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Recent literature: Pancreatic and gastric lipase inhibitor
Date Journal Article title
2020 Apr Am J Physiol Gastrointest... Responses of gut and pancreatic hormones, bile acids, and fibroblast growth factor-21 differ to glucose, protein, and fat ingestion after gastric bypass surgery.
2019 Dec Int Microbiol Screening of Gastrointestinal Lipase Inhibitors Produced by Microorganisms Isolated from Soil and Lake Sediments.
2012 LiverTox: Clinical and Re... Orlistat
2018 Oct Cell Mol Biol (Noisy-le-g... Inhibitory effects of various solvent extracts from Rhamnus frangula leaves on some inflammatory and metabolic enzymes.
2018 Jun J Clin Endocrinol Metab Orlistat Therapy for Children With Type 1 Hyperlipoproteinemia: A Randomized Clinical Trial.
2018 May Drug Alcohol Depend Novel prodrug PRX-P4-003, selectively activated by gut enzymes, may reduce the risk of iatrogenic addiction and abuse.
2018 Lancet Diabetes Endocrinol Progress and challenges in anti-obesity pharmacotherapy.
2016 Nov Eur J Med Chem Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis.
2013 F1000Res The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
2012 Nov J Med Chem Synthesis and kinetic evaluation of cyclophostin and cyclipostins phosphonate analogs as selective and potent inhibitors of microbial lipases.
2012 Ther Adv Drug Saf Does orlistat cause acute kidney injury?
2011 J Insect Physiol The effects of the broad-specificity lipase inhibitor, tetrahydrolipstatin, on the growth, development and survival of the larvae of Epiphyas postvittana (Walker) (Tortricidae, Lepidoptera).
2010 Dtsch Arztebl Int Pancreatic enzyme therapy.
2012 J Gastrointest Cancer A rare case of metastatic pancreatic hepatoid carcinoma treated with sorafenib.
2010 J Lipid Res GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene.
2010 Neurosci Res Effect of an intraduodenal injection of fat on the activities of the adrenal efferent sympathetic nerve and the gastric efferent parasympathetic nerve in urethane-anesthetized rats.
2010 Nutr Res Lipase inhibitor orlistat decreases incorporation of eicosapentaenoic and docosahexaenoic acids in rat tissues.
2009 Diabetes Obes Metab Effect of antiobesity medications in patients with type 2 diabetes mellitus.
2008 Int J Clin Pharmacol Ther Pharmacodynamic equivalence of two orlistat capsule formulations in healthy volunteers under fed conditions.
2007 Vasc Health Risk Manag Obesity management: update on orlistat.
2008 Drug Saf Orlistat-associated adverse effects and drug interactions: a critical review.
2007 Curr Opin Clin Nutr Metab... Lipases and lipolysis in the human digestive tract: where do we stand?
2006 Nov Biochemistry Use of an inhibitor to identify members of the hormone-sensitive lipase family.
2006 Biochim Biophys Acta Exploring the specific features of interfacial enzymology based on lipase studies.
2005 May JOP Does the pancreas really produce much more lipase than required for fat digestion?
2005 Mar Anal Biochem Discrimination between closed and open forms of lipases using electrophoretic techniques.
2004 Mar Chemistry Sterically hindered triacylglycerol analogues as potent inhibitors of human digestive lipases.
2003 Jan Chembiochem Novel trifluoromethyl ketones as potent gastric lipase inhibitors.
2003 Jan Biochem Pharmacol Effects of glycolipids from spinach on mammalian DNA polymerases.
2002 Clin Nutr Degree of in vivo inhibition of human gastric and pancreatic lipases by Orlistat (Tetrahydrolipstatin, THL) in the stomach and small intestine.
2001 Drugs Orlistat: in the prevention and treatment of type 2 diabetes mellitus.
2000 Heart Dis Orlistat.
2002 Jan J Biol Chem Crystal structure of the open form of dog gastric lipase in complex with a phosphonate inhibitor.
2001 Feb J Org Chem Bis-2-oxo amide triacylglycerol analogues: a novel class of potent human gastric lipase inhibitors.
2001 Am J Physiol Gastrointest... Inhibition of gastrointestinal lipolysis by Orlistat during digestion of test meals in healthy volunteers.
2000 Nov Chemistry Synthesis of 2-Oxo amide triacylglycerol analogues and study of their inhibition effect on pancreatic and gastric lipases.
2000 Pharmacotherapy Orlistat, a new lipase inhibitor for the management of obesity.
1999 Chem Phys Lipids Inhibition of human gastric and pancreatic lipases by chiral alkylphosphonates. A kinetic study with 1,2-didecanoyl-sn-glycerol monolayer.
1999 Nov Biochim Biophys Acta Gastric lipase: crystal structure and activity.
1999 Jun J Biol Chem Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest.
1998 Pancreas Pancreatic dysfunction and treatment options.
1997 Am J Physiol Role of lipase in the regulation of upper gastrointestinal function in humans.
1997 Int J Obes Relat Metab Di... Mode of action of orlistat.
1996 Dig Dis Sci Influence of orlistat on the regulation of gallbladder contraction in man: a randomized double-blind placebo-controlled crossover study.
1996 J Pediatr Gastroenterol Nutr Twenty-four hour ambulatory gastric and duodenal pH profiles in cystic fibrosis: effect of duodenal hyperacidity on pancreatic enzyme function and fat absorption.
1996 J Clin Lab Anal Plasma alpha 2-macroglobulin-trypsin complexlike stance (MTLS) in pancreatic disease.
1995 Obes Res Lipase inhibition and hormonal status, body composition and gastrointestinal processing of a liquid high-fat mixed meal in moderately obese jects.
1994 Pharm Res Synthesis and in vitro study of a diglyceride prodrug of a peptide.
1994 Am J Physiol Control of canine gastric emptying of fat by lipolytic products.
1994 Eur J Clin Pharmacol The effect of the gastrointestinal lipase inhibitor, orlistat, on serum lipids and lipoproteins in patients with primary hyperlipidaemia.
1993 Aliment Pharmacol Ther Does lansoprazole influence postprandial digestive function?
1993 Dig Dis Sci Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.
1993 Int J Obes Relat Metab Di... Lipase inhibition: a novel concept in the treatment of obesity.
1991 Oct Biochim Biophys Acta Inactivation of pancreatic and gastric lipases by THL and C12:0-TNB: a kinetic study with emulsified tributyrin.
1989 Feb Biochim Biophys Acta Effects of tetrahydrolipstatin, a lipase inhibitor, on absorption of fat from the intestine of the rat.
1988 Oct Biochim Biophys Acta Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin.
1988 Am J Physiol Changes in pattern of enzyme secretion by rat pancreas during repeated trypsin inhibitor treatment.
1988 J Nutr Effects of camostat, a synthetic protease inhibitor, on endocrine and exocrine pancreas of the rat.
1979 Vopr Pitan [Effect of the alimentary factor on certain indices of the functional state of the pancreas in young peptic ulcer patients and atrophic gastritis patients].