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Recent literature: μ-opioid receptor agonist
Date Journal Article title
2020 Jan Eur J Pharmacol Behavioral effects of the kappa opioid receptor partial agonist nalmefene in tests relevant to depression.
2020 Jan J Med Chem Aromatic-Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy Mu-Opioid Receptor (MOR)Delta-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability.
2020 Jan Br J Pharmacol Functional expression and pharmacological modulation of TRPM3 in human sensory neurons.
2020 Jan Eur J Pharmacol Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ amp; κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine.
2020 Jan Neuropharmacology Confronting the opioid crisis with basic research in neuropharmacology.
2020 Jan Respir Physiol Neurobiol Kölliker-FuseParabrachial complex mu opioid receptors contribute to fentanyl-induced apnea and respiratory rate depression.
2020 Jan J Pharmacol Exp Ther NR2A-NMDA receptor blockade reverses the lack of morphine analgesia without affecting chronic pain status in fibromyalgia-like mouse model.
2020 Genet Test Mol Biomarkers κ Opioid Receptor 1 Single Nucleotide Polymorphisms were Associated with the Methadone Dosage.
2020 Jan Brain Res Lateral Septum Mu Opioid Receptors in Stimulation of Feeding.
2019 Front Neurosci Activation of the G Protein-Coupled Estrogen Receptor Elicits Store Calcium Release and Phosphorylation of the Mu-Opioid Receptors in the Human Neuroblastoma SH-SY5Y Cells.
2020 Jan J Clin Psychiatry Perioperative Buprenorphine Continuous Maintenance and Administration Simultaneous With Full Opioid Agonist: Patient Priority at the Interface Between Medical Disciplines.
2020 Jan Psychopharmacology (Berl) Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration.
2019 Eur Heart J Case Rep Loperamide overdose causing torsades de pointes and requiring Impella temporary mechanical port: a case report.
2020 Jan Prog Neuropsychopharmacol... Opioid receptors mRNAs expression and opioids agonist-dependent G-protein activation in the rat brain following neuropathy.
2019 Dec Eur J Pharmacol Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia.
2019 Nov Ann Palliat Med Opioid utility function: methods and implications.
2020 Feb Eur J Pharmacol Dezocine attenuates the remifentanil-induced postoperative hyperalgesia by inhibition of phosphorylation of CaMKⅡα.
2019 Dec Molecules The Meta-Position of Phe4 in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors.
2019 Dec Elife Opioids modulate an emergent rhythmogenic process to depress breathing.
2019 Neurobiol Stress Mu opioid receptor regulation of glutamate efflux in the central amygdala in response to predator odor.
2019 Sci Adv Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.
2019 Dec Curr Biol Activation of Kappa Opioid Receptor Regulates the Hypothermic Response to Calorie Restriction and Limits Body Weight Loss.
2019 Nov Molecules Structure-Activity Relationships of 7-Substituted Dimethyltyrosine-Tetrahydroisoquinoline Opioid Peptidomimetics.
2019 Nov Mol Brain Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors.
2019 Nov Pain Ethnic disparities in pain processing among healthy adults: μ-opioid receptor binding potential as a putative mechanism.
2019 Dec Clin Sci (Lond) Angiotensin II inhibits DDAH1-nNOS signaling via AT1R and μOR dimerization to modulate blood pressure control in the central nervous system.
2020 J Pharmacol Exp Ther OREX-1019: A Novel Treatment of Opioid Use Disorder and Relapse Prevention.
2019 Nov Pharmaceutics Evaluation of the Effect of CYP2D6 Genotypes on Tramadol and iOi-Desmethyltramadol Pharmacokinetic Profiles in a Korean Population Using Physiologically-Based Pharmacokinetic Modeling.
2019 Dec J Med Chem 4-Aryl-1-oxa-4,9-diazaspiro[5.5]undecane Derivatives as Dual μ-Opioid Receptor Agonists and σ1 Receptor Antagonists for the Treatment of Pain.
2019 Front Immunol Naltrexone Restores Impaired Transient Receptor Potential Melastatin 3 Ion Channel Function in Natural Killer Cells From Myalgic EncephalomyelitisChronic Fatigue Syndrome Patients.
2019 Nov Sci Rep Sucrose intake lowers μ-opioid and dopamine D23 receptor availability in porcine brain.
2019 Nov Reprod Fertil Dev Mu opioid receptor expression and localisation in murine spermatozoa and its role in IVF.
2019 Oct Molecules Discovery of Novel µ-Opioid Receptor Inverse Agonist from a Combinatorial Library of Tetrapeptides through Structure-Based Virtual Screening.
2019 Nov Addict Biol Potent and selective NOP receptor activation reduces cocaine self-administration in rats by lowering hedonic set point.
2019 Nov Br J Pharmacol G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder.
2020 Neurochem Int Agonist binding of human mu opioid receptors expressed in the yeast Pichia pastoris: Effect of cholesterol complementation.
2019 Dec Bioorg Med Chem Lett Discovery of a novel bicyclic compound, DS54360155, as an orally potent analgesic without mu-opioid receptor agonist activity.
2019 Oct Biophys J Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation.
2019 Aug Cureus A Unique Case Report on Methadone Used for Treatment of Opioid-induced Hyperalgesia in a Cancer Patient at the End of Life.
2019 Nov Int J Neuropsychopharmacol Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats.
2019 Oct Proc Natl Acad Sci U S A A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.
2019 Oct Handb Exp Pharmacol Emerging Insights into Mu Opioid Pharmacology.
2019 Dec Eur J Pharmacol Spontaneous pain-associated facial expression and efficacy of clinically used drugs in the reserpine-induced rat model of fibromyalgia.
2019 Oct Behav Pharmacol Impact of order of fixed-ratio presentation on demand for self-administered remifentanil in male rats.
2019 Nov J Biol Chem Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation.
2019 Mol Pharmacol Homologous Regulation of Mu Opioid Receptor Recycling by G iβγi , Protein Kinase C, and Receptor Phosphorylation.
2019 Dec Eur J Pharmacol Nalbuphine, a kappa opioid receptor agonist and mu opioid receptor antagonist attenuates pruritus, decreases IL-31, and increases IL-10 in mice with contact dermatitis.
2019 Sep Pain Med Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study.
2019 Nov Life Sci Intrathecally injected tramadol reduces articular incapacitation and edema in a rat model of lipopolysaccharide (LPS)-induced reactive arthritis.
2019 J Psychopharmacol Chronic administration of buprenorphine in combination with samidorphan produces sustained effects in olfactory bulbectomised rats and Wistar-Kyoto rats.
2019 Pharmacol Biochem Behav Assessing the contribution of opioid- and dopamine-related genetic polymorphisms to the abuse liability of oxycodone.
2019 J Pharmacol Exp Ther Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine.
2019 Nov Eur J Med Chem Discovery of dual-acting opioid ligand and TRPV1 antagonists as novel therapeutic agents for pain.
2019 Dec Brain Res Clinically utilized kappa-opioid receptor agonist nalfurafine combined with low-dose naltrexone prevents alcohol relapse-like drinking in male and female mice.
2020 Neuropsychopharmacology A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal.
2020 Jan QJM Non-medical use of loperamide in the UK and the USA.
2019 Neurochem Int Activation of MORs in the VTA induces changes on cFos expression in different projecting regions: Effect of inflammatory pain.
2019 Aug Biomolecules Heterodimerization of Mu Opioid Receptor Protomer with Dopamine D2 Receptor Modulates Agonist-Induced Internalization of Mu Opioid Receptor.
2019 J Pharmacol Exp Ther Behavioral Effects of Opioid Full and Partial Agonists During Chronic Buprenorphine Treatment.
2019 Mol Pharmacol Separation of Acute Desensitization and Long-Term Tolerance of iµi-Opioid Receptors Is Determined by the Degree of C-Terminal Phosphorylation.
2019 Pain Dermorphin [D-Arg2, Lys4] (1-4) amide inhibits below-level heat hypersensitivity in mice after contusive thoracic spinal cord injury.
2019 Jul Pain Med Long-term Safety and Tolerability of NKTR-181 in Patients with Moderate to Severe Chronic Low Back Pain or Chronic Noncancer Pain: A Phase 3 Multicenter, Open-Label, 52-Week Study (SUMMIT-08 LTS).
2019 Oct ChemMedChem Discovery of Novel Biased Opioid Receptor Ligands through Structure-Based Pharmacophore Virtual Screening and Experiment.
2019 Oct Eur J Pharm Sci Biosensor-based kinetic and thermodynamic characterization of opioids interaction with human μ-opioid receptor.
2019 Mol Reprod Dev Implication of mu opioid receptor in the in vitro maturation of oocytes and its effects on sequent fertilization and embryo development in mice.
2019 Jul Neuropharmacology Biased agonism of clinically approved μ-opioid receptor agonists and TRV130 is not controlled by binding and signaling kinetics.
2019 Br J Pharmacol Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine.
2019 Anesthesiology Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice.
2019 Br J Pharmacol Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain.
2019 J Pharmacol Sci Possible biased analgesic of hydromorphone through the G protein-over β-arrestin-mediated pathway: cAMP, CellKey™, and receptor internalization analyses.
2019 Front Cell Neurosci Neuropathic Pain Induced Alterations in the Opioidergic Modulation of a Descending Pain Facilitatory Area of the Brain.
2019 Nov Neuropharmacology Effects of mu opioid receptors in paraventricular nucleus on ejaculation through mediating sympathetic nerve system activity.
2019 J Pharmacol Exp Ther Opioid-Induced Signaling and Antinociception Are Modulated by the Recently Deorphanized Receptor, GPR171.
2019 Drug Dev Res Effectiveness of nalbuphine, a κ-opioid receptor agonist and μ-opioid receptor antagonist, in the inhibition of INa , IK(M) , and IK(erg) unlinked to interaction with opioid receptors.
2019 Sep Drug Alcohol Depend Effects of the synthetic cannabinoid receptor agonist JWH-018 on abuse-related effects of opioids in rhesus monkeys.