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Recent literature: μ-opioid receptor agonist
Date Journal Article title
2019 Feb J Anal Toxicol Analysis of Acetyl Fentanyl in Postmortem Specimens by Gas Chromatography-Mass Spectrometry (GC-MS): Method Validation and Case Report.
2019 Feb Sci Rep Indispensable role of β-arrestin2 in the protection of remifentanil preconditioning against hepatic ischemic reperfusion injury.
2019 PLoS One Evaluating the pharmacological response in fluorescence microscopy images: The Δm algorithm.
2019 Feb Am J Physiol Cell Physiol The HECT ubiquitin E3 ligase Smurf2 degrades μ-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells.
2019 Jan Semin Perinatol Pharmacological treatment of opioid use disorder in pregnancy.
2019 Feb Pain Summit-07: A randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain.
2019 Feb Mol Pharm Novel kappa opioid receptor agonist as improved PET radiotracer: Development and in vivo evaluation.
2018 J Physiol Pharmacol The effect of selective agonists of opioid receptors on in vitro secretion of steroid hormones by porcine endometrium during the estrous cycle and early pregnancy.
2019 Jan Neuropharmacology Pharmacological activation of dopamine D4 receptor modulates morphine-induced changes in the expression of GAD6567 and GABAB receptors in the basal ganglia.
2019 Jan Pain Manag Perspectives on cannabis as a stitute for opioid analgesics.
2019 PLoS Comput Biol Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis.
2019 Jan Can J Anaesth Carfentanil: a narrative review of its pharmacology and public health concerns.
2019 Jan J Urol Re: Mechanisms of Inhibitory Action of TRK-130 (Naltalimide), a μ-Opioid Receptor Partial Agonist, on the Micturition Reflex.
2018 Dec Neuro Endocrinol Lett Mu Opioid Receptor Regulation of Gonadotropin-Releasing Hormone-Luteinizing Hormone Axis during Short-Term Food Deprivation: Role of Alpha1-Adrenoreceptor Signaling.
2019 Jan Bioanalysis Simultaneous quantification of high-dose naloxone and naloxone-3-β-d-glucuronide in human plasma by UHPLC-MSMS.
2019 Jan Neuropharmacology Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats.
2019 Jan Exp Neurol Opioid receptors inhibit the spinal AMPA receptor Ca2+ permeability that mediates latent pain sensitization.
2019 Jan Molecules Synthesis and Evaluation of Novel Biased μ-Opioid-Receptor (μOR) Agonists.
2019 Jan J Chem Inf Model Microswitches for the Activation of the Nociceptin Receptor Induced by Cebranopadol: Hints from Microsecond Molecular Dynamics.
2019 Feb Bioorg Med Chem Discovery of two novel branched peptidomimetics containing endomorphin-2 and RF9 pharmacophores: Synthesis and neuropharmacological evaluation.
2019 Jan Expert Opin Pharmacother The role of oxycodonenaloxone in the management of patients with pain and opioid-induced constipation.
2018 Front Pharmacol Mu-Opioid Receptor Agonist Induces Kir3 Currents in Mouse Peripheral Sensory Neurons - Effects of Nerve Injury.
2018 Dec Biomed Pharmacother An overview of tramadol and its usage in pain management and future perspective.
2018 Dec Neuron Pain Wars: A New Hope.
2019 Mar Neuropharmacology Locomotor and anti-immobility effects of buprenorphine in combination with the opioid receptor modulator samidorphan in rats.
2019 Feb Eur J Pharmacol Role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist Ro 64-6198 in rhesus monkeys.
2019 Biomed Pharmacother Involvement of opioid system in behavioral despair induced by social isolation stress in mice.
2018 Oct J Addict Med Buprenorphine Pharmacology Review: Update on Transmucosal and Long-acting Formulations.
2019 J Clin Psychopharmacol Assessment of the Abuse Potential of Cebranopadol in Nondependent Recreational Opioid Users: A Phase 1 Randomized Controlled Study.
2018 Dec Basic Clin Pharmacol Toxicol Optimization and pharmacological characterization of receptor-mediated Gio activation in postmortem human prefrontal cortex.
2018 Laeknabladid [Loperamide abuse - constipation or heart attack?]
2018 Nov ACS Chem Neurosci Analgesic effects of the GIRK Activator, VU0466551, alone and in combination with morphine in acute and persistent pain models.
2018 Drugs Tapentadol Prolonged Release: A Review in Pain Management.
2018 Trends Pharmacol Sci Pharmacological Research as a Key Component in Mitigating the Opioid Overdose Crisis.
2018 Nov J Neuroinflammation Anti-inflammatory effects induced by pharmaceutical stances on inflammatory active brain astrocytes-promising treatment of neuroinflammation.
2018 Br J Anaesth Remifentanil as an adjunct to anaesthesia for electroconvulsive therapy fails to confer long-term benefits.
2018 Nov Exp Mol Med Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via pressing PI3KAkt-MAPK signaling in a MOR-dependent manner.
2019 J Pharmacol Exp Ther Long-Lasting Effects of Methocinnamox on Opioid Self-Administration in Rhesus Monkeys.
2019 Peptides Determinants of opioid abuse potential: Insights using intracranial self-stimulation.
2018 Peptides Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain.
2018 Nov Chem Res Toxicol Lateral Flow Assessment and Unanticipated Toxicity of Kratom.
2019 Phytother Res Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking.
2019 Jan Scand J Pain Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery.
2019 Am J Emerg Med Approach to buprenorphine use for opioid withdrawal treatment in the emergency setting.
2018 Nov Life Sci Remifentanil attenuates lipopolysaccharide-induced oxidative injury by downregulating PKCβ2 activation and inhibiting autophagy in H9C2 cardiomyocytes.
2019 Methods Mol Biol Quantitation of Tapentadol by Liquid Chromatography: Tandem Mass Spectrometry.
2018 Trends Pharmacol Sci Abuse Potential of Biased Mu Opioid Receptor Agonists.
2018 Dec Neuroscience Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat.
2018 Oct Sci Rep Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation.
2018 Oct Behav Pharmacol Punishment and reinforcement by opioid receptor agonists in a choice procedure in rats.
2018 Front Cell Neurosci Activation of Astrocytic μ-opioid Receptor Elicits Fast Glutamate Release Through TREK-1-Containing K2P Channel in Hippocampal Astrocytes.
2018 Nov Neuroscience Sex Differences in the Rat Hippocampal Opioid System After Oxycodone Conditioned Place Preference.
2018 eNeuro Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice.
2018 Oct Proteomes Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA.
2019 Basic Clin Pharmacol Toxicol Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects.
2018 Nov Drug Alcohol Depend The G-protein biased mu-opioid agonist, TRV130, produces reinforcing and antinociceptive effects that are comparable to oxycodone in rats.
2018 Biomed Pharmacother Evaluation of the role of different neurotransmission systems in the anticonvulsant action of sildenafil in the 6 Hz-induced psychomotor seizure threshold test in mice.
2018 Sep Sci Rep Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist.
2018 Front Pharmacol iIn vitroi and iin vivoi Pharmacological Activities of 14-iOi-Phenylpropyloxymorphone, a Potent Mixed MuDeltaKappa-Opioid Receptor Agonist With Reduced Constipation in Mice.
2018 Sep Behav Pharmacol Sex differences in the effectiveness of buprenorphine to decrease rates of responding in rhesus monkeys.
2018 Neuropharmacology The combination of the opioid glycopeptide MMP-2200 and a NMDA receptor antagonist reduced l-DOPA-induced dyskinesia and MMP-2200 by itself reduced dopamine receptor 2-like agonist-induced dyskinesia.
2018 Oct J Med Chem Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias.
2018 Sep ACS Chem Neurosci Synthesis and Biological Evaluation of Fentanyl Analogues Modified at Phenyl Groups with Alkyls.
2018 Aug Sci Transl Med A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
2018 Sep ACS Chem Neurosci Structure-Activity Relationship Studies of 6α- and 6β-Indolylacetamidonaltrexamine Derivatives as Bitopic Mu Opioid Receptor Modulators and Elaboration of the "Message-Address Concept" To Comprehend Their Functional Conversion.
2018 Aug Mol Neurobiol Molecular Adaptations in the Rat Dorsal Striatum and Hippocampus Following Abstinence-Induced Incubation of Drug Seeking After Escalated Oxycodone Self-Administration.
2018 Oct J Neurosci Regulators of G-Protein Signaling (RGS) Proteins Promote Receptor Coupling to G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels.
2019 J Clin Pharmacol Abuse Potential of BuprenorphineSamidorphan Combination Compared to Buprenorphine and Placebo: A Phase 1 Randomized Controlled Trial.
2018 Sep Neuropharmacology Modulation of appetitive motivation by prefrontal cortical mu-opioid receptors is dependent upon local dopamine D1 receptor signaling.
2018 Jul Arthritis Res Ther A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance.
2018 Sep Neuropharmacology Naltrexone and nalmefene attenuate cocaine place preference in male mice.
2018 Jul Anesth Analg Pharmacological Characters of Oliceridine, a μ-Opioid Receptor G-Protein[FIGURE DASH]Biased Ligand in Mice.
2018 Sep Eur J Pharmacol Fentanyl and naloxone effects on glutamate and GABA release rates from anterior hypothalamus in freely moving rats.
2018 Jul Sci Signal Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.
2018 Pain Analgesic effects of a novel pH-dependent μ-opioid receptor agonist in models of neuropathic and abdominal pain.