosphorylated at serine 2056 at nuclear speckles and alters pre-mRNA alternative splicing.
2019 Apr ACS Infect Dis Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
2018 J BUON ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma.
2018 Front Oncol Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems.
2019 J Surg Res Topotecan Alleviates Lipopolysaccharide-Mediated Acute Lung Injury Via the NF-κB Signaling Pathway.
2019 Mar Eur J Med Chem Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitro and in vivo.
2019 Mol Cancer Ther A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia.
2019 Jan Anticancer Agents Med Chem Synthesis of Dual Target CPT-Ala-Nor Conjugates and Their Biological Activity Evaluation.
2019 Feb Mol Cell Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison.
2019 Mar J Biol Chem DNA polymerase θ (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse.
2019 Jan Leukemia The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia.
2019 Mar J Biol Chem Casein kinase II-dependent phosphorylation of DNA topoisomerase II presses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast.
2019 PLoS One Towards an understanding of C9orf82 proteinCAAP1 function.
2019 Feb Biochemistry Benzimidazoles: Selective Inhibitors of Topoisomerase I with Differential Modes of Action.
2019 Jan Nat Commun ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
2019 Jan Molecules Antiproliferative and Enzyme Docking Analysis of Engleromycin from iEngleromyces goetzeii.
2019 Feb Life Sci Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative.
2018 Dec Molecules MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells.
2019 Am J Rhinol Allergy Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa.
2018 Dec Leukemia Dasatinib and navitoclax act synergistically to target NUP98-NSD1+FLT3-ITD+ acute myeloid leukemia.
2018 Dec Nucleic Acids Res Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation.
2018 R Soc Open Sci Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining.
2018 Dec Invest New Drugs Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer.
2019 Jan Bioorg Med Chem Lett Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors.
2019 Biometals Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors.
2018 Biochim Biophys Acta Gene... Sensory domain of the cell cycle kinase CckA regulates the differential DNA binding of the master regulator CtrA in Caulobacter crescentus.
2018 Front Pharmacol Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction.
2018 Dec Food Funct Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture.
2018 Anim Cells Syst (Seoul) VIG-1 is required for maintenance of genome stability in iCaenorhabditis elegansi.
2018 Nov Cytometry A Concurrent detection of lysosome and tissue transglutaminase activation in relation to cell cycle position during apoptosis induced by different anticancer drugs.
2019 Jan Eur J Med Chem Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models.
2019 J Enzyme Inhib Med Chem Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines.
2019 Environ Mol Mutagen Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks.
2018 Oct Int J Mol Sci Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy.
2018 Arterioscler Thromb Vasc ... Inhibition of Vascular Calcification.
2018 Oct Xenobiotica Comprehensive Preclinical Pharmacokinetic Evaluations of Trastuzumab Deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in Cynomolgus Monkeys.
2018 Dec ChemMedChem Inhibition of Human Topoisomerase II by N,N,N-Trimethylethanammonium Iodide Alkylcarbazole Derivatives.
2018 Int J Nanomedicine Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy.
2019 Oncogene An HER3-targeting antibody-drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC.
2018 Oct Sci Rep Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
2018 Sep Cancers (Basel) Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules.
2018 J Photochem Photobiol B Monitoring of topoisomerase (I) inhibitor camptothecin release from endogenous redox-stimulated GO-polymer hybrid carrier.
2018 Oct Bioorg Med Chem A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships.
2018 Sep Molecules A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2iHi-chromen-4-ol Scaffold.
2018 Plasmid Plasmids for making multiple knockouts in a radioresistant bacterium Deinococcus radiodurans.
2018 Small Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy.
2019 Mol Inform HToPred: A Tool for Human Topoisomerase II Inhibitor Prediction.
2018 Sep Cell Death Dis PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin.
2018 Tuberculosis (Edinb) The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase.
2018 Cell Cycle P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage.