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Recent literature: 5-HT1A receptor agonist
Date Journal Article title
2019 Oct Pharmacology Pharmacological Characteristics of Anxiolytics on Acetylcholine-Induced Contractions in Rat Detrusor Smooth Muscle.
2019 Oct Neuropharmacology Serotonergic modulation of sacral dorsal root stimulation-induced locomotor output in newborn rat.
2019 Oct Neurobiol Learn Mem Facilitation of fear extinction by novelty is modulated by β-adrenergic and 5-HT1A serotoninergic receptors in hippocampus.
2019 Oct Acta Physiol (Oxf) Systemic serotonin inhibits brown adipose tissue sympathetic nerve activity via a GABA input to the dorsomedial hypothalamus, not via 5HT1A receptor activation in raphe pallidus.
2019 Dec Eur J Med Chem Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
2019 Oct Subst Use Misuse Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review.
2019 Drug Des Devel Ther Preclinical pharmacodynamic and pharmacokinetic characterization of the major metabolites of cariprazine.
2019 PLoS One Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism.
2019 Front Cell Neurosci Differential Hippocampal Expression of BDNF Isoforms and Their Receptors Under Diverse Configurations of the Serotonergic System in a Mice Model of Increased Neuronal Survival.
2019 Sep Biomed Pharmacother Review of antidepressants in clinic and active ingredients of traditional Chinese medicine targeting 5-HT1A receptors.
2019 Vet Anaesth Analg Dose-effect study of the serotonin agonist R-8-OH-DPAT on opioid-induced respiratory depression in blesbok (Damaliscus pygargus philipsi) and impala (Aepyceros melampus).
2019 J Pharmacol Exp Ther The Role of Dopamine D3 Receptor Partial Agonism in Cariprazine-Induced Neurotransmitter Efflux in Rat Hippocampus and Nucleus Accumbens.
2019 Sep Prim Care Companion CNS D... Effect of Tandospirone, a Partial Agonist of the 5-HT1A Receptor, in a Patient With Chronic Poststroke Emotional Incontinence With Anxiousness.
2019 CNS Spectr Keeping up with the therapeutic advances in schizophrenia: a review of novel and emerging pharmacological entities.
2019 Dec Behav Brain Res Serotonin1A receptors in the dorsal hippocampus regulate working memory and long-term habituation in the hemiparkinsonian rats.
2019 Malays J Med Sci Protective Effects of 5-HT1A Receptor Inhibition and 5-HT2A Receptor Stimulation Against Streptozotocin-Induced Apoptosis in the Hippocampus.
2019 Dec Brain Res Serotonin abnormalities in Dravet syndrome mice before and after the age of seizure onset.
2019 Aug Br J Pharmacol Characterization of binding, functional activity, and contractile responses of the selective 5-HT1F receptor agonist lasmiditan.
2019 Cell Signal Bell-shaped agonist activation of 5-HT1A receptor-coupled Gαi3 G-proteins: Receptor density-dependent switch in receptor signaling.
2019 Sep J Neurosci Dopamine D2L Receptor Deficiency Causes Stress Vulnerability through 5-HT1A Receptor Dysfunction in Serotonergic Neurons.
2019 Sep J Biol Chem Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of β-arrestin2.
2019 J Mol Cell Cardiol Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome.
2019 Drugs Today (Barc) Gepirone hydrochloride: a novel antidepressant with 5-HT1A agonistic properties.
2019 J Psychopharmacol Cortical 5-hydroxytryptamine 1A receptor biased agonist, NLX-101, displays rapid-acting antidepressant-like properties in the rat chronic mild stress model.
2019 Naunyn Schmiedebergs Arch... Biphasic effects of 5-HT1A agonism on impulsive responding are dissociable from effects on anxiety in the variable consecutive number task.
2019 Front Behav Neurosci Differences Between the Prenatal Effects of Fluoxetine or Buspirone Alone or in Combination on Pain and Affective Behaviors in Prenatally Stressed Male and Female Rats.
2019 Pharmacol Res Serotonergically dependent antidepressant-like activity on behavior and stress axis responsivity of acacetin.
2019 Sep Brain Res CRISPRCas9-mediated in vivo gene editing reveals that neuronal 5-HT1A receptors in the dorsal raphe nucleus contribute to body temperature regulation in mice.
2019 Front Cell Neurosci 5-HT1A Receptor Agonist Promotes Retinal Ganglion Cell Function by Inhibiting OFF-Type Presynaptic Glutamatergic Activity in a Chronic Glaucoma Model.
2019 Sep Neuropharmacology Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats.
2019 Aug Eur J Med Chem 1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.
2019 Jul Neuropharmacology Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT1A receptor sensitivity.
2019 Brain Res Bull Serotonin1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons.
2019 Apr CNS Spectr The role of dopamine D3 receptors in the mechanism of action of cariprazine.
2019 Jul ACS Chem Neurosci Serotonin 5-HT1A Receptor Biased Agonists Display Differential Anxiolytic Activity in a Rat Social Interaction Model.
2019 Psychopharmacology (Berl) Effects of combined escitalopram and aripiprazole in rats: role of the 5-HT1a receptor.
2019 May Neuroscience Serotonin 5-HT1A Receptor-Mediated Reduction of Excitatory Synaptic Transmission in Layers IIIII of the Paraiculum.
2019 Jun Neurosci Lett Cannabinoid CB1 receptors mediate the anxiolytic effects induced by systemic alprazolam and intra-periaqueductal gray 5-HT1A receptor activation.
2019 Jun Am J Psychiatry Cariprazine Treatment of Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Phase 3 Study.
2019 Apr Eur J Med Chem Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells.
2019 Front Cell Neurosci Resveratrol Improves Brain-Gut Axis by Regulation of 5-HT-Dependent Signaling in the Rat Model of Irritable Bowel Syndrome.
2019 J Psychopharmacol Cross state-dependency of learning between 5-HT1A andor 5-HT7 receptor agonists and muscimol in the mouse dorsal hippocampus.
2019 Eur Psychiatry The efficacy of cariprazine in negative symptoms of schizophrenia: Post hoc analyses of PANSS individual items and PANSS-derived factors.
2019 PLoS One Dissecting the roles of β-arrestin2 and GSK-3 signaling in 5-HT1BR-mediated perseverative behavior and prepulse inhibition deficits in mice.
2019 Mar Eur J Med Chem Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligands.
2019 Jan J Clin Psychiatry Long-Term Remission With Cariprazine Treatment in Patients With Schizophrenia: A Post Hoc Analysis of a Randomized, Double-Blind, Placebo-Controlled, Relapse Prevention Trial.
2019 J Chem Neuroanat Protective effects of 5-HT1A receptor antagonist and 5-HT2A receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease.
2019 Psychiatr Genet Buspirone for the treatment of anxiety-related symptoms in Angelman syndrome: a case series.
2019 Drugs Brexpiprazole: A Review in Schizophrenia.
2019 J Vet Pharmacol Ther Pharmacokinetics and bioavailability after intramuscular injection of the 5-HT1A serotonin agonist R-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in domestic goats (Capra aegagrus hircus).
2019 Bull Exp Biol Med Prenatal Stimulation of 5-HT1A Receptors Improves Adaptive Behavior in Prenatally Stressed Rats.
2019 Neuropeptides Melanin-concentrating hormone does not modulate serotonin release in primary cultures of fetal raphe nucleus neurons.
2018 Front Pharmacol 5-HT1A Receptor Function Makes Wound Healing a Happier Process.
2019 May ACS Chem Neurosci Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.
2019 Metab Brain Dis Serotonin 5-HT1A receptors modulate depression-related symptoms following mild traumatic brain injury in male adult mice.
2019 Jul ACS Chem Neurosci Serotonin 5-HT1A Receptor Biased Agonists Induce Different Cerebral Metabolic Responses: A [18F]-Fluorodesoxyglucose Positron Emission Tomography Study in Conscious and Anesthetized Rats.
2019 Feb J Neurosci Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma.
2018 Front Cell Neurosci Hypidone Hydrochloride (YL-0919) Produces a Fast-Onset Reversal of the Behavioral and Synaptic Deficits Caused by Chronic Stress Exposure.
2019 Psychopharmacology (Berl) Activation of somatodendritic 5-HT1A autoreceptors reduces the acquisition and expression of cued fear in the rat fear-potentiated startle test.
2019 Int Clin Psychopharmacol Long-term safety and tolerability of cariprazine as adjunctive therapy in major depressive disorder.
2019 Basic Clin Pharmacol Toxicol Optimization and pharmacological characterization of receptor-mediated Gio activation in postmortem human prefrontal cortex.
2019 Fundam Clin Pharmacol Anxiolytic-like effects of the new arylpiperazine derivatives containing isonicotinic and picolinic nuclei: behavioral and biochemical studies.
2019 Comput Biol Chem Molecular docking, dynamics simulations and 3D-QSAR modeling of arylpiperazine derivatives of 3,5-dioxo-(2H,4H)-1,2,4-triazine as 5-HT1AR agonists.
2018 Mov Disord Diverse serotonin actions of vilazodone reduce l-3,4-dihidroxyphenylalanine-induced dyskinesia in hemi-parkinsonian rats.
2019 Expert Opin Pharmacother Evaluation of vilazodone for the treatment of depressive and anxiety disorders.
2019 Eur Neuropsychopharmacol Efficacy of cariprazine across symptom domains in patients with acute exacerbation of schizophrenia: Pooled analyses from 3 phase IIIII studies.
2019 Psychopharmacology (Berl) Cannabinoid-induced lower lip retraction in rats.
2019 Expert Opin Drug Discov Vortioxetine: a novel antidepressant for the treatment of major depressive disorder.
2019 Mar Int J Neuropsychopharmacol Serotonin Signaling Trough Prelimbic 5-HT1A Receptors Modulates CSDS-Induced Behavioral Changes in Adult Female Voles.
2019 Food Chem Toxicol 5-HT1A receptor agonist 8-OH-DPAT induces serotonergic behaviors in mice via interaction between PKCδ and p47phox.
2018 J Pharmacol Sci Involvement of 5-HT2A receptor hyperfunction in the anxiety-like behavior induced by doxorubicin and cyclophosphamide combination treatment in rats.
2018 Oct Int J Mol Sci Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
2018 Mol Pharmacol Involvement of 5-HT1A and 5-HT2A Receptors but Not iαi 2-Adrenoceptors in the Acute Electrophysiological Effects of Cariprazine in the Rat Brain In Vivo.
2018 J Exp Neurosci Behavioral Mechanisms That Depend on Dopamine and Serotonin in iCaenorhabditis elegansi Interact With the Antipsychotics Risperidone and Aripiprazole.
2019 Feb Brain Res Breathing stimulation mediated by 5-HT1A and 5-HT3 receptors within the preBötzinger complex of the adult rabbit.