|
2019 Feb |
Stem Cell Res |
Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1. |
|
2019 |
FEBS Open Bio |
Genotoxic stress causes the accumulation of DNA-dependent protein kinase catalytic unit phosphorylated at serine 2056 at nuclear speckles and alters pre-mRNA alternative splicing. |
|
2019 Feb |
ACS Infect Dis |
Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase. |
|
2018 |
J BUON |
ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma. |
|
2018 |
Front Oncol |
Phosphodiesterase Type 5 (PDE5) Inhibitors Sensitize Topoisomerase II Inhibitors in Killing Prostate Cancer Through PDE5-Independent Impairment of HR and NHEJ DNA Repair Systems. |
|
2019 |
J Surg Res |
Topotecan Alleviates Lipopolysaccharide-Mediated Acute Lung Injury Via the NF-κB Signaling Pathway. |
|
2019 Mar |
Eur J Med Chem |
Identification of 3-(benzazol-2-yl)quinoxaline derivatives as potent anticancer compounds: Privileged structure-based design, synthesis, and bioactive evaluation in vitro and in vivo. |
|
2019 Jan |
Mol Cancer Ther |
A kinase inhibitor with anti-Pim kinase activity is a potent and selective cytotoxic agent towards acute myeloid leukemia. |
|
2019 Jan |
Anticancer Agents Med Chem |
Synthesis of Dual Target CPT-Ala-Nor Conjugates and Their Biological Activity Evaluation. |
|
2019 Jan |
Mol Cell |
Architecture of Microcin B17 Synthetase: An Octameric Protein Complex Converting a Ribosomally Synthesized Peptide into a DNA Gyrase Poison. |
|
2019 Jan |
J Biol Chem |
DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. |
|
2019 Jan |
Leukemia |
The transcriptional regulator FUBP1 influences disease outcome in murine and human myeloid leukemia. |
|
2019 Jan |
J Biol Chem |
Casein kinase II-dependent phosphorylation of DNA topoisomerase II presses the effect of a catalytic topo II inhibitor, ICRF-193, in fission yeast. |
|
2019 |
PLoS One |
Towards an understanding of C9orf82 proteinCAAP1 function. |
|
2019 Feb |
Biochemistry |
Benzimidazoles: Selective Inhibitors of Topoisomerase I with Differential Modes of Action. |
|
2019 Jan |
Nat Commun |
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks. |
|
2019 Jan |
Molecules |
Antiproliferative and Enzyme Docking Analysis of Engleromycin from iEngleromyces goetzeii. |
|
2019 Feb |
Life Sci |
Anti-lung cancer activity and inhibitory mechanisms of a novel Calothrixin A derivative. |
|
2018 Dec |
Molecules |
MHY440, a Novel Topoisomerase Ι Inhibitor, Induces Cell Cycle Arrest and Apoptosis via a ROS-Dependent DNA Damage Signaling Pathway in AGS Human Gastric Cancer Cells. |
|
2018 Dec |
Am J Rhinol Allergy |
Ivacaftor, a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator, Enhances Ciprofloxacin Activity Against Pseudomonas aeruginosa. |
|
2018 Dec |
Leukemia |
Dasatinib and navitoclax act synergistically to target NUP98-NSD1+FLT3-ITD+ acute myeloid leukemia. |
|
2018 Dec |
Nucleic Acids Res |
Genome-wide mapping of Topoisomerase I activity sites reveal its role in chromosome segregation. |
|
2018 |
R Soc Open Sci |
Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining. |
|
2018 Dec |
Invest New Drugs |
Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer. |
|
2019 Jan |
Bioorg Med Chem Lett |
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors. |
|
2019 |
Biometals |
Determination of in vitro absorption in Caco-2 monolayers of anticancer Ru(II)-based complexes acting as dual human topoisomerase and PARP inhibitors. |
|
2018 |
Biochim Biophys Acta Gene... |
Sensory domain of the cell cycle kinase CckA regulates the differential DNA binding of the master regulator CtrA in Caulobacter crescentus. |
|
2018 |
Front Pharmacol |
Lowering Etoposide Doses Shifts Cell Demise From Caspase-Dependent to Differentiation and Caspase-3-Independent Apoptosis via DNA Damage Response, Inducing AML Culture Extinction. |
|
2018 Dec |
Food Funct |
Alpha-terpineol affects synthesis and antitumor activity of triterpenoids from Antrodia cinnamomea mycelia in solid-state culture. |
|
2018 |
Anim Cells Syst (Seoul) |
VIG-1 is required for maintenance of genome stability in iCaenorhabditis elegansi. |
|
2018 Nov |
Cytometry A |
Concurrent detection of lysosome and tissue transglutaminase activation in relation to cell cycle position during apoptosis induced by different anticancer drugs. |
|
2019 Jan |
Eur J Med Chem |
Novel tyrosyl-DNA phosphodiesterase 1 inhibitors enhance the therapeutic impact of topoteсan on in vivo tumor models. |
|
2019 |
J Enzyme Inhib Med Chem |
Computational screening of chalcones acting against topoisomerase IIα and their cytotoxicity towards cancer cell lines. |
|
2019 |
Environ Mol Mutagen |
Bioflavonoids promote stable translocations between MLL-AF9 breakpoint cluster regions independent of normal chromosomal context: Model system to screen environmental risks. |
|
2018 Oct |
Int J Mol Sci |
Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma-Bench-to-Bedside Therapy. |
|
2018 |
Arterioscler Thromb Vasc ... |
Inhibition of Vascular Calcification. |
|
2018 Oct |
Xenobiotica |
Comprehensive Preclinical Pharmacokinetic Evaluations of Trastuzumab Deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in Cynomolgus Monkeys. |
|
2018 Dec |
ChemMedChem |
Inhibition of Human Topoisomerase II by N,N,N-Trimethylethanammonium Iodide Alkylcarbazole Derivatives. |
|
2018 |
Int J Nanomedicine |
Liposomal codelivery of an SN38 prodrug and a survivin siRNA for tumor therapy. |
|
2019 |
Oncogene |
An HER3-targeting antibody-drug conjugate incorporating a DNA topoisomerase I inhibitor U3-1402 conquers EGFR tyrosine kinase inhibitor-resistant NSCLC. |
|
2018 Oct |
Sci Rep |
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells. |
|
2018 Sep |
Cancers (Basel) |
Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules. |
|
2018 |
J Photochem Photobiol B |
Monitoring of topoisomerase (I) inhibitor camptothecin release from endogenous redox-stimulated GO-polymer hybrid carrier. |
|
2018 Oct |
Bioorg Med Chem |
A new phenolic series of indenopyridinone as topoisomerase inhibitors: Design, synthesis, and structure-activity relationships. |
|
2018 Sep |
Molecules |
A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2iHi-chromen-4-ol Scaffold. |
|
2018 |
Plasmid |
Plasmids for making multiple knockouts in a radioresistant bacterium Deinococcus radiodurans. |
|
2018 |
Small |
Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy. |
|
2019 |
Mol Inform |
HToPred: A Tool for Human Topoisomerase II Inhibitor Prediction. |
|
2018 Sep |
Cell Death Dis |
PARP-1-dependent RND1 transcription induced by topoisomerase I cleavage complexes confers cellular resistance to camptothecin. |
|
2018 |
Tuberculosis (Edinb) |
The EU approved antimalarial pyronaridine shows antitubercular activity and synergy with rifampicin, targeting RNA polymerase. |
|
2018 |
Cell Cycle |
P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage. |
|
2018 |
Biomed Pharmacother |
The telomerase inhibitor MST-312 synergistically enhances the apoptotic effect of doxorubicin in pre-B acute lymphoblastic leukemia cells. |
|
2018 |
Mol Cancer Ther |
Targeted Inhibition of ULK1 Promotes Apoptosis and Suppresses Tumor Growth and Metastasis in Neuroblastoma. |
|
2018 |
Mol Autism |
Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant iUbe3ai gene associated with Angelman syndrome. |
|
2018 Jul |
Oncotarget |
Topoisomerase I inhibitor, irinotecan, depletes regulatory T cells and up-regulates MHC class I and PD-L1 expression, resulting in a ra-additive antitumor effect when combined with anti-PD-L1 antibodies. |
|
2018 Aug |
Nanoscale |
Tobacco mosaic virus delivery of mitoxantrone for cancer therapy. |
|
2018 |
Adv Sci (Weinh) |
A Tumor Vascular-Targeted Interlocking Trimodal Nanosystem That Induces and Exploits Hypoxia. |
|
2018 Oct |
Eur J Pharm Sci |
Two novel camptothecin derivatives inhibit colorectal cancer proliferation via induction of cell cycle arrest and apoptosis in vitro and in vivo. |
|
2018 |
Biomed Pharmacother |
Upregulation of EID3 sensitizes breast cancer cells to ionizing radiation-induced cellular senescence. |
|
2018 Aug |
Molecules |
Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs. |
|
2018 Aug |
Sci Rep |
Isobenzofuranone derivative JVPH3, an inhibitor of L. donovani topoisomerase II, disrupts mitochondrial architecture in trypanosomatid parasites. |
|
2018 |
Front Microbiol |
Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of iMycobacterium tuberculosisi. |
|
2018 |
Int J Oncol |
Radiosensitization by irinotecan is attributed to G2M phase arrest, followed by enhanced apoptosis, probably through the ATMChkCdc25CCdc2 pathway in p53-mutant colorectal cancer cells. |
|
2018 |
Orv Hetil |
[Epigenetic effects affecting etoposide distribution and metabolism in the human body]. |
|
2018 |
Eur J Cancer |
Contribution of genotoxic anticancer treatments to the development of multiple primary tumours in the context of germline TP53 mutations. |
|
2018 Sep |
Mol Pharm |
Liposomal Irinotecan Achieves Significant Survival and Tumor Burden Control in a Triple Negative Breast Cancer Model of Spontaneous Metastasis. |
|
2019 |
J Clin Pharmacol |
Pharmacometabolomics Reveals Irinotecan Mechanism of Action in Cancer Patients. |
|
2018 Sep |
JAMA Surg |
Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. |
|
2018 Aug |
Eur J Med Chem |
Design, synthesis and screening of 1, 2, 4-triazinone derivatives as potential antitumor agents with apoptosis inducing activity on MCF-7 breast cancer cell line. |
|
2018 Aug |
Eur J Med Chem |
Novel indolo-sophoridinic scaffold as Topo I inhibitors: Design, synthesis and biological evaluation as anticancer agents. |
|
2018 |
Front Mol Biosci |
New Insights Into DNA Helicases as Druggable Targets for Cancer Therapy. |
|
2018 |
Nature |
CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. |
|
2018 |
Anticancer Res |
Preclinical Evaluation of Combined Topoisomerase and Proteasome Inhibition Against Pediatric Malignancies. |
|
2018 |
Int J Oncol |
Identification of cisplatin sensitizers through high-throughput combinatorial screening. |
|
2018 Aug |
Bioorg Med Chem |
Design, synthesis and anticancer evaluation of acridine hydroxamic acid derivatives as dual Topo and HDAC inhibitors. |