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Recent literature: 5-HT1A receptor agonist
Date Journal Article title
2019 Feb Eur Psychiatry The efficacy of cariprazine in negative symptoms of schizophrenia: Post hoc analyses of PANSS individual items and PANSS-derived factors.
2019 PLoS One Dissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice.
2019 Jan Eur J Med Chem Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands.
2019 Jan J Clin Psychiatry Long-Term Remission With Cariprazine Treatment in Patients With Schizophrenia: A Post Hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Relapse Prevention Trial.
2019 Jan J Chem Neuroanat Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease.
2019 Jan J Vet Pharmacol Ther Pharmacokinetics and bioavailability after intramuscular injection of the 5-HT1A serotonin agonist R-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in domestic goats (Capra aegagrus hircus).
2019 Bull Exp Biol Med Prenatal Stimulation of 5-HT1A Receptors Improves Adaptive Behavior in Prenatally Stressed Rats.
2018 Front Pharmacol 5-HT1A Receptor Function Makes Wound Healing a Happier Process.
2019 Jan ACS Chem Neurosci Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.
2019 Jan Metab Brain Dis Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice.
2018 Dec J Neurosci Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma.
2018 Front Cell Neurosci Hypidone Hydrochloride (YL-0919) Produces a Fast-Onset Reversal of the Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure.
2018 Dec Psychopharmacology (Berl) Activation of somatodendritic 5-HT1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test.
2019 Int Clin Psychopharmacol Long-term safety and tolerability of cariprazine as adjunctive therapy in major depressive disorder.
2018 Dec Basic Clin Pharmacol Toxicol Optimization and pharmacological characterization of receptor-mediated Gio activation in postmortem human prefrontal cortex.
2018 Dec Fundam Clin Pharmacol Anxiolytic-like effects of the new arylpiperazine derivatives containing isonicotinic and picolinic nuclei: behavioral and biochemical studies.
2018 Mov Disord Diverse serotonin actions of vilazodone reduce l-3,4-dihidroxyphenylalanine-induced dyskinesia in hemi-parkinsonian rats.
2019 Expert Opin Pharmacother Evaluation of vilazodone for the treatment of depressive and anxiety disorders.
2019 Eur Neuropsychopharmacol Efficacy of cariprazine across symptom domains in patients with acute exacerbation of schizophrenia: Pooled analyses from 3 phase IIIII studies.
2018 Nov Psychopharmacology (Berl) Cannabinoid-induced lower lip retraction in rats.
2019 Expert Opin Drug Discov Vortioxetine: a novel antidepressant for the treatment of major depressive disorder.
2019 Food Chem Toxicol 5-HT1A receptor agonist 8-OH-DPAT induces serotonergic behaviors in mice via interaction between PKCδ and p47phox.
2018 J Pharmacol Sci Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats.
2018 Oct Int J Mol Sci Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
2018 Mol Pharmacol Involvement of 5-HT1A and 5-HT2A Receptors but Not iαi 2-Adrenoceptors in the Acute Electrophysiological Effects of Cariprazine in the Rat Brain In Vivo.
2018 J Exp Neurosci Behavioral Mechanisms That Depend on Dopamine and Serotonin in iCaenorhabditis elegansi Interact With the Antipsychotics Risperidone and Aripiprazole.
2019 Feb Brain Res Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit.
2018 Sep Int J Mol Sci Deep Brain Stimulation Modified Autism-Like Deficits via the Serotonin System in a Valproic Acid-Induced Rat Model.
2018 Sep Sci Rep Critical roles of serotonin-oxytocin interaction during the neonatal period in social behavior in 15q dup mice with autistic traits.
2018 Nov Neurosci Lett Co-activation of both 5-HT1A and 5-HT7 receptors induced attenuation of glutamatergic synaptic transmission in the rat visual cortex.
2018 Neuropharmacology Reduced cortical serotonin 5-HT2A receptor binding and glutamate activity in high compulsive drinker rats.
2018 Sep Handb Exp Pharmacol Other Antidepressants.
2018 Neuropharmacology Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein.
2018 Neurobiol Aging Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD.
2018 Expert Opin Ther Pat 5-HT1A receptor ligands and their therapeutic applications: review of new patents.
2018 Neurogastroenterol Motil The central effects of buspirone on abdominal pain in rats.
2018 eNeuro Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol.
2018 Psychopharmacology (Berl) 5-HT1A parital agonism and 5-HT7 antagonism restore episodic memory in chronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA.
2018 Sep Neuropharmacology Interplay between 5-HT2C and 5-HT1A receptors in the dorsal periaqueductal gray in the modulation of fear-induced antinociception in mice.
2018 Sep Future Med Chem Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain.
2018 Psychopharmacology (Berl) The effect of NAD-299 and TCB-2 on learning and memory, hippocampal BDNF levels and amyloid plaques in Streptozotocin-induced memory deficits in male rats.
2018 Jul Addict Biol Modulation of serotonin and noradrenaline in the BLA by pindolol reduces long-term ethanol intake.
2018 Front Neurosci 5-HT1a Receptor Involvement in Temporal Memory and the Response to Temporal Ambiguity.
2018 Sep Neuropharmacology 5-HT1A receptor-mediated activation of neuroendocrine responses and multiple protein kinase pathways in the peripubertal rat hypothalamus.
2018 Psychopharmacology (Berl) 5-HT3 antagonists decrease discounting rate without affecting sensitivity to reward magnitude in the delay discounting task in mice.
2018 Exp Clin Psychopharmacol Effects of lorcaserin and buspirone, administered alone and as a mixture, on cocaine self-administration in male and female rhesus monkeys.
2018 Pharmacol Biochem Behav Neurochemical changes underlying schizophrenia-related behavior in a modified forced swim test in mice.
2018 Neuropharmacology The GABAergic Gudden's dorsal tegmental nucleus: A new relay for serotonergic regulation of sleep-wake behavior in the mouse.
2018 Neuropharmacology Enhanced central histaminergic transmission attenuates compulsive-like behavior in mice.
2018 Jun Molecules Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment.
2018 Oct ACS Chem Neurosci Dark Classics in Chemical Neuroscience: Mescaline.
2018 JAAPA Flibanserin for hypoactive sexual desire disorder in premenopausal women.
2018 Neuropharmacology 5-HT6 receptor agonist and memory-enhancing properties of hypidone hydrochloride (YL-0919), a novel 5-HT1A receptor partial agonist and SSRI.
2018 Nov Brain Res Monoaminergic and aminoacidergic receptors are involved in the antidepressant-like effect of ginsenoside Rb1 in mouse hippocampus (CA3) and prefrontal cortex.
2018 Pharmacol Biochem Behav Dopamine and serotonin metabolism associated with morphine reward and its inhibition with buspirone: A study in the rat striatum.
2018 Brain Struct Funct 18F-F13640 preclinical evaluation in rodent, cat and primate as a 5-HT1A receptor agonist for PET neuroimaging.
2018 Jul Bioorg Med Chem Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
2018 Exp Neurol Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain.
2018 Mol Biol (Mosk) [Functional Responses to the Chronic Activation of 5-HT1A Receptors in Mice with Genetic Predisposition to Catalepsy].
2018 Pharmacol Biochem Behav A behavioral mechanistic investigation of the role of 5-HT1A receptors in the mediation of rat maternal behavior.
2018 Jul J Neurophysiol Phrenic long-term depression evoked by intermittent hypercapnia is modulated by serotonergic and adrenergic receptors in raphe nuclei.
2018 Front Neural Circuits Emergence of Serotonergic Neurons After Spinal Cord Injury in Turtles.
2018 Neurochem Res Effects of the Serotonin 5-HT1A Receptor Biased Agonists, F13714 and F15599, on Striatal Neurotransmitter Levels Following L-DOPA Administration in Hemi-Parkinsonian Rats.
2017 Beilstein J Org Chem Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors.
2018 Drug Metab Dispos Activation of 5-HT1A Receptors in the Hypothalamic Paraventricular Nuclei Negatively Regulates Cytochrome P450 Expression and Activity in Rat Liver.
2018 Jun Brain Res NLX-112, a highly selective 5-HT1A receptor agonist, mediates analgesia and antidepressant-like activity in rats via spinal cord and prefrontal cortex 5-HT1A receptors, respectively.
2018 Front Psychiatry Repeated Exposure to the "Spice" Cannabinoid JWH-018 Induces Tolerance and Enhances Responsiveness to 5-HT1A Receptor Stimulation in Male Rats.
2018 Behav Pharmacol Estradiol presses ingestive response evoked by activation of 5-HT1A receptors in the lateral hypothalamus of ovariectomized rats.
2018 Ann Gastroenterol Evaluation and management of esophageal manifestations in systemic sclerosis.
2018 Psychiatry Investig Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling.
2018 Neuropsychopharmacology Positive regulation of raphe serotonin neurons by serotonin 2B receptors.
2018 Br J Pharmacol Mechanisms of imidazoline I2 receptor agonist-induced antinociception in rats: involvement of monoaminergic neurotransmission.
2018 FASEB J NK1R5-HT1AR interaction is related to the regulation of melanogenesis.
2018 Feb Sci Rep 5-HT1A receptor-dependent modulation of emotional and neurogenic deficits elicited by prolonged consumption of alcohol.
2018 J Ocul Pharmacol Ther Pharmacology of Serotonin Receptors Causing Contraction of Isolated Bovine Posterior Ciliary Arteries: Role in Ocular Blood Flow.