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Recent literature: Topoisomerase inhibitor
Date Journal Article title
2019 Aug Curr Comput Aided Drug Des Molecular Docking based analysis to elucidate the DNA Topoisomerase IIβ as the potential target for the Ganoderic acid, A natural therapeutic agent in cancer therapy.
2019 Aug Pharmacol Res Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production.
2019 Aug J Clin Invest cGASSTING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
2019 Aug Mol Cancer Ther U3-1402, a novel HER3-targeting antibody-drug conjugate, for the treatment of Colorectal Cancer.
2019 Aug Oncologist A Phase II Study of Irinotecan and Etoposide as Treatment for Refractory Metastatic Breast Cancer.
2019 Front Immunol Daurinol Attenuates Autoimmune Arthritis via Stabilization of Nrp1-PTEN-Foxp3 Signaling in Regulatory T Cells.
2019 Jul Bioorg Chem Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors.
2019 Aug Diagnostics (Basel) Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature Review.
2019 Jun J Inorg Biochem Computational studies, design and synthesis of Pd(II)-based complexes: Allosteric inhibitors of the Human Topoisomerase-IIα.
2019 Jul Transl Oncol DIVERSet JAG Compounds Inhibit Topoisomerase II and Are Effective Against Adult and Pediatric High-Grade Gliomas.
2019 Front Microbiol Transcriptional Response of iStreptomyces coelicolori to Rapid Chromosome Relaxation or Long-Term Supercoiling Imbalance.
2019 Expert Opin Investig Drugs Etirinotecan pegol in women with recurrent platinum-resistant or refractory ovarian cancer.
2019 Jul J Pharm Sci αVβ3-Targeted delivery of camptothecin-encapsulated CNT-cyclic RGD in 2D and 3D cancer cell culture.
2019 Jul FEBS J Complex genetic interactions between DNA polymerase β and the NHEJ ligase.
2019 Jul Eur J Med Chem Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
2019 Jul Sci Rep PARP1 regulates DNA damage-induced nucleolar-nucleoplasmic shuttling of WRN and XRCC1 in a toxicant and protein-specific manner.
2019 Jul BMC Plant Biol Metabolic and transcriptional analyses in response to potent inhibitors establish MEP pathway as major route for camptothecin biosynthesis in Nothapodytes nimmoniana (Graham) Mabb.
2019 Jul Arch Toxicol Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6.
2019 Immun Ageing Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections.
2019 Jul Mol Oncol Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology.
2019 Antimicrob Agents Chemother Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations.
2019 Jun Clin Cancer Res Targeting Topoisomerase I in the Era of Precision Medicine.
2019 Mol Pharmacol T-Cell Protein Tyrosine Phosphatase Is Irreversibly Inhibited by Etoposide-Quinone, a Reactive Metabolite of the Chemotherapy Drug Etoposide.
2019 Jul Proc Natl Acad Sci U S A SIPCacyBP promotes autophagy by regulating levels of BRUCEApollon, which stimulates LC3-I degradation.
2019 Jun Molecules Design, Synthesis and Cancer Cell Growth Inhibition Evaluation of New Aminoquinone Hybrid Molecules.
2019 Jun BMC Cancer Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene.
2019 Oxid Med Cell Longev p53-Mediated PI3KAKTmTOR Pathway Played a Role in PtoxDpt-Induced EMT Inhibition in Liver Cancer Cell Lines.
2019 Phytochemistry Repurposing of ginseng extract as topoisomerase I inhibitor based on the comparative analysis of gene expression patterns.
2019 Sep Eur J Med Chem Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.
2019 Jun Molecules Machine Learning Models Combined with Virtual Screening and Molecular Docking to Predict Human Topoisomerase I Inhibitors.
2019 May Molecules Potent Anti-Ovarian Cancer with Inhibitor Activities on both Topoisomerase II and V600EBRAF of Synthesized Substituted Estrone Candidates.
2019 Biochim Biophys Acta Gen ... PPEF: A bisbenzimdazole potent antimicrobial agent interacts at acidic triad of catalytic domain of E. coli topoisomerase IA.
2019 May Mol Med CKD-602, a topoisomerase I inhibitor, induces apoptosis and cell-cycle arrest and inhibits invasion in cervical cancer.
2019 Jul Bioorg Med Chem Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid.
2019 Target Oncol Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
2019 Jul Nucleic Acids Res RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.
2019 Apr Oncotarget A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs.
2019 May Int J Cancer [fam-] trastuzumab deruxtecan, antitumor activity is dependent on HER2 expression level rather than on HER2 amplification.
2019 Future Oncol ATTAIN: Phase III study of etirinotecan pegol versus treatment of physician's choice in patients with metastatic breast cancer and brain metastases.
2019 Front Oncol Synthesis and Anticancer Activity Evaluation of Novel Phenanthridine Derivatives.
2019 Jun Biochem Biophys Res Commun A novel mechanism of irinotecan targeting MDM2 and Bcl-xL.
2019 Lancet Oncol Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive gastric cancer: a dose-expansion, phase 1 study.
2019 Lancet Oncol Trastuzumab deruxtecan (DS-8201a) in patients with advanced HER2-positive breast cancer previously treated with trastuzumab emtansine: a dose-expansion, phase 1 study.
2019 Curr Oncol Second-line systemic therapies for metastatic urothelial carcinoma: a population-based cohort analysis.
2019 Apr Environ Mol Mutagen Epigallocatechin-3-gallate induces telomere shortening and clastogenic damage in glioblastoma cells.
2019 Apr Medicines (Basel) Camptothecin Induces PD-L1 and Immunomodulatory Cytokines in Colon Cancer Cells.
2019 Mol Biol Rep Comparison of the effect of three different topoisomerase II inhibitors combined with cisplatin in human glioblastoma cells sensitized with double strand break repair inhibitors.
2019 Cancer Chemother Pharmacol SN-38, the active metabolite of irinotecan, inhibits the acute inflammatory response by targeting toll-like receptor 4.
2019 May J Med Chem Novel Deazaflavin Analogues Potently Inhibited Tyrosyl DNA Phosphodiesterase 2 (TDP2) and Strongly Sensitized Cancer Cells toward Treatment with Topoisomerase II (TOP2) Poison Etoposide.
2019 Apr Mol Imaging Biol Evaluation of Glycolytic Response to Multiple Classes of Anti-glioblastoma Drugs by Noninvasive Measurement of Pyruvate Kinase M2 Using [18F]DASA-23.
2019 Sci Adv Targeting dePARylation selectively presses DNA repair-defective and PARP inhibitor-resistant malignancies.
2019 Apr Molecules Discovery of Novel Triazole-Containing Pyrazole Ester Derivatives as Potential Antibacterial Agents.
2019 Anticancer Drugs Ethyl-2-amino-pyrrole-3-carboxylates are active against imatinib-resistant gastrointestinal stromal tumors in vitro and in vivo.
2019 Int J Oncol Protective effect of curcumin against irinotecan‑induced intestinal mucosal injury via attenuation of NF‑κB activation, oxidative stress and endoplasmic reticulum stress.
2019 Jun Eur J Med Chem Probing structural requirements for human topoisomerase I inhibition by a novel N1-Biphenyl fluoroquinolone.
2019 May J Chromatogr B Analyt Tec... In-vitro metabolic profiling study of potential topoisomerase inhibitors 'pyrazolines' in RLMs by mass spectrometry.
2019 Apr Curr Pharm Des Synthetic optimization of ellipticine and antitumor activity of novel hexacyclic derivatives of ellipticine.
2019 Jun Eur J Med Chem A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade.
2019 J Enzyme Inhib Med Chem The antitumor activity of CYB-L10, a human topoisomerase IB catalytic inhibitor.
2019 Food Chem Toxicol Camptothecin induces mitotic arrest through Mad2-Cdc20 complex by activating the JNK-mediated Sp1 pathway.
2019 Comput Struct Biotechnol J Ligand-based Pharmacophore Modeling, Virtual Screening and Molecular Docking Studies for Discovery of Potential Topoisomerase I Inhibitors.
2019 Jun J Virol Cellular DNA Topoisomerases Are Required for the Synthesis of Hepatitis B Virus Covalently Closed Circular DNA.
2019 Mar Anticancer Agents Med Chem Recent Development in Indole Derivatives as Anticancer Agents for Breast Cancer.
2019 Jun Exp Cell Res Simultaneous induction of distinct protein phase separation events in multiple cellular compartments of a single cell.
2019 May Chem Res Toxicol Idarubicin Stimulates Cell Cycle- and TET2-Dependent Oxidation of DNA 5-Methylcytosine in Cancer Cells.
2019 Biochem Biophys Rep 15-deoxy-Δ12, 14-prostaglandin J2 enhances anticancer activities independently of VHL status in renal cell carcinomas.
2019 Ann Clin Lab Sci Therapeutic Effect of the Quinolone Levofloxacin on Inflammatory Fibroblast-like Synoviocytes.
2019 Int J Biochem Cell Biol Anti-cancer effect of Indanone-based thiazolyl hydrazone derivative on colon cancer cell lines.
2018 Ecancermedicalscience The cardioprotective effect of dexrazoxane (Cardioxane) is consistent with sequestration of poly(ADP-ribose) by self-assembly and not depletion of topoisomerase 2B.
2019 Feb Molecules Position-Selective Synthesis and Biological Evaluation of Four Isomeric A-Ring Amino Derivatives of the Alkaloid Luotonin A.
2019 Apr Eur J Med Chem An optimised series of stituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
2019 Stem Cell Res Constitutive activation of Notch2 signalling confers chemoresistance to neural stem cells via transactivation of fibroblast growth factor receptor-1.
2019 FEBS Open Bio Genotoxic stress causes the accumulation of DNA-dependent protein kinase catalytic unit phosphorylated at serine 2056 at nuclear speckles and alters pre-mRNA alternative splicing.
2019 Apr ACS Infect Dis Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.
2018 J BUON ki-67 and Topoisomerase IIa proliferation markers in colon adenocarcinoma.